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Conserved domains on  [gi|1870786862|ref|NP_001372301|]
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tudor domain-containing protein 1 isoform 10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
268-396 1.02e-70

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410479  Cd Length: 130  Bit Score: 231.10  E-value: 1.02e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  268 GTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH-EKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHV 346
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNnHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCI 396
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
944-1058 3.73e-66

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410482  Cd Length: 116  Bit Score: 218.08  E-value: 3.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  944 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 1023
Cdd:cd20411      1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLE 1058
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
517-598 9.76e-45

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410480  Cd Length: 82  Bit Score: 155.69  E-value: 9.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20409      1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80

                   ..
gi 1870786862  597 LL 598
Cdd:cd20409     81 LL 82
TUDOR pfam00567
Tudor domain;
715-832 4.77e-37

Tudor domain;


:

Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 135.17  E-value: 4.77e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  715 TVDVVVCVIYSPGEFYCHvlKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
zf-MYND pfam01753
MYND finger;
170-206 6.34e-12

MYND finger;


:

Pssm-ID: 426410  Cd Length: 39  Bit Score: 60.89  E-value: 6.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1870786862  170 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSAHSIVC 206
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
268-396 1.02e-70

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 231.10  E-value: 1.02e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  268 GTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH-EKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHV 346
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNnHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCI 396
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
944-1058 3.73e-66

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 218.08  E-value: 3.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  944 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 1023
Cdd:cd20411      1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLE 1058
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
517-598 9.76e-45

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 155.69  E-value: 9.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20409      1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80

                   ..
gi 1870786862  597 LL 598
Cdd:cd20409     81 LL 82
TUDOR pfam00567
Tudor domain;
715-832 4.77e-37

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 135.17  E-value: 4.77e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  715 TVDVVVCVIYSPGEFYCHvlKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
494-611 3.88e-33

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 124.00  E-value: 3.88e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  494 DEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCdQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVL 573
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYY-ASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  574 VGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAG 611
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
761-819 4.37e-33

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481  Cd Length: 59  Bit Score: 121.68  E-value: 4.37e-33
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  761 FKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 819
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
TUDOR pfam00567
Tudor domain;
940-1057 9.97e-31

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 117.07  E-value: 9.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  940 KTIQANVLEIISPNLFYALPKgmpENQEKLCMLTAELLEYCNAPKsRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDT 1018
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPK---SDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITEsLDDG 76
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1870786862 1019 DVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR pfam00567
Tudor domain;
264-383 4.43e-29

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 112.45  E-value: 4.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  264 MEIKGTVTEFKHPGDFYVQlySSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKk 343
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGL- 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1870786862  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVAN 383
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
zf-MYND pfam01753
MYND finger;
170-206 6.34e-12

MYND finger;


Pssm-ID: 426410  Cd Length: 39  Bit Score: 60.89  E-value: 6.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1870786862  170 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSAHSIVC 206
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
766-812 9.84e-11

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 58.05  E-value: 9.84e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1870786862   766 GQPCCAFFaGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELR 812
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLR 51
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
311-367 1.87e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 54.59  E-value: 1.87e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862   311 YIPVKGEVCIAKYTvDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHLNR 367
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKVD-GEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
542-597 4.34e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.43  E-value: 4.34e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1870786862   542 PAIGDICCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
989-1041 5.60e-07

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 47.27  E-value: 5.60e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862   989 YRPRIGDACCAKYTsDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKvDGEQLYEVFFIDYGNEEVVPPSDLRQL 53
 
Name Accession Description Interval E-value
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
268-396 1.02e-70

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 231.10  E-value: 1.02e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  268 GTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH-EKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHV 346
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNnHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCI 396
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
944-1058 3.73e-66

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 218.08  E-value: 3.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  944 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 1023
Cdd:cd20411      1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLE 1058
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
517-598 9.76e-45

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 155.69  E-value: 9.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20409      1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80

                   ..
gi 1870786862  597 LL 598
Cdd:cd20409     81 LL 82
TUDOR pfam00567
Tudor domain;
715-832 4.77e-37

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 135.17  E-value: 4.77e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  715 TVDVVVCVIYSPGEFYCHvlKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
494-611 3.88e-33

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 124.00  E-value: 3.88e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  494 DEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCdQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVL 573
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYY-ASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  574 VGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAG 611
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
761-819 4.37e-33

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481  Cd Length: 59  Bit Score: 121.68  E-value: 4.37e-33
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  761 FKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 819
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
TUDOR pfam00567
Tudor domain;
940-1057 9.97e-31

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 117.07  E-value: 9.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  940 KTIQANVLEIISPNLFYALPKgmpENQEKLCMLTAELLEYCNAPKsRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDT 1018
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPK---SDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITEsLDDG 76
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1870786862 1019 DVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR pfam00567
Tudor domain;
264-383 4.43e-29

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 112.45  E-value: 4.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  264 MEIKGTVTEFKHPGDFYVQlySSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKk 343
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGL- 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1870786862  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVAN 383
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
519-611 2.65e-28

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 110.23  E-value: 2.65e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  519 KLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLL 598
Cdd:cd20411     25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103
                           90
                   ....*....|...
gi 1870786862  599 ELPMQAIKCVLAG 611
Cdd:cd20411    104 ELPFQIIRCSLAG 116
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
498-624 1.82e-24

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 99.75  E-value: 1.82e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  498 GVVAHIQTPEDFF--CQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAY-ASEESVLV 574
Cdd:cd20408      1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  575 GYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAI 624
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
719-831 3.26e-24

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 98.29  E-value: 3.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  719 VVCVIySPGEFYC-HVLKEDALKKLNDLNKSLAEHCQ-QKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEIlPNGHVKVH 796
Cdd:cd20411      3 VLEVI-SPDLFYAlPKTGQVNVEKLKALMTELAEYCSkQSVPQQFRPRIGDACCARFTGDKNWYRAVVLET-SDSEVKVL 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862  797 FVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLA 831
Cdd:cd20411     81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
718-845 3.07e-20

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 87.43  E-value: 3.07e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  718 VVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQ-KLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGH-VKV 795
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASvNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGV 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  796 HFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAI 845
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
712-832 3.56e-20

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 87.09  E-value: 3.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  712 VDQTVDVVVCVIYSPGEFYCHVLKEDalKKLNDLNKSLAEHCQQKlpNGFKAEIGQPC---CAFFAGDGSWYRALVKEIL 788
Cdd:cd20437      1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV--SKELNPSCENFgllCAAKGKDGQWHRGFLQQLL 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1870786862  789 PNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:cd20437     77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLSC 120
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
967-1046 6.23e-20

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 85.20  E-value: 6.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  967 EKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSH 1045
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81

                   .
gi 1870786862 1046 L 1046
Cdd:cd20409     82 L 82
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
946-1057 2.42e-19

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 85.11  E-value: 2.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  946 VLEIISPNLFYALPKGmPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTD--VEVL 1023
Cdd:cd20408      3 VTEFKNPGEFYIQIYT-LEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQkkAGVF 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1870786862 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20408     82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCL 115
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
486-612 1.47e-18

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 82.54  E-value: 1.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  486 KVLTLNVGDEFCGVVAHIQTPEDFFCQqLQSgrKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLA 565
Cdd:cd20439      2 KEYLFKPGSVVDVKCSYVNSPGDFWCQ-LQT--KSSELKSLMKQIQSYYLIHNDPYKHGQIACVAKYSKDGKWYRAAVLK 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1870786862  566 YASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGV 612
Cdd:cd20439     79 QVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
509-614 1.79e-18

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514  Cd Length: 117  Bit Score: 82.13  E-value: 1.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  509 FFCQQLQSGRkLAELQASLSKYC--DQLPPRSDFYPAIGDICCAQFSEDDQWYRASVL------AYASEESVLVGYVDYG 580
Cdd:cd20443      4 FYVQVVSDQR-LSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYG 82
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1870786862  581 NFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20443     83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
718-830 4.20e-18

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 81.35  E-value: 4.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  718 VVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEhcQQKLPNGFKAEIGQP--CCAFFAGDGSWYRALVKEILPNGHVKV 795
Cdd:cd20440     14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAE--ISKLFNSQILDNCKTrlCLAKYFEDGQWYRALAHPVESSSHLSV 89
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  796 HFVDYGNIEEVTADELRMISSTFLNL---PFQGIRCQL 830
Cdd:cd20440     90 YFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
277-386 6.53e-18

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514  Cd Length: 117  Bit Score: 80.59  E-value: 6.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  277 GDFYVQLYSSEVLE-YMNQLSA-SLKETyANVhEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQ-----QKKAHVLYI 349
Cdd:cd20443      2 GRFYVQVVSDQRLSsIQQQLEGlSLKDK-ANP-PGGFNPKKGELVLAQFSADNSWNRAMVVNAPRQgtqspKDEYEVFYI 79
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1870786862  350 DYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20443     80 DYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
292-362 2.93e-17

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504  Cd Length: 84  Bit Score: 77.34  E-value: 2.93e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  292 MNQLSaslKETYAN-VHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRI 362
Cdd:cd20433      9 MEKLR---FEIASNpPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVE-GDKKVHVLYIDYGNREVLPSTRL 76
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
720-848 3.62e-17

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 79.08  E-value: 3.62e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  720 VCVIYSPGEFYCHVlkedALKKLNDLNKSLAEHCQQKLPNGFKA---EIGQPCCAFFAGDGSWYRALVKEILPNgHVKVH 796
Cdd:cd20426      5 ATAVDSPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVR 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  797 FVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRF 848
Cdd:cd20426     80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
740-828 3.83e-17

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 77.72  E-value: 3.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  740 KKLNDLNKSLAEHCQQK--LPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISST 817
Cdd:cd20412      4 LQLDKLVQEMTQYYESEenRHTLLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83
                           90
                   ....*....|.
gi 1870786862  818 FLNLPFQGIRC 828
Cdd:cd20412     84 FLSLPFQAIEC 94
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
516-595 7.84e-17

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504  Cd Length: 84  Bit Score: 76.18  E-value: 7.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  516 SGRKLAELQASLSKYCDQLPP-RSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPII 594
Cdd:cd20433      1 TGPQLEKLMEKLRFEIASNPPlPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                   .
gi 1870786862  595 P 595
Cdd:cd20433     81 P 81
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
765-814 2.61e-16

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 73.70  E-value: 2.61e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  765 IGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMI 814
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
498-623 7.64e-16

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 75.23  E-value: 7.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  498 GVVAHIQTPEDFFCQQLQSG-RKLAELQASLSKYCDQlppRSDFYPAI--GDICCAQFSEDDQWYRASVLAYASEEsVLV 574
Cdd:cd20426      3 AYATAVDSPEYFWCQFATEKiQCLAVKVQEAGEQVAD---RGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSV 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1870786862  575 GYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEA 623
Cdd:cd20426     79 RFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEA 127
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
717-849 1.22e-15

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 74.47  E-value: 1.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  717 DVVVCVIYSPGEFYCHvLKEDALKkLNDLNKSLAEHCQQ--KLpNGF--KAEIGQPCCAFFAGDGsWYRALVKEILPNGh 792
Cdd:cd20422      3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAFYSQasKL-DGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM- 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQ 849
Cdd:cd20422     78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
715-833 2.87e-15

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 73.29  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  715 TVDVVVCVIYSPGEFYCHVLKedalkKLNDLnKSLAEHCQQK-LPNGFKAEIGQ-PCCAFFAGDGSWYRALVKEILPNGH 792
Cdd:cd20439     11 VVDVKCSYVNSPGDFWCQLQT-----KSSEL-KSLMKQIQSYyLIHNDPYKHGQiACVAKYSKDGKWYRAAVLKQVSAKE 84
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1870786862  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADI 833
Cdd:cd20439     85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
983-1044 5.17e-15

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504  Cd Length: 84  Bit Score: 71.18  E-value: 5.17e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  983 PKSRPPYRPRIGDACCAKYTSDDFWYRA-VVLGTSDTDVEVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20433     20 PPLPGSYTPRKGDLCAAKFVEDGEWYRAkVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPA 82
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
540-598 9.71e-15

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481  Cd Length: 59  Bit Score: 69.29  E-value: 9.71e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  540 FYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLL 598
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
547-617 1.23e-14

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 69.82  E-value: 1.23e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  547 ICCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLG 617
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
496-629 1.30e-14

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 71.77  E-value: 1.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  496 FC-GVVAHIQTPEDFFCQQLQSGRKLAELQASLSkycdqlpprsDFY------------PAIGDICCAQFsEDDQWYRAS 562
Cdd:cd20422      1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMT----------AFYsqaskldgvvlkPQPGQLCCAKW-KEDRYYRAI 69
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862  563 VLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKK 629
Cdd:cd20422     70 VTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
318-390 1.45e-14

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 69.82  E-value: 1.45e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  318 VCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGN 390
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSGQ 80
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
716-830 1.97e-14

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 70.56  E-value: 1.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  716 VDVVVCVIYSPGEFYCHVLKEDAlkKLNDLNKSLAEHCQQKLPNGFKA-EIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQDED--ELSMISEKLNASKANDEEVECESlQLGDLICAEYPEDGLWYRAVVKEKIPNNLVS 79
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20425     80 VQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
725-833 3.56e-14

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 69.38  E-value: 3.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  725 SPGEFYCHVLK-EDALKKLNDLNKSLAEHCQQKLPNgfKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNI 803
Cdd:cd20441      1 SPSRFFIQLSEdEKVILQLAEELNETSEKSRENAAV--KLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNT 78
                           90       100       110
                   ....*....|....*....|....*....|
gi 1870786862  804 EEVTADELRMISSTFLNLPFQGIRCQLADI 833
Cdd:cd20441     79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
991-1057 5.82e-14

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 69.84  E-value: 5.82e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862  991 PRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20426     47 IYVGDPCIVKYSEDNHWYRALVTKINDNLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCL 113
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
968-1057 6.25e-14

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514  Cd Length: 117  Bit Score: 69.03  E-value: 6.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  968 KLCMLTAELLEYCNAPKSRPP--YRPRIGDACCAKYTSDDFWYRAVVLG-------TSDTDVEVLYADYGNIETLPLCRV 1038
Cdd:cd20443     13 RLSSIQQQLEGLSLKDKANPPggFNPKKGELVLAQFSADNSWNRAMVVNaprqgtqSPKDEYEVFYIDYGNQETVPLSAL 92
                           90
                   ....*....|....*....
gi 1870786862 1039 QPITSSHLALPFQIIRCSL 1057
Cdd:cd20443     93 RPLDPSVSSAPGLAQLCSL 111
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
538-616 6.79e-14

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 68.59  E-value: 6.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  538 SDFYPaiGDICCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPS 615
Cdd:cd20418      2 TDFRP--EMPCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPP 78

                   .
gi 1870786862  616 L 616
Cdd:cd20418     79 L 79
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
544-593 1.12e-13

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 66.00  E-value: 1.12e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  544 IGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPI 593
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
720-830 1.93e-13

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 67.86  E-value: 1.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  720 VCVIYSPGEFYCHVLKEDALKKLNDLNKSL-----AEHCQQK--LPNGFKAEiGQPCCAFFAGDGSWYRALVKEILPNGH 792
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMrrcysNEHVSERyvMPEAFIQP-GQVCCVRIPEDVWWYRVIIHQVLNKQE 80
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20419     81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
968-1056 3.83e-13

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 66.16  E-value: 3.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  968 KLCMLTAELLEYCNAPKSRPPYR-PRIGDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYADYGNIETLPLCRVQPITSSH 1045
Cdd:cd20412      5 QLDKLVQEMTQYYESEENRHTLLtVQVGDIVAAPFRHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDF 84
                           90
                   ....*....|.
gi 1870786862 1046 LALPFQIIRCS 1056
Cdd:cd20412     85 LSLPFQAIECS 95
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
500-609 3.87e-13

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 67.10  E-value: 3.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  500 VAHIQTPEDFFCQQlqsGRKLAELQASLSKYCD--QLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYV 577
Cdd:cd20440     16 ITHVYSPAKFYCQL---DRNTEILEALMEKIAEisKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFV 92
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862  578 DYGNFEILSLMRLCPI---IPKLLELPMQAIKCVL 609
Cdd:cd20440     93 DYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
315-365 4.30e-13

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 64.46  E-value: 4.30e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1870786862  315 KGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
737-818 4.81e-13

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504  Cd Length: 84  Bit Score: 65.40  E-value: 4.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  737 DALKKL-NDLNKSLAEHcqQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMIS 815
Cdd:cd20433      3 PQLEKLmEKLRFEIASN--PPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                   ...
gi 1870786862  816 STF 818
Cdd:cd20433     81 PAF 83
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
764-834 9.89e-13

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 64.15  E-value: 9.89e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  764 EIGQPCCAFFAGdgSWYRALVKEILPN-GHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20407      6 EVGVICAAPVMN--AWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
519-607 1.02e-12

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 65.01  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  519 KLAELQASLSKYCDQLPPRSDF-YPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:cd20412      5 QLDKLVQEMTQYYESEENRHTLlTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84
                           90
                   ....*....|
gi 1870786862  598 LELPMQAIKC 607
Cdd:cd20412     85 LSLPFQAIEC 94
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
766-835 1.60e-12

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 64.38  E-value: 1.60e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  766 GQPCCAFFAgDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQS 835
Cdd:cd20415     28 GQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
526-597 2.19e-12

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501  Cd Length: 75  Bit Score: 63.46  E-value: 2.19e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  526 SLSKYCDQLPPRSDfYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:cd20430      4 ELAEVCPTAPPLFG-TPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
490-609 2.51e-12

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 64.83  E-value: 2.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  490 LNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPP-RSDFYPaiGDICCAQFSeDDQWYRASVLAyaS 568
Cdd:cd20424      8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIIIT--N 82
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1870786862  569 EESVLVGYVDYGNFEILSLMRLCPI---IPKLLELPMQAIKCVL 609
Cdd:cd20424     83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
741-819 2.87e-12

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 63.24  E-value: 2.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  741 KLNDLNKSLAEHCQQKLPN-GFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 819
Cdd:cd20409      3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
768-834 3.16e-12

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 62.88  E-value: 3.16e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1870786862  768 PCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLI 75
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
993-1041 3.80e-12

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 61.76  E-value: 3.80e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  993 IGDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
989-1046 5.43e-12

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481  Cd Length: 59  Bit Score: 61.59  E-value: 5.43e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  989 YRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSHL 1046
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
717-830 6.18e-12

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 63.68  E-value: 6.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  717 DVVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAgDGSWYRALVKEILPNghVKVH 796
Cdd:cd20424     15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKNS--TEVF 89
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1870786862  797 FVDYGNIEEVTADELRMISS---TFLNLPFQGIRCQL 830
Cdd:cd20424     90 FVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
539-614 6.27e-12

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 62.83  E-value: 6.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  539 DFYPAIGDICCAQF----------SEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCV 608
Cdd:cd20427      9 EFYSKSSTAMCLRSpsvgqlvavkAEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCK 87

                   ....*.
gi 1870786862  609 LAGVKP 614
Cdd:cd20427     88 LAGLEP 93
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
270-379 6.27e-12

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 63.23  E-value: 6.27e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  270 VTEFKHPGDFY-VQLYSSEVLEYMNQLSASLKEtYANVHE--KDYIPVKGEVCIAKYTVDQTWNRAIIqnVDVQQKKAHV 346
Cdd:cd20411      3 VLEVISPDLFYaLPKTGQVNVEKLKALMTELAE-YCSKQSvpQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKV 79
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1870786862  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20411     80 LYADYGNTETLPLSRILPITKSHLELPFQIIRC 112
zf-MYND pfam01753
MYND finger;
170-206 6.34e-12

MYND finger;


Pssm-ID: 426410  Cd Length: 39  Bit Score: 60.89  E-value: 6.34e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1870786862  170 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSAHSIVC 206
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
498-629 7.85e-12

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 64.03  E-value: 7.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  498 GVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFY--PAIGDICCAQFSEDDQWYRAsVLAYASEESVLVG 575
Cdd:cd20438      9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRA-VITEVLDLKVSVY 87
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  576 YVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKK 629
Cdd:cd20438     88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
946-1057 1.15e-11

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 62.85  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  946 VLEIISPNLFYALPKGmPENQEKLCMLTAELLEYCNAPKSRPPYRP-----RIGDACCAKYTSDDFWYRAVVLGT-SDTD 1019
Cdd:cd20419      2 VEYIESPSQFYVRFYS-KDTSEMLEDMMIEMRRCYSNEHVSERYVMpeafiQPGQVCCVRIPEDVWWYRVIIHQVlNKQE 80
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862 1020 VEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20419     81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
717-846 1.78e-11

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 62.85  E-value: 1.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  717 DVVVCVIYSPGEFYCHVLKEdALKKLND-LNKSLAE-HCQQKLPNGFkaeIGQPCCA---FFAGDGSWYRALVKEILPNG 791
Cdd:cd20428      3 NVRVTNVCSDGTLYCQVPSK-GLSKLNEiLDKIEYYfHSRQMTSEYF---VSLPFCGkicLARYKGKWARVEITNVHSSR 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  792 HVKVHFVDYGNIEEVTADELRMISSTFL----NLPFQGIRCQLADIQSRNKHWSEEAIT 846
Cdd:cd20428     79 ALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDAVL 137
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
709-830 2.00e-11

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 62.44  E-value: 2.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  709 ELGVDQTVDVVVCVIYSPGEFYCHvlkedaLKKLNDLNKSLAEHCQQ------KLPNGFKAEI-GQPCCAFfAGDGSWYR 781
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCQ------LRSLSQELKRLSESMHQyyegrvGSGYETRPEKlGSPCAAR-GSDGRWYR 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  782 ALVKEILPNGH-VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20421     79 AVLQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
544-614 2.18e-11

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 60.68  E-value: 2.18e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  544 IGDICCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20407      7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
500-609 3.10e-11

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 61.32  E-value: 3.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  500 VAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDY 579
Cdd:cd20425      6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85
                           90       100       110
                   ....*....|....*....|....*....|
gi 1870786862  580 GNFEILSLMRLCPIIPKLLELPMQAIKCVL 609
Cdd:cd20425     86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
542-614 3.41e-11

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 60.53  E-value: 3.41e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  542 PAIGDICCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20415     25 PVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
989-1057 8.53e-11

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 59.37  E-value: 8.53e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  989 YRPRIGDACCAKYtSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20415     23 LCPVQGQACVALF-EDGAWYRARIIGlPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
766-812 9.84e-11

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 58.05  E-value: 9.84e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1870786862   766 GQPCCAFFaGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELR 812
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLR 51
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
996-1057 1.24e-10

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 58.65  E-value: 1.24e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  996 ACCAKYTSDDFWYRAVVLGTSDT--DVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
506-612 1.62e-10

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 58.98  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  506 PEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 585
Cdd:cd20441      2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81
                           90       100
                   ....*....|....*....|....*..
gi 1870786862  586 SLMRLCPIIPKLLELPMQAIKCVLAGV 612
Cdd:cd20441     82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
500-609 2.64e-10

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 59.00  E-value: 2.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  500 VAHIQTPEDF---FCQQLQSgRKLAELQASLsKYCDQLPPRSDFYPAI------GDICCAQFSEDDQWYRASVLAYASEE 570
Cdd:cd20419      2 VEYIESPSQFyvrFYSKDTS-EMLEDMMIEM-RRCYSNEHVSERYVMPeafiqpGQVCCVRIPEDVWWYRVIIHQVLNKQ 79
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1870786862  571 SVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVL 609
Cdd:cd20419     80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
990-1057 7.05e-10

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 58.25  E-value: 7.05e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1870786862  990 RPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20438     54 KPEPGLLCCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
497-610 7.84e-10

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 57.43  E-value: 7.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  497 CGVVAHIQ-----TPEDFFCQQLQSGRKLAELQASLSKYCD-----QLPPRSDFypaigDICCAQFSEDDQWYRASVLAY 566
Cdd:cd20437      1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYEsvskeLNPSCENF-----GLLCAAKGKDGQWHRGFLQQL 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1870786862  567 ASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLA 610
Cdd:cd20437     76 LPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
949-1057 9.02e-10

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 57.50  E-value: 9.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  949 IISPNLFYAlpkGMPENQEKLCMLTAELLEYCNApkSRPPYRPriGD-ACCAKYTSDDFWYRAVVLG-TSDTDVEVLYAD 1026
Cdd:cd20439     19 VNSPGDFWC---QLQTKSSELKSLMKQIQSYYLI--HNDPYKH--GQiACVAKYSKDGKWYRAAVLKqVSAKEVDVIFVD 91
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1870786862 1027 YGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20439     92 YGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
268-355 1.58e-09

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 56.73  E-value: 1.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  268 GTVTEFK-----HPGDFYVQLY--SSEVLEYMNQLsaslkETYANVHEKDYIPvkGEV-CIAKYTVDQTWNRAIIQNVdV 339
Cdd:cd20439      9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQI-----QSYYLIHNDPYKH--GQIaCVAKYSKDGKWYRAAVLKQ-V 80
                           90
                   ....*....|....*.
gi 1870786862  340 QQKKAHVLYIDYGNEE 355
Cdd:cd20439     81 SAKEVDVIFVDYGNQE 96
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
311-367 1.87e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 54.59  E-value: 1.87e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862   311 YIPVKGEVCIAKYTvDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHLNR 367
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKVD-GEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
267-400 2.00e-09

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 56.75  E-value: 2.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  267 KGTVTEFKHPGDFYVQLYSSEVLeyMNQLSASLKETYANVHEKDYI---PVKGEVCIAKYTvDQTWNRAIIqnVDVQQKK 343
Cdd:cd20422      3 DAQVEFVKDPSEFWIRLGEHAVP--FSKLMRSMTAFYSQASKLDGVvlkPQPGQLCCAKWK-EDRYYRAIV--TAVKGKM 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATK 400
Cdd:cd20422     78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
762-849 2.02e-09

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 57.10  E-value: 2.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  762 KAEIGQPCCAFFAGDGSWYRALVKEILpNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWS 841
Cdd:cd20438     54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132

                   ....*...
gi 1870786862  842 EEAITRFQ 849
Cdd:cd20438    133 KNANDFFK 140
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
276-384 2.30e-09

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 55.90  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  276 PGDFYVQLysSEVLEYMNQLSASLKETYANVHEKDYI-PVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNE 354
Cdd:cd20441      2 PSRFFIQL--SEDEKVILQLAEELNETSEKSRENAAVkLKVGDLVAAEYDEDLALYRAVITAV-LPGKSFKVEFIDYGNT 78
                           90       100       110
                   ....*....|....*....|....*....|
gi 1870786862  355 EIIPLNRIYHLNRNIDLFPPCAIKCFVANV 384
Cdd:cd20441     79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
267-379 2.62e-09

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 57.36  E-value: 2.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  267 KGTVTEFKHPGDFYVQLY-SSEVLEYMNQLSASLKETYANVHEKDYipVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAH 345
Cdd:cd20442      5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVEDI--KEGLECLAKSKKNLKWYRAVVEHLYPETEKML 82
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1870786862  346 VLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20442     83 VFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
286-362 3.98e-09

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 54.38  E-value: 3.98e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1870786862  286 SEVLEYMNQLSASLKETYAnvhEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPLNRI 362
Cdd:cd20409      2 RQLAELQESLSAYCKVAPA---SSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRL 74
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
776-826 4.11e-09

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 54.42  E-value: 4.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1870786862  776 DGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGI 826
Cdd:cd20429     41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
542-597 4.34e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.43  E-value: 4.34e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1870786862   542 PAIGDICCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
313-363 5.20e-09

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 53.08  E-value: 5.20e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1870786862  313 PVKGEVCIAKYtvDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIY 363
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLY 49
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
542-614 5.91e-09

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 55.33  E-value: 5.91e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  542 PAIGDICCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20435     50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127
Tudor_SPF30 cd20399
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar ...
765-816 6.38e-09

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410470 [Multi-domain]  Cd Length: 55  Bit Score: 52.69  E-value: 6.38e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  765 IGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISS 816
Cdd:cd20399      3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKPREE 54
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
951-1057 7.61e-09

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 54.36  E-value: 7.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  951 SPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGN 1029
Cdd:cd20441      1 SPSRFFI---QLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAvLPGKSFKVEFIDYGN 77
                           90       100
                   ....*....|....*....|....*...
gi 1870786862 1030 IETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20441     78 TAVVDKSNIYTLQEKFLSLPRLSIPCSL 105
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
266-393 1.81e-08

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 54.04  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  266 IKGTVTEFKHPGDFYVQlYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDvqQKKAH 345
Cdd:cd20426      1 IEAYATAVDSPEYFWCQ-FATEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIN--DNLVS 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862  346 VLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSS 393
Cdd:cd20426     78 VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
510-624 2.54e-08

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 53.99  E-value: 2.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  510 FCQQLQSG-RKLAELQASLSKYCDQLPPRSDFY---PAIGDICCAQFSedDQWYRASVLAYASEESVLVGYVDYGNFEIL 585
Cdd:cd20428     16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGTVASV 93
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1870786862  586 SLMRLCPIIPKLLE----LPMQAIKCVLAGVKPSLGIWTPEAI 624
Cdd:cd20428     94 KVSELREIPPPFLRelisIPPQALKCCLADLPLNIGMWTPDAV 136
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
270-379 2.69e-08

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 53.22  E-value: 2.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  270 VTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIP------VKGEVCIAKYTVDQTWNRAIIQNVdVQQKK 343
Cdd:cd20419      2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYVmpeafiQPGQVCCVRIPEDVWWYRVIIHQV-LNKQE 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1870786862  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20419     81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
316-365 3.37e-08

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 50.71  E-value: 3.37e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  316 GEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
943-1057 3.93e-08

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 52.46  E-value: 3.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  943 QANVLEIISPNLFYAlpkGMPENQEKLCMLTAELleycNAPKSRPPYRP----RIGDACCAKYTSDDFWYRAVVL-GTSD 1017
Cdd:cd20425      3 EVYVSHVNSPSDFYV---QLAQDEDELSMISEKL----NASKANDEEVEceslQLGDLICAEYPEDGLWYRAVVKeKIPN 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1870786862 1018 TDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20425     76 NLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
990-1057 4.38e-08

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 52.90  E-value: 4.38e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1870786862  990 RPRIGDACCAKYtSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20422     49 KPQPGQLCCAKW-KEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCL 115
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
499-611 4.67e-08

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 52.81  E-value: 4.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  499 VVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDF-YPAIGDICCAQFSEDDQWYRASVL-AYASEESVLVGY 576
Cdd:cd20421     16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYEtRPEKLGSPCAARGSDGRWYRAVLQqVFSANRVVEVLH 95
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862  577 VDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAG 611
Cdd:cd20421     96 VDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
748-811 4.79e-08

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501  Cd Length: 75  Bit Score: 51.14  E-value: 4.79e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  748 SLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADEL 811
Cdd:cd20430      4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSI 67
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
757-833 5.22e-08

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514  Cd Length: 117  Bit Score: 52.08  E-value: 5.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  757 LPNGFKAEIGQPCCAFFAGDGSWYRALVKE------ILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20443     32 PPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSL 111

                   ...
gi 1870786862  831 ADI 833
Cdd:cd20443    112 AHI 114
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
765-831 6.78e-08

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 51.64  E-value: 6.78e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  765 IGQPCCAFFAgDGSWYRALVKEILPNGHVK--VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLA 831
Cdd:cd20418      6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLA 73
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
276-381 7.83e-08

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 51.69  E-value: 7.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  276 PGDFYVQLYSSEVLeyMNQLSASLKETYANVHEKDYIPVK-GEVCIAKYTVDQTWNRAIiqnvdVQQKKA----HVLYID 350
Cdd:cd20425     12 PSDFYVQLAQDEDE--LSMISEKLNASKANDEEVECESLQlGDLICAEYPEDGLWYRAV-----VKEKIPnnlvSVQFID 84
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1870786862  351 YGNEEIIPLNRIYHLNRNIDLFPPCAIKCFV 381
Cdd:cd20425     85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
948-1049 1.17e-07

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 50.85  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  948 EIISPNLFYALpKGMPENQEKLCMLTAELLEYCNAPksrPPYRPRIGDACCAKYTSDDF--WYRAVVLGTSDTDVEVLYA 1025
Cdd:cd20431      2 EVVEVGHFWGY-RIDENSSEILQQLTAEINQRQLVP---LTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSAEVFFV 77
                           90       100
                   ....*....|....*....|....
gi 1870786862 1026 DYGNIETLPLCRVQPITSSHLALP 1049
Cdd:cd20431     78 DYGNTSQVPSSLLREIPETLLTLP 101
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
771-835 1.75e-07

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 50.12  E-value: 1.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1870786862  771 AFFAGDGSWYRALVKEILPNgHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQS 835
Cdd:cd20427     30 AVKAEEDAWLRAQVIEVEED-KVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
276-391 2.46e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 50.94  E-value: 2.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  276 PGDFYVQlysseVLEYMNQLSASLK---ETYANVHEKDYI---PVKGEVCIAKYTVDQTWNRAIIqnVDVQQKKAHVLYI 349
Cdd:cd20438     17 PSNFWIR-----TDEYNNEFQALMKniaDIYNLCGNDEELlkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFL 89
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1870786862  350 DYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNW 391
Cdd:cd20438     90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVW 131
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
935-1059 2.74e-07

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 50.50  E-value: 2.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  935 ELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEycNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG 1014
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYE--GRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQ 83
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1870786862 1015 T--SDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEE 1059
Cdd:cd20421     84 VfsANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
275-408 2.76e-07

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 50.88  E-value: 2.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  275 HPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVkGEVCIAKYTVDQTWNRAIIQNVdvQQKKAHVLYIDYGNE 354
Cdd:cd20436     10 HPKEVLVKFQGQYNSICELDYHILQNEIQNATKSKSSWGV-GEFCLVEDTTSGEWYRGRVLEK--IDEKYEVFLIDRGEV 86
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  355 EIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYC 408
Cdd:cd20436     87 LNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQVK 140
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
949-1057 3.01e-07

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 50.20  E-value: 3.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  949 IISPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKS-RPPYRPriGDACCAKYTsDDFWYRAVVLgTSDTDVEVLYADY 1027
Cdd:cd20424     21 VNDPWTFYC---QLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII-TNKNSTEVFFVDY 93
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1870786862 1028 GNIETLPLCRVQPITSSH---LALPFQIIRCSL 1057
Cdd:cd20424     94 GNTEKVEKEDMLPIPSDAyelLLLPMQAIKCSL 126
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
946-1057 3.72e-07

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 50.15  E-value: 3.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  946 VLEIISPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKSrPPYRPRIGDACCAKYTSDDFWYRAVVLGT-SDTDVEVLY 1024
Cdd:cd20440     16 ITHVYSPAKFYC---QLDRNTEILEALMEKIAEISKLFNS-QILDNCKTRLCLAKYFEDGQWYRALAHPVeSSSHLSVYF 91
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1870786862 1025 ADYGNIETLPLCRVQPI--TSSHLAL-PFQIIRCSL 1057
Cdd:cd20440     92 VDYGNKQIVEKNEVLPIpdTAVDLLLtPMQAIKCCL 127
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
766-814 3.99e-07

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 47.63  E-value: 3.99e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  766 GQPCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMI 814
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEItEESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
766-813 4.15e-07

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449  Cd Length: 47  Bit Score: 47.58  E-value: 4.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862  766 GQPCCAFFAGDGSWYRALVKEILPNGHVKVHFvDYGNIEEVTADELRM 813
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
989-1041 5.60e-07

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 47.27  E-value: 5.60e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862   989 YRPRIGDACCAKYTsDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKvDGEQLYEVFFIDYGNEEVVPPSDLRQL 53
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
727-839 7.23e-07

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 50.04  E-value: 7.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  727 GEFYCHVLKEDalKKLNDLNKSLAEHC-QQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPN-GHVKVHFVDYGNIE 804
Cdd:cd20442     15 GTFYVRLLRNS--EQLTDLESLIAKEAkKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPEtEKMLVFFVDHGITE 92
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1870786862  805 EVTADELRMISSTFLNLPFQGIRCQLADIQSRNKH 839
Cdd:cd20442     93 VVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKEL 127
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
311-359 1.35e-06

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481  Cd Length: 59  Bit Score: 46.57  E-value: 1.35e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1870786862  311 YIPVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPL 359
Cdd:cd20410      1 FKPIVGEPCCAFFSGDGNWYRAMVKEI-LPGGAVKVHFVDYGNVEEVTL 48
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
996-1057 1.36e-06

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 46.82  E-value: 1.36e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  996 ACCAKYTSDDfWYRAVVLGTS-DTD-VEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20407      9 VICAAPVMNA-WYRAQVVGVFeETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYL 71
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
545-593 1.64e-06

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 45.71  E-value: 1.64e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  545 GDICCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLMRLCPI 593
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
519-601 1.72e-06

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 47.38  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  519 KLAELQASLSKYcDQLPPRSDFYPaiGDICCAQFSEDDQ--WYRASVLaYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20431     21 ILQQLTAEINQR-QLVPLTTKPVP--NLLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFVDYGNTSQVPSSLLREIPET 96

                   ....*
gi 1870786862  597 LLELP 601
Cdd:cd20431     97 LLTLP 101
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
269-365 1.89e-06

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 48.19  E-value: 1.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  269 TVTEFKHPGDFYVQL--YSSEVleymNQLSASLKETYANVH---EKDYIPVKGEVCIAKyTVDQTWNRAIIQNVDVQQKK 343
Cdd:cd20421     16 VVTEVTDPHRIFCQLrsLSQEL----KRLSESMHQYYEGRVgsgYETRPEKLGSPCAAR-GSDGRWYRAVLQQVFSANRV 90
                           90       100
                   ....*....|....*....|..
gi 1870786862  344 AHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd20421     91 VEVLHVDYGRKEVVSVSNLRYL 112
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
294-386 2.27e-06

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 48.02  E-value: 2.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  294 QLSASLKETYAN-----VHEKdyiPVKGEVCIAKYTvDQTWNRAIIQNVDVQQKKAH-----VLYIDYGNEEIIPLNRIY 363
Cdd:cd20435     29 KLSMKLNMYYSDpsnriLHGK---VKVGDLCAVEDE-NNLYHRVKVLEITEKDDKTKprevlVKFIDEGRVETVVVSQLL 104
                           90       100
                   ....*....|....*....|...
gi 1870786862  364 HLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20435    105 ELPEELKSLPPQAVEVFLCNVKP 127
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
543-631 3.03e-06

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.80  E-value: 3.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  543 AIGDICCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPE 622
Cdd:cd20436     48 GVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSST 126

                   ....*....
gi 1870786862  623 AICLMKKLV 631
Cdd:cd20436    127 AVNYFSSLI 135
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
723-822 3.34e-06

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 46.61  E-value: 3.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  723 IYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKL-----PNGFkaeigqpCCAFFAgDGS---WYRALVKEILPNGhVK 794
Cdd:cd20431      3 VVEVGHFWGYRIDENSSEILQQLTAEINQRQLVPLttkpvPNLL-------CLAPFT-DADmkkYYRAKILYVSGSS-AE 73
                           90       100
                   ....*....|....*....|....*...
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLP 822
Cdd:cd20431     74 VFFVDYGNTSQVPSSLLREIPETLLTLP 101
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
313-357 3.70e-06

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501  Cd Length: 75  Bit Score: 45.75  E-value: 3.70e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1870786862  313 PVKGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEII 357
Cdd:cd20430     19 PDPNKIYGGKFSEDNCWYRCKVKSIL-SDEKCTVQYIDYGNTETV 62
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
994-1052 3.71e-06

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 45.50  E-value: 3.71e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  994 GDACCAKyTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPIT----SSHLALPFQI 1052
Cdd:cd20417      4 GEGCVVR-GSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVlypdIPQFCIPCQL 65
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
770-826 3.74e-06

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 47.25  E-value: 3.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  770 CAFFAGDGSWYRALVKEILPNGH------VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGI 826
Cdd:cd20435     56 CAVEDENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118
Tudor_SMN cd20398
Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also ...
544-596 3.97e-06

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.


Pssm-ID: 410469  Cd Length: 56  Bit Score: 44.95  E-value: 3.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  544 IGDICCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20398      3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
497-607 4.30e-06

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 47.73  E-value: 4.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  497 CGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCdqlpPRSDFYPAI----GDICCAQFSEDDQWYRASVL-AYASEES 571
Cdd:cd20442      5 KGTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEA----KKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEK 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1870786862  572 VLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKC 607
Cdd:cd20442     81 MLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
271-370 4.56e-06

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 46.23  E-value: 4.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  271 TEFKHPGDFYVQLYSSEVLEYMNQLSASLKE-TYANVHEKdyiPVKGEVCIAKYT--VDQTWNRAIIQNVDVQQkkAHVL 347
Cdd:cd20431      1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQrQLVPLTTK---PVPNLLCLAPFTdaDMKKYYRAKILYVSGSS--AEVF 75
                           90       100
                   ....*....|....*....|...
gi 1870786862  348 YIDYGNEEIIPLnriyHLNRNID 370
Cdd:cd20431     76 FVDYGNTSQVPS----SLLREIP 94
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
766-814 5.18e-06

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 44.64  E-value: 5.18e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  766 GQPCCAFFAGDGSWYRALVKEILPNGHVK-VHFVDYGNIEEVTADELRMI 814
Cdd:cd20413      4 GDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEVLLSDIKPI 53
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
270-380 5.24e-06

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 46.68  E-value: 5.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  270 VTEFKHPGDFYVQLYSSEvlEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQkKAHVLYI 349
Cdd:cd20440     16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS-HLSVYFV 92
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1870786862  350 DYGNEEIIPLNRIYHLNR---NIDLFPPCAIKCF 380
Cdd:cd20440     93 DYGNKQIVEKNEVLPIPDtavDLLLTPMQAIKCC 126
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
994-1041 6.22e-06

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 44.16  E-value: 6.22e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  994 GDACCAKYTSDDFWYRAVV--LGTSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIeeITEESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
270-379 6.32e-06

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 46.73  E-value: 6.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  270 VTEFKHPGDFYVQL-YSSEVLEYMNQLSASLKETYANvHEKDYIPvkGEVCIAKYTvDQTWNRAIIQNvdvQQKKAHVLY 348
Cdd:cd20424     18 ITYVNDPWTFYCQLaRNAGVLDQLASAISRLSSEIRK-LELSVNP--GTLCLAKYS-DQHWYRGIIIT---NKNSTEVFF 90
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1870786862  349 IDYGN------EEIIPL-NRIYHLNrnidLFPPCAIKC 379
Cdd:cd20424     91 VDYGNtekvekEDMLPIpSDAYELL----LLPMQAIKC 124
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
716-848 6.64e-06

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.03  E-value: 6.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  716 VDVVVCVIYSPGEFYCHVLKEDalKKLNDLN-KSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILpNGHVK 794
Cdd:cd20436      1 DLKITHRVCHPKEVLVKFQGQY--NSICELDyHILQNEIQNATKSKSSWGVGEFCLVEDTTSGEWYRGRVLEKI-DEKYE 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRF 848
Cdd:cd20436     78 VFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYF 131
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
975-1057 6.85e-06

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 45.50  E-value: 6.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  975 ELLEYCNAPKSRPPYR-PRIGDACCAKyTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQII 1053
Cdd:cd20427      6 EMKEFYSKSSTAMCLRsPSVGQLVAVK-AEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84

                   ....
gi 1870786862 1054 RCSL 1057
Cdd:cd20427     85 KCKL 88
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
308-386 1.28e-05

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 44.73  E-value: 1.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  308 EKDYIPVKGEVCIAKYTvDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20415     20 LEILCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
972-1033 1.52e-05

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501  Cd Length: 75  Bit Score: 43.82  E-value: 1.52e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  972 LTAELLEYCnaPKSRPPYR-PRIGDACCAKYTSDDFWYRAVVLGT-SDTDVEVLYADYGNIETL 1033
Cdd:cd20430      1 LSDELAEVC--PTAPPLFGtPDPNKIYGGKFSEDNCWYRCKVKSIlSDEKCTVQYIDYGNTETV 62
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
268-379 2.11e-05

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 44.72  E-value: 2.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  268 GTVTEFK-----HPGDFYVQLYSSEvlEYMNQLSASLKETYANVhEKDYIPVK---GEVCIAKYTvDQTWNRAIIQNV-- 337
Cdd:cd20437      2 GTTEKVKitaavSPSKFYCQLLSWE--PELSKLTTQMTLHYESV-SKELNPSCenfGLLCAAKGK-DGQWHRGFLQQLlp 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1870786862  338 DVQQKkahVLYIDYGNEEIIPLNRIYHLNRNIDLFP----PCAIKC 379
Cdd:cd20437     78 PSQVK---VWFIDYGNSEAVSSHSVLKLPPDFFSLPlmsfPCSLSC 120
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
992-1057 2.85e-05

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 43.94  E-value: 2.85e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  992 RIGDACCAKYtSDDFWYRAVVLGTSD-TDVEVL--YADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20418      5 RPEMPCLAEY-SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKL 72
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
994-1040 4.40e-05

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449  Cd Length: 47  Bit Score: 41.80  E-value: 4.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862  994 GDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYaDYGNIETLPLCRVQP 1040
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47
Tudor_vreteno-like_rpt2 cd20445
second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
777-822 5.42e-05

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410516  Cd Length: 56  Bit Score: 41.64  E-value: 5.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1870786862  777 GSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLP 822
Cdd:cd20445     11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56
Tudor_SPF30 cd20399
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar ...
544-592 8.00e-05

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410470 [Multi-domain]  Cd Length: 55  Bit Score: 41.14  E-value: 8.00e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1870786862  544 IGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCP 592
Cdd:cd20399      3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
992-1041 8.03e-05

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 41.17  E-value: 8.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1870786862  992 RIGDACCAKYTSDDFWYRAVV--LGTSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd20413      2 KPGDECLAKYWEDNKFYRAEVtaVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53
Tudor_SMN cd20398
Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also ...
316-374 1.40e-04

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.


Pssm-ID: 410469  Cd Length: 56  Bit Score: 40.72  E-value: 1.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  316 GEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNriyhlnrniDLFPP 374
Cdd:cd20398      4 GDKCRAVYSEDGIIYEATIVSIDAERGTCVVRYTGYGNEEEQNLS---------DLLPP 53
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
315-355 2.06e-04

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 40.02  E-value: 2.06e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1870786862  315 KGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEE 355
Cdd:cd20413      3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYE 43
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
950-1057 2.81e-04

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 41.63  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  950 ISPNLFYALPKGMpenQEKLCMLTAELLEYCNA-PKSRPPYRPRIGDACCAKyTSDDFWYRAVVLGT-SDTDVEVLYADY 1027
Cdd:cd20437     13 VSPSKFYCQLLSW---EPELSKLTTQMTLHYESvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLlPPSQVKVWFIDY 88
                           90       100       110
                   ....*....|....*....|....*....|
gi 1870786862 1028 GNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20437     89 GNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_SMN cd20398
Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also ...
764-817 3.57e-04

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.


Pssm-ID: 410469  Cd Length: 56  Bit Score: 39.56  E-value: 3.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1870786862  764 EIGQPCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMISST 817
Cdd:cd20398      2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
542-592 3.90e-04

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 39.21  E-value: 3.90e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  542 PAIGDICCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLMRL--CP 592
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
545-593 4.86e-04

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 38.86  E-value: 4.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1870786862  545 GDICCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLMRLCPI 593
Cdd:cd20413      4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
547-605 5.40e-04

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 40.16  E-value: 5.40e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  547 ICCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAI 605
Cdd:cd20429     35 VYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
969-1055 6.87e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 41.56  E-value: 6.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  969 LCMLTAELLEYCnapKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTD--VEVLYADYGNIETLPLCRVQPITSSHL 1046
Cdd:cd20442     31 LESLIAKEAKKC---KFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETekMLVFFVDHGITEVVSMGNIKQLSNDLL 107

                   ....*....
gi 1870786862 1047 ALPFQIIRC 1055
Cdd:cd20442    108 QIPRQAVLC 116
Tudor_SPF30 cd20399
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar ...
992-1044 8.74e-04

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410470 [Multi-domain]  Cd Length: 55  Bit Score: 38.44  E-value: 8.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1870786862  992 RIGDACCAKYTSDDFWYRAVVLGTS-DTDVEVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20399      2 KVGDKCMAVWSEDGQYYEATIEEISeDGTCTVTFDGYGNTEVTPLSQLKPREEG 55
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
944-1041 1.04e-03

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 40.31  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  944 ANVLEIISPNLfyALPKGMPENQEKLCMltaELLEYCNAPKSRPPY-RPRIGDACCAKYTSDDFwYRAVVLGTSDTD--- 1019
Cdd:cd20435      7 ARILEHRSSDG--EVTKSMSSTYLKLSM---KLNMYYSDPSNRILHgKVKVGDLCAVEDENNLY-HRVKVLEITEKDdkt 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862 1020 ----VEVLYADYGNIET--------LP--------------LCRVQPI 1041
Cdd:cd20435     81 kpreVLVKFIDEGRVETvvvsqlleLPeelkslppqavevfLCNVKPV 128
Tudor_vreteno-like_rpt2 cd20445
second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
997-1042 1.26e-03

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410516  Cd Length: 56  Bit Score: 37.79  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1870786862  997 CCAKYtsDDFWYRAVVL-GTSDTDVEVLYADYGNIETLPLCRVQPIT 1042
Cdd:cd20445      5 CIAKY--MDKWYRAVCLeSVGDGRPTVLFCDYGNILMARLTDIRPFP 49
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
545-592 1.28e-03

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449  Cd Length: 47  Bit Score: 37.57  E-value: 1.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862  545 GDICCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLMRLCP 592
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
770-806 1.78e-03

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 37.80  E-value: 1.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1870786862  770 CAFFAGDGSWYRALVKEILpNGHVKVHFVDYGNIEEV 806
Cdd:cd20417      7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKI 42
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
718-834 1.80e-03

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410505  Cd Length: 164  Bit Score: 40.10  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  718 VVVCVIYSPGEFYCHVLK--------EDALKKLND-LNKSLAEHCQQ----KLPNgfkAEIGQPCCAFFAGDGSWYRALV 784
Cdd:cd20434      1 IQVLKIEDPGCFWGRILKgsgdlvvnPEEYENLQDeMNQFYHKGYKDveeiKPST---LEEGQVCVVFCEELKCWCRAVV 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  785 KEILPNGH---VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20434     78 ESLMSSADdylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIK 130
Tudor_TDRD10 cd20432
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 ...
252-366 1.86e-03

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410503  Cd Length: 139  Bit Score: 39.72  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1870786862  252 FSDLRSLQLkkTMEIKGT----VTE-FKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH--EKDYIpVKGEVCIAKYT 324
Cdd:cd20432      6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTLAEVESQQPflAKEDV-HRGRRCLAECP 82
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1870786862  325 VDQ---TWNRAIIqnVDVQQKKAHVLYIDYGNEEIIPLNRIYHLN 366
Cdd:cd20432     83 LGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125
Tudor_SMN cd20398
Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also ...
992-1044 3.24e-03

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.


Pssm-ID: 410469  Cd Length: 56  Bit Score: 36.86  E-value: 3.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1870786862  992 RIGDACCAKYTSDDFWYRAVVL---GTSDTDVeVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20398      2 KVGDKCRAVYSEDGIIYEATIVsidAERGTCV-VRYTGYGNEEEQNLSDLLPPSGE 56
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
320-382 3.50e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 37.79  E-value: 3.50e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1870786862  320 IAKYTVDQTWNRAiiQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVA 382
Cdd:cd20427     29 VAVKAEEDAWLRA--QVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLA 89
Tudor_vreteno-like_rpt2 cd20445
second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
317-374 6.04e-03

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410516  Cd Length: 56  Bit Score: 35.86  E-value: 6.04e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1870786862  317 EVCIAKYtvDQTWNRAI-IQNVDvqQKKAHVLYIDYGNEEIIPLNriyhlnrNIDLFPP 374
Cdd:cd20445      3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLT-------DIRPFPP 50
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
765-818 6.28e-03

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 35.74  E-value: 6.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1870786862  765 IGQPCCAFFagDGSWYRALVKEIL-PNGHVKVHFVDYGNIEEVTADELRMISSTF 818
Cdd:cd20444      3 PGQMVIAKF--DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENLYECPEYL 55
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
316-363 7.80e-03

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449  Cd Length: 47  Bit Score: 35.25  E-value: 7.80e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1870786862  316 GEVCIAKYTVDQTWNRAIIQNVDVQQkKAHVLYiDYGNEEIIPLNRIY 363
Cdd:cd04508      1 GDRVEAKWSDDGQWYPATVVAVNDDG-KYTVLF-DDGNEEEVSEDDIR 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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