TFIIA-alpha and beta-like factor isoform 1 [Homo sapiens]
Protein Classification
transcription initiation factor IIA subunit 1 family protein( domain architecture ID 12042495)
transcription initiation factor IIA (TFIIA) subunit 1 family protein similar to TFIIA, a component of the transcription machinery of RNA polymerase II that plays an important role in transcriptional activation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||
| TFIIA | pfam03153 | Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a ... |
10-478 | 1.88e-94 | ||||||||
Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in pfam02268 and pfam02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription. : Pssm-ID: 460829 [Multi-domain] Cd Length: 344 Bit Score: 289.32 E-value: 1.88e-94
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| Name | Accession | Description | Interval | E-value | ||||||||
| TFIIA | pfam03153 | Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a ... |
10-478 | 1.88e-94 | ||||||||
Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in pfam02268 and pfam02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription. Pssm-ID: 460829 [Multi-domain] Cd Length: 344 Bit Score: 289.32 E-value: 1.88e-94
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| TFIIA_alpha_beta_like | cd07976 | Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A ... |
421-478 | 2.06e-28 | ||||||||
Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of TATA-binding protein (TBP) for DNA in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta) and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single gene (TFIIA_alpha_beta), its protein product is post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. TFIIA_alpha_beta alone is sufficient for transcription in early embryogenesis, but the cleaved forms, TFIIA alpha and TFIIA beta, represent the vast majority of TFIIA in most differentiated cells. The exact functional differences between cleaved and uncleaved forms are not yet clear. This model also contains paralogs of the canonical TFIIA_alpha_beta, such as the human ALF, which may be involved in gametogenesis and early embryogenesis (and is also subject to proteolytic cleavage). Pssm-ID: 199899 [Multi-domain] Cd Length: 102 Bit Score: 108.00 E-value: 2.06e-28
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| TOA1 | COG5149 | Transcription initiation factor IIA, large chain [Transcription]; |
314-478 | 4.14e-15 | ||||||||
Transcription initiation factor IIA, large chain [Transcription]; Pssm-ID: 227478 [Multi-domain] Cd Length: 293 Bit Score: 75.87 E-value: 4.14e-15
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| Name | Accession | Description | Interval | E-value | ||||||||
| TFIIA | pfam03153 | Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a ... |
10-478 | 1.88e-94 | ||||||||
Transcription factor IIA, alpha/beta subunit; Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in pfam02268 and pfam02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription. Pssm-ID: 460829 [Multi-domain] Cd Length: 344 Bit Score: 289.32 E-value: 1.88e-94
|
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| TFIIA_alpha_beta_like | cd07976 | Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A ... |
421-478 | 2.06e-28 | ||||||||
Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of TATA-binding protein (TBP) for DNA in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta) and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single gene (TFIIA_alpha_beta), its protein product is post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. TFIIA_alpha_beta alone is sufficient for transcription in early embryogenesis, but the cleaved forms, TFIIA alpha and TFIIA beta, represent the vast majority of TFIIA in most differentiated cells. The exact functional differences between cleaved and uncleaved forms are not yet clear. This model also contains paralogs of the canonical TFIIA_alpha_beta, such as the human ALF, which may be involved in gametogenesis and early embryogenesis (and is also subject to proteolytic cleavage). Pssm-ID: 199899 [Multi-domain] Cd Length: 102 Bit Score: 108.00 E-value: 2.06e-28
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| TFIIA_alpha_beta_like | cd07976 | Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A ... |
7-56 | 5.29e-21 | ||||||||
Precursor of TFIIA alpha and beta subunits and similar proteins; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of TATA-binding protein (TBP) for DNA in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta) and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single gene (TFIIA_alpha_beta), its protein product is post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. TFIIA_alpha_beta alone is sufficient for transcription in early embryogenesis, but the cleaved forms, TFIIA alpha and TFIIA beta, represent the vast majority of TFIIA in most differentiated cells. The exact functional differences between cleaved and uncleaved forms are not yet clear. This model also contains paralogs of the canonical TFIIA_alpha_beta, such as the human ALF, which may be involved in gametogenesis and early embryogenesis (and is also subject to proteolytic cleavage). Pssm-ID: 199899 [Multi-domain] Cd Length: 102 Bit Score: 87.58 E-value: 5.29e-21
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| TOA1 | COG5149 | Transcription initiation factor IIA, large chain [Transcription]; |
314-478 | 4.14e-15 | ||||||||
Transcription initiation factor IIA, large chain [Transcription]; Pssm-ID: 227478 [Multi-domain] Cd Length: 293 Bit Score: 75.87 E-value: 4.14e-15
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