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Conserved domains on  [gi|1375022883|ref|NP_001348988|]
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electron transfer flavoprotein regulatory factor 1 [Mus musculus]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448812)

LYR motif-containing protein similar to human electron transfer flavoprotein regulatory factor 1 (ETFRF1) that acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
6-79 2.82e-35

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380760  Cd Length: 74  Bit Score: 114.22  E-value: 2.82e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375022883  6 RGEVLTLYKNLLYLGRDYPKGADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKELEALYFLRKYRAMKQR 79
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
6-79 2.82e-35

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 114.22  E-value: 2.82e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375022883  6 RGEVLTLYKNLLYLGRDYPKGADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKELEALYFLRKYRAMKQR 79
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
8-63 1.62e-09

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 48.73  E-value: 1.62e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375022883  8 EVLTLYKNLLYLGRDYPKGA--DYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKE 63
Cdd:pfam05347  2 QVLSLYRALLRAARKFPDYNfrEYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
6-79 2.82e-35

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 114.22  E-value: 2.82e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375022883  6 RGEVLTLYKNLLYLGRDYPKGADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKELEALYFLRKYRAMKQR 79
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
8-63 1.62e-09

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 48.73  E-value: 1.62e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375022883  8 EVLTLYKNLLYLGRDYPKGA--DYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKE 63
Cdd:pfam05347  2 QVLSLYRALLRAARKFPDYNfrEYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
9-79 3.50e-09

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 433049  Cd Length: 79  Bit Score: 48.50  E-value: 3.50e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375022883  9 VLTLYKNLLYLGRDYPK-GADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKELEA---LYFLRKYRAMKQR 79
Cdd:pfam13233  1 VLSLYRALLRELRELPPeLRSLGDQYVRSEFRRHKHLTDPEEIAKFLKSWREYLELLERynpMTEEERVRLTARR 75
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
9-63 3.22e-08

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 45.23  E-value: 3.22e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375022883  9 VLTLYKNLLYLGR--DYPKGADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKE 63
Cdd:cd20251    1 VLKLYRDLLRLARkgLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
8-67 9.44e-07

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 41.74  E-value: 9.44e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375022883  8 EVLTLYKNLLYLGRDYPKGA--DYFKRRLKNVFLKNKDVEDPEKIKELIARGEfvmKELEAL 67
Cdd:cd20264    1 QVLSLYRALLREARKFPDYNfrEYFLRRIRDAFRENKNLKDPEEIKKLYEEGE---EQLEVL 59
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
8-58 1.54e-06

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 41.46  E-value: 1.54e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1375022883  8 EVLTLYKNLLYLGR----DYPKGADYFKRRLKNVFLKNKDVEDPEKIKELIARGE 58
Cdd:cd20261    1 EVLSLYRRILRLARtwpaDTEEEREYILNEARSLFRKNKNLTDPEEIEEKIQEAE 55
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
9-62 8.72e-05

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380764  Cd Length: 60  Bit Score: 36.84  E-value: 8.72e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375022883  9 VLTLYKNLLYLGRDYPKGA-DYFKRRLKNVFLKNKDVEDPEKIKELIARG----EFVMK 62
Cdd:cd20269    1 PLQLYRYLLRCCRRLPKDTrDYYRHYARQNFVSHRDEDDPERIQQIIERAyedaKWVLK 59
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
5-64 1.15e-04

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 36.36  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375022883  5 LRGEVLTLYKNLLYLGRDYPKGAD--YFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMKEL 64
Cdd:cd20262    2 LRAQVLSLYRDILRAIRKIPDPSTrrELRDWVREEFERNRNETDEDAIKYLLSQGKRQLKEL 63
Complex1_LYR_MIEF1-MP cd20272
LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein ...
9-62 2.61e-04

LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins; MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380767  Cd Length: 58  Bit Score: 35.32  E-value: 2.61e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1375022883  9 VLTLYKNLLYLGRDYP-KGADYFKRRLKNVFLKNKDVEDPEKIKELIARGEFVMK 62
Cdd:cd20272    3 VLSLYRALLRYGRQLRyTDKDYYRRRIRREFEKNQNLTDPEAIEFQYEKGQKFLK 57
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
31-72 4.71e-04

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 35.23  E-value: 4.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1375022883 31 KRRLKNVFLKNKDVEDPEKIKELIARGEfvmkelEALYFLRK 72
Cdd:cd20267   27 RQKIREEFEKNRNETDPEKIAELLKEAR------EAAEFLRK 62
Nckap1 pfam09735
Membrane-associated apoptosis protein; Expression of this protein was found to be markedly ...
27-81 2.33e-03

Membrane-associated apoptosis protein; Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease. It is involved in the regulation of actin polymerization in the brain as part of a WAVE2 signalling complex.


Pssm-ID: 430786  Cd Length: 1114  Bit Score: 34.93  E-value: 2.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1375022883   27 ADYFKRRLKNVFLKNKDVEDPeKIKELIargeFVMKELEALyfLRKYRAMKQRYY 81
Cdd:pfam09735  376 ADNVPKKSKKKYNKQEDLVDR-QIAELL----FYMEELRSL--VRKYSQVIQRYY 423
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
9-58 7.42e-03

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 32.15  E-value: 7.42e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1375022883  9 VLTLYKNLLYLGRDYPKGAD---YFKRRLKNVFLKNKDVEDPEKIKELIARGE 58
Cdd:cd20263    5 VLRLYRRALKTLLSWCVDRDifrYEAVLLRARFDANKDVKDPRKAEKLLEEGE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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