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Conserved domains on  [gi|1845865239|ref|NP_001344275|]
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lysozyme-like protein 4 precursor [Mus musculus]

Protein Classification

lysozyme C family protein( domain architecture ID 13014097)

lysozyme C family protein may catalyze the hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 21-143 9.49e-60

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


:

Pssm-ID: 340383  Cd Length: 126  Bit Score: 180.54  E-value: 9.49e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqDGSTGFGLFQIRDNEWC----GHGKNLCSVSCT 96
Cdd:cd16897     2 IFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENP-DGSTDYGIFQINSRYWCndgkTPSKNLCHISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1845865239  97 ALLNPNLKDTIQCAKKIVKGKHGMGAWPIWSKNCQLSDvLDRWLDGC 143
Cdd:cd16897    81 DLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRD-LSRWLDGC 126
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 21-143 9.49e-60

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 180.54  E-value: 9.49e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqDGSTGFGLFQIRDNEWC----GHGKNLCSVSCT 96
Cdd:cd16897     2 IFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENP-DGSTDYGIFQINSRYWCndgkTPSKNLCHISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1845865239  97 ALLNPNLKDTIQCAKKIVKGKHGMGAWPIWSKNCQLSDvLDRWLDGC 143
Cdd:cd16897    81 DLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRD-LSRWLDGC 126
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
21-143 2.83e-36

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 121.24  E-value: 2.83e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239   21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqDGSTGFGLFQIRDNEWCGHGK-----NLCSVSC 95
Cdd:smart00263   2 VFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNN-GGSTDYGIFQINSKYWCNDGKtpgsvNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1845865239   96 TALLNPNLKDTIQCAKKIVKgKHGMGAWPIWSKNCQLSDvLDRWLDGC 143
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVS-DQGIDAWVAWKNHCQGED-LSQWIRGC 126
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 21-141 1.09e-27

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 99.03  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVyeDPQDGSTGFGLFQIRDNEWCGHGK-----NLCSVSC 95
Cdd:pfam00062   2 QFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAI--VYNNGSTDYGIFQINDKYWCKDGKtpqsvNICGISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1845865239  96 TALLNPNLKDTIQCAKKIVKgKHGMGAWPIWSKNCqlSDVLDRWLD 141
Cdd:pfam00062  80 DKLLDDDITDDIMCAKKILD-PQGIDAWLAWKPHC--SEDLEQWIG 122
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 21-143 9.49e-60

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 180.54  E-value: 9.49e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqDGSTGFGLFQIRDNEWC----GHGKNLCSVSCT 96
Cdd:cd16897     2 IFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENP-DGSTDYGIFQINSRYWCndgkTPSKNLCHISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1845865239  97 ALLNPNLKDTIQCAKKIVKGKHGMGAWPIWSKNCQLSDvLDRWLDGC 143
Cdd:cd16897    81 DLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRD-LSRWLDGC 126
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
21-143 2.83e-36

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 121.24  E-value: 2.83e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239   21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqDGSTGFGLFQIRDNEWCGHGK-----NLCSVSC 95
Cdd:smart00263   2 VFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNN-GGSTDYGIFQINSKYWCNDGKtpgsvNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1845865239   96 TALLNPNLKDTIQCAKKIVKgKHGMGAWPIWSKNCQLSDvLDRWLDGC 143
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVS-DQGIDAWVAWKNHCQGED-LSQWIRGC 126
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 21-137 2.04e-31

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 108.47  E-value: 2.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDgglNYFEGYSLENWVCLAYFESKFNPSAVYEDPQDGSTGFGLFQIRDNEWCGHGK---NLCSVSCTA 97
Cdd:cd16899     2 IFTRCELARELRK---LGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGgsgNGCNVKCED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1845865239  98 LLNPNLKDTIQCAKKIvKGKHGMGAWPIWSKNCQ---LSDVLD 137
Cdd:cd16899    79 LLDDDISDDVKCAKKI-YKEQGFNAWVGWKNKCKgknLPSYSD 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-140 3.84e-28

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 100.20  E-value: 3.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVYEDPqdGSTGFGLFQIRDNEWCG-----HGKNLCSVSC 95
Cdd:cd16898     2 IFTKCELSQILKEHGLDGFNGISLPEWICVTFHTSGYDTQALVYNN--GSTEYGLFQISNKGWCDdsqepVSRNICGISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1845865239  96 TALLNPNLKDTIQCAKKIVKGKHGMGAWPIWSKNCqlSDVLDRWL 140
Cdd:cd16898    80 SKLLDDDITDDIACAKKILAIPKGIDYWKAHKPFC--REDLDQWR 122
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 21-141 1.09e-27

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 99.03  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  21 ILGRCTVAKMLYDGGLNYFEGYSLENWVCLAYFESKFNPSAVyeDPQDGSTGFGLFQIRDNEWCGHGK-----NLCSVSC 95
Cdd:pfam00062   2 QFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAI--VYNNGSTDYGIFQINDKYWCKDGKtpqsvNICGISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1845865239  96 TALLNPNLKDTIQCAKKIVKgKHGMGAWPIWSKNCqlSDVLDRWLD 141
Cdd:pfam00062  80 DKLLDDDITDDIMCAKKILD-PQGIDAWLAWKPHC--SEDLEQWIG 122
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 24-131 2.25e-25

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 93.40  E-value: 2.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  24 RCTVAKMLYDGGlnYFEGYSLENWVCLAYFESKFNPSAVYEDpQDGSTGFGLFQIRDNEWCGHGK-----NLCSVSCTAL 98
Cdd:cd00119     5 RCELARLLKDIG--GYGGISLPNWVCLMKHESGYDTQATNEN-NNGSTDYGLFQINSRYWCKDGQtpgarNICDISCSKL 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1845865239  99 LNPNLKDTIQCAKKIVKgKHGMGAWPIWSKNCQ 131
Cdd:cd00119    82 LTDDITDAIMCAKKIVD-DKGIDAWVAWKNHCQ 113
SLT_3 pfam18896
Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla ...
 39-123 1.27e-03

Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.


Pssm-ID: 436815 [Multi-domain]  Cd Length: 89  Bit Score: 35.85  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845865239  39 FEGYSLENWVCLAYFESKFNPSAVyEDPQD--GSTGFGLFQIRDN---EWCGHGKNLCSVSCTAllnpnlkdtiQCAKKI 113
Cdd:pfam18896   9 FTGDDAVTAVAVAMAESGGDPSAV-GDLANtkGSPSRGLWQINSLahpEVTGPDACAYDPQCNA----------KAAYAI 77

                          90
                  ....*....|
gi 1845865239 114 VKGKHGMGAW 123
Cdd:pfam18896  78 SSGGTNWSPW 87
Phage_lysozyme2 pfam18013
Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of ...
 37-77 1.80e-03

Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.


Pssm-ID: 465617  Cd Length: 139  Bit Score: 36.12  E-value: 1.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1845865239  37 NYF--EGYSLE-------NWvclaYFESKFNPSAVyEDPQDGSTGFGLFQ 77
Cdd:pfam18013   8 NFLksKGYSKAaaagilgNM----QRESGFNPGAV-EDEGGGGGGYGLVQ 52
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 46-113 2.07e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 34.69  E-value: 2.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1845865239  46 NWVCLAYFESKFNPSAvyeDPQDGSTGFGLFQIRDNEWCGHGKNlcsvsCTALLNpNLKDTIQCAKKI 113
Cdd:cd00442     1 VLAAIIGQESGGNKPA---NAGSGSGAAGLFQFMPGTWKAYGKN-----SSSDLN-DPEASIEAAAKY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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