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Conserved domains on  [gi|594140625|ref|NP_001277284|]
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NACHT domain- and WD repeat-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
722-1066 6.28e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 6.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  802 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 872
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  873 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 949
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  950 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 1024
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 594140625 1025 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 1066
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
943-1327 1.87e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  943 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 1022
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1023 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1100
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1101 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1179
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1180 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1256
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594140625 1257 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1327
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 179-264 1.41e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd00009:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 151  Bit Score: 40.59  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  179 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 258
Cdd:cd00009     2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                  ....*.
gi 594140625  259 CLAYGL 264
Cdd:cd00009    71 FLVRLL 76
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
722-1066 6.28e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 6.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  802 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 872
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  873 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 949
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  950 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 1024
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 594140625 1025 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 1066
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1021 1.62e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 804
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  805 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 883
Cdd:cd00200    81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  884 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 958
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594140625  959 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 1021
Cdd:cd00200   229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
943-1327 1.87e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  943 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 1022
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1023 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1100
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1101 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1179
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1180 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1256
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594140625 1257 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1327
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 992-1326 2.15e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  992 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 1069
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1070 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 1148
Cdd:cd00200    71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1149 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 1226
Cdd:cd00200   122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1227 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLqarkWKFEMSYTssyCRG----V 1301
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT---LSGhtnsV 264

                         330       340
                  ....*....|....*....|....*
gi 594140625 1302 QCACFSKDDKYVYVGLKDRSILVWS 1326
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
768-803 5.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.58e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 594140625   768 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 803
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 179-264 1.41e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.59  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  179 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 258
Cdd:cd00009     2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                  ....*.
gi 594140625  259 CLAYGL 264
Cdd:cd00009    71 FLVRLL 76
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1249-1281 1.85e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 594140625   1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1281
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 176-215 1.90e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.60  E-value: 1.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 594140625  176 TFCGRQELLARLGQQLRHDdSKQHTPLVLFGPPGIGKTAL 215
Cdd:NF040586    7 NFTGREELLERLRDQLRSG-GAAVVPQALHGLGGVGKTQL 45
WD40 pfam00400
WD domain, G-beta repeat;
1249-1281 2.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 594140625  1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1281
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 766-803 2.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.71e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 594140625    766 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 803
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 201-367 6.53e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 39.21  E-value: 6.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625   201 PLVLFGPPGIGKTALMCKLAE--QMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQvclaygLPLPPAQVLDAHTRV 278
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALlwAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQ------WPEPAAPVSEVWAVI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625   279 VQFFHTLLHTVScrNFESLVLLLDAMDDLDSVRHARRvPWLPLNCPPRVHLILSACSGALGvldTLQRVLLDPEaYWEVK 358
Cdd:pfam05729   76 LELPERLLLILD--GLDELVSDLGQLDGPCPVLTLLS-SLLRKKLLPGASLLLTVRPDALR---DLRRGLEEPR-YLEVR 148


                   ....*....
gi 594140625   359 PLSGNQGQQ 367
Cdd:pfam05729  149 GFSESDRKQ 157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
722-1066 6.28e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 6.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  802 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 872
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  873 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 949
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  950 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 1024
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 594140625 1025 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 1066
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1021 1.62e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  725 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 804
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  805 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 883
Cdd:cd00200    81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  884 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 958
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594140625  959 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 1021
Cdd:cd00200   229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
722-1109 4.14e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 4.14e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  722 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801
Cdd:COG2319    25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  802 WNLLSGQEKFTIWDggsknpaepqiwnlHVDEAHKVVYS------ASGS---KINAWNLETAEPVFHILGDASDPWmCMA 872
Cdd:COG2319   105 WDLATGLLLRTLTG--------------HTGAVRSVAFSpdgktlASGSadgTVRLWDLATGKLLRTLTGHSGAVT-SVA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  873 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 949
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDLATGKLLRtlTGHTGAVR------SVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLT 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  950 ---DAVRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEq 1025
Cdd:COG2319   244 ghsGSVRSVAFSPDGRLLAsGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1026 GTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKV 1103
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAfsPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS--GSADGTV 396


                  ....*.
gi 594140625 1104 TIWDLA 1109
Cdd:COG2319   397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
943-1327 1.87e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  943 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 1022
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1023 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 1100
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1101 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1179
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1180 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 1256
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594140625 1257 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1327
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
872-1283 2.14e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  872 AVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDA 951
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  952 VRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLD 1030
Cdd:COG2319    81 VLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1031 ILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD--------AHRSRVPApfldrtglTAVSHNGSYVYFpkIGDK 1100
Cdd:COG2319   157 TLTGHSGAVTSVAfsPDGKLLASGS-DDGTVRLWDLATgkllrtltGHTGAVRS--------VAFSPDGKLLAS--GSAD 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1101 NKVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 1179
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1180 AIA-YDNIVLVLDITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKAF-PLETHRSRV 1256
Cdd:COG2319   304 ASGsDDGTVRLWDLATGKLLRTLTGHTGAVR--------SVAFSPDgKTLASGSDDGTVRLWDLATGELLrTLTGHTGAV 375

                         410       420
                  ....*....|....*....|....*..
gi 594140625 1257 ACVEVSHKEQLVVSGSEDALLCLWDLQ 1283
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
956-1339 4.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 4.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  956 VVSEDESLLAAGFGRSVRIFLADSRGFRRFMAmdLEHEDMVETAVFGTENNLIITGSLDALIQVWsLSEQGTLLDILEGV 1035
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLL--LGLAAAVASLAASPDGARLAAGAGDLTLLLL-DAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1036 GAPVSLLA--RGGALVASASPQSSsFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKVTIWDLAEGEE 1113
Cdd:COG2319    78 TAAVLSVAfsPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGTVRLWDLATGKL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1114 QDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRLAIA-YDNIVLVLD 1191
Cdd:COG2319   155 LRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--VRSVAFSPDGKLLASGsADGTVRLWD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1192 ITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVV 1269
Cdd:COG2319   233 LATGKLLRTLTGHSGSVR--------SVAFSPDgRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLA 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1270 SGSEDALLCLWDLQARKWKFEMSytsSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 723-893 2.81e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  723 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLW 802
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  803 NLLSGQEKFTIWdgGSKNPaepqIWNLHVDEAHKVVYSASG-SKINAWNLETAEPVFHILGDASDPWmCMAVLASQATLL 881
Cdd:cd00200   205 DLSTGKCLGTLR--GHENG----VNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVT-SLAWSPDGKRLA 277

                         170
                  ....*....|..
gi 594140625  882 TVSRDGVVSLWS 893
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 992-1326 2.15e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  992 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 1069
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1070 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 1148
Cdd:cd00200    71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1149 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 1226
Cdd:cd00200   122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1227 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLqarkWKFEMSYTssyCRG----V 1301
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT---LSGhtnsV 264

                         330       340
                  ....*....|....*....|....*
gi 594140625 1302 QCACFSKDDKYVYVGLKDRSILVWS 1326
Cdd:cd00200   265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1120-1339 1.52e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1120 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPppEARKAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPC 1198
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1199 pvidgprYTFyTQLPETLSSVAILTDYRVVY-SMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVVSGSEDAL 1276
Cdd:cd00200    87 -------RTL-TGHTSYVSSVAFSPDGRILSsSSRDKTIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 594140625 1277 LCLWDLqaRKWKFEMSYTSSYcRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1339
Cdd:cd00200   159 IKLWDL--RTGKCVATLTGHT-GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 722-934 5.39e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 5.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  722 GGPLRATLSGcHKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLH 800
Cdd:cd00200    82 TGECVRTLTG-HTSyVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  801 LWNLLSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVfHILGDASDPWMCMAVLASQAT 879
Cdd:cd00200   161 LWDLRTGKCVATL--TGHTGE----VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYL 233

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 594140625  880 LLTVSRDGVVSLWSSATGKLqgkqhMSSIKEETPTC-AVSVQKQGK-LVTGFSNGSI 934
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGEC-----VQTLSGHTNSVtSLAWSPDGKrLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 720-803 4.00e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 4.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  720 PPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTL 799
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                  ....
gi 594140625  800 HLWN 803
Cdd:cd00200   286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1249-1354 1.23e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQarkwKFEMSYT-SSYCRGVQCACFSKDDKYVYVGLKDRSILVWSV 1327
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----TGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100
                  ....*....|....*....|....*....
gi 594140625 1328 LDGTLLTVQFVH--AVVNRIIPTTSGFIA 1354
Cdd:cd00200   123 ETGKCLTTLRGHtdWVNSVAFSPDGTFVA 151
WD40 pfam00400
WD domain, G-beta repeat;
768-803 5.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 5.58e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 594140625   768 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 803
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 179-264 1.41e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 40.59  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625  179 GRQELLARLgQQLRHDDSKQHtpLVLFGPPGIGKTALMCKLAeqmpRLLGHKTVTVLRLlgtsQMSSDARGLLKSICFQV 258
Cdd:cd00009     2 GQEEAIEAL-REALELPPPKN--LLLYGPPGTGKTTLARAIA----NELFRPGAPFLYL----NASDLLEGLVVAELFGH 70


                  ....*.
gi 594140625  259 CLAYGL 264
Cdd:cd00009    71 FLVRLL 76
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1249-1281 1.85e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 594140625   1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1281
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 176-215 1.90e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 42.60  E-value: 1.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 594140625  176 TFCGRQELLARLGQQLRHDdSKQHTPLVLFGPPGIGKTAL 215
Cdd:NF040586    7 NFTGREELLERLRDQLRSG-GAAVVPQALHGLGGVGKTQL 45
WD40 pfam00400
WD domain, G-beta repeat;
1249-1281 2.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.24e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 594140625  1249 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 1281
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 766-803 2.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.71e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 594140625    766 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 803
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 201-367 6.53e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 39.21  E-value: 6.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625   201 PLVLFGPPGIGKTALMCKLAE--QMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQvclaygLPLPPAQVLDAHTRV 278
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALlwAQGKLPQGFDFVFFLPCRELSRSGNARSLADLLFSQ------WPEPAAPVSEVWAVI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625   279 VQFFHTLLHTVScrNFESLVLLLDAMDDLDSVRHARRvPWLPLNCPPRVHLILSACSGALGvldTLQRVLLDPEaYWEVK 358
Cdd:pfam05729   76 LELPERLLLILD--GLDELVSDLGQLDGPCPVLTLLS-SLLRKKLLPGASLLLTVRPDALR---DLRRGLEEPR-YLEVR 148


                   ....*....
gi 594140625   359 PLSGNQGQQ 367
Cdd:pfam05729  149 GFSESDRKQ 157
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 728-781 7.45e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 7.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 594140625   728 TLSGCHKG--ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 781
Cdd:pfam12894   31 TLSPDKEDleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 176-225 7.99e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.64  E-value: 7.99e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 594140625   176 TFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPR 225
Cdd:pfam13191    1 RLVGREEELEQLLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALER 50
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1161-1288 8.37e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1161 PEARKAINCMSLS--KCEDRLAIAY-DNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTdyRVVYSMT-NGDL 1236
Cdd:cd22857    27 PDKSKAVQALSIAdrESEPLLAVARkNGTVEVLDPENGDLLASFSDSEPATKLSEEDHFVGLHLFS--GTLLTCTsKGSL 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140625 1237 FLY-----ECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQ---ARKWK 1288
Cdd:cd22857   105 RSTklpddSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDLEekpGKIWR 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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