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Conserved domains on  [gi|4507943|ref|NP_003391|]
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exportin-1 isoform 1 [Homo sapiens]

Protein Classification

exportin domain-containing protein( domain architecture ID 1000203)

exportin domain-containing protein similar to human exportin 1, a nuclear export receptor which is involved in the nuclear translocation of proteins and certain RNAs from the nucleus to the cytoplasm and is thus crucial for the correct localization of cellular components

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CRM1 super family cl34903
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
15-1044 0e+00

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5101:

Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 1174.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    15 QLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKIL 94
Cdd:COG5101    3 GILEFDKDLDIALLDKVVTTFYQGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    95 PRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLL 174
Cdd:COG5101   83 PEGMRQGIRNYVVQLVIEKSQDDKVRDKQKYVLNKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVCENNMIVLKLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   175 SEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKF 254
Cdd:COG5101  163 SEEVFDFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLESLLRFLEWIPLDYIFETNIIELVLEHF 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   255 LNVPMFRNVSLKCLTEIAGV-SVSQY----EEQFVTLFTLTMMQLKQ-MLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCT 328
Cdd:COG5101  243 NSMPDTRVATLSCLTEIVDLgRHPQEnaekERILVIHFQCIEFLKMYsNKPQEEDIYEVYGGMDKNEQIFVQKLAQFLSS 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   329 FLKEHDQLIEKRLNLrETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRE--SPFSTSASPLLSGS--------- 397
Cdd:COG5101  323 LYEVYISLLEAREMA-ENLLNAHGYLIQISRINEREIFKTALEYWNKLVADLYSEfqRLPATEMSPLIQLSvgsqaistn 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   398 --QHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERI 475
Cdd:COG5101  402 pnQDSTKPLRKHIYIGILSQLRLVLIENMVRPEEVLIVENDEGEIVREFVKETDTIELYKSMREVLVYLTHLIVDDTEKY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   476 MTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFL 555
Cdd:COG5101  482 MIGKLARQLDGKEWSWNNLNTLCWAIGSISGAMSEVNEKRFFVNVIKDLLALCEMKRGKDNKAVVASNIMYVVGQYPRFL 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   556 RAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYE 635
Cdd:COG5101  562 KAHWSFLKTVVKKLFEFMHEDHEGVQDMACDTFIKIVQKCPVHFVTQQEGESEPFIVYIIRNLPKTTGDLEPQQKHTFYE 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   636 AVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYL 715
Cdd:COG5101  642 ACGMVISEVPKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKTNVAKCTSLGYRFYPQTCSSYC 721
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   716 DMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAA 795
Cdd:COG5101  722 IMLFLYFAVSFDISNSVAAEGLIATKTPAVRGLRTIKKEILKLVATYISKARDLKFVQNDLVNMLCEAVLFDYKNNVPDA 801
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   796 REPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVL 875
Cdd:COG5101  802 RDAEVLNLGTTIVRNVESVIYLQRELFLISVFICTLIMIVKDFDEYPEHRKNFLLLLENINLFSFSAFLSFPQPSFKLVY 881
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   876 DSIIWAFKHTMRNVADTGLQILFTLLQNVA-QEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVE 954
Cdd:COG5101  882 NTILWSFKHINRDVSDLGLNILLILFKNCHeMGVPFINQFYAQYYMSTLENILGVLTDSDHKSGFDQQCLLLAFLIRLVK 961
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   955 EGKIST-SLNPGNPvnNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTsdl 1033
Cdd:COG5101  962 DNKISVpLYDGINP--NITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCGDDEIFKEHVEDFRVKVYEFGTDED--- 1036
                       1050
                 ....*....|.
gi 4507943  1034 fLEEREIALRQ 1044
Cdd:COG5101 1037 -LQEEIDLKNE 1046
 
Name Accession Description Interval E-value
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
15-1044 0e+00

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 1174.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    15 QLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKIL 94
Cdd:COG5101    3 GILEFDKDLDIALLDKVVTTFYQGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    95 PRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLL 174
Cdd:COG5101   83 PEGMRQGIRNYVVQLVIEKSQDDKVRDKQKYVLNKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVCENNMIVLKLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   175 SEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKF 254
Cdd:COG5101  163 SEEVFDFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLESLLRFLEWIPLDYIFETNIIELVLEHF 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   255 LNVPMFRNVSLKCLTEIAGV-SVSQY----EEQFVTLFTLTMMQLKQ-MLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCT 328
Cdd:COG5101  243 NSMPDTRVATLSCLTEIVDLgRHPQEnaekERILVIHFQCIEFLKMYsNKPQEEDIYEVYGGMDKNEQIFVQKLAQFLSS 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   329 FLKEHDQLIEKRLNLrETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRE--SPFSTSASPLLSGS--------- 397
Cdd:COG5101  323 LYEVYISLLEAREMA-ENLLNAHGYLIQISRINEREIFKTALEYWNKLVADLYSEfqRLPATEMSPLIQLSvgsqaistn 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   398 --QHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERI 475
Cdd:COG5101  402 pnQDSTKPLRKHIYIGILSQLRLVLIENMVRPEEVLIVENDEGEIVREFVKETDTIELYKSMREVLVYLTHLIVDDTEKY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   476 MTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFL 555
Cdd:COG5101  482 MIGKLARQLDGKEWSWNNLNTLCWAIGSISGAMSEVNEKRFFVNVIKDLLALCEMKRGKDNKAVVASNIMYVVGQYPRFL 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   556 RAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYE 635
Cdd:COG5101  562 KAHWSFLKTVVKKLFEFMHEDHEGVQDMACDTFIKIVQKCPVHFVTQQEGESEPFIVYIIRNLPKTTGDLEPQQKHTFYE 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   636 AVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYL 715
Cdd:COG5101  642 ACGMVISEVPKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKTNVAKCTSLGYRFYPQTCSSYC 721
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   716 DMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAA 795
Cdd:COG5101  722 IMLFLYFAVSFDISNSVAAEGLIATKTPAVRGLRTIKKEILKLVATYISKARDLKFVQNDLVNMLCEAVLFDYKNNVPDA 801
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   796 REPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVL 875
Cdd:COG5101  802 RDAEVLNLGTTIVRNVESVIYLQRELFLISVFICTLIMIVKDFDEYPEHRKNFLLLLENINLFSFSAFLSFPQPSFKLVY 881
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   876 DSIIWAFKHTMRNVADTGLQILFTLLQNVA-QEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVE 954
Cdd:COG5101  882 NTILWSFKHINRDVSDLGLNILLILFKNCHeMGVPFINQFYAQYYMSTLENILGVLTDSDHKSGFDQQCLLLAFLIRLVK 961
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   955 EGKIST-SLNPGNPvnNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTsdl 1033
Cdd:COG5101  962 DNKISVpLYDGINP--NITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCGDDEIFKEHVEDFRVKVYEFGTDED--- 1036
                       1050
                 ....*....|.
gi 4507943  1034 fLEEREIALRQ 1044
Cdd:COG5101 1037 -LQEEIDLKNE 1046
CRM1_C pfam08767
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ...
709-1027 1.86e-169

CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.


Pssm-ID: 430202  Cd Length: 323  Bit Score: 499.84  E-value: 1.86e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     709 QLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDY 788
Cdd:pfam08767    1 QLGRIYLDMLNLYRAYSELISQAVAANGEIATKTPKVRGLRTVKKEILKLIETYISKADDLELVLNNLVPPLLDAVLVDY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     789 QRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPP 868
Cdd:pfam08767   81 NRNVPDARDAEVLSLMTTIVNKLGNLITDEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINLHCFPALLSLPP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     869 TQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEA-AAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILA 947
Cdd:pfam08767  161 EQFKLVIDSIVWAFKHTNRDVADTGLNILLELLKNVEETDSeFANQFYQNYYLSILQEVFYVLTDTDHKSGFKLQALLLA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     948 YMFNLVEEGKISTSLNPGNPV---NNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKE 1024
Cdd:pfam08767  241 RLFRLVENGSITVPLYDPDQApgtSNQVFLSEYIANLLQNAFPNLTQEQIEIFVVGLFNLCNDLNKFKSHLRDFLIQLKE 320

                   ...
gi 4507943    1025 FAG 1027
Cdd:pfam08767  321 FGG 323
CRM1_C smart01102
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ...
709-1027 1.68e-166

CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.


Pssm-ID: 198170  Cd Length: 321  Bit Score: 492.27  E-value: 1.68e-166
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      709 QLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDY 788
Cdd:smart01102    1 QLGRIYLDMLNLYRAYSELISAAVAKEGTIATKTPKVRGLRTIKREILKLIETYISKAEDLEFVAENFVPPLLEAVLGDY 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      789 QRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPP 868
Cdd:smart01102   81 RRNVPDAREAEVLSLMTTIVNKLGNLLTPEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINSHCFPAFLSLPP 160
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      869 TQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVA-QEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILA 947
Cdd:smart01102  161 EQFKLVIDSIVWAFKHTDRDVADTGLNILLELLNNVSkKDSQIANEFYKQYYFSILQDIFSVLTDSDHKSGFKLQCLLLA 240
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      948 YMFNLVEEGKISTSLNPGNPV-NNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFA 1026
Cdd:smart01102  241 KLFRLVEENPISVPLYDAPPGtNNKNFLQEYLANLLSTAFPNLTQEQIKSFVVGLFELNGDDNAFKEHLRDFLIQIKEFG 320

                    .
gi 4507943     1027 G 1027
Cdd:smart01102  321 G 321
 
Name Accession Description Interval E-value
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
15-1044 0e+00

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 1174.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    15 QLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKIL 94
Cdd:COG5101    3 GILEFDKDLDIALLDKVVTTFYQGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943    95 PRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLL 174
Cdd:COG5101   83 PEGMRQGIRNYVVQLVIEKSQDDKVRDKQKYVLNKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVCENNMIVLKLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   175 SEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKF 254
Cdd:COG5101  163 SEEVFDFSAEQMTQVKKRLLKNQMKIEFPQIFGLCKQILEYSRDESLIEATLESLLRFLEWIPLDYIFETNIIELVLEHF 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   255 LNVPMFRNVSLKCLTEIAGV-SVSQY----EEQFVTLFTLTMMQLKQ-MLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCT 328
Cdd:COG5101  243 NSMPDTRVATLSCLTEIVDLgRHPQEnaekERILVIHFQCIEFLKMYsNKPQEEDIYEVYGGMDKNEQIFVQKLAQFLSS 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   329 FLKEHDQLIEKRLNLrETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRE--SPFSTSASPLLSGS--------- 397
Cdd:COG5101  323 LYEVYISLLEAREMA-ENLLNAHGYLIQISRINEREIFKTALEYWNKLVADLYSEfqRLPATEMSPLIQLSvgsqaistn 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   398 --QHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERI 475
Cdd:COG5101  402 pnQDSTKPLRKHIYIGILSQLRLVLIENMVRPEEVLIVENDEGEIVREFVKETDTIELYKSMREVLVYLTHLIVDDTEKY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   476 MTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFL 555
Cdd:COG5101  482 MIGKLARQLDGKEWSWNNLNTLCWAIGSISGAMSEVNEKRFFVNVIKDLLALCEMKRGKDNKAVVASNIMYVVGQYPRFL 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   556 RAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYE 635
Cdd:COG5101  562 KAHWSFLKTVVKKLFEFMHEDHEGVQDMACDTFIKIVQKCPVHFVTQQEGESEPFIVYIIRNLPKTTGDLEPQQKHTFYE 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   636 AVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYL 715
Cdd:COG5101  642 ACGMVISEVPKTRDYKRLVLDLMDLPNSAWLNIVIQADENINRLSDTMTVKIDANKMKTNVAKCTSLGYRFYPQTCSSYC 721
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   716 DMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAA 795
Cdd:COG5101  722 IMLFLYFAVSFDISNSVAAEGLIATKTPAVRGLRTIKKEILKLVATYISKARDLKFVQNDLVNMLCEAVLFDYKNNVPDA 801
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   796 REPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVL 875
Cdd:COG5101  802 RDAEVLNLGTTIVRNVESVIYLQRELFLISVFICTLIMIVKDFDEYPEHRKNFLLLLENINLFSFSAFLSFPQPSFKLVY 881
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   876 DSIIWAFKHTMRNVADTGLQILFTLLQNVA-QEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVE 954
Cdd:COG5101  882 NTILWSFKHINRDVSDLGLNILLILFKNCHeMGVPFINQFYAQYYMSTLENILGVLTDSDHKSGFDQQCLLLAFLIRLVK 961
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943   955 EGKIST-SLNPGNPvnNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTsdl 1033
Cdd:COG5101  962 DNKISVpLYDGINP--NITILSEYIVGLFVKSFPNITQESVKIFSVGLFELCGDDEIFKEHVEDFRVKVYEFGTDED--- 1036
                       1050
                 ....*....|.
gi 4507943  1034 fLEEREIALRQ 1044
Cdd:COG5101 1037 -LQEEIDLKNE 1046
CRM1_C pfam08767
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ...
709-1027 1.86e-169

CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.


Pssm-ID: 430202  Cd Length: 323  Bit Score: 499.84  E-value: 1.86e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     709 QLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDY 788
Cdd:pfam08767    1 QLGRIYLDMLNLYRAYSELISQAVAANGEIATKTPKVRGLRTVKKEILKLIETYISKADDLELVLNNLVPPLLDAVLVDY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     789 QRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPP 868
Cdd:pfam08767   81 NRNVPDARDAEVLSLMTTIVNKLGNLITDEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINLHCFPALLSLPP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     869 TQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEA-AAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILA 947
Cdd:pfam08767  161 EQFKLVIDSIVWAFKHTNRDVADTGLNILLELLKNVEETDSeFANQFYQNYYLSILQEVFYVLTDTDHKSGFKLQALLLA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     948 YMFNLVEEGKISTSLNPGNPV---NNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKE 1024
Cdd:pfam08767  241 RLFRLVENGSITVPLYDPDQApgtSNQVFLSEYIANLLQNAFPNLTQEQIEIFVVGLFNLCNDLNKFKSHLRDFLIQLKE 320

                   ...
gi 4507943    1025 FAG 1027
Cdd:pfam08767  321 FGG 323
CRM1_C smart01102
CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins ...
709-1027 1.68e-166

CRM1 C terminal; CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.


Pssm-ID: 198170  Cd Length: 321  Bit Score: 492.27  E-value: 1.68e-166
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      709 QLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDY 788
Cdd:smart01102    1 QLGRIYLDMLNLYRAYSELISAAVAKEGTIATKTPKVRGLRTIKREILKLIETYISKAEDLEFVAENFVPPLLEAVLGDY 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      789 QRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPP 868
Cdd:smart01102   81 RRNVPDAREAEVLSLMTTIVNKLGNLLTPEVPLILDAVFECTLDMINKDFEEYPEHRVNFFKLLRAINSHCFPAFLSLPP 160
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      869 TQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVA-QEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILA 947
Cdd:smart01102  161 EQFKLVIDSIVWAFKHTDRDVADTGLNILLELLNNVSkKDSQIANEFYKQYYFSILQDIFSVLTDSDHKSGFKLQCLLLA 240
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943      948 YMFNLVEEGKISTSLNPGNPV-NNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFA 1026
Cdd:smart01102  241 KLFRLVEENPISVPLYDAPPGtNNKNFLQEYLANLLSTAFPNLTQEQIKSFVVGLFELNGDDNAFKEHLRDFLIQIKEFG 320

                    .
gi 4507943     1027 G 1027
Cdd:smart01102  321 G 321
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
123-268 2.54e-49

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 429967  Cd Length: 147  Bit Score: 171.27  E-value: 2.54e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507943     123 EKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCNEF 202
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSNPTGCELLLRILKVLPEEIFDFSRTSLTQDRRNRLKDLLRSNM 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507943     203 SQIFQLCQFVMENSQNAP--LVHATLETLLRFLNWIPLGYIFETKLIStLIYKFLNVPMFRNVSLKCL 268
Cdd:pfam08389   81 EQILELLLQILENSQNANseLVEAVLKCLGSWLSWIPIGLIVNNPLLN-LLFQLLNDPDLREAAVECL 147
CRM1_repeat_2 pfam18784
CRM1 / Exportin repeat 2; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear ...
405-472 2.01e-39

CRM1 / Exportin repeat 2; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other. This Pfam entry includes some CRM1 repeats that fail to be detected with the pfam18777 model.


Pssm-ID: 436735  Cd Length: 68  Bit Score: 139.93  E-value: 2.01e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507943     405 RRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDT 472
Cdd:pfam18784    1 RRQLYSPILSQLRVVLIERMAKPEEVLIVENEEGEIVREFMKDTDTIALYKSMRETLVYLTHLDPDDT 68
CRM1_repeat_3 pfam18787
CRM1 / Exportin repeat 3; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear ...
485-535 7.19e-34

CRM1 / Exportin repeat 3; Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other. This Pfam entry includes some CRM1 repeats that fail to be detected with the pfam18777 model.


Pssm-ID: 436736  Cd Length: 51  Bit Score: 123.83  E-value: 7.19e-34
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 4507943     485 NGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKD 535
Cdd:pfam18787    1 DGSEWSWNNLNTLCWAIGSISGAMSEEDEKRFLVTVIKDLLNLCEMKRGKD 51
CRM1_repeat pfam18777
Chromosome region maintenance or exportin repeat; Chromosome region maintenance 1 or exportin ...
345-381 4.07e-16

Chromosome region maintenance or exportin repeat; Chromosome region maintenance 1 or exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-terminal, C-terminal and central repeats show slightly different structural arrangements, with N- and C- termini repeats interacting with each other. This entry represents the central repeats of CRM1.


Pssm-ID: 436729  Cd Length: 37  Bit Score: 72.52  E-value: 4.07e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4507943     345 ETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELY 381
Cdd:pfam18777    1 ELLLAALQYLVKISEVDDREIFKICLEYWNKLVSELY 37
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
46-112 7.99e-15

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 69.96  E-value: 7.99e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507943       46 AQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIK 112
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
IBN_N pfam03810
Importin-beta N-terminal domain;
46-112 2.63e-08

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 51.47  E-value: 2.63e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507943      46 AQEVLTHLKEHPDAWTRVDTILEFSQN-MNTKYYGLQILENVIKTRW----KILPRNQCEGIKKYVVGLIIK 112
Cdd:pfam03810    1 AEKQLEQFEKSPGFWSKLLQILSNSENpLEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLGS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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