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Conserved domains on  [gi|1862723015|ref|NP_001371750|]
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protein PRRC2B isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BAT2_N pfam07001
BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the ...
1-189 7.75e-64

BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin.


:

Pssm-ID: 429240 [Multi-domain]  Cd Length: 191  Bit Score: 215.96  E-value: 7.75e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015    1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPpANLPSLKSENKGNDPNIVIV 80
Cdd:pfam07001    1 MSTLSGQRGKGKDGKSKYSSLDLNDTYKGKSLEPQKTAVPRKHGLQSLGKVPSARRMPP-ANLPSLKAENKGNDPNVNLV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015   81 PKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQksvsnlQKPTQSISQENTNSVPG------GPKSWAQLNGKPVGH 154
Cdd:pfam07001   80 PKDGSGWASKQGQTEQKSTSQSAAQQPSHQNQQTAQ------SPKRPPASQETSQGVASggggtaGSKSWAPASVSHGGQ 153
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1862723015  155 -EGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKG 189
Cdd:pfam07001  154 gDAGGKGSNRLSPFSRQEFPTLQAAGDQDKAGSENS 189
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1869-2178 9.44e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 427171 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 9.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1869 PEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLdghvFASQPRLVPQTIPQQQS 1948
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL----IQQTPTLHPQRLPSPHP 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1949 YQQAAAAQQIPIslHTSLQAQAQLGLRG-GLPVSQSQEIFSSL-------QPFRSQVYMHPSLSPPSTMILSGGTA---- 2016
Cdd:pfam03154  248 PLQPMTQPPPPS--QVSPQPLPQPSLHGqMPPMPHSLQTGPSHmqhpvppQPFPLTPQSSQSQVPPGPSPAAPGQSqqri 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2017 -LKPPYSAFPGMQP------------LEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSqlPQLTMPLPRYG 2083
Cdd:pfam03154  326 hTPPSQSQLQSQQPpreqplppaplsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP--PPALKPLSSLS 403
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2084 SGQQPLILPQSIQLPPgqslsvgAPRRIPPPGSQPPVLNTSRE-----PSQMEMKGFHFADSKQNVPSGGPVPSPQtyrP 2158
Cdd:pfam03154  404 THHPPSAHPPPLQLMP-------QSQQLPPPPAQPPVLTQSQSlpppaASHPPTSGLHQVPSQSPFPQHPFVPGGP---P 473
                          330       340
                   ....*....|....*....|
gi 1862723015 2159 SSASPSGKPSGSAVNMGSVQ 2178
Cdd:pfam03154  474 PITPPSGPPTSTSSAMPGIQ 493
 
Name Accession Description Interval E-value
BAT2_N pfam07001
BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the ...
1-189 7.75e-64

BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin.


Pssm-ID: 429240 [Multi-domain]  Cd Length: 191  Bit Score: 215.96  E-value: 7.75e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015    1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPpANLPSLKSENKGNDPNIVIV 80
Cdd:pfam07001    1 MSTLSGQRGKGKDGKSKYSSLDLNDTYKGKSLEPQKTAVPRKHGLQSLGKVPSARRMPP-ANLPSLKAENKGNDPNVNLV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015   81 PKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQksvsnlQKPTQSISQENTNSVPG------GPKSWAQLNGKPVGH 154
Cdd:pfam07001   80 PKDGSGWASKQGQTEQKSTSQSAAQQPSHQNQQTAQ------SPKRPPASQETSQGVASggggtaGSKSWAPASVSHGGQ 153
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1862723015  155 -EGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKG 189
Cdd:pfam07001  154 gDAGGKGSNRLSPFSRQEFPTLQAAGDQDKAGSENS 189
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1869-2178 9.44e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 427171 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 9.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1869 PEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLdghvFASQPRLVPQTIPQQQS 1948
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL----IQQTPTLHPQRLPSPHP 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1949 YQQAAAAQQIPIslHTSLQAQAQLGLRG-GLPVSQSQEIFSSL-------QPFRSQVYMHPSLSPPSTMILSGGTA---- 2016
Cdd:pfam03154  248 PLQPMTQPPPPS--QVSPQPLPQPSLHGqMPPMPHSLQTGPSHmqhpvppQPFPLTPQSSQSQVPPGPSPAAPGQSqqri 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2017 -LKPPYSAFPGMQP------------LEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSqlPQLTMPLPRYG 2083
Cdd:pfam03154  326 hTPPSQSQLQSQQPpreqplppaplsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP--PPALKPLSSLS 403
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2084 SGQQPLILPQSIQLPPgqslsvgAPRRIPPPGSQPPVLNTSRE-----PSQMEMKGFHFADSKQNVPSGGPVPSPQtyrP 2158
Cdd:pfam03154  404 THHPPSAHPPPLQLMP-------QSQQLPPPPAQPPVLTQSQSlpppaASHPPTSGLHQVPSQSPFPQHPFVPGGP---P 473
                          330       340
                   ....*....|....*....|
gi 1862723015 2159 SSASPSGKPSGSAVNMGSVQ 2178
Cdd:pfam03154  474 PITPPSGPPTSTSSAMPGIQ 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
1779-2172 2.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1779 PVP-PIEFGVSPKDSDFSLPPGSAS-----GPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLT 1852
Cdd:PHA03247  2573 PAPrPSEPAVTSRARRPDAPPQSARprapvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP 2652
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1853 LKMESARKAwENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHVF 1932
Cdd:PHA03247  2653 RDDPAPGRV-SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1933 ASQPRL--VPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMI 2010
Cdd:PHA03247  2732 SPALPAapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2011 LSGGTALKPPYSAFPGMQPLEMVKPQSGS-------PYQPMSGNQA----LVYEGQLSQAAGLGA-------SQMLDSQL 2072
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTAPPpppgpppPSLPLGGSVApggdVRRRPPSRSPAAKPAaparppvRRLARPAV 2891
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2073 PQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPG----SQPPVLNTSREPSQMEMKGF-------HFADSK 2141
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPppprPQPPLAPTTDPAGAGEPSGAvpqpwlgALVPGR 2971
                          410       420       430
                   ....*....|....*....|....*....|.
gi 1862723015 2142 QNVPSgGPVPSPQTYRPSSASPSGKPSGSAV 2172
Cdd:PHA03247  2972 VAVPR-FRVPQPAPSREAPASSTPPLTGHSL 3001
 
Name Accession Description Interval E-value
BAT2_N pfam07001
BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the ...
1-189 7.75e-64

BAT2 N-terminus; This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin.


Pssm-ID: 429240 [Multi-domain]  Cd Length: 191  Bit Score: 215.96  E-value: 7.75e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015    1 MSDRLGQITKGKDGKSKYSTLSLFDKYKGKSVDAIRSSVIPRHGLQSLGKVAAARRMPPpANLPSLKSENKGNDPNIVIV 80
Cdd:pfam07001    1 MSTLSGQRGKGKDGKSKYSSLDLNDTYKGKSLEPQKTAVPRKHGLQSLGKVPSARRMPP-ANLPSLKAENKGNDPNVNLV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015   81 PKDGTGWANKQDQQDPKSSSATASQPPESLPQPGLQksvsnlQKPTQSISQENTNSVPG------GPKSWAQLNGKPVGH 154
Cdd:pfam07001   80 PKDGSGWASKQGQTEQKSTSQSAAQQPSHQNQQTAQ------SPKRPPASQETSQGVASggggtaGSKSWAPASVSHGGQ 153
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1862723015  155 -EGGLRGSSRLLSFSPEEFPTLKAAGGQDKAGKEKG 189
Cdd:pfam07001  154 gDAGGKGSNRLSPFSRQEFPTLQAAGDQDKAGSENS 189
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1869-2178 9.44e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 427171 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 9.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1869 PEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLdghvFASQPRLVPQTIPQQQS 1948
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL----IQQTPTLHPQRLPSPHP 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1949 YQQAAAAQQIPIslHTSLQAQAQLGLRG-GLPVSQSQEIFSSL-------QPFRSQVYMHPSLSPPSTMILSGGTA---- 2016
Cdd:pfam03154  248 PLQPMTQPPPPS--QVSPQPLPQPSLHGqMPPMPHSLQTGPSHmqhpvppQPFPLTPQSSQSQVPPGPSPAAPGQSqqri 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2017 -LKPPYSAFPGMQP------------LEMVKPQSGSPYQPMSGNQALVYEGQLSQAAGLGASQMLDSqlPQLTMPLPRYG 2083
Cdd:pfam03154  326 hTPPSQSQLQSQQPpreqplppaplsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP--PPALKPLSSLS 403
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2084 SGQQPLILPQSIQLPPgqslsvgAPRRIPPPGSQPPVLNTSRE-----PSQMEMKGFHFADSKQNVPSGGPVPSPQtyrP 2158
Cdd:pfam03154  404 THHPPSAHPPPLQLMP-------QSQQLPPPPAQPPVLTQSQSlpppaASHPPTSGLHQVPSQSPFPQHPFVPGGP---P 473
                          330       340
                   ....*....|....*....|
gi 1862723015 2159 SSASPSGKPSGSAVNMGSVQ 2178
Cdd:pfam03154  474 PITPPSGPPTSTSSAMPGIQ 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
1779-2172 2.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1779 PVP-PIEFGVSPKDSDFSLPPGSAS-----GPTGSPVVKLQDALASNAGLTQSIPILRRDHHIQRAIGLSPMSFPTADLT 1852
Cdd:PHA03247  2573 PAPrPSEPAVTSRARRPDAPPQSARprapvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERP 2652
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1853 LKMESARKAwENSPSLPEQSSPGGAGSGIQPPSSVGASSGVNYSSFGGVSMPPMPVASVAPSASMPGSHLPPLYLDGHVF 1932
Cdd:PHA03247  2653 RDDPAPGRV-SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 1933 ASQPRL--VPQTIPQQQSYQQAAAAQQIPISLHTSLQAQAQLGLRGGLPVSQSQEIFSSLQPFRSQVYMHPSLSPPSTMI 2010
Cdd:PHA03247  2732 SPALPAapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2011 LSGGTALKPPYSAFPGMQPLEMVKPQSGS-------PYQPMSGNQA----LVYEGQLSQAAGLGA-------SQMLDSQL 2072
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTAPPpppgpppPSLPLGGSVApggdVRRRPPSRSPAAKPAaparppvRRLARPAV 2891
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862723015 2073 PQLTMPLPRYGSGQQPLILPQSIQLPPGQSLSVGAPRRIPPPG----SQPPVLNTSREPSQMEMKGF-------HFADSK 2141
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPppprPQPPLAPTTDPAGAGEPSGAvpqpwlgALVPGR 2971
                          410       420       430
                   ....*....|....*....|....*....|.
gi 1862723015 2142 QNVPSgGPVPSPQTYRPSSASPSGKPSGSAV 2172
Cdd:PHA03247  2972 VAVPR-FRVPQPAPSREAPASSTPPLTGHSL 3001
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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