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Conserved domains on  [gi|962597264|ref|NP_001304865|]
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zinc finger protein 517 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-66 1.71e-17

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.71e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264    14 VVFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN-------LASLALISLLEQGEEPG 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNlvslgfqVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-452 4.17e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 280 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 354 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 422
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 962597264 423 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 452
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-335 8.69e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 196 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 267
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 962597264 268 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 335
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-66 1.71e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.71e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264    14 VVFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN-------LASLALISLLEQGEEPG 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNlvslgfqVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-49 4.11e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.81  E-value: 4.11e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 962597264   14 VVFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRN 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-49 5.73e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 5.73e-15
                         10        20        30
                 ....*....|....*....|....*....|....
gi 962597264  16 FEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN 49
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-452 4.17e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 280 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 354 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 422
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 962597264 423 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 452
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-335 8.69e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 196 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 267
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 962597264 268 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 335
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-209 2.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*
gi 962597264  185 LLRHQIIHTGAKPFQCTECGKAFKQ 209
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 2.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 962597264  389 FECAECGKAFGRKSNLTLHQKIH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-66 1.71e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.71e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264    14 VVFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN-------LASLALISLLEQGEEPG 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNlvslgfqVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-49 4.11e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.81  E-value: 4.11e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 962597264   14 VVFEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRN 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-49 5.73e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 5.73e-15
                         10        20        30
                 ....*....|....*....|....*....|....
gi 962597264  16 FEDVAVYFTRIEWSCLAPDQQALYRDVMLENYGN 49
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-452 4.17e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 280 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 354 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 422
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 962597264 423 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 452
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-335 8.69e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 196 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 267
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 962597264 268 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 335
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-452 1.99e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 175 CGKAFRYNSLLLRHQIIHTGAKPFQCT--ECGKAFKQSSILLRHQLIHTEEKPFQC--GECGKAFRQSTQLAAHHRVHTR 250
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 251 ErPYACGECGKAFS---------RSSRLLQHQKFHTG---------------EKPFACTECGKAFCRRFTLneHGRIHSG 306
Cdd:COG5048  119 D-NNLLSSHSLPPSsrdpqlpdlLSISNLRNNPLPGNnsssvntpqsnslhpPLPANSLSKDPSSNLSLLI--SSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 307 ERPYRCLRCGQRFIRGSSLLKHHRLHAQEGAQDGGVGQGALLG--AAQRPQAGDPPHECPVCG----------RPFRHNS 374
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKslLSQSPSSLSSSDSSSSASesprsslptaSSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 375 LLLLHLRLHTGEKPFECAECGKAFGRKSNLTLHQ--KIHTKE--KPFACTE--CGKAFRRSYTLNEHYRLHSGERPYRCR 448
Cdd:COG5048  276 NESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355


                 ....
gi 962597264 449 ACGR 452
Cdd:COG5048  356 LLNS 359
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-302 3.28e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962597264 175 CGKAFRYNSLLLRHQIIHTGAKPFQC--TECGKAFKQSSILLRHQLIH-----TEEKPFQC--GECGKAFRQSTQLAAHH 245
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 962597264 246 RVHTRERPYAC--GECGKAFSRSSRLLQHQKFHTgEKPFACTECGKAFCRRFTLNEHGR 302
Cdd:COG5048  409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-209 2.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*
gi 962597264  185 LLRHQIIHTGAKPFQCTECGKAFKQ 209
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-291 2.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.70e-04
                          10        20
                  ....*....|....*....|....
gi 962597264  268 RLLQHQKFHTGEKPFACTECGKAF 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
387-452 4.92e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.92e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 962597264 387 KPFECAECGKAFGRKSNLTLHQKIHTKEKPFACT--ECGKAFRRSYTLNEHYRLHSGERPYRCRACGR 452
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-237 7.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.72e-04
                          10        20
                  ....*....|....*....|....*
gi 962597264  213 LLRHQLIHTEEKPFQCGECGKAFRQ 237
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-312 1.56e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 962597264 252 RPYACGECGKAFSRSSRLLQHQKFHTGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERPYRC 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 2.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 962597264  389 FECAECGKAFGRKSNLTLHQKIH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 226-248 3.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|...
gi 962597264  226 FQCGECGKAFRQSTQLAAHHRVH 248
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 417-439 6.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.87e-03
                          10        20
                  ....*....|....*....|...
gi 962597264  417 FACTECGKAFRRSYTLNEHYRLH 439
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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