Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 1148300673 561 YQCSICNKRFTQKSSLNVHMRLH 583
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1148300673 535 CSICWRSFSLKDYLIKHMVTHTgvraYQCSICNKRFTQKSSLNVH-MRLHR 584
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHK 50

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 1148300673 505 YECTLCNKTFTAKQNYVKHMFVH 527
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  21 LNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGVLrVSQSE 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEItlddVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*..
gi 1148300673  97 ALQILTAASILQIKTVIDECTRIVSQN 123
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKS 106

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 1148300673 561 YQCSICNKRFTQKSSLNVHMRLH 583
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 1148300673 575 SLNVHMRLHRGEKSYECYICKKKFSH 600
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1148300673 535 CSICWRSFSLKDYLIKHMVTHTgvraYQCSICNKRFTQKSSLNVH-MRLHR 584
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHK 50

hypothetical protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673 279 ESEECTEDTDQAEGTESEPKGESFDSGVSS-----SIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTnql 353
Cdd:PHA03169  119 SPENTSGSSPESPASHSPPPSPPSHPGPHEpappeSHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQS--- 195

                          90
                  ....*....|....*.
gi 1148300673 354 ETGASSPERSNEVEMD 369
Cdd:PHA03169  196 ETPTSSPPPQSPPDEP 211

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673 432 NTYLPALFTTQPAGSGPKPFLFSLPQPLAGQqtqfVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCN 511
Cdd:COG5048   221 ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS----DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1148300673 512 KTFTAKQNYVKHMF--VHTGE--KPHQC--SICWRSFSLKDYLIKHMVTHTGVRAYQC--SICNKRFTQKS 574
Cdd:COG5048   297 ISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  13 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRV 92
Cdd:cd18229     1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVRQLVEFMYSGSLVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148300673  93 SQSEALQILTAASILQIKTVIDECTRIVSQN 123
Cdd:cd18229    81 AQSEALQILTAASILQIKTVIDECTQIISQS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  12 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLL-GYSDIEIPSVVSVQSVQKLIDFMYSGVL 90
Cdd:cd18210     3 EITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLkNMSSISLPGVMDPGAFESVLASAYTGKL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1148300673  91 RVSQSEALQILTAASILQIKTVIDECTRIV 120
Cdd:cd18210    83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  13 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-IEIPSVVSVQSVQKLIDFMYSGVLR 91
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNcLVLPSVIEAAAFENLLQLIYSGRLT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148300673  92 VSQSEALQILTAASILQIKTVIDECTRIVSQ 122
Cdd:cd18200    81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673   1 MTERIHsINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDkLLLGYSD--IEIPSVVSVQSV 78
Cdd:cd18289     1 MSQMLH-IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRD-LFSGNSKsaFELPATVPPACF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1148300673  79 QKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIV 120
Cdd:cd18289    79 QQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  13 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG-YSDIEIPSVVSVQSVQKLIDFMYSGVLR 91
Cdd:cd18220     8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALStMSGLSISVIKNPNVFEQLLSFCYTGRMS 87

                          90       100
                  ....*....|....*....|....*....
gi 1148300673  92 VSQSEALQILTAASILQIKTVIDECTRIV 120
Cdd:cd18220    88 LQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673   9 NLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFMYS 87
Cdd:cd18214     4 RFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSrEVQISILQNSEVGRQLLLSCYT 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1148300673  88 GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 122
Cdd:cd18214    84 GVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEI------PSVVSVQSV-----QKLI 82
Cdd:cd18228     3 SQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagKCVLDLHHVtvtgfAPLL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1148300673  83 DFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNV 124
Cdd:cd18228    83 EYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLL----LGYSDIEIPSVVSVQSVQKLIDFMYSGV 89
Cdd:cd18332     3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSgrvgEGVSVLTLPSGLEARGFQLLLDFMYTSR 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148300673  90 LRVSQSEALQILTAASILQIKTVIDECTRIV 120
Cdd:cd18332    83 LPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  17 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIpSVVSVQSVQK-----LIDFMYSGVLR 91
Cdd:cd18256     7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK-DVVQIHGVEPdifhiLLDFIYTGVVE 85

                          90       100
                  ....*....|....*....|....*
gi 1148300673  92 VSQSEALQILTAASILQIKTVIDEC 116
Cdd:cd18256    86 VTVSNVQELLVAADMLQLTEVVEIC 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673   32 DVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG----YSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASIL 107
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 1148300673  108 QIKTVIDECTRIVSQN 123
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  18 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEI--PSVVSVQSVQKLIDFMYSGVLRVSQS 95
Cdd:cd18217     6 LERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFldQSQVSADGFQKLLEFIYTGNLNLDSW 85

                          90       100
                  ....*....|....*....|..
gi 1148300673  96 EALQILTAASILQIKTVIDECT 117
Cdd:cd18217    86 NVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  15 NSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSVQSVQKLIDFMYSGVLRVS 93
Cdd:cd18197    10 DAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSkQVRITILQSAEVGRKLLLSCYTGALEVK 89

                          90       100
                  ....*....|....*....|....
gi 1148300673  94 QSEALQILTAASILQIKTVIDECT 117
Cdd:cd18197    90 KKELLKYLTAASYLQMVHIVEKCT 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLLGYSDIEIPSV-----VSVQSVQKLIDFMYSG 88
Cdd:cd18326     9 SSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFK-KLFTSGAVVDQQNVyeidfVSAEALTALLDFAYTA 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1148300673  89 VLRVSQSEALQILTAASILQIKTVIDECTRIV 120
Cdd:cd18326    88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYS-DIEIPSVVSvQSVQKLIDFMYSGVLRV 92
Cdd:cd18232     2 SVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSgSVVLPESFA-EVFGLLLDFFYTGELAL 80

                          90       100
                  ....*....|....*....|....*.
gi 1148300673  93 SQSEALQILTAASILQIKTVIDECTR 118
Cdd:cd18232    81 TRENRDRVLLAAKELRVPEAVELCQR 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  13 FSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF------------QDKLLLGysDIEiPSVVSVqsvqk 80
Cdd:cd18247     2 LPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFhamfthdmveskQDEITMQ--GIE-PSALEA----- 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1148300673  81 LIDFMYSGVLRVSQSEALQILTAASILQIKTVIDEC 116
Cdd:cd18247    74 LINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDAC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQ-------DKLLLGYSDIEIpsvVSVQSVQKLIDFMY 86
Cdd:cd18323     7 SRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHmfykeqlDKRDLVCINNEI---VTAPAFSLLLEFMY 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1148300673  87 SGVLRVSQSEALQILTAASILQIKTVIDECTR 118
Cdd:cd18323    84 EGRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  18 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSvVSVQSVQKLIDFMYSGVLRV 92
Cdd:cd18238     3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAEskqdsITIKD-IDEEAVELLVDFAYTGKLTL 81

                          90       100
                  ....*....|....*....|....*.
gi 1148300673  93 SQSEALQILTAASILQIKTVIDECTR 118
Cdd:cd18238    82 TVDNVQSLLYAASLLQVEEVAKACCE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  17 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF-----QDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLR 91
Cdd:cd18230     8 LLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktlycQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA 87

                          90       100
                  ....*....|....*....|....*
gi 1148300673  92 VSQSEALQILTAASILQIKTVIDEC 116
Cdd:cd18230    88 LTSKNVIEVMSAASYLQMTDIVQAC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKlLLGYSD----IEIPSVVSVQSVQKLIDFMYSGV 89
Cdd:cd18277    11 STNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSR-IVGQADaelnITLPEEVTVKGFEPLIQFAYTAK 89

                          90       100
                  ....*....|....*....|....*..
gi 1148300673  90 LRVSQSEALQILTAASILQIKTVIDEC 116
Cdd:cd18277    90 LILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYSGV 89
Cdd:cd18242     5 AKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVelqgLTASTMEILLDFVYTET 84

                          90       100
                  ....*....|....*....|....*....
gi 1148300673  90 LRVSQSEALQILTAASILQIKTVIDECTR 118
Cdd:cd18242    85 VHVTVENVQELLPAACLLQLKGVKQACCE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148300673  14 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQdKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVS 93
Cdd:cd18206     6 SQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFR-MLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLS 84

                          90       100
                  ....*....|....*....|....*...
gi 1148300673  94 QSEALQILTAASILQIKTVIDECTRIVS 121
Cdd:cd18206    85 PENVDDVLAVATFLQMQDIVTACHALKS 112