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Conserved domains on  [gi|7657461|ref|NP_055404|]
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group IIE secretory phospholipase A2 precursor [Homo sapiens]

Protein Classification

phospholipase A2 family protein( domain architecture ID 10062756)

phospholipase A2 (PLA2) family protein such as PLA2 that catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLA2c cd00125
PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca ...
 20-135 5.09e-53

PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.


:

Pssm-ID: 153091  Cd Length: 115  Bit Score: 163.19  E-value: 5.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461   20 NLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAG-R 98
Cdd:cd00125   1 NLLQFGKMIKCTTGRSALDYNGYGCYCGLGGSGTPVDDTDRCCQVHDCCYDRAEKGGCSPYFTSYSYTCSDGQITCSDaN 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7657461   99 TTCQRLTCECDKRAALCFRRNLgtYNRKYAHYPNKLC 135
Cdd:cd00125  81 DKCARALCECDRAAALCFARAP--YNPKYRNYDKKRC 115
 
Name Accession Description Interval E-value
PLA2c cd00125
PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca ...
 20-135 5.09e-53

PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.


Pssm-ID: 153091  Cd Length: 115  Bit Score: 163.19  E-value: 5.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461   20 NLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAG-R 98
Cdd:cd00125   1 NLLQFGKMIKCTTGRSALDYNGYGCYCGLGGSGTPVDDTDRCCQVHDCCYDRAEKGGCSPYFTSYSYTCSDGQITCSDaN 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7657461   99 TTCQRLTCECDKRAALCFRRNLgtYNRKYAHYPNKLC 135
Cdd:cd00125  81 DKCARALCECDRAAALCFARAP--YNPKYRNYDKKRC 115
Phospholip_A2_1 pfam00068
Phospholipase A2; Phospholipase A2 releases fatty acids from the second carbon group of ...
 21-127 1.06e-49

Phospholipase A2; Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.


Pssm-ID: 459659  Cd Length: 108  Bit Score: 154.30  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461     21 LVQFGVMIEKMTGK-SALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGC-EPKLEKYLFSVSERGIFCAGR 98
Cdd:pfam00068   1 LWQFGEMIKCTTGRnPPLDYNDYGCYCGLGGSGTPVDATDRCCQAHDCCYERLKKLGCgNPYLLSYNYSCSDGTITCSGN 80

                          90       100
                  ....*....|....*....|....*....
gi 7657461     99 TTCQRLTCECDKRAALCFRRNlgTYNRKY 127
Cdd:pfam00068  81 SSCEKQLCECDKAAAECFARA--TYNKKY 107
PA2c smart00085
Phospholipase A2;
20-135 2.88e-40

Phospholipase A2;


Pssm-ID: 214508  Cd Length: 117  Bit Score: 130.79  E-value: 2.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461      20 NLVQFGVMIEKMTGKSA-LQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAG- 97
Cdd:smart00085   1 NLWQFGNMIQCATGKRAwLSYGDYGCYCGWGGSGTPVDATDRCCFVHDCCYGKAEKEGCNPKTTTYSYSCDNGFITCGGk 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 7657461      98 RTTCQRLTCECDKRAALCFRRNLgtYNRK-YAHYPNKLC 135
Cdd:smart00085  81 NTACLVFVCECDRAAAICFAKNP--YNKKnYNIDTKKRC 117
 
Name Accession Description Interval E-value
PLA2c cd00125
PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca ...
 20-135 5.09e-53

PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.


Pssm-ID: 153091  Cd Length: 115  Bit Score: 163.19  E-value: 5.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461   20 NLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAG-R 98
Cdd:cd00125   1 NLLQFGKMIKCTTGRSALDYNGYGCYCGLGGSGTPVDDTDRCCQVHDCCYDRAEKGGCSPYFTSYSYTCSDGQITCSDaN 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7657461   99 TTCQRLTCECDKRAALCFRRNLgtYNRKYAHYPNKLC 135
Cdd:cd00125  81 DKCARALCECDRAAALCFARAP--YNPKYRNYDKKRC 115
Phospholip_A2_1 pfam00068
Phospholipase A2; Phospholipase A2 releases fatty acids from the second carbon group of ...
 21-127 1.06e-49

Phospholipase A2; Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.


Pssm-ID: 459659  Cd Length: 108  Bit Score: 154.30  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461     21 LVQFGVMIEKMTGK-SALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGC-EPKLEKYLFSVSERGIFCAGR 98
Cdd:pfam00068   1 LWQFGEMIKCTTGRnPPLDYNDYGCYCGLGGSGTPVDATDRCCQAHDCCYERLKKLGCgNPYLLSYNYSCSDGTITCSGN 80

                          90       100
                  ....*....|....*....|....*....
gi 7657461     99 TTCQRLTCECDKRAALCFRRNlgTYNRKY 127
Cdd:pfam00068  81 SSCEKQLCECDKAAAECFARA--TYNKKY 107
PA2c smart00085
Phospholipase A2;
20-135 2.88e-40

Phospholipase A2;


Pssm-ID: 214508  Cd Length: 117  Bit Score: 130.79  E-value: 2.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461      20 NLVQFGVMIEKMTGKSA-LQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAG- 97
Cdd:smart00085   1 NLWQFGNMIQCATGKRAwLSYGDYGCYCGWGGSGTPVDATDRCCFVHDCCYGKAEKEGCNPKTTTYSYSCDNGFITCGGk 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 7657461      98 RTTCQRLTCECDKRAALCFRRNLgtYNRK-YAHYPNKLC 135
Cdd:smart00085  81 NTACLVFVCECDRAAAICFAKNP--YNKKnYNIDTKKRC 117
PLA2_like cd00618
PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are ...
 40-119 2.88e-21

PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.


Pssm-ID: 153092  Cd Length: 83  Bit Score: 81.46  E-value: 2.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461   40 NDYGCYCGIGGS----HWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERgIFCAGRTTCQRLTCECDKRAALC 115
Cdd:cd00618   1 LPYGCYCGPGGSacpsGQPVDETDRCCRKHDCCYDQISDGGCCDGCLSYSFSEGGV-TCLTNSDLCTRSHCDCDRRLAIC 79


                ....
gi 7657461  116 FRRN 119
Cdd:cd00618  80 LARA 83
otoconin_90 cd04707
otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal ...
 23-140 2.11e-14

otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The PLA2-like domains in otoconins may have lost their metal-binding sites.


Pssm-ID: 153096  Cd Length: 117  Bit Score: 64.80  E-value: 2.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657461   23 QFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGC--EPKLEKYLFSVSERgIFCAGRTT 100
Cdd:cd04707   1 QLGEMLKCLTGRCPREFEDYGCYCGQEGEGLPVDELDRCCFQHRCCLEQASEMGClqDRKLSTEVTCVDHK-PKCEGVSV 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 7657461  101 CQRLTCECDKRAALCFRRNLgtYNRKYAHYPNKLCTGPTP 140
Cdd:cd04707  80 CEKLLCTCDKTAAECMAAAH--FNSSLNSLDVSSCPGQVP 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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