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Conserved domains on  [gi|2032329391|ref|NP_001381667|]
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phosphatase and actin regulator 2 isoform 6 [Homo sapiens]

Protein Classification

RPEL domain-containing protein( domain architecture ID 13681330)

RPEL domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
383-407 1.68e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*
gi 2032329391  383 KLVRRLSQRPTTEELEQRNILKQKN 407
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
62-83 1.91e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 426961  Cd Length: 24  Bit Score: 38.41  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|..
gi 2032329391  62 LERKISTRQSREELIRRGVLKE 83
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
420-445 3.62e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  420 RRLSRKLSLRPTVAELQARRILRFNE 445
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL super family cl29414
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
344-369 7.19e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


The actual alignment was detected with superfamily member smart00707:

Pssm-ID: 452986  Cd Length: 26  Bit Score: 36.69  E-value: 7.19e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  344 DTLAIKLGNRPSKKELEDKNILQRTS 369
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
383-407 1.68e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*
gi 2032329391  383 KLVRRLSQRPTTEELEQRNILKQKN 407
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
383-405 9.59e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 426961  Cd Length: 24  Bit Score: 39.19  E-value: 9.59e-05
                          10        20
                  ....*....|....*....|...
gi 2032329391 383 KLVRRLSQRPTTEELEQRNILKQ 405
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
62-83 1.91e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 426961  Cd Length: 24  Bit Score: 38.41  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|..
gi 2032329391  62 LERKISTRQSREELIRRGVLKE 83
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
420-445 3.62e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  420 RRLSRKLSLRPTVAELQARRILRFNE 445
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
60-85 5.96e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.07  E-value: 5.96e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391   60 AVLERKISTRQSREELIRRGVLKELP 85
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
344-369 7.19e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 7.19e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  344 DTLAIKLGNRPSKKELEDKNILQRTS 369
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
383-407 1.68e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*
gi 2032329391  383 KLVRRLSQRPTTEELEQRNILKQKN 407
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
383-405 9.59e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 426961  Cd Length: 24  Bit Score: 39.19  E-value: 9.59e-05
                          10        20
                  ....*....|....*....|...
gi 2032329391 383 KLVRRLSQRPTTEELEQRNILKQ 405
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
62-83 1.91e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 426961  Cd Length: 24  Bit Score: 38.41  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|..
gi 2032329391  62 LERKISTRQSREELIRRGVLKE 83
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
420-445 3.62e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.84  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  420 RRLSRKLSLRPTVAELQARRILRFNE 445
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
60-85 5.96e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.07  E-value: 5.96e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391   60 AVLERKISTRQSREELIRRGVLKELP 85
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
344-369 7.19e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 7.19e-04
                           10        20
                   ....*....|....*....|....*.
gi 2032329391  344 DTLAIKLGNRPSKKELEDKNILQRTS 369
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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