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Conserved domains on  [gi|459175660|ref|NP_001264003|]
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coiled-coil domain-containing protein 12 isoform 2 [Homo sapiens]

Protein Classification

CCDC12/cwf18 family protein( domain architecture ID 10550863)

CCDC12/cwf18 family protein similar to human coiled-coil domain-containing protein 12 (CCDC12) and Schizosaccharomyces pombe pre-mRNA-splicing factor cwf18 which associates with cdc5 and other cwf proteins as part of the spliceosome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cwf18 pfam08315
cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been ...
 11-143 1.34e-40

cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe.


:

Pssm-ID: 462423  Cd Length: 135  Bit Score: 133.12  E-value: 1.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459175660   11 LEEEALRRKERLKALREKTGRKDKEDGEPKTKhlrEEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKP-VAVEEKVKEQ 89
Cdd:pfam08315   2 LEEAALARKERLAALRSLKRKQPSEDDDEENS---SEPEEEEELPVLKFRNYDPETRGLKLGFVAPPTPgETVEEQAAEL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 459175660   90 LEAAKPEPVI---EEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERL 143
Cdd:pfam08315  79 LEETKAEDEEdadEELDLFNLAPKKPNWDLKRDLAKKLEKLERRTQNAIAELIRERL 135
 
Name Accession Description Interval E-value
cwf18 pfam08315
cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been ...
 11-143 1.34e-40

cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe.


Pssm-ID: 462423  Cd Length: 135  Bit Score: 133.12  E-value: 1.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459175660   11 LEEEALRRKERLKALREKTGRKDKEDGEPKTKhlrEEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKP-VAVEEKVKEQ 89
Cdd:pfam08315   2 LEEAALARKERLAALRSLKRKQPSEDDDEENS---SEPEEEEELPVLKFRNYDPETRGLKLGFVAPPTPgETVEEQAAEL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 459175660   90 LEAAKPEPVI---EEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERL 143
Cdd:pfam08315  79 LEETKAEDEEdadEELDLFNLAPKKPNWDLKRDLAKKLEKLERRTQNAIAELIRERL 135
 
Name Accession Description Interval E-value
cwf18 pfam08315
cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been ...
 11-143 1.34e-40

cwf18 pre-mRNA splicing factor; The cwf18 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe.


Pssm-ID: 462423  Cd Length: 135  Bit Score: 133.12  E-value: 1.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 459175660   11 LEEEALRRKERLKALREKTGRKDKEDGEPKTKhlrEEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKP-VAVEEKVKEQ 89
Cdd:pfam08315   2 LEEAALARKERLAALRSLKRKQPSEDDDEENS---SEPEEEEELPVLKFRNYDPETRGLKLGFVAPPTPgETVEEQAAEL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 459175660   90 LEAAKPEPVI---EEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERL 143
Cdd:pfam08315  79 LEETKAEDEEdadEELDLFNLAPKKPNWDLKRDLAKKLEKLERRTQNAIAELIRERL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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