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Conserved domains on  [gi|1917203561|ref|NP_001374968|]
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replication initiator 1 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416201)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203561 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203561 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203561 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203561 558 NLVSHRRIHTGERPYACPDCDRSFSQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203561 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
PHA00733 PHA00733
hypothetical protein
 571-624 9.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1917203561 571 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 624
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203561 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-622 3.22e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 319 RPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFR----------------HKPNLLSHSKIHKRSEGSAQAAP 382
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsrplelsrhlrthhnNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 383 GPGS-------------------PQLP---------------------AGPQESAAEPtPAVPLKPAQEPPPGAPPEHPQ 422
Cdd:COG5048   112 SSSSnsndnnllsshslppssrdPQLPdllsisnlrnnplpgnnsssvNTPQSNSLHP-PLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 423 DPIEAPPSLYSCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTHL 475
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 476 VAHSRVHSGER-------PFACEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGEK 542
Cdd:COG5048   271 QSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 543 PYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFDD 611
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNR 430

                         410
                  ....*....|.
gi 1917203561 612 EERLLAHQKKH 622
Cdd:COG5048   431 HYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
311-597 1.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 311 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEgSAQAAPGPGSPQLP 390
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS-SSSASESPRSSLPT 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 391 AGPQESAAEPTPAVPLKpaqepppgappehpqdpieAPPSLYSCDDCGRSFRLERFLRAHQRQ--HTGE--RPFTCAE-- 464
Cdd:COG5048   268 ASSQSSSPNESDSSSEK-------------------GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 465 CGKNFGKKTHLVAHSRVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPDRPFVC--PDCGKAFRHKPYLAAHR 535
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1917203561 536 RIHTGEKPYVC--PDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 597
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
292-481 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 292 PFQCACCGKRFRHKPNLIAHRR--VHTGE--RPHQCPE--CGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLl 365
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL- 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 366 shskiHKRSEGSAQAAPGP--GSPQLPAGPQESAAEPTPAVPLKpaqepppgappeHPQDPIEAPPSLYSCDDCGRSFRL 443
Cdd:COG5048   368 -----NNEPPQSLQQYKDLknDKKSETLSNSCIRNFKRDSNLSL------------HIITHLSFRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1917203561 444 ERFLRAHQRQHTGERPFTCAECGKNFGKKtHLVAHSRV 481
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203561 558 NLVSHRRIHTGERPYACPDCDRSFSQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
530-555 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203561 530 YLAAHRRIHTGEKPYVCPDCGKAFSQ 555
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 3.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203561 335 YLTSHRRIHTGEKPYPCKECGRRFRH 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-332 4.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203561 307 NLIAHRRVHTGERPHQCPECGKRFTN 332
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 6.52e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|...
gi 1917203561 544 YVCPDCGKAFSQKSNLVSHRRIH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-594 2.27e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|...
gi 1917203561 572 YACPDCDRSFSQKSNLITHRKSH 594
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 321-343 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|...
gi 1917203561 321 HQCPECGKRFTNKPYLTSHRRIH 343
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 6.67e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.67e-03
                          10        20
                  ....*....|....*....|...
gi 1917203561 516 FVCPDCGKAFRHKPYLAAHRRIH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203561 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203561 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-469 8.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.92e-03
                          10        20
                  ....*....|....*....|...
gi 1917203561 447 LRAHQRQHTGERPFTCAECGKNF 469
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 571-624 9.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1917203561 571 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 624
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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