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Conserved domains on  [gi|498917331|ref|NP_001265104|]
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zinc finger protein 33A isoform f [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-721 4.85e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 361 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 438
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 439 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 511
Cdd:COG5048  109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 512 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 575
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 576 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 629
Cdd:COG5048  259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 630 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 700
Cdd:COG5048  339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420
                 ....*....|....*....|.
gi 498917331 701 EMDIRNFQPQVSLHNASEYSH 721
Cdd:COG5048  419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-438 1.09e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331  64 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 132
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 133 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 192
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 193 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 271
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 272 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 338
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 339 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 407
Cdd:COG5048  356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|.
gi 498917331 408 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 438
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-721 4.85e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 361 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 438
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 439 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 511
Cdd:COG5048  109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 512 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 575
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 576 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 629
Cdd:COG5048  259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 630 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 700
Cdd:COG5048  339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420
                 ....*....|....*....|.
gi 498917331 701 EMDIRNFQPQVSLHNASEYSH 721
Cdd:COG5048  419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-438 1.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331  64 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 132
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 133 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 192
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 193 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 271
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 272 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 338
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 339 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 407
Cdd:COG5048  356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|.
gi 498917331 408 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 438
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 5.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 498917331  293 NLTKHQRSHTGEKPFECNECGKAFSH 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 8.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.88e-04
                          10        20
                  ....*....|....*....|....*
gi 498917331  377 HLKVHQRTHTGEKPFECLECGKSFS 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-721 4.85e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 361 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 438
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 439 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 511
Cdd:COG5048  109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 512 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 575
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 576 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 629
Cdd:COG5048  259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 630 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 700
Cdd:COG5048  339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420
                 ....*....|....*....|.
gi 498917331 701 EMDIRNFQPQVSLHNASEYSH 721
Cdd:COG5048  419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-596 1.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 251 FECNECGKAFWEKSHLTRHQRVHTGQKPFQCN--ECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRT 328
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 329 HTGE-KPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSFRVTS----------------------HLKVHQRTH 385
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 386 TGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACG------------------------KTFYHKSLLTRHQIIH 441
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssaSESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 442 TGW-----------KPYECYECGKTFCLKSDLTVHQRT--HTGQ--KPFACPE--CGKFFSHKSTLSQHYRTHTGEKPYE 504
Cdd:COG5048  274 SPNesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 505 CHECGKIFYNKSYLTK-------HNRTHTGEKPYEC--NECGKAFYQKSQLTQHQRIHIGEKP--YKCNECGKAFCHKSA 573
Cdd:COG5048  354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|...
gi 498917331 574 LIVHQRTHTQEKPYKCNECGKSF 596
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-438 1.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331  64 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 132
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 133 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 192
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 193 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 271
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 272 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 338
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498917331 339 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 407
Cdd:COG5048  356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|.
gi 498917331 408 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 438
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 5.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 498917331  293 NLTKHQRSHTGEKPFECNECGKAFSH 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 8.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.88e-04
                          10        20
                  ....*....|....*....|....*
gi 498917331  377 HLKVHQRTHTGEKPFECLECGKSFS 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-289 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*
gi 498917331  265 HLTRHQRVHTGQKPFQCNECEKAFW 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
657-682 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 498917331  657 ELAQHQRSHTGEKPYECNTCRKTFSQ 682
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-486 3.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 498917331  461 DLTVHQRTHTGQKPFACPECGKFFSH 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 498917331  517 YLTKHNRTHTGEKPYECNECGKAFYQ 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
546-568 4.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|...
gi 498917331  546 LTQHQRIHIGEKPYKCNECGKAF 568
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-596 4.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|....
gi 498917331  573 ALIVHQRTHTQEKPYKCNECGKSF 596
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-372 7.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....
gi 498917331  349 DLTKHQRTHTGLKPYECYECGKSF 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 335-357 7.81e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.81e-03
                          10        20
                  ....*....|....*....|...
gi 498917331  335 YQCNACGKTFCQKSDLTKHQRTH 357
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 559-581 8.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.70e-03
                          10        20
                  ....*....|....*....|...
gi 498917331  559 YKCNECGKAFCHKSALIVHQRTH 581
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-512 9.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|...
gi 498917331  490 LSQHYRTHTGEKPYECHECGKIF 512
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-626 9.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.76e-03
                          10        20
                  ....*....|....*....|....*
gi 498917331  602 LIFHERKHTGEKPYECNECGKFFRH 626
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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