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Conserved domains on  [gi|557878683|ref|NP_001273626|]
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zinc finger protein 79 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-413 8.91e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 8.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 182 SSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGE-------KPYR 254
Cdd:COG5048  212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIK 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 255 CSECEKAFSDCSALVQHQR--IHTGE--KPYEC--SDCGKAFRHSANLTNHQRTHTGEKPYKCSEC-------GKAFSYC 321
Cdd:COG5048  292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEP 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 322 AAFIQHQRIHTGEKPYRCA--ACGKAFSQSANLTNHQRTHTGEKP--YKCSECGKAFSQSTNLIIHQKTHTgEKPYKCNE 397
Cdd:COG5048  372 PQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCS 450
                        250
                 ....*....|....*.
gi 557878683 398 CGKFFSESSALIRHHI 413
Cdd:COG5048  451 ILKSFRRDLDLSNHGK 466
KRAB super family cl42959
krueppel associated box;
16-74 2.77e-08

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.28  E-value: 2.77e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 557878683    16 FSSVTVAFAQERWRCLVSTPRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWM 74
Cdd:smart00349   3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 1.70e-04

Zinc-finger double domain;


:

Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 38.49  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  435 SLSQHQRIHTGVKPYECSECGKAFRC 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 3.98e-04

Zinc-finger double domain;


:

Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 37.34  E-value: 3.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  407 ALIRHHIIHTGEKPYECNECGKAFNQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-413 8.91e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 8.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 182 SSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGE-------KPYR 254
Cdd:COG5048  212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIK 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 255 CSECEKAFSDCSALVQHQR--IHTGE--KPYEC--SDCGKAFRHSANLTNHQRTHTGEKPYKCSEC-------GKAFSYC 321
Cdd:COG5048  292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEP 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 322 AAFIQHQRIHTGEKPYRCA--ACGKAFSQSANLTNHQRTHTGEKP--YKCSECGKAFSQSTNLIIHQKTHTgEKPYKCNE 397
Cdd:COG5048  372 PQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCS 450
                        250
                 ....*....|....*.
gi 557878683 398 CGKFFSESSALIRHHI 413
Cdd:COG5048  451 ILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
16-74 2.77e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.28  E-value: 2.77e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 557878683    16 FSSVTVAFAQERWRCLVSTPRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWM 74
Cdd:smart00349   3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 3.17e-05

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 40.80  E-value: 3.17e-05
                          10        20
                  ....*....|....*....|....*.
gi 557878683  351 NLTNHQRTHTGEKPYKCSECGKAFSQ 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 1.70e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 38.49  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  435 SLSQHQRIHTGVKPYECSECGKAFRC 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 3.98e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 37.34  E-value: 3.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  407 ALIRHHIIHTGEKPYECNECGKAFNQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
195-243 2.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 557878683 195 KPYeCSECGKAFSQSSSLIQHQRIHTgekpYKCSECGRAFSQNANLTKH 243
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-413 8.91e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 8.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 182 SSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGE-------KPYR 254
Cdd:COG5048  212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIK 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 255 CSECEKAFSDCSALVQHQR--IHTGE--KPYEC--SDCGKAFRHSANLTNHQRTHTGEKPYKCSEC-------GKAFSYC 321
Cdd:COG5048  292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEP 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 322 AAFIQHQRIHTGEKPYRCA--ACGKAFSQSANLTNHQRTHTGEKP--YKCSECGKAFSQSTNLIIHQKTHTgEKPYKCNE 397
Cdd:COG5048  372 PQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCS 450
                        250
                 ....*....|....*.
gi 557878683 398 CGKFFSESSALIRHHI 413
Cdd:COG5048  451 ILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-451 5.24e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 182 SSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRA--FSQNANLTKHQRTHTGEKPYRCS--- 256
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSksl 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 257 -------------ECEKAFSDCSALVQH---QRIHTGEKPYECSDC---------------------------------G 287
Cdd:COG5048   99 plsnskasssslsSSSSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvntpqsnslhpplpanslsK 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 288 KAFRHSANLTNHQRTHTGEKPYKCSECGKAFSYcAAFIQHQRIHTGEKPYRCAACGKAFSQSANLTNHQRTHTGEKPYKC 367
Cdd:COG5048  179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSI-PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 368 SECGKAFSQSTNLIIHQKTHTGE-------KPYKCNECGKFFSESSALIRH--HIIHTGE--KPYECNE--CGKAFNQSS 434
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRND 337
                        330
                 ....*....|....*..
gi 557878683 435 SLSQHQRIHTGVKPYEC 451
Cdd:COG5048  338 ALKRHILLHTSISPAKE 354
KRAB smart00349
krueppel associated box;
16-74 2.77e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 50.28  E-value: 2.77e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 557878683    16 FSSVTVAFAQERWRCLVSTPRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWM 74
Cdd:smart00349   3 FEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-473 2.38e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 207 SQSSSLIQHQRIHTGE----KPYKCSECGRAFSQNANLTKHQRTHTGEKPYRCS--ECEKAFSDCSALVQHQRIHTGEKP 280
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 281 YECSDCGKAFRHSA------------------------NLTNHQRTHTGEKPYKCSEC---------------------- 314
Cdd:COG5048   92 DLNSKSLPLSNSKAsssslsssssnsndnnllsshslpPSSRDPQLPDLLSISNLRNNplpgnnsssvntpqsnslhppl 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 315 -----GKAFSYCAAFIQHQRIHTGEKPYRCAACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTG 389
Cdd:COG5048  172 panslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 390 EKPYKCNECGKFFSESSALIRHHIIHTGE-------KPYECNECGKAFNQSSSLSQHQR--IHTG--VKPYECSE--CGK 456
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGK 331
                        330
                 ....*....|....*..
gi 557878683 457 AFRCSSAFVRHQRLHAG 473
Cdd:COG5048  332 LFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-462 1.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 307 KPYKCSECGKAFSYCAAFIQHQR--IHTGE--KPYRC--AACGKAFSQSANLTNHQRTHTGEKPYKC--SECGKAFSQST 378
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 379 N-----LIIHQKTHTGEKPYKC--NECGKFFSESSALIRHHIIHTGEKPYECN--ECGKAFNQSSSLSQHQRIHTGVKPY 449
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447
                        170
                 ....*....|...
gi 557878683 450 ECSECGKAFRCSS 462
Cdd:COG5048  448 LCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 3.17e-05

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 40.80  E-value: 3.17e-05
                          10        20
                  ....*....|....*....|....*.
gi 557878683  351 NLTNHQRTHTGEKPYKCSECGKAFSQ 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 3.43e-05

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 40.42  E-value: 3.43e-05
                          10        20
                  ....*....|....*....|....*.
gi 557878683  295 NLTNHQRTHTGEKPYKCSECGKAFSY 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 9.98e-05

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 39.26  E-value: 9.98e-05
                          10        20
                  ....*....|....*....|....*.
gi 557878683  183 SLSQHQKSHTGEKPYECSECGKAFSQ 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 1.03e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 39.26  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  267 ALVQHQRIHTGEKPYECSDCGKAFRH 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-263 1.16e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 38.88  E-value: 1.16e-04
                          10        20
                  ....*....|....*....|....*
gi 557878683  239 NLTKHQRTHTGEKPYRCSECEKAFS 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 1.70e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 38.49  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  435 SLSQHQRIHTGVKPYECSECGKAFRC 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-236 1.75e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 38.49  E-value: 1.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  211 SLIQHQRIHTGEKPYKCSECGRAFSQ 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
225-247 2.96e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.96e-04
                          10        20
                  ....*....|....*....|...
gi 557878683  225 YKCSECGRAFSQNANLTKHQRTH 247
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
281-303 3.33e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.33e-04
                          10        20
                  ....*....|....*....|...
gi 557878683  281 YECSDCGKAFRHSANLTNHQRTH 303
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 3.98e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 37.34  E-value: 3.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 557878683  407 ALIRHHIIHTGEKPYECNECGKAFNQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-348 6.01e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 36.95  E-value: 6.01e-04
                          10        20
                  ....*....|....*....|...
gi 557878683  326 QHQRIHTGEKPYRCAACGKAFSQ 348
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-403 7.84e-04

Zinc-finger double domain;


Pssm-ID: 433230 [Multi-domain]  Cd Length: 26  Bit Score: 36.57  E-value: 7.84e-04
                          10        20
                  ....*....|....*....|....*
gi 557878683  379 NLIIHQKTHTGEKPYKCNECGKFFS 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
361-439 8.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 361 GEKPYKCS--ECGKAFSQSTNLIIHQKThtgekpykcNECGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQ 438
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 .
gi 557878683 439 H 439
Cdd:COG5189  417 H 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
365-387 8.70e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 8.70e-04
                          10        20
                  ....*....|....*....|...
gi 557878683  365 YKCSECGKAFSQSTNLIIHQKTH 387
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
197-219 1.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|...
gi 557878683  197 YECSECGKAFSQSSSLIQHQRIH 219
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
277-360 1.63e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 277 GEKPYECS--DCGKAFRHSANLTNHQrthtgekpyKCSECGKAFSYCAAFIQHQRIHTGEKPYRCAACGKAFSQSANLTN 354
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 ....*.
gi 557878683 355 HqRTHT 360
Cdd:COG5189  417 H-RKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
195-243 2.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 557878683 195 KPYeCSECGKAFSQSSSLIQHQRIHTgekpYKCSECGRAFSQNANLTKH 243
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
421-443 2.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|...
gi 557878683  421 YECNECGKAFNQSSSLSQHQRIH 443
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
363-411 3.40e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 3.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 557878683 363 KPYkCSECGKAFSQSTNLIIHQKTHTgekpYKCNECGKFFSESSALIRH 411
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
337-359 4.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.44e-03
                          10        20
                  ....*....|....*....|...
gi 557878683  337 YRCAACGKAFSQSANLTNHQRTH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
167-248 6.26e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 167 KPYACN--ECGKAFSYCSSLSQHQKShtgekpyecSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFsQNANLTKHQ 244
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY-KNLNGLKYH 417

                 ....
gi 557878683 245 RTHT 248
Cdd:COG5189  418 RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
221-304 6.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 221 GEKPYKCS--ECGRAFsQNANLTKHQRTHtgekpyrcSECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTN 298
Cdd:COG5189  346 DGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 ....*.
gi 557878683 299 HqRTHT 304
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
193-271 9.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878683 193 GEKPYECS--ECGKAFSQSSSLIQHqRIHtgekpykcSECGRAFSQNANLTKHQRTHTGEKPYRCSECEKAFSDCSALVQ 270
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 .
gi 557878683 271 H 271
Cdd:COG5189  417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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