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Conserved domains on  [gi|1128611449|ref|NP_001335007|]
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lon protease homolog 2, peroxisomal isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Lon super family cl33893
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
11-838 0e+00

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0466:

Pssm-ID: 223542 [Multi-domain]  Cd Length: 782  Bit Score: 846.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  11 SRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLqstILGVIPNTPDPASDAQDlpPLHRIGTAALAVQVVg 90
Cdd:COG0466     8 IELPVLPLRDVVVFPGMVIPLFVGREKSIKALEEAMKNDQKY---ILLVTQKDASTDEPTED--DLYEVGTLAKILQIL- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  91 sNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTcKMREELGELSEQFYKYA--------VQLVEMLD 162
Cdd:COG0466    82 -KLPDGTVKVLVEGLQRVRISKLSDEEEFFEAEIELLPDEPIDEER-EIEALVRSILSEFEEYAklnkkippEELQSLNS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 163 MSVPavaklrrlldslprEALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQK-TRKPKQDDDKR 241
Cdd:COG0466   160 IDDP--------------GKLADTIAAHLPLKLEEKQEILETLDVKERLEKLLDLLEKEIDLLQLEKRiRKKVKEQMEKS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 242 VIA------IRPIRRithisgtlEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLE 315
Cdd:COG0466   226 QREyylreqLKAIQK--------ELGEDDDDKDEVEELREKIEKLKLPKEAKEKAEKELKKLETMSPMSAEATVIRNYLD 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 316 LMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGRE 395
Cdd:COG0466   298 WLLDLPWGKRSKDKLDLKKAEKILDKDHYGLEKVKERILEYLAVQKLTKKLKGPILCLVGPPGVGKTSLGKSIAKALGRK 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 396 FHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHY 475
Cdd:COG0466   378 FVRISLGGVRDEAEIRGHRRTYIGAMPGKIIQGMKKAGVKNPVFLLDEIDKMGSSFRGDPASALLEVLDPEQNNTFSDHY 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 476 LNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRY 555
Cdd:COG0466   458 LEVPYDLSKVMFIATANSLDTIPAPLLDRMEVIRLSGYTEDEKLEIAKRHLIPKQLKEHGLKKGELTITDEAIKDIIRYY 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 556 TREAGVRSLDRKLGAICRAVAVKvaegqhkeakldrsdvteregcrehILEDEKPESISdttdlalppempilIDFHALK 635
Cdd:COG0466   538 TREAGVRNLEREIAKICRKAAKK-------------------------ILLKKEKSIVK--------------IDEKNLK 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 636 DILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYqltn 715
Cdd:COG0466   579 KYLGVPVFRYGKAEEEDQVGVVTGLAWTEVGGDLLTIEAVKMPGKGKLTLTGSLGDVMKESAQAALSYVRSRAEKL---- 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 716 aFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGL 795
Cdd:COG0466   655 -GIDPDFFEKRDIHIHVPEGATPKDGPSAGITMATALVSLLTGKPVRADVAMTGEITLRGRVLPIGGLKEKLLAAHRGGI 733
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 1128611449 796 KQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGG 838
Cdd:COG0466   734 KTVIIPKDNERDLEEIPDNVKEGLEIHPVKTIDEVLKLALVGN 776
 
Name Accession Description Interval E-value
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
11-838 0e+00

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 223542 [Multi-domain]  Cd Length: 782  Bit Score: 846.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  11 SRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLqstILGVIPNTPDPASDAQDlpPLHRIGTAALAVQVVg 90
Cdd:COG0466     8 IELPVLPLRDVVVFPGMVIPLFVGREKSIKALEEAMKNDQKY---ILLVTQKDASTDEPTED--DLYEVGTLAKILQIL- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  91 sNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTcKMREELGELSEQFYKYA--------VQLVEMLD 162
Cdd:COG0466    82 -KLPDGTVKVLVEGLQRVRISKLSDEEEFFEAEIELLPDEPIDEER-EIEALVRSILSEFEEYAklnkkippEELQSLNS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 163 MSVPavaklrrlldslprEALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQK-TRKPKQDDDKR 241
Cdd:COG0466   160 IDDP--------------GKLADTIAAHLPLKLEEKQEILETLDVKERLEKLLDLLEKEIDLLQLEKRiRKKVKEQMEKS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 242 VIA------IRPIRRithisgtlEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLE 315
Cdd:COG0466   226 QREyylreqLKAIQK--------ELGEDDDDKDEVEELREKIEKLKLPKEAKEKAEKELKKLETMSPMSAEATVIRNYLD 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 316 LMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGRE 395
Cdd:COG0466   298 WLLDLPWGKRSKDKLDLKKAEKILDKDHYGLEKVKERILEYLAVQKLTKKLKGPILCLVGPPGVGKTSLGKSIAKALGRK 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 396 FHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHY 475
Cdd:COG0466   378 FVRISLGGVRDEAEIRGHRRTYIGAMPGKIIQGMKKAGVKNPVFLLDEIDKMGSSFRGDPASALLEVLDPEQNNTFSDHY 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 476 LNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRY 555
Cdd:COG0466   458 LEVPYDLSKVMFIATANSLDTIPAPLLDRMEVIRLSGYTEDEKLEIAKRHLIPKQLKEHGLKKGELTITDEAIKDIIRYY 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 556 TREAGVRSLDRKLGAICRAVAVKvaegqhkeakldrsdvteregcrehILEDEKPESISdttdlalppempilIDFHALK 635
Cdd:COG0466   538 TREAGVRNLEREIAKICRKAAKK-------------------------ILLKKEKSIVK--------------IDEKNLK 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 636 DILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYqltn 715
Cdd:COG0466   579 KYLGVPVFRYGKAEEEDQVGVVTGLAWTEVGGDLLTIEAVKMPGKGKLTLTGSLGDVMKESAQAALSYVRSRAEKL---- 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 716 aFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGL 795
Cdd:COG0466   655 -GIDPDFFEKRDIHIHVPEGATPKDGPSAGITMATALVSLLTGKPVRADVAMTGEITLRGRVLPIGGLKEKLLAAHRGGI 733
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 1128611449 796 KQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGG 838
Cdd:COG0466   734 KTVIIPKDNERDLEEIPDNVKEGLEIHPVKTIDEVLKLALVGN 776
lon TIGR00763
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ...
14-835 0e+00

endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273258 [Multi-domain]  Cd Length: 775  Bit Score: 812.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  14 PLLLTHEGVLLPGSTMRTSVDSARNLQLVRsrllKGTSLQSTILGVIPNTPDPaSDAQDLPPLHRIGTAALAVQVVGS-N 92
Cdd:TIGR00763   1 PLLPLRRRPLFPGMIKPIDVGREKSIKLIK----EALRLKQPYLGLFLQKDDD-NEEPEEDDIYSVGVVAQILEMLPLpS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  93 WPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVeqlDRLEEFPNTcKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLR 172
Cdd:TIGR00763  76 SGTATYKVVVEGLRRIRIKELSDKGGYLVVRV---DNLKEEPFD-KDDEEIKALTREIKETFRELISLSKLFREQPALLS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 173 RLLDSLPREALPDILTSIIRTSNKEKLQ-ILDAVSLEERFKMTIPLLVRQIEGLKLLQK-TRKPKQ---DDDKRVIAIRP 247
Cdd:TIGR00763 152 ALEDIDEPGRLADFVAASLQLKEKDELQeVLETVNIEKRLKKALELLKKELELLKLQNKiTKKVEEkmeKTQREYYLREQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 248 IRRITHISGTlededEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTT 327
Cdd:TIGR00763 232 LKAIKKELGI-----EKDDKDELEKLKEKLEELKLPEEVKKVIEKELTKLSLLEPSSSEFTVTRNYLDWLTDLPWGKYSK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 328 DRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQ 407
Cdd:TIGR00763 307 ENLDLKRAKEILDEDHYGLKKVKERILEYLAVQKLRGKMKGPILCLVGPPGVGKTSLGKSIAKALNRKFVRFSLGGVRDE 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 408 SDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLF 487
Cdd:TIGR00763 387 AEIRGHRRTYVGAMPGRIIQGLKKAKTKNPLFLLDEIDKIGSSFRGDPASALLEVLDPEQNNAFSDHYLDVPFDLSKVIF 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 488 IATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRK 567
Cdd:TIGR00763 467 IATANSIDTIPRPLLDRMEVIELSGYTEEEKLEIAKKYLIPKALEDHGLKPDELKITDEALLLLIKYYTREAGVRNLERQ 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 568 LGAICRAVAVKVAEGQHKEAkldrsdvteregcrehiledEKPESISDTTDLalppempilidfhaLKDILGPPMYEMEV 647
Cdd:TIGR00763 547 IEKICRKAAVKLVEQGEKKK--------------------SEAESVVITPDN--------------LKKYLGKPVFTYER 592
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 648 SQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNafgsfDLLDNTD 727
Cdd:TIGR00763 593 AYEVTPPGVVMGLAWTPMGGDTLFIETTKVAGKGSLELTGQLGDVMKESAQIALTYVRSIAADLGISP-----NFFEKAD 667
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 728 IHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKD 807
Cdd:TIGR00763 668 IHLHVPEGATPKDGPSAGITMATALLSLATGKPVRPDVAMTGEITLRGKVLPIGGLKEKTIAAKRAGIKTIILPEKNRRD 747
                         810       820
                  ....*....|....*....|....*...
gi 1128611449 808 LEGIPGNVRQDLSFVTASCLDEVLNAAF 835
Cdd:TIGR00763 748 LEELPENVKEGLEIHFVKHYDEVLKKAF 775
PRK10787 PRK10787
DNA-binding ATP-dependent protease La; Provisional
65-835 0e+00

DNA-binding ATP-dependent protease La; Provisional


Pssm-ID: 182730 [Multi-domain]  Cd Length: 784  Bit Score: 543.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  65 DPASDAQDLPPLHRIGTAALAVQVVgsNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLD--RLEEFPNTCKMREE 142
Cdd:PRK10787   57 EASTDEPGVNDLFTVGTVASILQML--KLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLEspTIDEREQEVLVRTA 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 143 LGELsEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPREaLPDILtsiirtsnKEKLQILDAVSLEERFKMTIPLLVRQI 222
Cdd:PRK10787  135 ISQF-EGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAH-MPLKL--------ADKQSVLEMSDVNERLEYLMAMMESEI 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 223 EGLKLLQKTR---KPKQDDDKRVIAI-RPIRRITHISGTLEDEDEDEDNddivmLEKKIRTSSMPEQAHKVCVKEIKRLK 298
Cdd:PRK10787  205 DLLQVEKRIRnrvKKQMEKSQREYYLnEQMKAIQKELGEMDDAPDENEA-----LKRKIDAAKMPKEAKEKAEAELQKLK 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 299 KMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPG 378
Cdd:PRK10787  280 MMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPG 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 379 VGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAA 458
Cdd:PRK10787  360 VGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASA 439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 459 LLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTaTIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTP 538
Cdd:PRK10787  440 LLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSM-NIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKK 518
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 539 QQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAvAVKVaegqhkeakldrsdvteregcrehILEDEKPESisdttd 618
Cdd:PRK10787  519 GELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRK-AVKQ------------------------LLLDKSLKH------ 567
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 619 lalppempILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAH 698
Cdd:PRK10787  568 --------IEINGDNLHDYLGVQRFDYGRADNENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQ 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 699 LAISWLRSNAKKYQLTNAFgsfdlLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVL 778
Cdd:PRK10787  640 AALTVVRARAEKLGINPDF-----YEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVL 714
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1128611449 779 PVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAF 835
Cdd:PRK10787  715 PIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLAL 771
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
332-513 2.66e-121

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 364.96  E-value: 2.66e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 332 IRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIR 411
Cdd:cd19500     1 IKKARKVLDADHYGLEDVKERILEYLAVRKLKGSMKGPILCLVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 412 GHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATA 491
Cdd:cd19500    81 GHRRTYVGAMPGRIIQALKKAGTNNPVFLLDEIDKIGSSFRGDPASALLEVLDPEQNSTFSDHYLDVPFDLSKVLFIATA 160
                         170       180
                  ....*....|....*....|..
gi 1128611449 492 NTTATIPAALLDRMEIIQVPGY 513
Cdd:cd19500   161 NSLDTIPGPLLDRMEIIELSGY 182
Lon_C pfam05362
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyze ATP ...
634-837 4.83e-94

Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyze ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.


Pssm-ID: 428442 [Multi-domain]  Cd Length: 205  Bit Score: 294.53  E-value: 4.83e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 634 LKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQL 713
Cdd:pfam05362   7 LEKYLGVPRFRYGEAEKEDQVGVVTGLAWTEVGGDLLTIEAVIMPGKGKLTLTGQLGDVMKESAQAALSYVRSRAEELGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 714 tnafgSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRA 793
Cdd:pfam05362  87 -----DPDFFEKKDIHIHVPEGATPKDGPSAGVTMATALVSALTGIPVRKDVAMTGEITLRGRVLPIGGLKEKLLAAHRA 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1128611449 794 GLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDG 837
Cdd:pfam05362 162 GIKTVIIPKENEKDLEDIPENVREGLEIIPVEHVDEVLKHALVG 205
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
367-505 1.78e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  367 KGPILCFVGPPGVGKTSVGRSVAKTLGREFHRI-------ALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTV--GVNNP 437
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgedILEEVLDQLLLIIVGGKKASGSGELRLRLALALarKLKPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1128611449  438 VFLLDEVDKLGKSLQgdpaAALLEVLDPEQNHNFTDHYLNvafdlsqVLFIATANTTATIPAALLDRM 505
Cdd:smart00382  81 VLILDEITSLLDAEQ----EALLLLLEELRLLLLLKSEKN-------LTVILTTNDEKDLGPALLRRR 137
 
Name Accession Description Interval E-value
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
11-838 0e+00

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 223542 [Multi-domain]  Cd Length: 782  Bit Score: 846.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  11 SRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLqstILGVIPNTPDPASDAQDlpPLHRIGTAALAVQVVg 90
Cdd:COG0466     8 IELPVLPLRDVVVFPGMVIPLFVGREKSIKALEEAMKNDQKY---ILLVTQKDASTDEPTED--DLYEVGTLAKILQIL- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  91 sNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTcKMREELGELSEQFYKYA--------VQLVEMLD 162
Cdd:COG0466    82 -KLPDGTVKVLVEGLQRVRISKLSDEEEFFEAEIELLPDEPIDEER-EIEALVRSILSEFEEYAklnkkippEELQSLNS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 163 MSVPavaklrrlldslprEALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQK-TRKPKQDDDKR 241
Cdd:COG0466   160 IDDP--------------GKLADTIAAHLPLKLEEKQEILETLDVKERLEKLLDLLEKEIDLLQLEKRiRKKVKEQMEKS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 242 VIA------IRPIRRithisgtlEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLE 315
Cdd:COG0466   226 QREyylreqLKAIQK--------ELGEDDDDKDEVEELREKIEKLKLPKEAKEKAEKELKKLETMSPMSAEATVIRNYLD 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 316 LMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGRE 395
Cdd:COG0466   298 WLLDLPWGKRSKDKLDLKKAEKILDKDHYGLEKVKERILEYLAVQKLTKKLKGPILCLVGPPGVGKTSLGKSIAKALGRK 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 396 FHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHY 475
Cdd:COG0466   378 FVRISLGGVRDEAEIRGHRRTYIGAMPGKIIQGMKKAGVKNPVFLLDEIDKMGSSFRGDPASALLEVLDPEQNNTFSDHY 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 476 LNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRY 555
Cdd:COG0466   458 LEVPYDLSKVMFIATANSLDTIPAPLLDRMEVIRLSGYTEDEKLEIAKRHLIPKQLKEHGLKKGELTITDEAIKDIIRYY 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 556 TREAGVRSLDRKLGAICRAVAVKvaegqhkeakldrsdvteregcrehILEDEKPESISdttdlalppempilIDFHALK 635
Cdd:COG0466   538 TREAGVRNLEREIAKICRKAAKK-------------------------ILLKKEKSIVK--------------IDEKNLK 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 636 DILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYqltn 715
Cdd:COG0466   579 KYLGVPVFRYGKAEEEDQVGVVTGLAWTEVGGDLLTIEAVKMPGKGKLTLTGSLGDVMKESAQAALSYVRSRAEKL---- 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 716 aFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGL 795
Cdd:COG0466   655 -GIDPDFFEKRDIHIHVPEGATPKDGPSAGITMATALVSLLTGKPVRADVAMTGEITLRGRVLPIGGLKEKLLAAHRGGI 733
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 1128611449 796 KQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGG 838
Cdd:COG0466   734 KTVIIPKDNERDLEEIPDNVKEGLEIHPVKTIDEVLKLALVGN 776
lon TIGR00763
endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat ...
14-835 0e+00

endopeptidase La; This protein, the ATP-dependent serine endopeptidase La, is induced by heat shock and other stresses in E. coli, B. subtilis, and other species. The yeast member, designated PIM1, is located in the mitochondrial matrix, required for mitochondrial function, and also induced by heat shock. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273258 [Multi-domain]  Cd Length: 775  Bit Score: 812.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  14 PLLLTHEGVLLPGSTMRTSVDSARNLQLVRsrllKGTSLQSTILGVIPNTPDPaSDAQDLPPLHRIGTAALAVQVVGS-N 92
Cdd:TIGR00763   1 PLLPLRRRPLFPGMIKPIDVGREKSIKLIK----EALRLKQPYLGLFLQKDDD-NEEPEEDDIYSVGVVAQILEMLPLpS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  93 WPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVeqlDRLEEFPNTcKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLR 172
Cdd:TIGR00763  76 SGTATYKVVVEGLRRIRIKELSDKGGYLVVRV---DNLKEEPFD-KDDEEIKALTREIKETFRELISLSKLFREQPALLS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 173 RLLDSLPREALPDILTSIIRTSNKEKLQ-ILDAVSLEERFKMTIPLLVRQIEGLKLLQK-TRKPKQ---DDDKRVIAIRP 247
Cdd:TIGR00763 152 ALEDIDEPGRLADFVAASLQLKEKDELQeVLETVNIEKRLKKALELLKKELELLKLQNKiTKKVEEkmeKTQREYYLREQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 248 IRRITHISGTlededEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTT 327
Cdd:TIGR00763 232 LKAIKKELGI-----EKDDKDELEKLKEKLEELKLPEEVKKVIEKELTKLSLLEPSSSEFTVTRNYLDWLTDLPWGKYSK 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 328 DRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQ 407
Cdd:TIGR00763 307 ENLDLKRAKEILDEDHYGLKKVKERILEYLAVQKLRGKMKGPILCLVGPPGVGKTSLGKSIAKALNRKFVRFSLGGVRDE 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 408 SDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLF 487
Cdd:TIGR00763 387 AEIRGHRRTYVGAMPGRIIQGLKKAKTKNPLFLLDEIDKIGSSFRGDPASALLEVLDPEQNNAFSDHYLDVPFDLSKVIF 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 488 IATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRK 567
Cdd:TIGR00763 467 IATANSIDTIPRPLLDRMEVIELSGYTEEEKLEIAKKYLIPKALEDHGLKPDELKITDEALLLLIKYYTREAGVRNLERQ 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 568 LGAICRAVAVKVAEGQHKEAkldrsdvteregcrehiledEKPESISDTTDLalppempilidfhaLKDILGPPMYEMEV 647
Cdd:TIGR00763 547 IEKICRKAAVKLVEQGEKKK--------------------SEAESVVITPDN--------------LKKYLGKPVFTYER 592
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 648 SQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNafgsfDLLDNTD 727
Cdd:TIGR00763 593 AYEVTPPGVVMGLAWTPMGGDTLFIETTKVAGKGSLELTGQLGDVMKESAQIALTYVRSIAADLGISP-----NFFEKAD 667
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 728 IHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKD 807
Cdd:TIGR00763 668 IHLHVPEGATPKDGPSAGITMATALLSLATGKPVRPDVAMTGEITLRGKVLPIGGLKEKTIAAKRAGIKTIILPEKNRRD 747
                         810       820
                  ....*....|....*....|....*...
gi 1128611449 808 LEGIPGNVRQDLSFVTASCLDEVLNAAF 835
Cdd:TIGR00763 748 LEELPENVKEGLEIHFVKHYDEVLKKAF 775
PRK10787 PRK10787
DNA-binding ATP-dependent protease La; Provisional
65-835 0e+00

DNA-binding ATP-dependent protease La; Provisional


Pssm-ID: 182730 [Multi-domain]  Cd Length: 784  Bit Score: 543.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  65 DPASDAQDLPPLHRIGTAALAVQVVgsNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLD--RLEEFPNTCKMREE 142
Cdd:PRK10787   57 EASTDEPGVNDLFTVGTVASILQML--KLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLEspTIDEREQEVLVRTA 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 143 LGELsEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPREaLPDILtsiirtsnKEKLQILDAVSLEERFKMTIPLLVRQI 222
Cdd:PRK10787  135 ISQF-EGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAH-MPLKL--------ADKQSVLEMSDVNERLEYLMAMMESEI 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 223 EGLKLLQKTR---KPKQDDDKRVIAI-RPIRRITHISGTLEDEDEDEDNddivmLEKKIRTSSMPEQAHKVCVKEIKRLK 298
Cdd:PRK10787  205 DLLQVEKRIRnrvKKQMEKSQREYYLnEQMKAIQKELGEMDDAPDENEA-----LKRKIDAAKMPKEAKEKAEAELQKLK 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 299 KMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPG 378
Cdd:PRK10787  280 MMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPG 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 379 VGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAA 458
Cdd:PRK10787  360 VGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASA 439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 459 LLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTaTIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTP 538
Cdd:PRK10787  440 LLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSM-NIPAPLLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKK 518
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 539 QQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAvAVKVaegqhkeakldrsdvteregcrehILEDEKPESisdttd 618
Cdd:PRK10787  519 GELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRK-AVKQ------------------------LLLDKSLKH------ 567
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 619 lalppempILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAH 698
Cdd:PRK10787  568 --------IEINGDNLHDYLGVQRFDYGRADNENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQ 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 699 LAISWLRSNAKKYQLTNAFgsfdlLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVL 778
Cdd:PRK10787  640 AALTVVRARAEKLGINPDF-----YEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVL 714
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1128611449 779 PVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAF 835
Cdd:PRK10787  715 PIGGLKEKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLAL 771
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
332-513 2.66e-121

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 364.96  E-value: 2.66e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 332 IRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIR 411
Cdd:cd19500     1 IKKARKVLDADHYGLEDVKERILEYLAVRKLKGSMKGPILCLVGPPGVGKTSLGKSIARALGRKFVRISLGGVRDEAEIR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 412 GHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATA 491
Cdd:cd19500    81 GHRRTYVGAMPGRIIQALKKAGTNNPVFLLDEIDKIGSSFRGDPASALLEVLDPEQNSTFSDHYLDVPFDLSKVLFIATA 160
                         170       180
                  ....*....|....*....|..
gi 1128611449 492 NTTATIPAALLDRMEIIQVPGY 513
Cdd:cd19500   161 NSLDTIPGPLLDRMEIIELSGY 182
Lon_C pfam05362
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyze ATP ...
634-837 4.83e-94

Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyze ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.


Pssm-ID: 428442 [Multi-domain]  Cd Length: 205  Bit Score: 294.53  E-value: 4.83e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 634 LKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQL 713
Cdd:pfam05362   7 LEKYLGVPRFRYGEAEKEDQVGVVTGLAWTEVGGDLLTIEAVIMPGKGKLTLTGQLGDVMKESAQAALSYVRSRAEELGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 714 tnafgSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRA 793
Cdd:pfam05362  87 -----DPDFFEKKDIHIHVPEGATPKDGPSAGVTMATALVSALTGIPVRKDVAMTGEITLRGRVLPIGGLKEKLLAAHRA 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1128611449 794 GLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDG 837
Cdd:pfam05362 162 GIKTVIIPKENEKDLEDIPENVREGLEIIPVEHVDEVLKHALVG 205
LON_substr_bdg pfam02190
ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be ...
13-220 6.09e-28

ATP-dependent protease La (LON) substrate-binding domain; This domain has been shown to be part of the PUA superfamily. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, pfam05362. ATP-dependent Lon proteases are conserved in all living organisms and catalyze rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins.


Pssm-ID: 426647 [Multi-domain]  Cd Length: 195  Bit Score: 111.66  E-value: 6.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  13 LPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGtslQSTILGVIPNTpDPASDAQDLPPLHRIGTAALAVQVVGSn 92
Cdd:pfam02190   2 LPLLPLRNTVLFPGMVLPLFVGRPRSIAAIEAALNKD---KLYGVLLVSQK-DAEDEEPTPDDLYEVGTVAKIVQILKL- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  93 wPKPHYTLLITGLCRFQIVQVL-KEKPYPIAEVEQLDrleefpntcKMREELGELSEQFYKYAVQ-LVEMLDMSVPAVAK 170
Cdd:pfam02190  77 -PDGTYKVLVEGLERVRIVELVkKEEPYLRAEVEDLP---------EDSDELSEALKALVKELIEkLRRLLKLLLPLELL 146
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1128611449 171 LRRLLDSLPrEALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVR 220
Cdd:pfam02190 147 LKIKDIENP-GRLADLVAAILPLSPEEKQELLETLDVKERLEKVLELLNR 195
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
371-513 9.36e-27

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 425416 [Multi-domain]  Cd Length: 130  Bit Score: 106.14  E-value: 9.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 371 LCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDqsdirghrrTYVGSMPGRIINGLKTVGVNNP-VFLLDEVDKLGK 449
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVS---------KYVGESEKRLRELFEAAKKLAPcVIFIDEIDALAG 71
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1128611449 450 SLQG-------DPAAALLEVLDPEQNHNftdhylnvafdlSQVLFIATANTTATIPAALLDRMEIIQVPGY 513
Cdd:pfam00004  72 SRGSggdsesrRVVNQLLTELDGFTSSN------------SKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
LonB COG1067
Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones] ...
551-840 2.96e-24

Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 223994 [Multi-domain]  Cd Length: 647  Bit Score: 108.60  E-value: 2.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 551 IITRYTREAGVRSL----DRKLGAICRAVA-------VKVAEGQHKEAKLDRSdVTEREGCREHILEDEKPESISDTTDl 619
Cdd:COG1067   347 LIREAARRAGDQNKltlrLRDLGNLVREAGdiavsegRKLITAEDVEEALQKR-ELREGQLAERYIEDIKGGQILIETE- 424
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 620 alppempilidfhalkdilGPpmyemEVSQRLsqpgvaiGLAWTPLGGEIMFVEASRM-----DGEGQLTLTGQLGDvMK 694
Cdd:COG1067   425 -------------------GE-----RVGQIN-------GLSVIEVPGHHAFGEPARIscavhKGDGEIVDIERKAE-LA 472
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 695 ESAHLAISWLrsnaKKYQLTNAFgsfdlldNTDIHLHFPAGAV------TKDGPSAGVTIVTCLASLFSGRLVRSDVAMT 768
Cdd:COG1067   473 GNIHNKGMMI----KQAFLMSIL-------NYDIHIPFSASLVfeqsygEVDGDSASLAEACALISALSKIPVDQDIAIT 541
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 769 GEITLRGLVLPVGGIKDKV-------LAAHRAGLKQVIIPRRNEKDL---EGIPGNVRQDLSFVTASC-LDEVLNAAFDG 837
Cdd:COG1067   542 GSIDQFGEVQPVGGVNEKIegffrvcQAAGLTGEQGVIIPKANVKDLslsEDVVKAVKEGKFEIWPVEtIDEALELLLGK 621

                  ...
gi 1128611449 838 GFT 840
Cdd:COG1067   622 GEG 624
MoxR COG0714
MoxR-like ATPase [General function prediction only];
365-598 6.65e-16

MoxR-like ATPase [General function prediction only];


Pssm-ID: 223786 [Multi-domain]  Cd Length: 329  Bit Score: 79.79  E-value: 6.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 365 NLKGPILcFVGPPGVGKTSVGRSVAKTLGREFHRI----------ALGGVCDQSDIRGHRRTyvgsmpgRIINGLKTVGV 434
Cdd:COG0714    41 LAGGHVL-LEGPPGVGKTLLARALARALGLPFVRIqctpdllpsdLLGTYAYAALLLEPGEF-------RFVPGPLFAAV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 435 nNPVFLLDEVDKLGKSLQgdpaAALLEVLDPEQ--NHNFTDHYLNVAFdlsqvLFIATANT-----TATIPAALLDRMEI 507
Cdd:COG0714   113 -RVILLLDEINRAPPEVQ----NALLEALEERQvtVPGLTTIRLPPPF-----IVIATQNPgeyegTYPLPEALLDRFLL 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 508 IQVPGYT---QEEKIEIAHRHLIPKQLEQHGLTPQ---------QIQIPQVTTLDIITRYTRE---AGVRSLDRKLGAIC 572
Cdd:COG0714   183 RIYVDYPdseEEERIILARVGGVDELDLESLVKPVlsdeellrlQKEVKKVPVSDEVIDYIVTlvaALREAPDVALGASP 262
                         250       260
                  ....*....|....*....|....*.
gi 1128611449 573 RAVAVKVAEGQHKeAKLDRSDVTERE 598
Cdd:COG0714   263 RASLALLAALRAL-ALLDGRDAVIPD 287
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
345-504 3.41e-14

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 70.77  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 345 AMEKLKKRVLEYLAVRQL--KNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSdirghrRTYVGSMP 422
Cdd:cd19481     1 LKASLREAVEAPRRGSRLrrYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKY------VGESEKNL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 423 GRIINGLKTVGvnNPVFLLDEVDKLGK--SLQGDPAA------ALLEVLDPEQNhnftdhylnvafdLSQVLFIATANTT 494
Cdd:cd19481    75 RKIFERARRLA--PCILFIDEIDAIGRkrDSSGESGElrrvlnQLLTELDGVNS-------------RSKVLVIAATNRP 139
                         170
                  ....*....|
gi 1128611449 495 ATIPAALLDR 504
Cdd:cd19481   140 DLLDPALLRP 149
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
352-513 4.01e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 61.78  E-value: 4.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 352 RVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGR---EFHRIALGGVCDQSDIRGHRRTYvgsmPGRIING 428
Cdd:cd00009     3 QEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRpgaPFLYLNASDLLEGLVVAELFGHF----LVRLLFE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 429 LKTVGvNNPVFLLDEVDKLGKSLQgdpaAALLEVLDpeqnhnfTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEII 508
Cdd:cd00009    79 LAEKA-KPGVLFIDEIDSLSRGAQ----NALLRVLE-------TLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIR 146

                  ....*
gi 1128611449 509 QVPGY 513
Cdd:cd00009   147 IVIPL 151
COG1750 COG1750
Predicted archaeal serine protease, S18 family [General function prediction only];
741-806 1.26e-09

Predicted archaeal serine protease, S18 family [General function prediction only];


Pssm-ID: 224664  Cd Length: 579  Bit Score: 61.72  E-value: 1.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1128611449 741 GPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEK 806
Cdd:COG1750   114 GPSAGGYMTVAIYAALMGWSIRKDVMMTGMINPDGSIGPVGGILEKLEAAAKAGAKIFLIPVGQRI 179
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
345-526 5.48e-08

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 223540 [Multi-domain]  Cd Length: 494  Bit Score: 56.37  E-value: 5.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 345 AMEKLKKRV---LEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIalggvcDQSDIRGHrrtYVGSM 421
Cdd:COG0464   250 AKEELKEAIetpLKRPELFRKLGLRPPKGVLLYGPPGTGKTLLAKAVALESRSRFISV------KGSELLSK---WVGES 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 422 PGRIINGLKTVGVNNP-VFLLDEVDKLGKSLQGDPAAALLEVLdpeQNHNFTdhyLNVAFDLSQVLFIATANTTATIPAA 500
Cdd:COG0464   321 EKNIRELFEKARKLAPsIIFIDEIDSLASGRGPSEDGSGRRVV---GQLLTE---LDGIEKAEGVLVIAATNRPDDLDPA 394
                         170       180
                  ....*....|....*....|....*....
gi 1128611449 501 LLDRM---EIIQVPGYTQEEKIEIAHRHL 526
Cdd:COG0464   395 LLRPGrfdRLIYVPLPDLEERLEIFKIHL 423
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
371-505 5.63e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 52.29  E-value: 5.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 371 LCFVGPPGVGKTSVGRSVAK-TLGREFHRIALGGVCDQSDIRGHRRtyVGSMPGRIING-LKTVGVNNPVFLLDEVDKLG 448
Cdd:pfam07728   2 VLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRN--IDPGGASWVDGpLVRAAREGEIAVLDEINRAN 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1128611449 449 KSLQGdpaaALLEVLDPEQNHNFTDHYLnVAFDLSQVLFIATANT----TATIPAALLDRM 505
Cdd:pfam07728  80 PDVLN----SLLSLLDERRLLLPDGGEL-VKAAPDGFRLIATMNPldrgLNELSPALRSRF 135
aroK PRK00131
shikimate kinase; Reviewed
366-396 2.15e-06

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 48.65  E-value: 2.15e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1128611449 366 LKGPILCFVGPPGVGKTSVGRSVAKTLGREF 396
Cdd:PRK00131    2 LKGPNIVLIGFMGAGKSTIGRLLAKRLGYDF 32
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
373-524 1.08e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 48.93  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 373 FVGPPGVGKTSVGRSVAKTLGREFHRI--ALGGVcdqSDIRghrrtyvgsmpgRIINGLKT--VGVNNPVFLLDEVDKLG 448
Cdd:PRK13342   41 LWGPPGTGKTTLARIIAGATDAPFEALsaVTSGV---KDLR------------EVIEEARQrrSAGRRTILFIDEIHRFN 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 449 KSLQgDpaaALLEVLdpEQNHnftdhylnvafdlsqVLFIATanTTA----TIPAALLDRMEIIQVPGYTQEEKIEIAHR 524
Cdd:PRK13342  106 KAQQ-D---ALLPHV--EDGT---------------ITLIGA--TTEnpsfEVNPALLSRAQVFELKPLSEEDIEQLLKR 162
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
373-528 1.21e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 46.42  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 373 FVGPPGVGKTSVGRSVAKTLG---REFHRIalggvcDQSDIrgHRRTYV----GSMPGRII---NGLKTVGV-NNP--VF 439
Cdd:pfam07724   8 FLGPTGVGKTELAKALAELLFgdeRALIRI------DMSEY--MEEHSVsrliGAPPGYVGyeeGGQLTEAVrRKPysIV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 440 LLDEVDKLGKSLQGDpaaaLLEVLDpeqNHNFTDHY-LNVAFDlsQVLFIATANTTATIPaalLDRMEIIQVPGY--TQE 516
Cdd:pfam07724  80 LIDEIEKAHPGVQND----LLQILE---GGTLTDKQgRTVDFK--NTLFIMTGNFGSEKI---SDASRLGDSPDYelLKE 147
                         170
                  ....*....|..
gi 1128611449 517 EKIEIAHRHLIP 528
Cdd:pfam07724 148 EVMDLLKKGFIP 159
Sms COG1066
Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, ...
734-836 1.21e-05

Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 223993 [Multi-domain]  Cd Length: 456  Bit Score: 48.76  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 734 AGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIpg 813
Cdd:COG1066   361 AGGVKVTEPAADLAVALALVSSFRNRPLPQDTVVFGEVGLSGEIRPVPRGERRLKEAAKLGFKRAIVPKGNIPLPEGI-- 438
                          90       100
                  ....*....|....*....|...
gi 1128611449 814 nvrqdlSFVTASCLDEVLNAAFD 836
Cdd:COG1066   439 ------KVIGVSTLAEALEVVFD 455
44 PHA02544
clamp loader, small subunit; Provisional
369-522 1.30e-05

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 48.06  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 369 PILCFVGP-PGVGKTSVGRSVAKTLGREFHRIAlGGVCDQSDIRGHRRTYVGSMpgriinglkTVGVNNPVFLLDEVDKL 447
Cdd:PHA02544   43 PNMLLHSPsPGTGKTTVAKALCNEVGAEVLFVN-GSDCRIDFVRNRLTRFASTV---------SLTGGGKVIIIDEFDRL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 448 G-----KSLQGdpaaaLLEvldpeqnhnftdhylnvAFDlSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIA 522
Cdd:PHA02544  113 GladaqRHLRS-----FME-----------------AYS-KNCSFIITANNKNGIIEPLRSRCRVIDFGVPTKEEQIEMM 169
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
358-508 1.41e-05

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 46.40  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 358 AVRQLKNNLKGP-----ILCFVGPPGVGKTSVGRSVAKTL-GREFHRIALggvcDQS-DIRGHRRTYVGSMPGRIIngLK 430
Cdd:cd19499    26 AIRRARAGLSDPnrpigSFLFLGPTGVGKTELAKALAELLfGDEDNLIRI----DMSeYMEKHSVSRLIGAPPGYV--GY 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 431 TVG-------VNNP--VFLLDEVDKLGKSLQGdpaaALLEVLDpeqNHNFTDHYLNVAfDLSQVLFIATANttaTIPAAL 501
Cdd:cd19499   100 TEGgqlteavRRKPysVVLLDEIEKAHPDVQN----LLLQVLD---DGRLTDSHGRTV-DFKNTIIIMTSN---HFRPEF 168

                  ....*..
gi 1128611449 502 LDRMEII 508
Cdd:cd19499   169 LNRIDEI 175
SdrC COG3480
Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms];
740-804 1.59e-05

Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms];


Pssm-ID: 226011 [Multi-domain]  Cd Length: 342  Bit Score: 48.17  E-value: 1.59e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1128611449 740 DGPSAGVTIVTCLAS-LFSGRLVRS-DVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRN 804
Cdd:COG3480   233 GGPSAGLMFSLAIYDqLTKGDLTGGrFIAGTGTIEVDGKVGPIGGIDQKVVAAAKAGADVFFVPADN 299
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
373-556 1.67e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 225165 [Multi-domain]  Cd Length: 436  Bit Score: 48.38  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 373 FVGPPGVGKTSVGRSVAKTLGREFHRI--ALGGVcdqSDIRghrrtyvgsmpGRIINGLKTVGVNN-PVFLLDEVDKLGK 449
Cdd:COG2256    53 LWGPPGTGKTTLARLIAGTTNAAFEALsaVTSGV---KDLR-----------EIIEEARKNRLLGRrTILFLDEIHRFNK 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 450 SLQgDpaaALLEVLdpEQNHnftdhylnvafdlsqVLFIA--TANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLi 527
Cdd:COG2256   119 AQQ-D---ALLPHV--ENGT---------------IILIGatTENPSFELNPALLSRARVFELKPLSSEDIKKLLKRAL- 176
                         170       180
                  ....*....|....*....|....*....
gi 1128611449 528 pkQLEQHGLTPQQIQIPQvTTLDIITRYT 556
Cdd:COG2256   177 --LDEERGLGGQIIVLDE-EALDYLVRLS 202
LON COG2802
Uncharacterized protein, LON-like domain, ASCH/PUA-like superfamily [Function unknown];
4-144 1.72e-05

Uncharacterized protein, LON-like domain, ASCH/PUA-like superfamily [Function unknown];


Pssm-ID: 225362 [Multi-domain]  Cd Length: 221  Bit Score: 47.02  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449   4 VSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLlkgtsLQSTILGVIPNTPDPASDAQDLPPLHRIGTAA 83
Cdd:COG2802     3 SSPDDLPLELPLFPLPGAVLLPGGLLPLNIFEPRYLAMVRTCL-----AEGRRFGVVLIDRGREVGGGLPPELSDVGCLA 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1128611449  84 LAVQVvgSNWPKPHYTLLITGLCRFQIVQVL-KEKPYPIAEVEQLDRLEEFPNTCKMREELG 144
Cdd:COG2802    78 RITEF--EELGDGRYLILVRGGQRFRVLEELaDDDPYRRARVPFWPDLPSDPDGAEEVDRRL 137
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
367-505 1.78e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  367 KGPILCFVGPPGVGKTSVGRSVAKTLGREFHRI-------ALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTV--GVNNP 437
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgedILEEVLDQLLLIIVGGKKASGSGELRLRLALALarKLKPD 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1128611449  438 VFLLDEVDKLGKSLQgdpaAALLEVLDPEQNHNFTDHYLNvafdlsqVLFIATANTTATIPAALLDRM 505
Cdd:smart00382  81 VLILDEITSLLDAEQ----EALLLLLEELRLLLLLKSEKN-------LTVILTTNDEKDLGPALLRRR 137
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
374-396 9.33e-05

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 43.70  E-value: 9.33e-05
                          10        20
                  ....*....|....*....|...
gi 1128611449 374 VGPPGVGKTSVGRSVAKTLGREF 396
Cdd:cd00464     5 IGMMGAGKTTVGRLLAKALGLPF 27
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
373-492 4.66e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 44.06  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 373 FVGPPGVGKTSVGRSVAKTLGREFHRIalggvcDQSDIrGHRRT---YVGSMPGRI---INGLKTVGV-NNP--VFLLDE 443
Cdd:PRK11034  493 FAGPTGVGKTEVTVQLSKALGIELLRF------DMSEY-MERHTvsrLIGAPPGYVgfdQGGLLTDAViKHPhaVLLLDE 565
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1128611449 444 VDKlgksLQGDPAAALLEVLDpeqNHNFTDHYLNVAfDLSQVLFIATAN 492
Cdd:PRK11034  566 IEK----AHPDVFNLLLQVMD---NGTLTDNNGRKA-DFRNVVLVMTTN 606
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism];
373-396 7.22e-04

Shikimate kinase [Amino acid transport and metabolism];


Pssm-ID: 223775 [Multi-domain]  Cd Length: 172  Bit Score: 41.43  E-value: 7.22e-04
                          10        20
                  ....*....|....*....|....
gi 1128611449 373 FVGPPGVGKTSVGRSVAKTLGREF 396
Cdd:COG0703     7 LIGFMGAGKSTIGRALAKALNLPF 30
COG4930 COG4930
Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, ...
651-812 8.82e-04

Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227267 [Multi-domain]  Cd Length: 683  Bit Score: 42.99  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 651 LSQPGVAIGLAWTPLGGEIMF-VEASRMDGEGQLTLTGqLGD--VMKESAHLAISWLRSNAKKYQLTNAFgsfdllDNTD 727
Cdd:COG4930   500 MPKPGVVHLVTQAESGMTGLYrFETQMTAGNGKHSVSG-LGSstSAKEAIRVGFDYFKGNLSRVSATAKF------SEHE 572
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 728 IHLHfpAGAVTKDGPSAGVTIvTCLASLFSGRLVRS---DVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRN 804
Cdd:COG4930   573 YHLH--VVELHNTGPSTATSL-AALIALCSVLLAKPvqeQMVVLGSMTLGGVINPVQDLAASLQLAFDSGAKKVLLPMSS 649

                  ....*...
gi 1128611449 805 EKDLEGIP 812
Cdd:COG4930   650 AVDIPTVP 657
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
369-529 1.52e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227596 [Multi-domain]  Cd Length: 4600  Bit Score: 42.68  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  369 PILcFVGPPGVGKTSVGRSVAKTLGREFHRIALG---GVCD--QSDIRGHRRTYVGSMPGRIINGLKtvgvNNPVFLLDE 443
Cdd:COG5271   1545 PIL-LEGSPGVGKTSLITALARKTGKKLIRINLSeqtDLCDlfGSDLPVEEGGEFRWMDAPFLHAMR----DGGWVLLDE 1619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449  444 VDKLGKS-LQGdpaaaLLEVLD-------PEQNHNFTDHylnvafdlSQVLFIATANTTAT------IPAALLDRMEIIQ 509
Cdd:COG5271   1620 INLASQSvLEG-----LNACLDhrreayiPELDKTFDVH--------PNFRVFAAQNPQDQgggrkgLPKSFLNRFSVVK 1686
                          170       180
                   ....*....|....*....|
gi 1128611449  510 VPGYTQEEKIEIAhRHLIPK 529
Cdd:COG5271   1687 MDGLTTDDITHIA-NKMYPQ 1705
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
375-504 2.25e-03

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 39.08  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611449 375 GPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRG------HRRTYVgSMPGriinglktvgvnnPVF----LLDEV 444
Cdd:pfam07726   6 GVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGtevfdqKTREFE-FRPG-------------PVFanvlLADEI 71
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1128611449 445 DKLGKSLQgdpaAALLEVLdpeQNHNFTdhYLNVAFDLSQVLF-IATANT-----TATIPAALLDR 504
Cdd:pfam07726  72 NRAPPKTQ----SALLEAM---QERQVT--IDGETHPLPEPFFvLATQNPieqegTYPLPEAQLDR 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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