NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2168696588|ref|NP_037205|]
View 

protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform b [Rattus norvegicus]

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 12014395)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
66-274 1.10e-112

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 323.55  E-value: 1.10e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  66 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 141
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 142 DVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGFAEEAPYDAIHVGAAAP 221
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168696588 222 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSVKMKPLMGVIYVPL 274
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
66-274 1.10e-112

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 323.55  E-value: 1.10e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  66 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 141
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 142 DVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGFAEEAPYDAIHVGAAAP 221
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168696588 222 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSVKMKPLMGVIYVPL 274
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 62-281 5.84e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 225.48  E-value: 5.84e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  62 KSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEG 137
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 138 AKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVG 217
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVT 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168696588 218 AAAPVVPQALIDQLKPGGRLILPVGPagGNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKEKQW 281
Cdd:TIGR00080 154 AAGPKIPEALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 70-278 6.15e-53

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 171.74  E-value: 6.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  70 ELIHNLRKNGIIKTDKVFEVMLATDR----SHYAKSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGS 145
Cdd:PRK13942    8 RVIEELIREGYIKSKKVIDALLKVPRhlfvPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 146 GSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPVVPQ 225
Cdd:PRK13942   86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168696588 226 ALIDQLKPGGRLILPVGPAggNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKE 278
Cdd:PRK13942  161 PLIEQLKDGGIMVIPVGSY--SQELIRVEK-DNGKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 75-275 6.85e-52

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 168.34  E-value: 6.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  75 LRKNGIiKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGIL 150
Cdd:COG2518     4 LRPRGV-TDPRVLDAMRAVPRELFVpealRELAYADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTGSGYQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 151 TACFARMVGHsgkVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPVVPQALIDQ 230
Cdd:COG2518    81 AAVLARLAGR---VYSVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQ 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2168696588 231 LKPGGRLILPVGPaGGNQMLEQYDKLQDGsVKMKPLMGVIYVPLT 275
Cdd:COG2518   153 LAPGGRLVAPVGE-GGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 139-241 3.12e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.81  E-value: 3.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 139 KALDVGSGSGILTACFARmvGHSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMG-FAEEAPYDAIHVG 217
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2168696588 218 AAAPVV---PQALIDQ----LKPGGRLILPV 241
Cdd:cd02440    74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
66-274 1.10e-112

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 323.55  E-value: 1.10e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  66 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 141
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVpesfKSYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 142 DVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGFAEEAPYDAIHVGAAAP 221
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168696588 222 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSVKMKPLMGVIYVPL 274
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 62-281 5.84e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 225.48  E-value: 5.84e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  62 KSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEG 137
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 138 AKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVG 217
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVT 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168696588 218 AAAPVVPQALIDQLKPGGRLILPVGPagGNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKEKQW 281
Cdd:TIGR00080 154 AAGPKIPEALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 70-278 6.15e-53

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 171.74  E-value: 6.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  70 ELIHNLRKNGIIKTDKVFEVMLATDR----SHYAKSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGS 145
Cdd:PRK13942    8 RVIEELIREGYIKSKKVIDALLKVPRhlfvPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 146 GSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPVVPQ 225
Cdd:PRK13942   86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168696588 226 ALIDQLKPGGRLILPVGPAggNQMLEQYDKlQDGSVKMKPLMGVIYVPLTDKE 278
Cdd:PRK13942  161 PLIEQLKDGGIMVIPVGSY--SQELIRVEK-DNGKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 75-275 6.85e-52

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 168.34  E-value: 6.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  75 LRKNGIiKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSGSGIL 150
Cdd:COG2518     4 LRPRGV-TDPRVLDAMRAVPRELFVpealRELAYADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTGSGYQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 151 TACFARMVGHsgkVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPVVPQALIDQ 230
Cdd:COG2518    81 AAVLARLAGR---VYSVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQ 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2168696588 231 LKPGGRLILPVGPaGGNQMLEQYDKLQDGsVKMKPLMGVIYVPLT 275
Cdd:COG2518   153 LAPGGRLVAPVGE-GGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
71-278 1.66e-46

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 154.98  E-value: 1.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  71 LIHNLRKNGIiKTDKVFEVMLATDRS--------HYAksnpYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALD 142
Cdd:PRK00312   12 LVLRLRAEGI-LDERVLEAIEATPRElfvpeafkHKA----YENRALPIGCGQTISQPYMVARMTELL--ELKPGDRVLE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 143 VGSGSGILTACFARMVGHsgkVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPV 222
Cdd:PRK00312   85 IGTGSGYQAAVLAHLVRR---VFSVERIKTLQWEAKRRLKQ-----LGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168696588 223 VPQALIDQLKPGGRLILPVGpaGGNQMLEQYDKLQDGSVKMKPLMGVIYVPLTDKE 278
Cdd:PRK00312  157 IPRALLEQLKEGGILVAPVG--GEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGE 210
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 71-274 3.73e-33

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 120.30  E-value: 3.73e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  71 LIHNLRKNGIIKTDKVFEVMLATDRSHYA----KSNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSG 146
Cdd:PRK13944    5 LVEELVREGIIKSERVKKAMLSVPREEFVmpeyRMMAYEDRPLPLFAGATISAPHMVAMMCELI--EPRPGMKILEVGTG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 147 SGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmLLSSGRVRLVVGDGRMGFAEEAPYDAIHVGAAAPVVPQA 226
Cdd:PRK13944   83 SGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIER----LGYWGVVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2168696588 227 LIDQLKPGGRLILPVGPAGGnQMLEQYDKLQDGsVKMKPLMGVIYVPL 274
Cdd:PRK13944  159 LVRQLKDGGVLVIPVEEGVG-QVLYKVVKRGEK-VEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 69-241 1.66e-20

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 90.12  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  69 SELIHNLRKNGIIKTDKVFEVMLATDRSHYAKSNP----YM----------DSPQSIgfqATISAPHMHAYALELLfdQL 134
Cdd:TIGR04364   6 AALVDELREDGVIRSPRVEAAFRTVPRHLFAPGAPlekaYAanravvtkrdEDGRAL---SSVSAPHIQAMMLEQA--GV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 135 HEGAKALDVGSGsGILTACFARMVGHSGKVIGIDHIKELVDdsitnvkKDDPMLLSSG--RVRLVVGDGRMGFAEEAPYD 212
Cdd:TIGR04364  81 EPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTD-------RARACLAAAGypQVTVVLADAEAGVPELAPYD 152

                         170       180
                  ....*....|....*....|....*....
gi 2168696588 213 AIHVGAAAPVVPQALIDQLKPGGRLILPV 241
Cdd:TIGR04364 153 RIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 64-241 1.58e-19

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 86.44  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588  64 GGASHSELIHNLRKNGIikTDKVFEVMLATDRS-----HYAKSNPYMD----SPQSIGFQATISAPHMHAYALELLfdQL 134
Cdd:PRK13943    3 EFFMREKLFWILKKYGI--SDHIAKAFLEVPREefltkSYPLSYVYEDivlvSYDDGEEYSTSSQPSLMALFMEWV--GL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 135 HEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRMGFAEEAPYDAI 214
Cdd:PRK13943   79 DKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR-----LGIENVIFVCGDGYYGVPEFAPYDVI 153

                         170       180
                  ....*....|....*....|....*..
gi 2168696588 215 HVGAAAPVVPQALIDQLKPGGRLILPV 241
Cdd:PRK13943  154 FVTVGVDEVPETWFTQLKEGGRVIVPI 180
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 134-238 4.16e-12

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 64.41  E-value: 4.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 134 LHEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmLLSSGRVRLVVGDGRMGFAEEaPYDA 213
Cdd:COG2519    89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER----FGLPDNVELKLGDIREGIDEG-DVDA 163

                          90       100
                  ....*....|....*....|....*..
gi 2168696588 214 IHVGAAAP--VVPQAlIDQLKPGGRLI 238
Cdd:COG2519   164 VFLDMPDPweALEAV-AKALKPGGVLV 189
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 134-246 4.44e-10

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 59.68  E-value: 4.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 134 LHEGAKALDVGSGSGILTACFARMVGhsgkvigidhikelvDDSITNVKKDdPMLLSSGRVRL---------VVGDGRMG 204
Cdd:TIGR04188 105 VEDGHRVLEIGTGTGYSAALLCHRLG---------------DDNVTSVEVD-PGLAARAASALaaagyaptvVTGDGLLG 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2168696588 205 FAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVG---PAGG 246
Cdd:TIGR04188 169 HPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLSgwlYGGG 213
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 128-239 4.50e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.18  E-value: 4.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 128 ELLFDQLHEGAKALDVGSGSGILTACFARMvGHsgKVIGIDhikeLVDDSITNVKKddpmLLSSGRVRLVVGDGR-MGFA 206
Cdd:COG2227    16 ALLARLLPAGGRVLDVGCGTGRLALALARR-GA--DVTGVD----ISPEALEIARE----RAAELNVDFVQGDLEdLPLE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2168696588 207 EEaPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 239
Cdd:COG2227    85 DG-SFDLVicsevleHLPDPAALL-RELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
136-239 1.42e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 136 EGAKALDVGSGSGILTACFARMVGHsGKVIGIDhikeLVDDSITNVKKDDPmllssgRVRLVVGDGRmGFAEEAPYDAIH 215
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPG-ARVTGVD----LSPEMLARARARLP------NVRFVVADLR-DLDPPEPFDLVV 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 2168696588 216 VGAA------APVVPQALIDQLKPGGRLIL 239
Cdd:COG4106    69 SNAAlhwlpdHAALLARLAAALAPGGVLAV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 126-239 1.90e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 55.32  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 126 ALELLFD--QLHEGAKALDVGSGSGILTACFARMVGHsgKVIGID-------HIKELVDDsitnvkkddpmLLSSGRVRL 196
Cdd:COG2230    39 KLDLILRklGLKPGMRVLDIGCGWGGLALYLARRYGV--RVTGVTlspeqleYARERAAE-----------AGLADRVEV 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2168696588 197 VVGDGRmGFAEEAPYDAI-------HVGAAA-PVVPQALIDQLKPGGRLIL 239
Cdd:COG2230   106 RLADYR-DLPADGQFDAIvsigmfeHVGPENyPAYFAKVARLLKPGGRLLL 155
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
127-239 3.02e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 56.72  E-value: 3.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 127 LELLFDQLHEGAKALDVGSGSGILtACFARMVGHsGKVIGIDhIKEL-VDDSITNVKKDDpmllSSGRVRLVVGDGRmgf 205
Cdd:COG2264   139 LEALEKLLKPGKTVLDVGCGSGIL-AIAAAKLGA-KRVLAVD-IDPVaVEAARENAELNG----VEDRIEVVLGDLL--- 208

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2168696588 206 aEEAPYDAIhVgA---AAPVVPQA--LIDQLKPGGRLIL 239
Cdd:COG2264   209 -EDGPYDLV-V-AnilANPLIELApdLAALLKPGGYLIL 244
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 123-239 3.83e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.23  E-value: 3.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 123 HAYALELLfdQLHEGAKALDVGSGSGILTACFARmvgHSGKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDG- 201
Cdd:COG2226    11 REALLAAL--GLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERAAEAGL------NVEFVVGDAe 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2168696588 202 RMGFAEEApYDAIHVGAAAPVVP--QALIDQ----LKPGGRLIL 239
Cdd:COG2226    80 DLPFPDGS-FDLVISSFVLHHLPdpERALAEiarvLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 141-235 5.70e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.57  E-value: 5.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 141 LDVGSGSGILTACFARMVGHsgKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDGR-MGFAEEaPYDAIHVGAA 219
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGA--RVTGVDLSPEMLERARERAAEAGL------NVEFVQGDAEdLPFPDG-SFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 2168696588 220 APVVPQALIDQ--------LKPGG 235
Cdd:pfam13649  73 LHHLPDPDLEAalreiarvLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 126-269 1.61e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.38  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 126 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGHsgKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRM-G 204
Cdd:COG0500    16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFGG--RVIGIDLSPEAIALARARAAK-----AGLGNVEFLVADLAElD 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168696588 205 FAEEAPYDAI-------HVgaaAPVVPQALID----QLKPGGRLILPVGPAGGNQMLEQYDKLQDGSVKMKPLMGV 269
Cdd:COG0500    89 PLPAESFDLVvafgvlhHL---PPEEREALLRelarALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 139-241 3.12e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.81  E-value: 3.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 139 KALDVGSGSGILTACFARmvGHSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMG-FAEEAPYDAIHVG 217
Cdd:cd02440     1 RVLDLGCGTGALALALAS--GPGARVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2168696588 218 AAAPVV---PQALIDQ----LKPGGRLILPV 241
Cdd:cd02440    74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 117-241 3.17e-07

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 48.09  E-value: 3.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 117 ISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGhSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRL 196
Cdd:TIGR02469   2 MTKREVRALTLAKL--RLRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNLRR-----FGVSNIVI 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2168696588 197 VVGDgrmgfAEEAPY------DAIHVGAAA---PVVPQALIDQLKPGGRLILPV 241
Cdd:TIGR02469  74 VEGD-----APEAPEallpdpDAVFVGGSGgllQEILEAVERRLRPGGRIVLNA 122
PRK08317 PRK08317
hypothetical protein; Provisional
 124-239 3.77e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.94  E-value: 3.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 124 AYALELLfdQLHEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDPmllssgRVRLVVGDG-R 202
Cdd:PRK08317    9 ARTFELL--AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGLGP------NVEFVRGDAdG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2168696588 203 MGFAEEApYDAI-------HVGAaapvvPQALIDQ----LKPGGRLIL 239
Cdd:PRK08317   81 LPFPDGS-FDAVrsdrvlqHLED-----PARALAEiarvLRPGGRVVV 122
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 134-239 1.48e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.03  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 134 LHEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDgrmgfAEEAP--- 210
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK-----LGFDNVEFEQGD-----IEELPell 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2168696588 211 ----YD------AIHVGAAAPVVPQALIDQLKPGGRLIL 239
Cdd:pfam13847  71 eddkFDvvisncVLNHIPDPDKVLQEILRVLKPGGRLII 109
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 137-239 6.48e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 137 GAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDdsitNVKKDDPMLLSSGRVRLVVGDgrmgfAEEAPY----- 211
Cdd:PRK00216   52 GDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLA----VGREKLRDLGLSGNVEFVQGD-----AEALPFpdnsf 122

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2168696588 212 DAIHVGAAAPVVPQalIDQ--------LKPGGRL-IL 239
Cdd:PRK00216  123 DAVTIAFGLRNVPD--IDKalremyrvLKPGGRLvIL 157
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 141-239 7.17e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 43.81  E-value: 7.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 141 LDVGSGSGILTACFARMVGHsgkVIGIDHIKELVDDSITNVKKDDpmllssgrVRLVVGDG-RMGFAEEApYDAIHVGAA 219
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR---VTGVDISPEMLELAREKAPREG--------LTFVVGDAeDLPFPDNS-FDLVLSSEV 68

                          90       100
                  ....*....|....*....|....*.
gi 2168696588 220 A---PVVPQAL--IDQ-LKPGGRLIL 239
Cdd:pfam08241  69 LhhvEDPERALreIARvLKPGGILII 94
arsM PRK11873
arsenite methyltransferase;
131-174 8.60e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 46.09  E-value: 8.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2168696588 131 FDQLHEGAKALDVGSGSGIltACF--ARMVGHSGKVIGIDHIKELV 174
Cdd:PRK11873   72 LAELKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEML 115
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 126-241 1.65e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 44.79  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 126 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDPMllssGRVRLVVGDGRMGF 205
Cdd:PRK00377   30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEKFGVL----NNIVLIKGEAPEIL 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2168696588 206 AEEAP-YDAIHVGAAA---PVVPQALIDQLKPGGRLILPV 241
Cdd:PRK00377  106 FTINEkFDRIFIGGGSeklKEIISASWEIIKKGGRIVIDA 145
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
136-238 4.78e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 43.58  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 136 EGAKALDVGSGSGILTACFARMVGHSGKVIGIDhikelVDDSITNVKKDDPMLLSSGRVRLVVGDGRMGFAEEAPYDAIH 215
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLD-----INENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVT 116

                          90       100
                  ....*....|....*....|....*....
gi 2168696588 216 VGAA---APVVPQALIDQ---LKPGGRLI 238
Cdd:pfam01209 117 ISFGlrnFPDYLKVLKEAfrvLKPGGRVV 145
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
127-239 6.25e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 127 LELLFDQLHEGAKALDVGSGSGILtACFARMVGHsGKVIGIDhIKEL-VDDSITNVKKDDpmllssgrVRLVVGDGrmgf 205
Cdd:PRK00517  110 LEALEKLVLPGKTVLDVGCGSGIL-AIAAAKLGA-KKVLAVD-IDPQaVEAARENAELNG--------VELNVYLP---- 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2168696588 206 AEEAPYDAIhVgA---AAPVVpqALIDQ----LKPGGRLIL 239
Cdd:PRK00517  175 QGDLKADVI-V-AnilANPLL--ELAPDlarlLKPGGRLIL 211
PRK14968 PRK14968
putative methyltransferase; Provisional
 128-168 1.30e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2168696588 128 ELLFDQLHE--GAKALDVGSGSGILTACFARMvghSGKVIGID 168
Cdd:PRK14968   13 FLLAENAVDkkGDRVLEVGTGSGIVAIVAAKN---GKKVVGVD 52
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 128-239 1.53e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 41.71  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 128 ELLFDQL--HEGAKALDVGSGSGILTACFARMVGHSgKVIGIDhIKEL-VDDSITNVKKDDPmllssGRVRLVVGDGRMG 204
Cdd:COG2813    39 RLLLEHLpePLGGRVLDLGCGYGVIGLALAKRNPEA-RVTLVD-VNARaVELARANAAANGL-----ENVEVLWSDGLSG 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2168696588 205 FAEEaPYDAI------HVGAAAPV-VPQALIDQ----LKPGGRLIL 239
Cdd:COG2813   112 VPDG-SFDLIlsnppfHAGRAVDKeVAHALIADaarhLRPGGELWL 156
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 133-235 3.23e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.55  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 133 QLHEGAKALDVGSGSGILTACFARMVGHSGKVIGIDHIKELVDDSITNVKKDDpmllSSGRVRLVVGDGR--MGFAEEAP 210
Cdd:COG4122    13 RLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAG----LADRIRLILGDALevLPRLADGP 88

                          90       100
                  ....*....|....*....|....*...
gi 2168696588 211 YDAIHVGAAAPVVP---QALIDQLKPGG 235
Cdd:COG4122    89 FDLVFIDADKSNYPdylELALPLLRPGG 116
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
121-239 4.01e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.37  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 121 HMHAYALELLFDQlhEGAKALDVGSGSGILTACFARMVGHsgkVIGIDHIKELVDdsITNVKKDDpmllssgrVRLVVGD 200
Cdd:COG4976    33 LLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRGYR---LTGVDLSEEMLA--KAREKGVY--------DRLLVAD 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2168696588 201 GRMGFAEEAPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 239
Cdd:COG4976    98 LADLAEPDGRFDLIvaadvltYLGDLAAVF-AGVARALKPGGLFIF 142
PLN02366 PLN02366
spermidine synthase
 184-235 6.06e-04

spermidine synthase


Pssm-ID: 215208 [Multi-domain]  Cd Length: 308  Bit Score: 40.78  E-value: 6.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168696588 184 DDPmllssgRVRLVVGDGR--MGFAEEAPYDAIHVGAAAPVVP-QALIDQ---------LKPGG 235
Cdd:PLN02366  143 DDP------RVNLHIGDGVefLKNAPEGTYDAIIVDSSDPVGPaQELFEKpffesvaraLRPGG 200
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
124-239 4.83e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 37.29  E-value: 4.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 124 AYALELLfdQLHEGAKALDVGSGSG---ILTAC-FARMvghsgKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVG 199
Cdd:PRK08287   21 ALALSKL--ELHRAKHLIDVGAGTGsvsIEAALqFPSL-----QVTAIERNPDALRLIKENRQR-----FGCGNIDIIPG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2168696588 200 DGRMGFAEEApyDAIHVGAAAPVVpQALID----QLKPGGRLIL 239
Cdd:PRK08287   89 EAPIELPGKA--DAIFIGGSGGNL-TAIIDwslaHLHPGGRLVL 129
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 131-239 5.06e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 131 FDQLHEGaKALDVGSGSGILTACFARMVGHsGKVIGIDHIKELVDDSITNVKKDDPMllssgRVRLVVGDGRMGFaEEAP 210
Cdd:pfam05175  27 LPKDLSG-KVLDLGCGAGVLGAALAKESPD-AELTMVDINARALESARENLAANGLE-----NGEVVASDVYSGV-EDGK 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2168696588 211 YDAI------HVG-AAAPVVPQALI----DQLKPGGRLIL 239
Cdd:pfam05175  99 FDLIisnppfHAGlATTYNVAQRFIadakRHLRPGGELWI 138
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 124-239 9.65e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 37.07  E-value: 9.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168696588 124 AYALELLfdQLHEGAKALDVGSGSGILTACFARMVGhSGKVIGIDHIKELVDDSITNVKKddpmlLSSGRVRLVVGDGRM 203
Cdd:COG2242   237 ALTLAKL--ALRPGDVLWDIGAGSGSVSIEAARLAP-GGRVYAIERDPERAALIRANARR-----FGVPNVEVVEGEAPE 308

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2168696588 204 GFAEEAPYDAIHVG---AAAPVVPQALIDQLKPGGRLIL 239
Cdd:COG2242   309 ALADLPDPDAVFIGgsgGNLPEILEACWARLRPGGRLVA 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH