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Conserved domains on  [gi|1802563974|ref|NP_001364960|]
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coiled-coil domain-containing protein 78 isoform 4 [Homo sapiens]

Protein Classification

DUF4472 domain-containing protein( domain architecture ID 10631677)

DUF4472 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4472 pfam14739
Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members ...
56-165 3.02e-29

Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, pfam00225.


:

Pssm-ID: 434172 [Multi-domain]  Cd Length: 107  Bit Score: 109.68  E-value: 3.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  56 EQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAvpvesDPRHPRAAAQELRHKAQV 135
Cdd:pfam14739   3 EEKLQISKELVDLQIENNKLREQYEAEKFELKNKVLNLENRVLELELEREKAAREIQ-----DLRERLKELEDDRQELAE 77
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802563974 136 PGHSDDHRFQVQPKNTMNPENEQHRLGSGL 165
Cdd:pfam14739  78 EYVALKKNYQALPKEFEAEVAKNQELSLEL 107
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
80-384 2.97e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974   80 EAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQH 159
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE 776
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  160 RLgsglQGEVKWalEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKL 239
Cdd:TIGR02168  777 LA----EAEAEI--EELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL 850
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  240 KDEyVLRLQHcawqavEHAD-GAGQAPATTALRTFLE--ATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELlva 316
Cdd:TIGR02168  851 SED-IESLAA------EIEElEELIEELESELEALLNerASLEEALALLRSELEELSEELRELESKRSELRRELEEL--- 920
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1802563974  317 yrgldAASWAQIHQKLrdfsRSTQAELERERAQLLVRATMAEEQLSELQEYVDQHLGRYKHEILRLRK 384
Cdd:TIGR02168  921 -----REKLAQLELRL----EGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
 
Name Accession Description Interval E-value
DUF4472 pfam14739
Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members ...
56-165 3.02e-29

Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, pfam00225.


Pssm-ID: 434172 [Multi-domain]  Cd Length: 107  Bit Score: 109.68  E-value: 3.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  56 EQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAvpvesDPRHPRAAAQELRHKAQV 135
Cdd:pfam14739   3 EEKLQISKELVDLQIENNKLREQYEAEKFELKNKVLNLENRVLELELEREKAAREIQ-----DLRERLKELEDDRQELAE 77
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802563974 136 PGHSDDHRFQVQPKNTMNPENEQHRLGSGL 165
Cdd:pfam14739  78 EYVALKKNYQALPKEFEAEVAKNQELSLEL 107
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
80-384 2.97e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974   80 EAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQH 159
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE 776
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  160 RLgsglQGEVKWalEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKL 239
Cdd:TIGR02168  777 LA----EAEAEI--EELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL 850
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  240 KDEyVLRLQHcawqavEHAD-GAGQAPATTALRTFLE--ATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELlva 316
Cdd:TIGR02168  851 SED-IESLAA------EIEElEELIEELESELEALLNerASLEEALALLRSELEELSEELRELESKRSELRRELEEL--- 920
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1802563974  317 yrgldAASWAQIHQKLrdfsRSTQAELERERAQLLVRATMAEEQLSELQEYVDQHLGRYKHEILRLRK 384
Cdd:TIGR02168  921 -----REKLAQLELRL----EGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
176-388 8.08e-04

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 41.55  E-value: 8.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974 176 QEARQQALVTRVATlGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKLKDEYvlRLQHCAWQAV 255
Cdd:COG4372    94 QGEKRAAETEREAA-RSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKTLAEQR--RQLEAQAQSL 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974 256 EHADGAGQAPATTALRTFLEATLEDIRAAHRSRE-QQLARAARSYHKRLVDLSRRHEELLVAYRGLDaaswAQIHQklRD 334
Cdd:COG4372   171 QASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNlATRANAAQARTEELARRAAAAQQTAQAIQQRD----AQISQ--KA 244
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1802563974 335 FSRSTQAELERERAQllvRATMAEEQLSELQEYVDQhLGRYKHEILRLRKLAGA 388
Cdd:COG4372   245 QQIAARAEQIRERER---QLQRLETAQARLEQEVAQ-LEAYYQAYVRLRQQAAA 294
 
Name Accession Description Interval E-value
DUF4472 pfam14739
Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members ...
56-165 3.02e-29

Domain of unknown function (DUF4472); This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, pfam00225.


Pssm-ID: 434172 [Multi-domain]  Cd Length: 107  Bit Score: 109.68  E-value: 3.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  56 EQQLQISKELVDIQITTHHLHEQHEAEIFQLKSEILRLESRVLELELRGDGTSQGCAvpvesDPRHPRAAAQELRHKAQV 135
Cdd:pfam14739   3 EEKLQISKELVDLQIENNKLREQYEAEKFELKNKVLNLENRVLELELEREKAAREIQ-----DLRERLKELEDDRQELAE 77
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802563974 136 PGHSDDHRFQVQPKNTMNPENEQHRLGSGL 165
Cdd:pfam14739  78 EYVALKKNYQALPKEFEAEVAKNQELSLEL 107
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
80-384 2.97e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974   80 EAEIFQLKSEILRLESRVLELELRGDGTSQGCAVPVESDPRHPRAAAQELRHKAQVPGHSDDHRFQVQPKNTMNPENEQH 159
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE 776
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  160 RLgsglQGEVKWalEHQEARQQALVTRVATLGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKL 239
Cdd:TIGR02168  777 LA----EAEAEI--EELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL 850
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974  240 KDEyVLRLQHcawqavEHAD-GAGQAPATTALRTFLE--ATLEDIRAAHRSREQQLARAARSYHKRLVDLSRRHEELlva 316
Cdd:TIGR02168  851 SED-IESLAA------EIEElEELIEELESELEALLNerASLEEALALLRSELEELSEELRELESKRSELRRELEEL--- 920
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1802563974  317 yrgldAASWAQIHQKLrdfsRSTQAELERERAQLLVRATMAEEQLSELQEYVDQHLGRYKHEILRLRK 384
Cdd:TIGR02168  921 -----REKLAQLELRL----EGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
176-388 8.08e-04

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 41.55  E-value: 8.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974 176 QEARQQALVTRVATlGRQLQGAREEARAAGQRLATQAVVLCSCQGQLRQAEAENARLQLQLKKLKDEYvlRLQHCAWQAV 255
Cdd:COG4372    94 QGEKRAAETEREAA-RSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKTLAEQR--RQLEAQAQSL 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563974 256 EHADGAGQAPATTALRTFLEATLEDIRAAHRSRE-QQLARAARSYHKRLVDLSRRHEELLVAYRGLDaaswAQIHQklRD 334
Cdd:COG4372   171 QASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNlATRANAAQARTEELARRAAAAQQTAQAIQQRD----AQISQ--KA 244
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1802563974 335 FSRSTQAELERERAQllvRATMAEEQLSELQEYVDQhLGRYKHEILRLRKLAGA 388
Cdd:COG4372   245 QQIAARAEQIRERER---QLQRLETAQARLEQEVAQ-LEAYYQAYVRLRQQAAA 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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