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Conserved domains on  [gi|1045560849|ref|NP_001316587|]
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zinc finger protein 25 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 9.11e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.11e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1045560849    1 MLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-417 2.85e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 108 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQK------- 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 179 ---------PHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEK-------PYECKECGKAFSQKSHLTVHQR 242
Cdd:COG5048   112 ssssnsndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 243 MHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFY 316
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 317 YKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEKP 389
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350
                  ....*....|....*....|....*....|
gi 1045560849 390 YECQECGETFIQKSQLTA--HQKTHTKKRN 417
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 9.11e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.11e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1045560849    1 MLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-417 2.85e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 108 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQK------- 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 179 ---------PHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEK-------PYECKECGKAFSQKSHLTVHQR 242
Cdd:COG5048   112 ssssnsndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 243 MHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFY 316
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 317 YKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEKP 389
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350
                  ....*....|....*....|....*....|
gi 1045560849 390 YECQECGETFIQKSQLTA--HQKTHTKKRN 417
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-233 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560849 208 YLMVHQKTHTGEKPYECKECGKAFSQ 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 9.11e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 9.11e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1045560849    1 MLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-417 2.85e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 108 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQK------- 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 179 ---------PHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEK-------PYECKECGKAFSQKSHLTVHQR 242
Cdd:COG5048   112 ssssnsndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 243 MHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFY 316
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 317 YKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEKP 389
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350
                  ....*....|....*....|....*....|
gi 1045560849 390 YECQECGETFIQKSQLTA--HQKTHTKKRN 417
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-396 9.63e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 9.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 144 KKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFF--------YVKAYLMvHQKT 215
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqsPSSLSSS-DSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 216 HTGEKPYECKeCGKAFSQKSHLTVHQRMHTG-EKPYKCKECGKFFSRNSHLKTHQRS--HTGE--KPYECKE--CRKCFY 288
Cdd:COG5048   256 SASESPRSSL-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 289 QKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTK-------HQRKHTGEKPYECT--ECGKSFAVNSVLRLHQRTHTGE 359
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1045560849 360 KPYACK--ECGKSFSQKSHFIIHQRKHTGEKPYECQECG 396
Cdd:COG5048   415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
135-420 1.63e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 135 DKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQ--CEKSFYQKPHLTEHQKTHTGEKPFECT-ECGKFFYVKAYLMV 211
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 212 HQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKEC-GKFFSRNSHLKTHQRSHTgekpyecKECRKCFYQK 290
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 291 SALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECGKSFAVNSVLRLHQRTHTGE----------- 359
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDssssasesprs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 360 ------------------------KPYACKECGKSFSQKSHFIIHQRK--HTGE--KPYEC--QECGETFIQKSQLTAHQ 409
Cdd:COG5048   264 slptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330
                  ....*....|.
gi 1045560849 410 KTHTKKRNAEK 420
Cdd:COG5048   344 LLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-375 1.69e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 220 KPYECKECGKAFSQKSHLTVHQRM--HTGE--KPYKCKE--CGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSAL 293
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 294 T-------VHQRTHTGEKPFEC--NKCGKTFYYKSDLTKHQRKHTGEKPYEC--TECGKSFAVNSVLRLHQRTHTGEKPY 362
Cdd:COG5048   368 NneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 1045560849 363 ACKECGKSFSQKS 375
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-376 1.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849  59 SQAGNSRNGELTKHQKTHttekacECKECGKFFCQKSALIVHQHTHSKGKSYDC--DKCGKSFSKNEDLIRHQKIHTRDK 136
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPD------SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 137 TYECkeCKKIFYHLSSLSRHLRTHAGEKPYECNQCE-------------KSFYQKPHLTEHQKTHTGEKPFECTEC---- 199
Cdd:COG5048    91 SDLN--SKSLPLSNSKASSSSLSSSSSNSNDNNLLSshslppssrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSnslh 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 200 --------GKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQRS 271
Cdd:COG5048   169 pplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 272 HTGEKPYECKECRKCFYQKSALTVHQRTHTGE-------KPFECNKCGKTFYYKSDLTKHQRK--HTGE--KPYECTE-- 338
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1045560849 339 CGKSFAVNSVLRLHQRTHTGEKPYACK--ECGKSFSQKSH 376
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-268 4.94e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849  71 KHQKTHTTEKACECKECGKFFCQKSALIVHQHTHS-------KGKSYDCDKCGKSFSKNEDLIRHQ--KIHTR--DKTYE 139
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560849 140 CKE--CKKIFYHLSSLSRHLRTHAGEKPYEC--NQCEKSFYQKPH-----LTEHQKTHTGEKPFECT--ECGKFFYVKAY 208
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSN 403

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1045560849 209 LMVHQKTHTGEKPYECK--ECGKAFSQKSHLTVHQRMHTGEKPYKCkECGKFFSRNSHLKTH 268
Cdd:COG5048   404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-233 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560849 208 YLMVHQKTHTGEKPYECKECGKAFSQ 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-373 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....*
gi 1045560849 349 LRLHQRTHTGEKPYACKECGKSFSQ 373
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-261 2.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560849 236 HLTVHQRMHTGEKPYKCKECGKFFSR 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-344 3.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1045560849 320 DLTKHQRKHTGEKPYECTECGKSFA 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560849 264 HLKTHQRSHTGEKPYECKECRKCFYQ 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 250-272 4.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|...
gi 1045560849 250 YKCKECGKFFSRNSHLKTHQRSH 272
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 222-244 5.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.80e-03
                          10        20
                  ....*....|....*....|...
gi 1045560849 222 YECKECGKAFSQKSHLTVHQRMH 244
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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