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Conserved domains on  [gi|1269208478|ref|NP_001344162.1|]
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M-phase phosphoprotein 6 isoform 3 [Mus musculus]

Protein Classification

MPP6 family protein( domain architecture ID 10562780)

MPP6 family protein similar to Homo sapiens M-phase phosphoprotein 6, which is a RNA-binding protein that associates with the RNA exosome complex, is involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA

Gene Ontology:  GO:0000460|GO:0003723

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for ...
8-134 1.57e-35

M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).


:

Pssm-ID: 431112  Cd Length: 131  Bit Score: 119.84  E-value: 1.57e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208478   8 KLSKNLLRMKFMQRGLDSETKKQLEEEER--KMISDEHWYLDLPELKEKESFIVEEQSFSLCEDLLYGRMSFRGFNP--E 83
Cdd:pfam10175   1 KLSSRVLNMKFMQRAKDAEEKEQLEEEESdkKLIDESEWVLDGPELLEKKNKIKSEPSYVGCENLIFGRMSFGGFNPeiE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1269208478  84 KLMLQMNSKNRAEAAEEDEtVEVDVSDEEMARRY-ETLVGTIGKKFVKKRDR 134
Cdd:pfam10175  81 KLMKKEEKKEEEEEEEEKE-KEEDVSDEEMAKRYkSTLVGTISKKFKKKRKR 131
 
Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for ...
8-134 1.57e-35

M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).


Pssm-ID: 431112  Cd Length: 131  Bit Score: 119.84  E-value: 1.57e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208478   8 KLSKNLLRMKFMQRGLDSETKKQLEEEER--KMISDEHWYLDLPELKEKESFIVEEQSFSLCEDLLYGRMSFRGFNP--E 83
Cdd:pfam10175   1 KLSSRVLNMKFMQRAKDAEEKEQLEEEESdkKLIDESEWVLDGPELLEKKNKIKSEPSYVGCENLIFGRMSFGGFNPeiE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1269208478  84 KLMLQMNSKNRAEAAEEDEtVEVDVSDEEMARRY-ETLVGTIGKKFVKKRDR 134
Cdd:pfam10175  81 KLMKKEEKKEEEEEEEEKE-KEEDVSDEEMAKRYkSTLVGTISKKFKKKRKR 131
 
Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for ...
8-134 1.57e-35

M-phase phosphoprotein 6; This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).


Pssm-ID: 431112  Cd Length: 131  Bit Score: 119.84  E-value: 1.57e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208478   8 KLSKNLLRMKFMQRGLDSETKKQLEEEER--KMISDEHWYLDLPELKEKESFIVEEQSFSLCEDLLYGRMSFRGFNP--E 83
Cdd:pfam10175   1 KLSSRVLNMKFMQRAKDAEEKEQLEEEESdkKLIDESEWVLDGPELLEKKNKIKSEPSYVGCENLIFGRMSFGGFNPeiE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1269208478  84 KLMLQMNSKNRAEAAEEDEtVEVDVSDEEMARRY-ETLVGTIGKKFVKKRDR 134
Cdd:pfam10175  81 KLMKKEEKKEEEEEEEEKE-KEEDVSDEEMAKRYkSTLVGTISKKFKKKRKR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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