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Conserved domains on  [gi|148612795|ref|NP_055668|]
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small G protein signaling modulator 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
18-197 7.48e-126

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


:

Pssm-ID: 439066  Cd Length: 180  Bit Score: 380.43  E-value: 7.48e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAE 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   98 GRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVG 177
Cdd:cd17704    81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVG 160
                         170       180
                  ....*....|....*....|
gi 148612795  178 PCALEYTKLKTADHYWTDPS 197
Cdd:cd17704   161 PCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
256-424 3.32e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 310.03  E-value: 3.32e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  256 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 329
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  330 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 408
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 148612795  409 GTGRATDYVFRIIYPG 424
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
839-1007 2.06e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540  Cd Length: 216  Bit Score: 154.39  E-value: 2.06e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    839 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 915
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    916 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 993
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 148612795    994 FIALALVEAYREII 1007
Cdd:smart00164  202 RVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
18-197 7.48e-126

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 380.43  E-value: 7.48e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAE 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   98 GRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVG 177
Cdd:cd17704    81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVG 160
                         170       180
                  ....*....|....*....|
gi 148612795  178 PCALEYTKLKTADHYWTDPS 197
Cdd:cd17704   161 PCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
256-424 3.32e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 310.03  E-value: 3.32e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  256 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 329
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  330 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 408
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 148612795  409 GTGRATDYVFRIIYPG 424
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
DUF3548 pfam12068
Domain of unknown function (DUF3548); This presumed domain is functionally uncharacterized. ...
257-392 1.05e-50

Domain of unknown function (DUF3548); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 184 to 216 amino acids in length. This domain is found associated with pfam00566. This domain is found at the N-terminus of GYP7 proteins.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   257 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 325
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148612795   326 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 392
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
839-1007 2.06e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540  Cd Length: 216  Bit Score: 154.39  E-value: 2.06e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    839 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 915
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    916 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 993
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 148612795    994 FIALALVEAYREII 1007
Cdd:smart00164  202 RVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
838-1007 9.42e-31

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 425753 [Multi-domain]  Cd Length: 216  Bit Score: 120.55  E-value: 9.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   838 NLHRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR----- 911
Cdd:pfam00566   46 TESQIRKDVPRTFPHSFFFDnGPGQNSLRRILKAYSNYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrd 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   912 -MSQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHissEH 990
Cdd:pfam00566  126 fYTPDFPG---LKRDFYVFEELLKKYDPKLYKHLKELG-LDPDLFASQWFLTLFSREFPLSTVLRIWDYFLLEGE---KF 198
                          170
                   ....*....|....*..
gi 148612795   991 FVLFIALALVEAYREII 1007
Cdd:pfam00566  199 VLFRVALAILKRFREEL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
42-189 6.59e-29

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 426965  Cd Length: 136  Bit Score: 112.40  E-value: 6.59e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    42 ALCGAVEACLLHQLRRRA-----------AGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAegrkpsgvsqealr 110
Cdd:pfam02759    1 SLCAALEALLSHGLKRKAlsaslsliegyYGLLPERSFWDLLERVGKLVPPAEELLSSVQALEQIH-------------- 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   111 rqgsasgkapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLK 187
Cdd:pfam02759   67 ------------TSDGRGRAWIRLALNEKLLEQWLNLLLSNKellSKYYEPWALLRDPEFVEILLGLLVGLSALDFNLCL 134

                   ..
gi 148612795   188 TA 189
Cdd:pfam02759  135 DL 136
COG5210 COG5210
GTPase-activating protein [General function prediction only];
839-1050 2.77e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 95.64  E-value: 2.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  839 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 913
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  914 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 992
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 148612795  993 LFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIEN 1050
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN smart00593
domain involved in Ras-like GTPase signaling;
128-184 9.05e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 66.87  E-value: 9.05e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    128 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 184
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
18-197 7.48e-126

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 380.43  E-value: 7.48e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAE 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   98 GRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVG 177
Cdd:cd17704    81 GRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVG 160
                         170       180
                  ....*....|....*....|
gi 148612795  178 PCALEYTKLKTADHYWTDPS 197
Cdd:cd17704   161 PCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
256-424 3.32e-99

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 310.03  E-value: 3.32e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  256 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 329
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  330 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 408
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160
                         170
                  ....*....|....*.
gi 148612795  409 GTGRATDYVFRIIYPG 424
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
18-197 8.89e-99

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 308.86  E-value: 8.89e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAE 97
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   98 GRKPSG-VSQEALRRqgsaSGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLV 176
Cdd:cd17703    81 NKRNQMqGLQENVRK----MPKLPNLSPQAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLV 156
                         170       180
                  ....*....|....*....|.
gi 148612795  177 GPCALEYTKLKTADHYWTDPS 197
Cdd:cd17703   157 GPCALEYTKMKTADHFWTDPS 177
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
18-185 4.84e-82

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 263.38  E-value: 4.84e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAE 97
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   98 GRKPSGVSqealrrqGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVG 177
Cdd:cd17687    81 NKRSSSSS-------GSNSSNSHGNSSSNRKILWIRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLLVG 153

                  ....*...
gi 148612795  178 PCALEYTK 185
Cdd:cd17687   154 PCALDYTK 161
DUF3548 pfam12068
Domain of unknown function (DUF3548); This presumed domain is functionally uncharacterized. ...
257-392 1.05e-50

Domain of unknown function (DUF3548); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 184 to 216 amino acids in length. This domain is found associated with pfam00566. This domain is found at the N-terminus of GYP7 proteins.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   257 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 325
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148612795   326 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFP 392
Cdd:pfam12068   81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
839-1007 2.06e-42

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540  Cd Length: 216  Bit Score: 154.39  E-value: 2.06e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    839 LHRIDKDVQRCDRNYWYFT---PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQN 915
Cdd:smart00164   47 VHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKLMERYGPN 126
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    916 F--PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYfCYRWFLLDFKRELLYEDVFAVWEVIWAARHisseHFVL 993
Cdd:smart00164  127 FylPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPLEIVLRIWDVLFAEGS----DFLF 201
                           170
                    ....*....|....
gi 148612795    994 FIALALVEAYREII 1007
Cdd:smart00164  202 RVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
838-1007 9.42e-31

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 425753 [Multi-domain]  Cd Length: 216  Bit Score: 120.55  E-value: 9.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   838 NLHRIDKDVQRCDRNYWYFT-PPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKR----- 911
Cdd:pfam00566   46 TESQIRKDVPRTFPHSFFFDnGPGQNSLRRILKAYSNYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENyllrd 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   912 -MSQNFPNggaMDTHFANMRSLIQILDSELFELMHQNGdYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHissEH 990
Cdd:pfam00566  126 fYTPDFPG---LKRDFYVFEELLKKYDPKLYKHLKELG-LDPDLFASQWFLTLFSREFPLSTVLRIWDYFLLEGE---KF 198
                          170
                   ....*....|....*..
gi 148612795   991 FVLFIALALVEAYREII 1007
Cdd:pfam00566  199 VLFRVALAILKRFREEL 215
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
42-189 6.59e-29

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 426965  Cd Length: 136  Bit Score: 112.40  E-value: 6.59e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    42 ALCGAVEACLLHQLRRRA-----------AGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAegrkpsgvsqealr 110
Cdd:pfam02759    1 SLCAALEALLSHGLKRKAlsaslsliegyYGLLPERSFWDLLERVGKLVPPAEELLSSVQALEQIH-------------- 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   111 rqgsasgkapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLK 187
Cdd:pfam02759   67 ------------TSDGRGRAWIRLALNEKLLEQWLNLLLSNKellSKYYEPWALLRDPEFVEILLGLLVGLSALDFNLCL 134

                   ..
gi 148612795   188 TA 189
Cdd:pfam02759  135 DL 136
COG5210 COG5210
GTPase-activating protein [General function prediction only];
839-1050 2.77e-20

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 95.64  E-value: 2.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  839 LHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMK--RMS 913
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKnyGLP 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  914 QNF-PNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFyFCYRWFLLDFKRELLYEDVFAVWEVIWAarHISSEHFV 992
Cdd:COG5210   337 GYFlKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL--EGSSMLFQ 413
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 148612795  993 LFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIEN 1050
Cdd:COG5210   414 LALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGTDRDILLFIED 471
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
18-181 5.16e-16

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 76.31  E-value: 5.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   18 KEVKQIMEEAVTRK--------FVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDkmaalftkvgktcpvageICHKV 89
Cdd:cd17671     1 KAVKELLESFADNGeaddsaalTLTDDDPVVGRLCAALEAILSHGLKPKRFGGGKVS------------------FWDFL 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   90 QELQQQAEGRKPSGVSQEA--LRRQGSASGKApalspqalkHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLAD 164
Cdd:cd17671    63 EALEKLLPAPSLKQAIRDInsLSNVKTDDGRG---------RAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLRD 133
                         170
                  ....*....|....*..
gi 148612795  165 PVFGPILASLLVGPCAL 181
Cdd:cd17671   134 PEEAELFLSLLVGLSSL 150
RUN smart00593
domain involved in Ras-like GTPase signaling;
128-184 9.05e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 66.87  E-value: 9.05e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    128 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 184
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
262-367 8.24e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 47.78  E-value: 8.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795  262 KNHVLVQPKEDMEAVPGYLSLHQSaeslTLKWTPNQLMngtlgdseleksvywDYALVVPFSQVVCIHCHQQ-KSGGTLV 340
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDG---------------GLELSIPISDIVNVNVSPQgPSSRYLV 62
                          90       100
                  ....*....|....*....|....*..
gi 148612795  341 LVSQDGIQRPPLHFPQGGHLLSFLSCL 367
Cdd:cd00900    63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
9-177 9.07e-04

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 41.04  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795    9 KEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHI-IALCGAVEACLLHQLR----RRAAGFLRSDkMAALFTKVgkTCPVAG 83
Cdd:cd17679     1 KKSLTKELSSSVKELQLEYVSSDEVVTSSDDGaNTLCCVLEAIFLHGLKdkfiSKVSSVFSGD-VDKLPEPN--FWPLLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   84 EICHK--VQELQQqaegrkpsgvsqeaLRRQGSASGKAPAlspqalkhvWVRTALIEKVLDkvvQYLA------ENCSKY 155
Cdd:cd17679    78 KFSHRdvIDQIEH--------------LSQITTDVGRCRA---------WIRLALNDGLLE---SYLEailkdkSALKSY 131
                         170       180
                  ....*....|....*....|..
gi 148612795  156 YEKEALLADPVFGPILASLLVG 177
Cdd:cd17679   132 YNPSAFLRDPEQLDILKSLLQG 153
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
47-177 3.21e-03

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 39.21  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   47 VEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELqqqaegrkpsgvsqealrrqgsasgkaPAL-SPQ 125
Cdd:cd17696    41 MEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDL---------------------------PGLkTPV 93
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148612795  126 ALKHVWVRTALIEKVLDKVVQYL---AENCSKYYEKEALLADPVfGPILASLLVG 177
Cdd:cd17696    94 GRGRAWLRLALMQKKLSEYMKALinrKDLLSEFYEPNALMMEEE-GAIIAGLLVG 147
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
35-175 3.62e-03

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 39.13  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612795   35 EDSSHIIALCGAVEACLLHQLRRRAAGFLRS----DKMAALfTKVGKTCPVAGEIChkVQELQQQAEGRkpsgvsqealr 110
Cdd:cd17682    19 PDNPYLRPFCETLEKILRKGLKEKVSLGGRRkdywDWLEEL-LKKLNKIPKSLSDA--VKFVKSCKKVK----------- 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148612795  111 rqgSASGKAPALspqalkhvwVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLL 175
Cdd:cd17682    85 ---TNQGRGRLF---------IRYALNKKCLHDPVQQLVKNpklLSDYYSPDSILGNEILSEILLSLL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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