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Conserved domains on  [gi|116292184|ref|NP_031892|]
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delta-like protein 3 precursor [Mus musculus]

Protein Classification

EGF_CA and EGF domain-containing protein( domain architecture ID 10935983)

protein containing domains MNNL, EGF_CA, and EGF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MNNL super family cl06622
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 25-173 1.40e-18

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


The actual alignment was detected with superfamily member pfam07657:

Pssm-ID: 462222  Cd Length: 157  Bit Score: 83.12  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   25 AGVFELQIHSF---------GP--GPGLGTPRSPCnaRGPCRLFFRVCLKPGVSQEATESLCALGAAlSTSVPvytehpG 93
Cdd:pfam07657   1 SGYFELQLLSFenpngrlanGNccDGGRSSSDGQC--RDECDTYFRVCLKEYQANVSPDGPCTFGSG-STPVL------G 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   94 ESAAALPLP-----DGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWEL 168
Cdd:pfam07657  72 GNSFTLPGLlkgsfRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAEL 151


                  ....*
gi 116292184  169 HFSYR 173
Cdd:pfam07657 152 EYSYR 156
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 277-308 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.61e-06
                         10        20        30
                 ....*....|....*....|....*....|..
gi 116292184 277 DGNPCANGGSCSETSGSFECACPRGFYGLRCE 308
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 389-424 6.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 6.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 389 DLDDCA-GRACANGGTCVEGGGSRRCSCALGFGGRDC 424
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.80e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 352 VDRC-SLQPCQNGGLCLDLGHALRCRCRAGFAGPRCE 387
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 314-347 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116292184  314 CADGPCFNGGLCVggeDPDSAYVCHCPPGFQGSN 347
Cdd:pfam00008   1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-463 9.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 9.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 116292184 429 DPCASR-PCAHGGRCYAHFSGLVCACAPGYMGVRCE 463
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 25-173 1.40e-18

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 83.12  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   25 AGVFELQIHSF---------GP--GPGLGTPRSPCnaRGPCRLFFRVCLKPGVSQEATESLCALGAAlSTSVPvytehpG 93
Cdd:pfam07657   1 SGYFELQLLSFenpngrlanGNccDGGRSSSDGQC--RDECDTYFRVCLKEYQANVSPDGPCTFGSG-STPVL------G 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   94 ESAAALPLP-----DGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWEL 168
Cdd:pfam07657  72 GNSFTLPGLlkgsfRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAEL 151


                  ....*
gi 116292184  169 HFSYR 173
Cdd:pfam07657 152 EYSYR 156
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 277-308 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.61e-06
                         10        20        30
                 ....*....|....*....|....*....|..
gi 116292184 277 DGNPCANGGSCSETSGSFECACPRGFYGLRCE 308
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
277-308 3.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.26e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 116292184   277 DGNPCANGGSCSETSGSFECACPRGFY-GLRCE 308
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 276-306 4.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 4.31e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116292184  276 CDGNPCANGGSCSETSGSFECACPRGFYGLR 306
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 389-424 6.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 6.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 389 DLDDCA-GRACANGGTCVEGGGSRRCSCALGFGGRDC 424
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.80e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 352 VDRC-SLQPCQNGGLCLDLGHALRCRCRAGFAGPRCE 387
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 314-347 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116292184  314 CADGPCFNGGLCVggeDPDSAYVCHCPPGFQGSN 347
Cdd:pfam00008   1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 355-385 3.14e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116292184  355 CSLQPCQNGGLCLDLGHALRCRCRAGFAGPR 385
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-349 3.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 3.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 314 CADG-PCFNGGLCVGGEDpdsAYVCHCPPGFQGSNCE 349
Cdd:cd00054    5 CASGnPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-463 9.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 9.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 116292184 429 DPCASR-PCAHGGRCYAHFSGLVCACAPGYMGVRCE 463
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 25-173 1.40e-18

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 83.12  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   25 AGVFELQIHSF---------GP--GPGLGTPRSPCnaRGPCRLFFRVCLKPGVSQEATESLCALGAAlSTSVPvytehpG 93
Cdd:pfam07657   1 SGYFELQLLSFenpngrlanGNccDGGRSSSDGQC--RDECDTYFRVCLKEYQANVSPDGPCTFGSG-STPVL------G 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292184   94 ESAAALPLP-----DGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWEL 168
Cdd:pfam07657  72 GNSFTLPGLlkgsfRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAEL 151


                  ....*
gi 116292184  169 HFSYR 173
Cdd:pfam07657 152 EYSYR 156
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 277-308 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.61e-06
                         10        20        30
                 ....*....|....*....|....*....|..
gi 116292184 277 DGNPCANGGSCSETSGSFECACPRGFYGLRCE 308
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
277-308 3.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.26e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 116292184   277 DGNPCANGGSCSETSGSFECACPRGFY-GLRCE 308
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 276-306 4.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 4.31e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116292184  276 CDGNPCANGGSCSETSGSFECACPRGFYGLR 306
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 389-424 6.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 6.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 389 DLDDCA-GRACANGGTCVEGGGSRRCSCALGFGGRDC 424
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.80e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 1.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 352 VDRC-SLQPCQNGGLCLDLGHALRCRCRAGFAGPRCE 387
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 314-347 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 116292184  314 CADGPCFNGGLCVggeDPDSAYVCHCPPGFQGSN 347
Cdd:pfam00008   1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 355-385 3.14e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116292184  355 CSLQPCQNGGLCLDLGHALRCRCRAGFAGPR 385
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 279-308 3.34e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 3.34e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 116292184 279 NPCANGGSCSETSGSFECACPRGFYG-LRCE 308
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-349 3.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 3.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 116292184 314 CADG-PCFNGGLCVGGEDpdsAYVCHCPPGFQGSNCE 349
Cdd:cd00054    5 CASGnPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-463 9.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 9.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 116292184 429 DPCASR-PCAHGGRCYAHFSGLVCACAPGYMGVRCE 463
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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