NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|124028525|ref|NP_005678|]
View 

phenylalanine--tRNA ligase beta subunit [Homo sapiens]

Protein Classification

phenylalanine--tRNA ligase beta subunit( domain architecture ID 1004798)

phenylalanine--tRNA ligase beta subunit is involved in the process of aminoacylation which attaching an amino acid to a tRNA

CATH:  3.30.56.10
EC:  6.1.1.20
Gene Ontology:  GO:0005524|GO:0046872|GO:0004826|GO:0003723

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02265 super family cl33446
probable phenylalanyl-tRNA synthetase beta chain
 1-589 0e+00

probable phenylalanyl-tRNA synthetase beta chain


The actual alignment was detected with superfamily member PLN02265:

Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 895.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   1 MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG----NVKAAGASDVVLYKIDVPANRYDLLC 76
Cdd:PLN02265   1 MPTVSVGRDRLFAALGRTYTQEEFDELCFEFGIELDDVTTEKAIIRKEKHldeeEDGGADDDEEVIYKIDVPANRYDLLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  77 LEGLVRGLQVFKERIKAPVYK-RVMPDGKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRA 155
Cdd:PLN02265  81 LEGLARALRVFLGTEPIPTYRlAEISKGSILKMHVKPETSLIRPFVVCAVLRGVTFDEARYNSFIDLQDKLHQNICRRRT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 156 LVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPP 235
Cdd:PLN02265 161 LVAIGTHDLDTLQGPFTYEALPPEDINFVPLKQTKSFRADELMEFYKSDMKLKKFLHIIENSPVFPVIYDSNRTVLSLPP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 236 IINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLIN 315
Cdd:PLN02265 241 IINGAHSAITLDTKNVFIECTATDLTKAKIVLNTMVTMFSEYCARKFEVEPVEVVYPDGKSTVYPDLSVRTMEVDLSYIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 316 KKVGIRETPENLAKLLTRMYLKSEVIG-DGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLN 394
Cdd:PLN02265 321 SSIGVSLDAEEVASLLNKMQLQAEQSSdDGCTIRVSVPPTRSDILHPCDVAEDVAIAYGYNNIPKRKPKSMTVGKQQPLN 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 395 KLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKL 474
Cdd:PLN02265 401 QFSDLLRAEVAMAGFTEVLTWILCSHKENFAMLNREDDGNSAVIIGNPRSADFEVVRTSLLPGLLKTLGHNKDAPKPIKL 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 475 FEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGE--DKGGYVIKASEGPAFFPGRCAEIF 552
Cdd:PLN02265 481 FEVSDVVLLDESKDVGARNSRRLAALYCGTTSGFEVIHGLVDRIMEVLGIPFVEigDNNGYYVEPSNEPEYFPGRQASII 560

                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 124028525 553 ARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPFL 589
Cdd:PLN02265 561 YKGKHVGTFGIVHPEVLNNFDIPDPCSFLELDLEPLL 597
 
Name Accession Description Interval E-value
PLN02265 PLN02265
probable phenylalanyl-tRNA synthetase beta chain
 1-589 0e+00

probable phenylalanyl-tRNA synthetase beta chain


Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 895.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   1 MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG----NVKAAGASDVVLYKIDVPANRYDLLC 76
Cdd:PLN02265   1 MPTVSVGRDRLFAALGRTYTQEEFDELCFEFGIELDDVTTEKAIIRKEKHldeeEDGGADDDEEVIYKIDVPANRYDLLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  77 LEGLVRGLQVFKERIKAPVYK-RVMPDGKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRA 155
Cdd:PLN02265  81 LEGLARALRVFLGTEPIPTYRlAEISKGSILKMHVKPETSLIRPFVVCAVLRGVTFDEARYNSFIDLQDKLHQNICRRRT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 156 LVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPP 235
Cdd:PLN02265 161 LVAIGTHDLDTLQGPFTYEALPPEDINFVPLKQTKSFRADELMEFYKSDMKLKKFLHIIENSPVFPVIYDSNRTVLSLPP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 236 IINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLIN 315
Cdd:PLN02265 241 IINGAHSAITLDTKNVFIECTATDLTKAKIVLNTMVTMFSEYCARKFEVEPVEVVYPDGKSTVYPDLSVRTMEVDLSYIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 316 KKVGIRETPENLAKLLTRMYLKSEVIG-DGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLN 394
Cdd:PLN02265 321 SSIGVSLDAEEVASLLNKMQLQAEQSSdDGCTIRVSVPPTRSDILHPCDVAEDVAIAYGYNNIPKRKPKSMTVGKQQPLN 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 395 KLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKL 474
Cdd:PLN02265 401 QFSDLLRAEVAMAGFTEVLTWILCSHKENFAMLNREDDGNSAVIIGNPRSADFEVVRTSLLPGLLKTLGHNKDAPKPIKL 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 475 FEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGE--DKGGYVIKASEGPAFFPGRCAEIF 552
Cdd:PLN02265 481 FEVSDVVLLDESKDVGARNSRRLAALYCGTTSGFEVIHGLVDRIMEVLGIPFVEigDNNGYYVEPSNEPEYFPGRQASII 560

                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 124028525 553 ARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPFL 589
Cdd:PLN02265 561 YKGKHVGTFGIVHPEVLNNFDIPDPCSFLELDLEPLL 597
pheT_arch TIGR00471
phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA ...
 1-589 4.66e-170

phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from eukaryotic cytosol, the Archaea, and spirochetes. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273096 [Multi-domain]  Cd Length: 551  Bit Score: 494.27  E-value: 4.66e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525    1 MPTVSVKRDLLFqalgRTYTDEEFDELCFEFGLELDEItsekEIISKEQGNVKaagasdvvlykIDVPANRYDLLCLEGL 80
Cdd:TIGR00471   1 MPTVTVYKDDLE----DLLIGTDRDEILEELPMMGDEI----EGFDEESPEIK-----------VEFNPNRPDLLSVEGL 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   81 VRGLQVFKERIKAPVYKRVMPDGkiQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIG 160
Cdd:TIGR00471  62 ARSLRGYLGIEKGLKSYDSKKGD--VKLTVDESVLQIRPFITGAVVKGIILNDKVLESLIELQEKLHWNIGRNRRKVAIG 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  161 THDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDnhlKHYLHIIENKPLYPVIYDSNGVVLSMPPIINGD 240
Cdd:TIGR00471 140 IHDLDKVEFPFHYKAVSPNGIKFVPLNSDQEMTPDEILEEHPKG---IRYAHIIEDSDKFPLILDSKDDVLSMPPIINSE 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  241 HSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEaaEVVFPNGKSHtFPELAYRKEMVRADLINKKVGI 320
Cdd:TIGR00471 217 LTKLTVNTRNLLIDVTGTDKTAVEITLNIACTMFADRGDGRITVV--EVERPDEHLG-QPNLAPRFMEVSVEYINSLLGL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  321 RETPENLAKLLTRMYLKSEVigDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELL 400
Cdd:TIGR00471 294 NLSADEIAHSLKKMRLDAVQ--SDEKLKVVIPAYRVDILHEVDIIEDVAIGYGYNNFPPELPLINTIGRLKPLNKVSDII 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  401 RHDMAAAGFTEALTFALCSQEDIADKLgvDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKLFEISDI 480
Cdd:TIGR00471 372 REIMVGLGFQEVIPLTLTSEEVNFKRM--RIEDNNDVKVANPKTLEYTIVRTSLLPGLLETLSENKHHELPQKIFEIGDV 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  481 VIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVppgedkgGYVIKASEGPAFFPGRCAEIFARGQSVGK 560
Cdd:TIGR00471 450 VVKDDKSETRSRVVTKLAVGITHSEANFNEIKSIVAALARELGI-------EYEIEESEHPSFIPGRGAKIVFEGKAIGH 522

                         570       580
                  ....*....|....*....|....*....
gi 124028525  561 LGVLHPDVITKFELTMPCSSLEINVGPFL 589
Cdd:TIGR00471 523 FGEIHPEVLTNFELEFPVSAFEVNIEVFL 551
tRNA_synthFbeta pfam17759
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ...
 377-585 3.68e-61

Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.


Pssm-ID: 465487 [Multi-domain]  Cd Length: 214  Bit Score: 201.63  E-value: 3.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  377 IQMTLPKTYTIANQ-FPLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDISATKAVHISNPKTAEFQVARTTLL 455
Cdd:pfam17759   1 IPSTLPKGPTTGGGlTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKD-LDKLLEDDPRRKAVKLANPLSEELSVMRTSLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  456 PGLLKTIAANRKMPLP-LKLFEISDIVIKDSnTDVGAKNYRHLCAVYYNK-----------NPGFEIIHGLLDRIMQLLD 523
Cdd:pfam17759  80 PGLLETLAYNLNRGNPdVRLFEIGRVFLPDE-LEELPREPRRLAGLLTGKrlpeswqgkarPVDFYDLKGIVEALLAALG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124028525  524 VppgedkGGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINV 585
Cdd:pfam17759 159 I------DDYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELDL 214
PheRS_beta_core cd00769
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ...
 392-588 5.99e-52

Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.


Pssm-ID: 238392 [Multi-domain]  Cd Length: 198  Bit Score: 176.68  E-value: 5.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 392 PLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDisATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMP-L 470
Cdd:cd00769    1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEE-AELFDGG--LDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKnK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 471 PLKLFEISDIVIKDSNtdvGAKNYRHLCAVYYNK-----------NPGFEIIHGLLDRIMQLLdvppgEDKGGYVIKASE 539
Cdd:cd00769   78 PLRLFEIGRVFLKDED---GPEEEEHLAALLSGNrepeswqgkgrPVDFYDAKGILEALLRAL-----GIIVEFELEELD 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 124028525 540 GPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPF 588
Cdd:cd00769  150 ADLFHPGRSAKIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 222-585 1.31e-48

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 181.13  E-value: 1.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 222 VIYDSNGVVlSMPPIINGDHSRITVNTRNIFIEC----------T----------------GTDFTKAKIVLDIIVTMFS 275
Cdd:COG0072  303 VIADDEGPL-ALAGVMGGEDSEVTEETTDVLLESayfdpvsirrTarrlglhsdasyrferGVDPALTVAALERATQLIL 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 276 EYCENQFTVEAAEVVfpngkshtfPELAYRKE-MVRADLINKKVGIRETPENLAKLLTRmyLKSEVIGDGNQIEIEIPPT 354
Cdd:COG0072  382 EIAGGEVGPGIVDVY---------PEPPEPKTiTLRLARINRLLGVEIPAEEIEEILER--LGFEVEEDGDGLTVTVPSW 450

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 355 RADIIHACDIVEDaaIA--YGYNNIQMTLPK-TYTIANQFPLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDi 431
Cdd:COG0072  451 RFDIEIEADLIEE--VAriYGYDNIPSTLPRaPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPED-ADLFGLR- 526

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 432 saTKAVHISNPKTAEFQVARTTLLPGLLKTIAAN--RKMPlPLKLFEISDIVIKDSNTDvgAKNYRHLCAVYY-NKNPG- 507
Cdd:COG0072  527 --REAVRLANPISEDLSVMRTSLLPGLLEAAAYNlnRGQK-DVRLFEIGRVFLPDEGEE--PREPLHLAGVLTgNREPEs 601

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 508 ----------FEIIhGLLDRIMQLLDVPpgedkgGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMP 577
Cdd:COG0072  602 wggkarpvdfFDLK-GDVEALLAALGVP------KLEFEAAEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGP 674


                 ....*...
gi 124028525 578 CSSLEINV 585
Cdd:COG0072  675 VYVFELDL 682
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 118-279 1.07e-30

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 117.75  E-value: 1.07e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   118 RPFAVAAVLRNIKFTkdrYDSFIELQEKLHQNICRKRaLVAIGTHDLDTLSGPFTYTAKRPSDIKFK--PLNKTKEYTAC 195
Cdd:smart00873   1 CPRYLGRVIRGVKNT---RPSPEWLQERLHRAGIRPI-NNVVDITNYVSLETGQPLHAFDLDKIKGKdiPLRRAKEGEKF 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   196 ELMNiyKTDNHLKHYLHIIENKPLYPVIYDSNGV----------VLSMPPIINGDHS-RITVNTRNIFIECT-----GTD 259
Cdd:smart00873  77 ETLD--GKEYELDEGDLVIADDEGPLALAGVMGGeesevtenttVIFLEPAIFSPRTiRITARTLNLFTDASgrferGVD 154

                          170       180
                   ....*....|....*....|
gi 124028525   260 FTKAKIVLDIIVTMFSEYCE 279
Cdd:smart00873 155 PELVELALDRAAALLLEICG 174
 
Name Accession Description Interval E-value
PLN02265 PLN02265
probable phenylalanyl-tRNA synthetase beta chain
 1-589 0e+00

probable phenylalanyl-tRNA synthetase beta chain


Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 895.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   1 MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG----NVKAAGASDVVLYKIDVPANRYDLLC 76
Cdd:PLN02265   1 MPTVSVGRDRLFAALGRTYTQEEFDELCFEFGIELDDVTTEKAIIRKEKHldeeEDGGADDDEEVIYKIDVPANRYDLLC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  77 LEGLVRGLQVFKERIKAPVYK-RVMPDGKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRA 155
Cdd:PLN02265  81 LEGLARALRVFLGTEPIPTYRlAEISKGSILKMHVKPETSLIRPFVVCAVLRGVTFDEARYNSFIDLQDKLHQNICRRRT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 156 LVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPP 235
Cdd:PLN02265 161 LVAIGTHDLDTLQGPFTYEALPPEDINFVPLKQTKSFRADELMEFYKSDMKLKKFLHIIENSPVFPVIYDSNRTVLSLPP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 236 IINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFPELAYRKEMVRADLIN 315
Cdd:PLN02265 241 IINGAHSAITLDTKNVFIECTATDLTKAKIVLNTMVTMFSEYCARKFEVEPVEVVYPDGKSTVYPDLSVRTMEVDLSYIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 316 KKVGIRETPENLAKLLTRMYLKSEVIG-DGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLN 394
Cdd:PLN02265 321 SSIGVSLDAEEVASLLNKMQLQAEQSSdDGCTIRVSVPPTRSDILHPCDVAEDVAIAYGYNNIPKRKPKSMTVGKQQPLN 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 395 KLTELLRHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKL 474
Cdd:PLN02265 401 QFSDLLRAEVAMAGFTEVLTWILCSHKENFAMLNREDDGNSAVIIGNPRSADFEVVRTSLLPGLLKTLGHNKDAPKPIKL 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 475 FEISDIVIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGE--DKGGYVIKASEGPAFFPGRCAEIF 552
Cdd:PLN02265 481 FEVSDVVLLDESKDVGARNSRRLAALYCGTTSGFEVIHGLVDRIMEVLGIPFVEigDNNGYYVEPSNEPEYFPGRQASII 560

                        570       580       590
                 ....*....|....*....|....*....|....*..
gi 124028525 553 ARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPFL 589
Cdd:PLN02265 561 YKGKHVGTFGIVHPEVLNNFDIPDPCSFLELDLEPLL 597
pheT_arch TIGR00471
phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA ...
 1-589 4.66e-170

phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from eukaryotic cytosol, the Archaea, and spirochetes. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273096 [Multi-domain]  Cd Length: 551  Bit Score: 494.27  E-value: 4.66e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525    1 MPTVSVKRDLLFqalgRTYTDEEFDELCFEFGLELDEItsekEIISKEQGNVKaagasdvvlykIDVPANRYDLLCLEGL 80
Cdd:TIGR00471   1 MPTVTVYKDDLE----DLLIGTDRDEILEELPMMGDEI----EGFDEESPEIK-----------VEFNPNRPDLLSVEGL 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   81 VRGLQVFKERIKAPVYKRVMPDGkiQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIG 160
Cdd:TIGR00471  62 ARSLRGYLGIEKGLKSYDSKKGD--VKLTVDESVLQIRPFITGAVVKGIILNDKVLESLIELQEKLHWNIGRNRRKVAIG 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  161 THDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNIYKTDnhlKHYLHIIENKPLYPVIYDSNGVVLSMPPIINGD 240
Cdd:TIGR00471 140 IHDLDKVEFPFHYKAVSPNGIKFVPLNSDQEMTPDEILEEHPKG---IRYAHIIEDSDKFPLILDSKDDVLSMPPIINSE 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  241 HSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEaaEVVFPNGKSHtFPELAYRKEMVRADLINKKVGI 320
Cdd:TIGR00471 217 LTKLTVNTRNLLIDVTGTDKTAVEITLNIACTMFADRGDGRITVV--EVERPDEHLG-QPNLAPRFMEVSVEYINSLLGL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  321 RETPENLAKLLTRMYLKSEVigDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELL 400
Cdd:TIGR00471 294 NLSADEIAHSLKKMRLDAVQ--SDEKLKVVIPAYRVDILHEVDIIEDVAIGYGYNNFPPELPLINTIGRLKPLNKVSDII 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  401 RHDMAAAGFTEALTFALCSQEDIADKLgvDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKLFEISDI 480
Cdd:TIGR00471 372 REIMVGLGFQEVIPLTLTSEEVNFKRM--RIEDNNDVKVANPKTLEYTIVRTSLLPGLLETLSENKHHELPQKIFEIGDV 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  481 VIKDSNTDVGAKNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVppgedkgGYVIKASEGPAFFPGRCAEIFARGQSVGK 560
Cdd:TIGR00471 450 VVKDDKSETRSRVVTKLAVGITHSEANFNEIKSIVAALARELGI-------EYEIEESEHPSFIPGRGAKIVFEGKAIGH 522

                         570       580
                  ....*....|....*....|....*....
gi 124028525  561 LGVLHPDVITKFELTMPCSSLEINVGPFL 589
Cdd:TIGR00471 523 FGEIHPEVLTNFELEFPVSAFEVNIEVFL 551
tRNA_synthFbeta pfam17759
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ...
 377-585 3.68e-61

Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.


Pssm-ID: 465487 [Multi-domain]  Cd Length: 214  Bit Score: 201.63  E-value: 3.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  377 IQMTLPKTYTIANQ-FPLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDISATKAVHISNPKTAEFQVARTTLL 455
Cdd:pfam17759   1 IPSTLPKGPTTGGGlTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKD-LDKLLEDDPRRKAVKLANPLSEELSVMRTSLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  456 PGLLKTIAANRKMPLP-LKLFEISDIVIKDSnTDVGAKNYRHLCAVYYNK-----------NPGFEIIHGLLDRIMQLLD 523
Cdd:pfam17759  80 PGLLETLAYNLNRGNPdVRLFEIGRVFLPDE-LEELPREPRRLAGLLTGKrlpeswqgkarPVDFYDLKGIVEALLAALG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124028525  524 VppgedkGGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINV 585
Cdd:pfam17759 159 I------DDYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELDL 214
PheRS_beta_core cd00769
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ...
 392-588 5.99e-52

Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.


Pssm-ID: 238392 [Multi-domain]  Cd Length: 198  Bit Score: 176.68  E-value: 5.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 392 PLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDisATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMP-L 470
Cdd:cd00769    1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEE-AELFDGG--LDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKnK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 471 PLKLFEISDIVIKDSNtdvGAKNYRHLCAVYYNK-----------NPGFEIIHGLLDRIMQLLdvppgEDKGGYVIKASE 539
Cdd:cd00769   78 PLRLFEIGRVFLKDED---GPEEEEHLAALLSGNrepeswqgkgrPVDFYDAKGILEALLRAL-----GIIVEFELEELD 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 124028525 540 GPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPF 588
Cdd:cd00769  150 ADLFHPGRSAKIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 222-585 1.31e-48

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 181.13  E-value: 1.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 222 VIYDSNGVVlSMPPIINGDHSRITVNTRNIFIEC----------T----------------GTDFTKAKIVLDIIVTMFS 275
Cdd:COG0072  303 VIADDEGPL-ALAGVMGGEDSEVTEETTDVLLESayfdpvsirrTarrlglhsdasyrferGVDPALTVAALERATQLIL 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 276 EYCENQFTVEAAEVVfpngkshtfPELAYRKE-MVRADLINKKVGIRETPENLAKLLTRmyLKSEVIGDGNQIEIEIPPT 354
Cdd:COG0072  382 EIAGGEVGPGIVDVY---------PEPPEPKTiTLRLARINRLLGVEIPAEEIEEILER--LGFEVEEDGDGLTVTVPSW 450

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 355 RADIIHACDIVEDaaIA--YGYNNIQMTLPK-TYTIANQFPLNKLTELLRHDMAAAGFTEALTFALCSQEDiADKLGVDi 431
Cdd:COG0072  451 RFDIEIEADLIEE--VAriYGYDNIPSTLPRaPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPED-ADLFGLR- 526

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 432 saTKAVHISNPKTAEFQVARTTLLPGLLKTIAAN--RKMPlPLKLFEISDIVIKDSNTDvgAKNYRHLCAVYY-NKNPG- 507
Cdd:COG0072  527 --REAVRLANPISEDLSVMRTSLLPGLLEAAAYNlnRGQK-DVRLFEIGRVFLPDEGEE--PREPLHLAGVLTgNREPEs 601

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 508 ----------FEIIhGLLDRIMQLLDVPpgedkgGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMP 577
Cdd:COG0072  602 wggkarpvdfFDLK-GDVEALLAALGVP------KLEFEAAEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGP 674


                 ....*...
gi 124028525 578 CSSLEINV 585
Cdd:COG0072  675 VYVFELDL 682
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 53-585 1.16e-47

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 178.44  E-value: 1.16e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  53 KAAGASDVVLyKIDVPANRYDLLCLEGLVRGLQV-FKERIKAPVYKRVMPDGKIQKLIITEETAKIRPFAvAAVLRNIKF 131
Cdd:PRK00629 148 EYLGLDDTVI-EISLTPNRADCLSVRGIARELAAlLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYA-GRVIKGVKN 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 132 TKDrydSFIELQEKLHQNICR-KRALVAI--------G--TH--DLDTLSGPFTytAKR-PSDIKFKPLNKtKEYTaceL 197
Cdd:PRK00629 226 IAP---SPLWLQERLRAAGIRpINNVVDItnyvmlelGqpLHafDLDKIGGGIV--VRRaKEGEKLTTLDG-KERT---L 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 198 mniykTDNHLkhylhiienkplypVIYDSNGVVlSMPPIINGDHSRITVNTRNIFIEC------------------T--- 256
Cdd:PRK00629 297 -----DPEDL--------------VIADDKKPL-ALAGVMGGEDSEVTENTTNVLLESayfdpvsirktarrlglrTdas 356

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 257 -----GTDFTKAKIVLDIIVTMFSEYCENQfTVEAAEVVFPNGKSHTFPelayrkemVRADLINKKVGIRETPENLAKLL 331
Cdd:PRK00629 357 yrferGVDPALTLLALERATALILELGGGE-VVEGVVDVYPLPKEPTIT--------LRLERINRLLGTEISDEEIVDIL 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 332 TRMYLKSEVIGDGnQIEIEIPPTRADIIHACDIVEDaaIA--YGYNNIQMTLPK-TYTIANQFPLNKLTELLRHDMAAAG 408
Cdd:PRK00629 428 KRLGFEVTEVDGD-GLTVTVPSWRFDIEIEEDLVEE--VAriYGYDNIPSTPPVaALTMGGLTEAQRLLRRLRRALAALG 504

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 409 FTEALTFALCSQEDiADKLGVDisaTKAVHISNPKTAEFQVARTTLLPGLLKTIAAN--RKMPLpLKLFEISDIVIKDsn 486
Cdd:PRK00629 505 YQEVITYSFVSPED-AKLFGLN---PEPLLLLNPISEELSVMRTSLLPGLLEAVAYNlnRGNKD-VALFEIGRVFLPD-- 577

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 487 tDVGAKNYRHLCAVYYNKNPG-----------FEIIhGLLDRIMQLLDVPPGEdkggyVIKASEGPAFFPGRCAEIFARG 555
Cdd:PRK00629 578 -GDLPREPEHLAGVLTGNRVEeswggkrpvdfFDLK-GDVEALLEALGLPEVE-----FVAEFEAAALHPGRSAEIYLDG 650

                        570       580       590
                 ....*....|....*....|....*....|
gi 124028525 556 QSVGKLGVLHPDVITKFELTMPCSSLEINV 585
Cdd:PRK00629 651 KVIGFIGELHPKVLKKLDLPGRTYVFELDL 680
PhetRS_B1 pfam18262
Phe-tRNA synthetase beta subunit B1 domain; This is the N-terminal domain found in human ...
 1-90 3.16e-37

Phe-tRNA synthetase beta subunit B1 domain; This is the N-terminal domain found in human cytosolic phenylalanyl tRNA synthetase beta subunit.


Pssm-ID: 408077  Cd Length: 83  Bit Score: 132.93  E-value: 3.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525    1 MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEiiskeqgNVKAAGASDVVLYKIDVPANRYDLLCLEGL 80
Cdd:pfam18262   1 MPTISVKKVRLFKVLGRVYTEEEFSDLCFEFGLELDEITSEEN-------QLKTSWRSEEVVYKIDIPANRYDLLCVEGL 73

                          90
                  ....*....|
gi 124028525   81 VRGLQVFKER 90
Cdd:pfam18262  74 ATALLIFKGK 83
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 118-279 1.07e-30

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 117.75  E-value: 1.07e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   118 RPFAVAAVLRNIKFTkdrYDSFIELQEKLHQNICRKRaLVAIGTHDLDTLSGPFTYTAKRPSDIKFK--PLNKTKEYTAC 195
Cdd:smart00873   1 CPRYLGRVIRGVKNT---RPSPEWLQERLHRAGIRPI-NNVVDITNYVSLETGQPLHAFDLDKIKGKdiPLRRAKEGEKF 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   196 ELMNiyKTDNHLKHYLHIIENKPLYPVIYDSNGV----------VLSMPPIINGDHS-RITVNTRNIFIECT-----GTD 259
Cdd:smart00873  77 ETLD--GKEYELDEGDLVIADDEGPLALAGVMGGeesevtenttVIFLEPAIFSPRTiRITARTLNLFTDASgrferGVD 154

                          170       180
                   ....*....|....*....|
gi 124028525   260 FTKAKIVLDIIVTMFSEYCE 279
Cdd:smart00873 155 PELVELALDRAAALLLEICG 174
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 117-278 5.30e-19

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 84.52  E-value: 5.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  117 IRPFAVAAVLRNIKFTKDrydSFIELQEKLHQniCRKR---ALV------------AIGTHDLDTLSGPFTytakrpsdi 181
Cdd:pfam03483   1 ACPRYFGRVIRGVKKNRP---SPEWLQRRLRR--AGIRpinNVVditnyvmlelgqPLHAFDLDKIAGDIV--------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  182 kfKPLNKTKEytacELMNIYKTDNHLKhylhiienkPLYPVIYDSNGVVlSMPPIINGDHSRITVNTRNIFIECT----- 256
Cdd:pfam03483  67 --VRLAKGGE----KFTTLDGKERELD---------PGDLVIADDDGPV-ALAGIMGGEESEVTEDTTNIFLESAgfdpv 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 124028525  257 ---------------------GTDFTKAKIVLDIIVTMFSEYC 278
Cdd:pfam03483 131 airktarrlglrtdasyrferGVDPELVEAALDRATALLLELC 173
B5 pfam03484
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
 309-374 2.94e-17

tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.


Pssm-ID: 460942 [Multi-domain]  Cd Length: 67  Bit Score: 76.28  E-value: 2.94e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124028525  309 VRADLINKKVGIRETPENLAKLLTRMYLKSEVIgDGNQIEIEIPPTRADIIHACDIVEDAAIAYGY 374
Cdd:pfam03484   3 LRLDRINRLLGIDLSAEEIVEILERLGFEVEEE-DGDTLTVTVPSYRPDILHEADLIEEVARIYGY 67
B5 smart00874
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
 305-374 1.06e-16

tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.


Pssm-ID: 197942 [Multi-domain]  Cd Length: 68  Bit Score: 74.45  E-value: 1.06e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525   305 RKEMVRADLINKKVGIRETPENLAKLLTRMYLKSEVIGDGnqIEIEIPPTRADIIHACDIVEDAAIAYGY 374
Cdd:smart00874   1 RTITLRLERINRLLGLEILAEEIEEILKRLGFEVEVSGDT--LEVTVPSYRFDILIEADLIEEVARIYGY 68
syfB CHL00192
phenylalanyl-tRNA synthetase beta chain; Provisional
 32-587 5.40e-12

phenylalanyl-tRNA synthetase beta chain; Provisional


Pssm-ID: 214391 [Multi-domain]  Cd Length: 704  Bit Score: 68.58  E-value: 5.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525  32 GLELDEITSekeiiskeqgnVKAAGASDVVLyKIDVPANRYDLLCLEGLVRGLQVF--KERIKAPVYKRVMPDGKIQKLI 109
Cdd:CHL00192  30 GFEVEDILS-----------VKIGGESDIIL-DISSTANRSDVLSIQGLSREISALfnSDPIKLKYYNPSISWFDKLKNL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 110 ITEETAKIR-PFAVAAVLRNIKftkdRYDSFIELQEKLhqnicrkralVAIGTHDLDTLSGPFTYTA-KRPSDIKFKPLN 187
Cdd:CHL00192  98 ISNDSSKLNcSMFIAVIIENIE----IKDSPKWLQNRL----------SSSGFKSLNNLTDIQNYIMlETGQPIEIYDLD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 188 KtkeytacelmnIYKTDNhlKHYLHIIENKPLYP---VIYDS--------------NGVVLSMPPIINGDHSRITVNTRN 250
Cdd:CHL00192 164 K-----------IYSKNT--TSSLALSSKFALQKssfIASNSknielennilvvqaNNVIISIAGIISNEEIICDKNTKS 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 251 IFIEctGTDFTKAKI-----VLDIiVTMFSEYCENQFTVEAAEVVF-----------PNGKSHTFPELAYRKEMVRADLI 314
Cdd:CHL00192 231 ILIE--ASIFDAAVIrkssrKLGL-RTDRSIRYEKSLKNDNLLEAYyrlvsllrilnPKLKCKFHFIYKKIKNSSRRIKL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 315 NKK-------------VGIRETPENLAKLLTRMYLKSEVIGDGNQIEIEIPPTRA-DIIHACDIVEDAAIAYGYNNIQMT 380
Cdd:CHL00192 308 SYKkikdilgpikintNTRYLSPKEITNALKRLNFKITYDSLKLNWEVLIPSYRKdDIVREIDVIEEIARIYGFNNFLSK 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 381 LPKTYTIAN-----QFpLNKLTELLRHdmaaAGFTEALTFALCSQEDIADklgvdisatKAVHISNPKTAEFQVARTTLL 455
Cdd:CHL00192 388 LPNIKFIGRldidyNT-RDKIRSYLRN----LGLTELIHYSLVKQESFSK---------NEIKLKNPLIKDYSTLRSSLL 453

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 456 PGLLKTIAAN-RKMPLPLKLFEISDIVIKDSNTDVGAKNYRHLCA-------VYYNKNPGFEIIH--GLLDRIMQLLDVP 525
Cdd:CHL00192 454 PGLIEAVQENlKQGNSTLEGFEIGHVFNLDSSSIIEETELAGGIFggidirsSWSEKAQSLNWFEakGIIENFFQKLNLP 533

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124028525 526 pgedkggYVIKAS----EGPAFFPGRCAEIF-ARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGP 587
Cdd:CHL00192 534 -------IYWKKYsdldEKINFHPYCTSEIFlSNGQKIGIFGQLHPLLANKLNLNTEIYLFEINLDI 593
B3/B4 COG3382
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ...
 154-283 2.89e-07

B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];


Pssm-ID: 442609 [Multi-domain]  Cd Length: 233  Bit Score: 51.78  E-value: 2.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124028525 154 RALVAIGTHDLDTLSGPFTYTAKRPSDIkFKPLNKTKEytacelmniyktdnhlkhyLHIIENKPLYpviYDSNGVVLSM 233
Cdd:COG3382  111 RYLLPIGGYDLDKIEGDLRLRLARGGES-FLPIGGDEE-------------------EPPEPGEVVY---ADDEGVFCRR 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124028525 234 PPIINGDHSRITVNTRNIF--IEC-TGTDFTKAKIVLDIIVTMFSEYCENQFT 283
Cdd:COG3382  168 WPWRDSERTKVTEETKNALfiIEGlPGVSAEDLEAALDELAELLERYLGGEVV 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH