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Conserved domains on  [gi|1179685205|ref|NP_001337336|]
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dyslexia-associated protein KIAA0319 isoform h precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 1.69e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 153.27  E-value: 1.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDS--PVLRLSNLD-PGNYSFRLTVT 506
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTatPSFTAPEVTaDTVLTFQLVVS 1261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  507 DSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQTPYLH 586
Cdd:NF038112  1262 DGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGATTATAT 1336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  587 LSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFYHWEHV 663
Cdd:NF038112  1337 FTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTYAWTQT 1413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  664 RGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNSITLDG 740
Cdd:NF038112  1414 AGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGSTVTLDA 1490

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1179685205  741 SRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1491 SATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 9.47e-22

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


:

Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.59  E-value: 9.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205   20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765   1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                           90
                   ....*....|....*.
gi 1179685205   87 NCepkKMGPIRSYLTF 102
Cdd:smart00765  81 VC---KFKPHEGYTSY 93
PARM super family cl37917
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 2.40e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


The actual alignment was detected with superfamily member pfam17061:

Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 41.00  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061  78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685205 272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061 158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 1.69e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 153.27  E-value: 1.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDS--PVLRLSNLD-PGNYSFRLTVT 506
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTatPSFTAPEVTaDTVLTFQLVVS 1261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  507 DSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQTPYLH 586
Cdd:NF038112  1262 DGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGATTATAT 1336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  587 LSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFYHWEHV 663
Cdd:NF038112  1337 FTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTYAWTQT 1413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  664 RGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNSITLDG 740
Cdd:NF038112  1414 AGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGSTVTLDA 1490

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1179685205  741 SRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1491 SATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-720 2.56e-30

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 130.16  E-value: 2.56e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  404 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 481
Cdd:NF038112  1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  482 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 556
Cdd:NF038112  1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  557 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 632
Cdd:NF038112  1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  633 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 709
Cdd:NF038112  1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555

                          330
                   ....*....|.
gi 1179685205  710 AVKKENNSPPR 720
Cdd:NF038112  1556 TVKNVNRAPDG 1566
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 9.47e-22

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.59  E-value: 9.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205   20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765   1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                           90
                   ....*....|....*.
gi 1179685205   87 NCepkKMGPIRSYLTF 102
Cdd:smart00765  81 VC---KFKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 546-826 4.50e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 62.90  E-value: 4.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 546 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 617
Cdd:pfam02010   1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 618 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 675
Cdd:pfam02010  80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 676 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 747
Cdd:pfam02010 157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 748 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 814
Cdd:pfam02010 235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313

                         330
                  ....*....|..
gi 1179685205 815 SGLVELTLQVGV 826
Cdd:pfam02010 314 GGTCSVTPTEGT 325
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 435-521 1.12e-09

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 55.54  E-value: 1.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  435 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 514
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71


                   ....*..
gi 1179685205  515 TTAALIV 521
Cdd:smart00089  72 ATVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 626-711 3.39e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 51.73  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 626 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 705
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 1179685205 706 TLTVAV 711
Cdd:cd00146    76 TTTVVV 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
481-818 3.21e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 481 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 559
Cdd:COG3401   186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 560 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 638
Cdd:COG3401   262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 639 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 707
Cdd:COG3401   334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 708 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 787
Cdd:COG3401   412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1179685205 788 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 818
Cdd:COG3401   491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 56-87 6.06e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.60  E-value: 6.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1179685205  56 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 87
Cdd:pfam07502  38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 398-625 1.16e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  398 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 469
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  470 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 536
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  537 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 599
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445

                          250       260
                   ....*....|....*....|....*.
gi 1179685205  600 KVTDSSRQQSTAvVTVIVQPenNRPP 625
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
PARM pfam17061
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 2.40e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 41.00  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061  78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685205 272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061 158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 170-331 7.17e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 170 PSGKQEPRGSAEYTDWGLLP---GSEGAFNSSVGDSPAVPAETQQDPelhyLNESASTPAPKLPERsvllPLPTTPSSGe 246
Cdd:PLN03209  324 PSQRVPPKESDAADGPKPVPtkpVTPEAPSPPIEEEPPQPKAVVPRP----LSPYTAYEDLKPPTS----PIPTPPSSS- 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 247 vleKEKASQLQEQSSNSSGKevLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSI-------PTPPTSAAPSESTPS 319
Cdd:PLN03209  395 ---PASSKSVDAVAKPAEPD--VVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLkpptspsPTAPTGVSPSVSSTS 469

                         170
                  ....*....|..
gi 1179685205 320 ELPISPTTAPRT 331
Cdd:PLN03209  470 SVPAVPDTAPAT 481
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 1.69e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 153.27  E-value: 1.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDS--PVLRLSNLD-PGNYSFRLTVT 506
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTatPSFTAPEVTaDTVLTFQLVVS 1261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  507 DSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQTPYLH 586
Cdd:NF038112  1262 DGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGATTATAT 1336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  587 LSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFYHWEHV 663
Cdd:NF038112  1337 FTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTYAWTQT 1413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  664 RGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNSITLDG 740
Cdd:NF038112  1414 AGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGSTVTLDA 1490

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1179685205  741 SRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1491 SATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-720 2.56e-30

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 130.16  E-value: 2.56e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  404 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 481
Cdd:NF038112  1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  482 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 556
Cdd:NF038112  1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  557 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 632
Cdd:NF038112  1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  633 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 709
Cdd:NF038112  1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555

                          330
                   ....*....|.
gi 1179685205  710 AVKKENNSPPR 720
Cdd:NF038112  1556 TVKNVNRAPDG 1566
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 9.47e-22

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.59  E-value: 9.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205   20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765   1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                           90
                   ....*....|....*.
gi 1179685205   87 NCepkKMGPIRSYLTF 102
Cdd:smart00765  81 VC---KFKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 546-826 4.50e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 62.90  E-value: 4.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 546 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 617
Cdd:pfam02010   1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 618 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 675
Cdd:pfam02010  80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 676 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 747
Cdd:pfam02010 157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 748 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 814
Cdd:pfam02010 235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313

                         330
                  ....*....|..
gi 1179685205 815 SGLVELTLQVGV 826
Cdd:pfam02010 314 GGTCSVTPTEGT 325
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 435-521 1.12e-09

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 55.54  E-value: 1.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  435 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 514
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71


                   ....*..
gi 1179685205  515 TTAALIV 521
Cdd:smart00089  72 ATVTVVV 78
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 392-717 3.84e-09

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 60.21  E-value: 3.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 392 TLNLSQLSVGLYVFKVTVSSE---NAFGEGFVNVTVKPArrvnlPPVAV-------VSPQLQELTLpltsaliDGSQSTD 461
Cdd:pfam02010  44 TIPSGTLPYGTYVFTLTVSLSstpSLAGTDIITVTVQPS-----PLVAVidggssrVVGYNQDLTL-------DGSESYD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 462 ------DTEIVSYHWEEINGPFIEEKTSVDSPV-----LRLSNLDPGN---------------YSFRLTVTDSDGATNST 515
Cdd:pfam02010 112 pdvdpgSSSGLTYLWSCRRSSSGDNPLLNNDPVcfsdqNEGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSAST 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 516 TAALIVNNavDYPP------VANAGpnhTITLPQNS---ITLNGNQSSDDHQIVLYEWsLGPGSEGKHVV--------MQ 578
Cdd:pfam02010 192 TQTILVVD--GNPPiiilscISNCN---RKNNPVDRlvlLASTCLNCSSDLSDVTYRW-LSLGSENTSLVldqlnsqtST 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 579 GVQTPYLHLSA--MQEG-DYTFQLKVTDSSRQQS-TAVVTVIvqpeNNRPPVAVA-------GPDKELIFPVESatldgS 647
Cdd:pfam02010 266 GRSGPYLVIKAgvLQSGvSYRFTLIVTVYPGLVSgLASISFI----TNAPPTGGTcsvtpteGTALETKFTVTC-----Q 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 648 SSSDDHGIVFYHWEHVRGPSAVEMENI------DKAIATVTGLQVGTYHFRLT----VKDQQGLSSTSTLTVAVKKENNS 717
Cdd:pfam02010 337 GWTDDDLPLTYQFGDISFREASEEWFLlyegssQISISTFLPPGLPANDYQVTvvvvVYDSLGAATSVSLTITVTPPSSS 416
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 530-618 1.24e-08

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 52.84  E-value: 1.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  530 VANAGPNHTITLPQNSITLNGnQSSDDHQIVLYEWSLGPG--SEGKHVVMQGVQtpylhlsamqEGDYTFQLKVTDSSRq 607
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTA-TSSDDGSIVSYTWDFGDGtsSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                           90
                   ....*....|.
gi 1179685205  608 QSTAVVTVIVQ 618
Cdd:smart00089  69 SASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 626-712 1.27e-08

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 52.84  E-value: 1.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  626 VAVAGPDKELIFPVESATLDGSSSsDDHGIVFYHWEHVRGPSAVEmenidkAIATVTGLQVGTYHFRLTVKDQQGlSSTS 705
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTATSS-DDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SASA 72


                   ....*..
gi 1179685205  706 TLTVAVK 712
Cdd:smart00089  73 TVTVVVQ 79
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 489-810 1.39e-08

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 58.28  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 489 LRLSNLDPGNYSFRLTVTDSDgaTNSTTAALIVNNAVDYPP-VANAGPNHTITLPQNS-ITLNGNQSSD------DHQIV 560
Cdd:pfam02010  45 IPSGTLPYGTYVFTLTVSLSS--TPSLAGTDIITVTVQPSPlVAVIDGGSSRVVGYNQdLTLDGSESYDpdvdpgSSSGL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 561 LYEWSLGPGSEGKHVVM--QGVQTPYLH-LSAMQEGD---------------YTFQLKVTDSSRQQSTAVVTVIVQPENn 622
Cdd:pfam02010 123 TYLWSCRRSSSGDNPLLnnDPVCFSDQNeGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSASTTQTILVVDGN- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 623 rPP---VAVAGPDKELIFPVES---ATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENI--DKAIATVTG---------LQ 685
Cdd:pfam02010 202 -PPiiiLSCISNCNRKNNPVDRlvlLASTCLNCSSDLSDVTYRWLSLGSENTSLVLDQlnSQTSTGRSGpylvikagvLQ 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 686 VGT-YHFRLTVKDQQGLSSTSTlTVAVKkeNNSPPRaraGGRhVLVLPNN------SITLDGSRSTDD------------ 746
Cdd:pfam02010 281 SGVsYRFTLIVTVYPGLVSGLA-SISFI--TNAPPT---GGT-CSVTPTEgtaletKFTVTCQGWTDDdlpltyqfgdis 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1179685205 747 --QRIVSYLWIRDGQSPaagdvidgSDHSVALQLTNLVEG-VYTFHLRVTDSQGASDTDTATVEVQP 810
Cdd:pfam02010 354 frEASEEWFLLYEGSSQ--------ISISTFLPPGLPANDyQVTVVVVVYDSLGAATSVSLTITVTP 412
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 626-711 3.39e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 51.73  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 626 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 705
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                  ....*.
gi 1179685205 706 TLTVAV 711
Cdd:cd00146    76 TTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 720-809 1.36e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 49.76  E-value: 1.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  720 RARAGGRHVLVLPNNSITLDGSrSTDDQRIVSYLWirdgqspaagDVIDGSD-HSVALQLTNLVEGVYTFHLRVTDSQGa 798
Cdd:smart00089   1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW----------DFGDGTSsTGPTVTHTYTKPGTYTVTLTVTNAVG- 68

                           90
                   ....*....|.
gi 1179685205  799 SDTDTATVEVQ 809
Cdd:smart00089  69 SASATVTVVVQ 79
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 622-711 3.11e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 48.81  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 622 NRPPVAVAGPDKElIFPVESATLDGSSSSD-DHGIVFYHWEHVRGpSAVEMENIDKAIATvtglqVGTYHFRLTVKDQQG 700
Cdd:pfam18911   1 NAAPVADAGGDRI-VAEGETVTFDASASDDpDGDILSYRWDFGDG-TTATGANVSHTYAA-----PGTYTVTLTVTDDSG 73

                          90
                  ....*....|..
gi 1179685205 701 LS-STSTLTVAV 711
Cdd:pfam18911  74 ASnSTATDTVTV 85
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 719-808 5.04e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 48.26  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 719 PRARAGGRHVlVLPNNSITLDGSrSTDDQRIVSYLWIRDGqspaaGDVIDGSDHSValQLTNLVEGVYTFHLRVTDSQGA 798
Cdd:cd00146     1 PTASVSAPPV-AELGASVTFSAS-DSSGGSIVSYKWDFGD-----GEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGS 71

                          90
                  ....*....|
gi 1179685205 799 SDTDTATVEV 808
Cdd:cd00146    72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 529-617 1.01e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.49  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 529 PVANAGPNHTITLPQnSITLNGNqSSDDHQIVLYEWSLGPGSegkhVVMQGVQTPylHLSAMQEGDYTFQLKVTDSSRQQ 608
Cdd:cd00146     1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFGDGE----VSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                  ....*....
gi 1179685205 609 STAVVTVIV 617
Cdd:cd00146    73 STKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 433-521 1.94e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 46.72  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 433 PPVAVVSPQLQELTLPLT-SAlidgsQSTDDTEIVSYHWEEINGPFIeektSVDSPVLRLSNLDPGNYSFRLTVTDSDGA 511
Cdd:cd00146     1 PTASVSAPPVAELGASVTfSA-----SDSSGGSIVSYKWDFGDGEVS----SSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                          90
                  ....*....|
gi 1179685205 512 TNSTTAALIV 521
Cdd:cd00146    72 SSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 528-617 3.28e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.11  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 528 PPVANAGPNHTITLPQnSITLNGNQSSD-DHQIVLYEWSLGPGSEG-----KHVvmqgvqtpYlhlsaMQEGDYTFQLKV 601
Cdd:pfam18911   3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGDGTTAtganvSHT--------Y-----AAPGTYTVTLTV 68

                          90
                  ....*....|....*..
gi 1179685205 602 TDSS-RQQSTAVVTVIV 617
Cdd:pfam18911  69 TDDSgASNSTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 716-808 3.87e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 45.72  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 716 NSPPRARAGGRhVLVLPNNSITLDGSRSTD-DQRIVSYLWirdgqspaagDVIDGSdhsvALQLTNLV-----EGVYTFH 789
Cdd:pfam18911   1 NAAPVADAGGD-RIVAEGETVTFDASASDDpDGDILSYRW----------DFGDGT----TATGANVShtyaaPGTYTVT 65

                          90       100
                  ....*....|....*....|
gi 1179685205 790 LRVTDSQGASD-TDTATVEV 808
Cdd:pfam18911  66 LTVTDDSGASNsTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 431-521 4.66e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 45.72  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 431 NLPPVAVVSPQlQELTLPLTSALiDGSQSTD-DTEIVSYHWEEINGpfieekTSVDSPVLRLSNLDPGNYSFRLTVTDSD 509
Cdd:pfam18911   1 NAAPVADAGGD-RIVAEGETVTF-DASASDDpDGDILSYRWDFGDG------TTATGANVSHTYAAPGTYTVTLTVTDDS 72

                          90
                  ....*....|...
gi 1179685205 510 GATNST-TAALIV 521
Cdd:pfam18911  73 GASNSTaTDTVTV 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
481-818 3.21e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 481 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 559
Cdd:COG3401   186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 560 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 638
Cdd:COG3401   262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 639 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 707
Cdd:COG3401   334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 708 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 787
Cdd:COG3401   412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1179685205 788 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 818
Cdd:COG3401   491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 56-87 6.06e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.60  E-value: 6.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1179685205  56 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 87
Cdd:pfam07502  38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 398-625 1.16e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  398 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 469
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  470 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 536
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205  537 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 599
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445

                          250       260
                   ....*....|....*....|....*.
gi 1179685205  600 KVTDSSRQQSTAvVTVIVQPenNRPP 625
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
PARM pfam17061
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 2.40e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 41.00  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061  78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685205 272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061 158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 170-331 7.17e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 170 PSGKQEPRGSAEYTDWGLLP---GSEGAFNSSVGDSPAVPAETQQDPelhyLNESASTPAPKLPERsvllPLPTTPSSGe 246
Cdd:PLN03209  324 PSQRVPPKESDAADGPKPVPtkpVTPEAPSPPIEEEPPQPKAVVPRP----LSPYTAYEDLKPPTS----PIPTPPSSS- 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685205 247 vleKEKASQLQEQSSNSSGKevLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSI-------PTPPTSAAPSESTPS 319
Cdd:PLN03209  395 ---PASSKSVDAVAKPAEPD--VVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLkpptspsPTAPTGVSPSVSSTS 469

                         170
                  ....*....|..
gi 1179685205 320 ELPISPTTAPRT 331
Cdd:PLN03209  470 SVPAVPDTAPAT 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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