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Conserved domains on  [gi|1887789577|ref|NP_057722|]
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ADP-ribosylation factor-like protein 6-interacting protein 4 isoform 2 [Homo sapiens]

Protein Classification

SR-25 domain-containing protein( domain architecture ID 12106432)

SR-25 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR-25 pfam10500
Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation ...
 31-216 2.74e-62

Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.


:

Pssm-ID: 463119  Cd Length: 226  Bit Score: 193.59  E-value: 2.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  31 DTSRNCSASTSQ-----------ERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKK-----RGKYKDKRRK 94
Cdd:pfam10500  26 SSRRSCSASPSQghkasstsnkeERSKEKKKRKRRRSSSSSSSSSSSSSSSSSSSSSSSSSGRKKrgkhkDKKRKKKKKK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  95 KKKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETG 174
Cdd:pfam10500 106 KRKKKLKKKGKEKAKAAAQQAEALPGPSLDQWQREAGEE-HGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETG 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1887789577 175 RTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGL 216
Cdd:pfam10500 185 RTRLIKGDGEVLEEIVSKERHKEINKQATRGDGLAFQMRAGL 226
 
Name Accession Description Interval E-value
SR-25 pfam10500
Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation ...
 31-216 2.74e-62

Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.


Pssm-ID: 463119  Cd Length: 226  Bit Score: 193.59  E-value: 2.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  31 DTSRNCSASTSQ-----------ERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKK-----RGKYKDKRRK 94
Cdd:pfam10500  26 SSRRSCSASPSQghkasstsnkeERSKEKKKRKRRRSSSSSSSSSSSSSSSSSSSSSSSSSGRKKrgkhkDKKRKKKKKK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  95 KKKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETG 174
Cdd:pfam10500 106 KRKKKLKKKGKEKAKAAAQQAEALPGPSLDQWQREAGEE-HGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETG 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1887789577 175 RTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGL 216
Cdd:pfam10500 185 RTRLIKGDGEVLEEIVSKERHKEINKQATRGDGLAFQMRAGL 226
 
Name Accession Description Interval E-value
SR-25 pfam10500
Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation ...
 31-216 2.74e-62

Nuclear RNA-splicing-associated protein; SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localization signals strongly implies that this is a nuclear protein that may contribute to RNA splicing. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway.


Pssm-ID: 463119  Cd Length: 226  Bit Score: 193.59  E-value: 2.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  31 DTSRNCSASTSQ-----------ERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKK-----RGKYKDKRRK 94
Cdd:pfam10500  26 SSRRSCSASPSQghkasstsnkeERSKEKKKRKRRRSSSSSSSSSSSSSSSSSSSSSSSSSGRKKrgkhkDKKRKKKKKK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1887789577  95 KKKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEeDGPVLTDEQKSRIQAMKPMTKEEWDARQSIIRKVVDPETG 174
Cdd:pfam10500 106 KRKKKLKKKGKEKAKAAAQQAEALPGPSLDQWQREAGEE-HGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETG 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1887789577 175 RTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGL 216
Cdd:pfam10500 185 RTRLIKGDGEVLEEIVSKERHKEINKQATRGDGLAFQMRAGL 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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