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Conserved domains on  [gi|4506499|ref|NP_003712|]
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DNA-binding protein RFXANK isoform a [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
128-218 6.49e-20

Ankyrin repeats (3 copies);


:

Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 81.71  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 207
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 4506499    208 ALLARGADLTT 218
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-258 2.83e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 78.33  E-value: 2.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   73 LTNRQRGNEVSALPATLDSLSIHQLAAQGELDQL------------KEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV 140
Cdd:COG0666  10 LINKCFLDLLLVALLLLLSLDLSNPSDKKLNLYLelallpaaslseLLLKLIVDRHLAARDLDGRLPLHSAASKGDDKIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  141 RFLLEWGADPHILAKERESALSLASTGG-----YTDIVGLLLER--DVDINIY-DWNGGTPLLYAVRGNHVKCVEALLAR 212
Cdd:COG0666  90 KLLLASGADVNAKDADGDTPLHLAALNGnppegNIEVAKLLLEAgaDLDVNNLrDEDGNTPLHWAALNGDADIVELLLEA 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4506499  213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPAD 258
Cdd:COG0666 170 GADPNSRNSYGVTALDPAAKNGRIELVKLLLDKGLHLSLLKFNLEG 215
 
Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
128-218 6.49e-20

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 81.71  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 207
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 4506499    208 ALLARGADLTT 218
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-258 2.83e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 78.33  E-value: 2.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   73 LTNRQRGNEVSALPATLDSLSIHQLAAQGELDQL------------KEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV 140
Cdd:COG0666  10 LINKCFLDLLLVALLLLLSLDLSNPSDKKLNLYLelallpaaslseLLLKLIVDRHLAARDLDGRLPLHSAASKGDDKIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  141 RFLLEWGADPHILAKERESALSLASTGG-----YTDIVGLLLER--DVDINIY-DWNGGTPLLYAVRGNHVKCVEALLAR 212
Cdd:COG0666  90 KLLLASGADVNAKDADGDTPLHLAALNGnppegNIEVAKLLLEAgaDLDVNNLrDEDGNTPLHWAALNGDADIVELLLEA 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4506499  213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPAD 258
Cdd:COG0666 170 GADPNSRNSYGVTALDPAAKNGRIELVKLLLDKGLHLSLLKFNLEG 215
PHA03100 PHA03100
ankyrin repeat protein; Provisional
117-232 5.42e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 5.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 176
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506499   177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 232
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
60-251 1.31e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    60 SPQAGSSLKHSTTLTNRQRGNEVSAlPATLDSLSIHQLAA-QGELDQLKEHLRK---GDNLVNKPDergftpliWASAFG 135
Cdd:PTZ00322   1 MSFLVCSVASSAFAAQLFFGTEGSR-KRRAKPISFERMAAiQEEIARIDTHLEAleaTENKDATPD--------HNLTTE 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   136 EIetvrfllewgADP---HILAKEresALSLASTGgytDIVG--LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
Cdd:PTZ00322  72 EV----------IDPvvaHMLTVE---LCQLAASG---DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL 135
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 4506499   211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQ 251
Cdd:PTZ00322 136 EFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
94-144 3.98e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 3.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4506499     94 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLL 144
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
189-217 5.33e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.33e-04
                           10        20
                   ....*....|....*....|....*....
gi 4506499     189 NGGTPLLYAVRGNHVKCVEALLARGADLT 217
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
126-218 2.93e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  126 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 197
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96
                        90       100
                ....*....|....*....|.
gi 4506499  198 VRGNHVKCVEALLARGADLTT 218
Cdd:cd22192  97 VVNQNLNLVRELIARGADVVS 117
 
Name Accession Description Interval E-value
Ank_2 pfam12796
Ankyrin repeats (3 copies);
128-218 6.49e-20

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 81.71  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 207
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
                          90
                  ....*....|.
gi 4506499    208 ALLARGADLTT 218
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-258 2.83e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 223738 [Multi-domain]  Cd Length: 235  Bit Score: 78.33  E-value: 2.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   73 LTNRQRGNEVSALPATLDSLSIHQLAAQGELDQL------------KEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV 140
Cdd:COG0666  10 LINKCFLDLLLVALLLLLSLDLSNPSDKKLNLYLelallpaaslseLLLKLIVDRHLAARDLDGRLPLHSAASKGDDKIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  141 RFLLEWGADPHILAKERESALSLASTGG-----YTDIVGLLLER--DVDINIY-DWNGGTPLLYAVRGNHVKCVEALLAR 212
Cdd:COG0666  90 KLLLASGADVNAKDADGDTPLHLAALNGnppegNIEVAKLLLEAgaDLDVNNLrDEDGNTPLHWAALNGDADIVELLLEA 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4506499  213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPAD 258
Cdd:COG0666 170 GADPNSRNSYGVTALDPAAKNGRIELVKLLLDKGLHLSLLKFNLEG 215
PHA03100 PHA03100
ankyrin repeat protein; Provisional
117-232 5.42e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 5.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 176
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506499   177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 232
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
161-238 4.30e-14

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 4.30e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506499    161 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAdlTTEADSGYTPMDLAVALGYRKV 238
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEI 76
PHA02874 PHA02874
ankyrin repeat protein; Provisional
117-244 8.69e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 8.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 4506499   197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
Cdd:PHA02874 197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINN 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
94-187 1.28e-12

Ankyrin repeats (3 copies);


Pssm-ID: 432791 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499     94 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEwgadpHILAKER---ESALSLASTGGYT 170
Cdd:pfam12796   1 LMLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKdngRTALHYAARSGHL 74
                          90
                  ....*....|....*..
gi 4506499    171 DIVGLLLERDVDINIYD 187
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
136-253 6.20e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 6.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   136 EIETVRFLLEWGADPHILAKERESALSLASTGGYT-----DIVGLLLERDVDINIYDWNGGTPLLYAV--RGNHVKCVEA 208
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 4506499   209 LLARGADLTTEADSGYTPmdLAVALGYRKvqqvIENHILKLFQSN 253
Cdd:PHA03100 127 LLDNGANVNIKNSDGENL--LHLYLESNK----IDLKILKLLIDK 165
PHA02875 PHA02875
ankyrin repeat protein; Provisional
94-215 1.31e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.78  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 173
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 4506499   174 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
60-251 1.31e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    60 SPQAGSSLKHSTTLTNRQRGNEVSAlPATLDSLSIHQLAA-QGELDQLKEHLRK---GDNLVNKPDergftpliWASAFG 135
Cdd:PTZ00322   1 MSFLVCSVASSAFAAQLFFGTEGSR-KRRAKPISFERMAAiQEEIARIDTHLEAleaTENKDATPD--------HNLTTE 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   136 EIetvrfllewgADP---HILAKEresALSLASTGgytDIVG--LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
Cdd:PTZ00322  72 EV----------IDPvvaHMLTVE---LCQLAASG---DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL 135
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 4506499   211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQ 251
Cdd:PTZ00322 136 EFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02874 PHA02874
ankyrin repeat protein; Provisional
136-244 2.69e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.90  E-value: 2.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   136 EIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182
                         90       100       110
                 ....*....|....*....|....*....|
gi 4506499   216 LTTEADSGYTPMDLAVALG-YRKVQQVIEN 244
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGdYACIKLLIDH 212
PHA03100 PHA03100
ankyrin repeat protein; Provisional
117-185 2.42e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 2.42e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4506499   117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA03095 PHA03095
ankyrin-like protein; Provisional
110-232 3.05e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 3.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   110 LRKGDNlVNKPDERGFTPL--IWASAFGEIETVRFLLEWGADP-----------HILA---KERES-------------- 159
Cdd:PHA03095 139 LRKGAD-VNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVyavddrfrsllHHHLqsfKPRARivreliragcdpaa 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   160 -------ALSLASTGGYTD--IVGLLLERDVDINIYDWNGGTPLLYA-VRGNHVKCVEaLLARGADLTTEADSGYTPMDL 229
Cdd:PHA03095 218 tdmlgntPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACRR-LIALGADINAVSSDGNTPLSL 296

                 ...
gi 4506499   230 AVA 232
Cdd:PHA03095 297 MVR 299
PHA02878 PHA02878
ankyrin repeat protein; Provisional
136-249 3.51e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 3.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   136 EIETVRFLLEWGADPHILAKER-ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 214
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 4506499   215 DLTTEADSGYTPMDLAVAlgyrkvqQVIENHILKL 249
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-------YCKDYDILKL 253
PHA02875 PHA02875
ankyrin repeat protein; Provisional
101-245 3.93e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 3.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   101 GELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 180
Cdd:PHA02875  13 GELDIARRLLDIGIN-PNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4506499   181 VDIN--IYDwNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
Cdd:PHA02875  92 KFADdvFYK-DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157
Ank_5 pfam13857
Ankyrin repeats (many copies);
175-230 7.65e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 7.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506499    175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
94-248 1.08e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    94 IHQLAAQGELDQLKEHLRKGDNLvNKPDERGFTPLIWASAFGEIETVRFLLEWGAdpHILAKERESALSLASTGGYTDIV 173
Cdd:PHA02874 161 IHIAIKHNFFDIIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNRSA 237
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506499   174 GLLLERDVDINIYDWNGGTPLLYAVRGN-HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK--VQQVIENHILK 248
Cdd:PHA02874 238 IELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDpvIKDIIANAVLI 315
PHA02876 PHA02876
ankyrin repeat protein; Provisional
78-255 1.12e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.37  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    78 RGNEVSALpatlDSLSIHQLAAQGELDQLKEH----LRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
Cdd:PHA02876 330 LGADVNAA----DRLYITPLHQASTLDRNKDIvitlLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAL 404
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   154 AKERESAL--SLASTGGYTDiVGLLLERDVDINIYDWNGGTPLLYAVRGN-HVKCVEALLARGADLTTEADSGYTPmdLA 230
Cdd:PHA02876 405 SQKIGTALhfALCGTNPYMS-VKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYP--LL 481
                        170       180
                 ....*....|....*....|....*
gi 4506499   231 VALGYRKVQQVIENHILKLFQSNLV 255
Cdd:PHA02876 482 IALEYHGIVNILLHYGAELRDSRVL 506
PHA02876 PHA02876
ankyrin repeat protein; Provisional
93-235 1.27e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    93 SIHQLAAQGELdQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI 172
Cdd:PHA02876 148 LIKERIQQDEL-LIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   173 VGLLLERDVDINIYD------------------WNGG-----------TPLLYAVRGNHV-KCVEALLARGADLTTEADS 222
Cdd:PHA02876 227 IKAIIDNRSNINKNDlsllkairnedletslllYDAGfsvnsiddcknTPLHHASQAPSLsRLVPKLLERGADVNAKNIK 306
                        170
                 ....*....|...
gi 4506499   223 GYTPMDLAVALGY 235
Cdd:PHA02876 307 GETPLYLMAKNGY 319
PHA02874 PHA02874
ankyrin repeat protein; Provisional
101-231 2.14e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   101 GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL---- 176
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLidng 91
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4506499   177 -------------------LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAV 231
Cdd:PHA02874  92 vdtsilpipciekdmiktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
Ank_4 pfam13637
Ankyrin repeats (many copies);
157-210 4.39e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 4.39e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 4506499    157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
117-231 6.19e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 6.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDE-RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLL 195
Cdd:PHA02878 160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 4506499   196 YAV-RGNHVKCVEALLARGADLTTEAD-SGYTPMDLAV 231
Cdd:PHA02878 240 ISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
103-228 8.19e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 8.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   103 LDQLKEHLRKGDNlVNKPDERGFTPL-IWASAFGE--IETVRFLLEWGADphILAKER--ESALSLASTGGYT-DIVGLL 176
Cdd:PHA03095  27 VEEVRRLLAAGAD-VNFRGEYGKTPLhLYLHYSSEkvKDIVRLLLEAGAD--VNAPERcgFTPLHLYLYNATTlDVIKLL 103
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4506499   177 LERDVDINIYDWNGGTPL-LYAVRGN-HVKCVEALLARGADLTTEADSGYTPMD 228
Cdd:PHA03095 104 IKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02875 PHA02875
ankyrin repeat protein; Provisional
85-185 1.43e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    85 LPATLDSLSIHQLAAQGELDQLkEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SALSL 163
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGI-ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCY 208
                         90       100
                 ....*....|....*....|..
gi 4506499   164 ASTGGYTDIVGLLLERDVDINI 185
Cdd:PHA02875 209 AIENNKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
94-216 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFG-EIETVRFLLEWGADPHILAKERESALSLAST-GGYTD 171
Cdd:PHA02876 277 LHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKD 356
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 4506499   172 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401
PHA02875 PHA02875
ankyrin repeat protein; Provisional
117-242 1.95e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDERgfTPLIWASAFGEIETVRFLLEWG--ADpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 194
Cdd:PHA02875  63 VKYPDIE--SELHDAVEEGDVKAVEELLDLGkfAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 4506499   195 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
Ank_5 pfam13857
Ankyrin repeats (many copies);
110-164 5.13e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 5.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4506499    110 LRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
143-197 3.56e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 3.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4506499    143 LLEWG-ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
97-235 3.73e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
Cdd:PLN03192 498 LQHHKELHDLNVGDLLGDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVL 577
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   177 LERDVDINIYDWNGGTPL--------------LY-----------------AVRGNHVKCVEALLARGADLTTEADSGYT 225
Cdd:PLN03192 578 LKHACNVHIRDANGNTALwnaisakhhkifriLYhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGAT 657
                        170
                 ....*....|
gi 4506499   226 PMDLAVALGY 235
Cdd:PLN03192 658 ALQVAMAEDH 667
Ank_4 pfam13637
Ankyrin repeats (many copies);
126-177 3.76e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 3.76e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4506499    126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 177
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
88-237 5.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 5.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    88 TLDSLSIHQLAAQGE-LDQLKEHLRKGDNlVNKPDergfTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLAS- 165
Cdd:PHA02876 208 ALDDLSVLECAVDSKnIDTIKAIIDNRSN-INKND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASq 282
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4506499   166 TGGYTDIVGLLLERDVDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGADLTTeADSGY-TPMDLAVALGYRK 237
Cdd:PHA02876 283 APSLSRLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA-ADRLYiTPLHQASTLDRNK 355
PHA03095 PHA03095
ankyrin-like protein; Provisional
117-222 1.04e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdphilakeresalslastggytdivglllerdvDINIYDWNGGTPLLY 196
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFNNPRACRRLIALGA---------------------------------DINAVSSDGNTPLSL 296
                         90       100
                 ....*....|....*....|....*.
gi 4506499   197 AVRGNHVKCVEALLARGADLTTEADS 222
Cdd:PHA03095 297 MVRNNNGRAVRAALAKNPSAETVAAT 322
Ank_4 pfam13637
Ankyrin repeats (many copies);
94-144 3.98e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 3.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4506499     94 IHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPLIWASAFGEIETVRFLL 144
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
123-152 4.07e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 425426 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 4.07e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4506499    123 RGFTPLIWASA-FGEIETVRFLLEWGADPHI 152
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNA 31
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
189-217 5.33e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.33e-04
                           10        20
                   ....*....|....*....|....*....
gi 4506499     189 NGGTPLLYAVRGNHVKCVEALLARGADLT 217
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02791 PHA02791
ankyrin-like protein; Provisional
105-224 6.05e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.41  E-value: 6.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499   105 QLKEHLRKGDNLvnKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILakERESALSLASTGGYTDIVGLLLERDVDIN 184
Cdd:PHA02791  13 QLKSFLSSKDAF--KADVHGHSALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDS 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 4506499   185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
Cdd:PHA02791  89 QFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLMFYGKTGW 128
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
189-216 8.20e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 404492 [Multi-domain]  Cd Length: 30  Bit Score: 36.09  E-value: 8.20e-04
                          10        20
                  ....*....|....*....|....*...
gi 4506499    189 NGGTPLLYAVRGNHVKCVEALLARGADL 216
Cdd:pfam13606   1 DGNTPLHLAARNGNLEIVKLLLERGADI 28
PHA02878 PHA02878
ankyrin repeat protein; Provisional
86-199 1.59e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499    86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNlVNKPDERGFTPL-IWASAFGEIETVRFLLEWGADPHILAKERE-SALSL 163
Cdd:PHA02878 197 PDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGlTALHS 275
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 4506499   164 ASTGgyTDIVGLLLERDVDINIYDWNGGTPLLYAVR 199
Cdd:PHA02878 276 SIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVK 309
Ank_4 pfam13637
Ankyrin repeats (many copies);
190-238 1.93e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4506499    190 GGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEV 49
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
123-152 2.92e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 404492 [Multi-domain]  Cd Length: 30  Bit Score: 34.55  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 4506499    123 RGFTPLIWASAFGEIETVRFLLEWGADPHI 152
Cdd:pfam13606   1 DGNTPLHLAARNGNLEIVKLLLERGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
126-218 2.93e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  126 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 197
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96
                        90       100
                ....*....|....*....|.
gi 4506499  198 VRGNHVKCVEALLARGADLTT 218
Cdd:cd22192  97 VVNQNLNLVRELIARGADVVS 117
PHA02792 PHA02792
ankyrin-like protein; Provisional
182-246 5.46e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 38.01  E-value: 5.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4506499   182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 246
Cdd:PHA02792 402 DINKIDKHGRSILYYCIESHSVSLVEWLIDNGADINITTKYGSTCIGICVILAHACIPEIAELYI 466
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
116-256 5.71e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.68  E-value: 5.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  116 LVNKPDE----RGFTPLIWASAFGEIETVRFLLEWGAD--------------PHILAKERESALSLASTGGYTDIVGLLL 177
Cdd:cd22192  77 LVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADvvspratgtffrpgPKNLIYYGEHPLSFAACVGNEEIVRLLI 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506499  178 ERDVDINIYDWNGGTPL-LYAVRGNHVKCVEA---LLARGADLTTEA------DSGYTPMDLAVALGyrkvQQVIENHIL 247
Cdd:cd22192 157 EHGADIRAQDSLGNTVLhILVLQPNKTFACQMydlILSYDKEDDLQPldlvpnNQGLTPFKLAAKEG----NIVMFQHLV 232
                       170
                ....*....|..
gi 4506499  248 ---KLFQSNLVP 256
Cdd:cd22192 233 qkrRHIQWTYGP 244
PHA03095 PHA03095
ankyrin-like protein; Provisional
171-229 7.95e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.31  E-value: 7.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506499   171 DIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC---VEALLARGADLTTEADSGYTPMDL 229
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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