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Conserved domains on  [gi|984880681|ref|NP_001306168|]
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zinc finger CCCH domain-containing protein 11A isoform 1 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein 11( domain architecture ID 12174178)

zinc finger CCCH domain-containing protein 11 such as ZC3H11A, an RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export

Gene Ontology:  GO:0008270|GO:0003729
PubMed:  12665246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 1-110 4.17e-85

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


:

Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 265.48  E-value: 4.17e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984880681    1 MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNC 80
Cdd:pfam15663   1 MENKGDDCYFFYYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDKNRKEIPCYWENQPGGCQKPHC 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 984880681   81 AFHHNRGRYVDGLFLPPSKTVLPTVPESPE 110
Cdd:pfam15663  81 AFHHTKPRYVDGLFLPPSKTEVPSANENPE 110
 
Name Accession Description Interval E-value
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 1-110 4.17e-85

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 265.48  E-value: 4.17e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984880681    1 MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNC 80
Cdd:pfam15663   1 MENKGDDCYFFYYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDKNRKEIPCYWENQPGGCQKPHC 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 984880681   81 AFHHNRGRYVDGLFLPPSKTVLPTVPESPE 110
Cdd:pfam15663  81 AFHHTKPRYVDGLFLPPSKTEVPSANENPE 110
ZnF_C3H1 smart00356
zinc finger;
6-28 2.18e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.07  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|...
gi 984880681     6 EDCYFFFYSTCTKGDSCPFRHCE 28
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 1-110 4.17e-85

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 265.48  E-value: 4.17e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984880681    1 MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNC 80
Cdd:pfam15663   1 MENKGDDCYFFYYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDKNRKEIPCYWENQPGGCQKPHC 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 984880681   81 AFHHNRGRYVDGLFLPPSKTVLPTVPESPE 110
Cdd:pfam15663  81 AFHHTKPRYVDGLFLPPSKTEVPSANENPE 110
ZnF_C3H1 smart00356
zinc finger;
6-28 2.18e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.07  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|...
gi 984880681     6 EDCYFFFYSTCTKGDSCPFRHCE 28
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
 7-26 7.42e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 34.41  E-value: 7.42e-03
                          10        20
                  ....*....|....*....|
gi 984880681    7 DCYFFfySTCTKGDSCPFRH 26
Cdd:pfam14608   1 PCRFG--GNCTFGPKCPFSH 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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