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Conserved domains on  [gi|386643034|ref|NP_001245362|]
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protein NDRG1 isoform 3 [Homo sapiens]

Protein Classification

NDRG family protein( domain architecture ID 11140417)

N-myc downstream-regulated gene (NDRG) family protein may be involved in cellular differentiation events; similar to Homo sapiens protein NDRG1, which is a stress-responsive protein involved in hormone responses, cell growth, and differentiation; belongs to the alpha/beta hydrolase superfamily

PubMed:  12369917|19508187|20667976

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 1-235 2.67e-137

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


:

Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 390.18  E-value: 2.67e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034    1 MQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 80
Cdd:pfam03096  49 MQEILENFCIYHVDAPGQEDGAASFPGGYPYPSMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   81 LINVNPCAEGWMDWAASKIS-------GWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSR 153
Cdd:pfam03096 129 LINPTPKAAGWIEWFYNKLSskllyyyGMTDSAKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  154 RDLEIERPMPGThtvtlQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGY 233
Cdd:pfam03096 209 RDLTIERPGLET-----KCPVLLVVGDNSPHVDAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGY 283


                  ..
gi 386643034  234 MP 235
Cdd:pfam03096 284 YP 285
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 1-235 2.67e-137

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 390.18  E-value: 2.67e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034    1 MQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 80
Cdd:pfam03096  49 MQEILENFCIYHVDAPGQEDGAASFPGGYPYPSMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   81 LINVNPCAEGWMDWAASKIS-------GWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSR 153
Cdd:pfam03096 129 LINPTPKAAGWIEWFYNKLSskllyyyGMTDSAKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  154 RDLEIERPMPGThtvtlQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGY 233
Cdd:pfam03096 209 RDLTIERPGLET-----KCPVLLVVGDNSPHVDAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGY 283


                  ..
gi 386643034  234 MP 235
Cdd:pfam03096 284 YP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-230 1.75e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 59.63  E-value: 1.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   1 MQEITQHFAVCHVDAPGQqdGAASFPAGYMypSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 80
Cdd:COG0596   43 IPALAAGYRVIAPDLRGH--GRSDKPAGGY--TLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  81 LINvnpcaegwmdwaaskisgwtqalpdmvvshlfgkeemqsnvEVVHTYRQHIvnDMNPGNLHLFINAYNSRRDLEIER 160
Cdd:COG0596  119 LVD-----------------------------------------EVLAALAEPL--RRPGLAPEALAALLRALARTDLRE 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386643034 161 PMPgthtvTLQCPALLVVGDSSPAV-----DAVVECNSkldptKTTLLKMADCGGLPQISQPAKLAEAFKYFVQG 230
Cdd:COG0596  156 RLA-----RITVPTLVIWGEKDPIVppalaRRLAELLP-----NAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
2-108 3.33e-06

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 47.70  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   2 QEITQHFAVCHVDAPGqqdgaasFPAGYMYPSMdQLAEMLPGVLQQFGLKSIiGMGTGAGAYILTRFALNNPEMVEGLVL 81
Cdd:PRK10349  34 EELSSHFTLHLVDLPG-------FGRSRGFGAL-SLADMAEAVLQQAPDKAI-WLGWSLGGLVASQIALTHPERVQALVT 104

                         90       100       110
                 ....*....|....*....|....*....|
gi 386643034  82 INVNPC---AEGWMDWAASKISGWTQALPD 108
Cdd:PRK10349 105 VASSPCfsaRDEWPGIKPDVLAGFQQQLSD 134
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 1-235 2.67e-137

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 390.18  E-value: 2.67e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034    1 MQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 80
Cdd:pfam03096  49 MQEILENFCIYHVDAPGQEDGAASFPGGYPYPSMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   81 LINVNPCAEGWMDWAASKIS-------GWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSR 153
Cdd:pfam03096 129 LINPTPKAAGWIEWFYNKLSskllyyyGMTDSAKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  154 RDLEIERPMPGThtvtlQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGY 233
Cdd:pfam03096 209 RDLTIERPGLET-----KCPVLLVVGDNSPHVDAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGY 283


                  ..
gi 386643034  234 MP 235
Cdd:pfam03096 284 YP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-230 1.75e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 59.63  E-value: 1.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   1 MQEITQHFAVCHVDAPGQqdGAASFPAGYMypSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 80
Cdd:COG0596   43 IPALAAGYRVIAPDLRGH--GRSDKPAGGY--TLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  81 LINvnpcaegwmdwaaskisgwtqalpdmvvshlfgkeemqsnvEVVHTYRQHIvnDMNPGNLHLFINAYNSRRDLEIER 160
Cdd:COG0596  119 LVD-----------------------------------------EVLAALAEPL--RRPGLAPEALAALLRALARTDLRE 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386643034 161 PMPgthtvTLQCPALLVVGDSSPAV-----DAVVECNSkldptKTTLLKMADCGGLPQISQPAKLAEAFKYFVQG 230
Cdd:COG0596  156 RLA-----RITVPTLVIWGEKDPIVppalaRRLAELLP-----NAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
2-108 3.33e-06

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 47.70  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034   2 QEITQHFAVCHVDAPGqqdgaasFPAGYMYPSMdQLAEMLPGVLQQFGLKSIiGMGTGAGAYILTRFALNNPEMVEGLVL 81
Cdd:PRK10349  34 EELSSHFTLHLVDLPG-------FGRSRGFGAL-SLADMAEAVLQQAPDKAI-WLGWSLGGLVASQIALTHPERVQALVT 104

                         90       100       110
                 ....*....|....*....|....*....|
gi 386643034  82 INVNPC---AEGWMDWAASKISGWTQALPD 108
Cdd:PRK10349 105 VASSPCfsaRDEWPGIKPDVLAGFQQQLSD 134
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 49-154 2.72e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 39.12  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386643034  49 GLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLI---NVNPCAEGWMDWAASKISGWtqalPDMVVSHLFgkeemQSNVE 125
Cdd:PLN02894 174 NLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVgpaGFSSESDDKSEWLTKFRATW----KGAVLNHLW-----ESNFT 244

                         90       100
                 ....*....|....*....|....*....
gi 386643034 126 vvhtyRQHIVNDMNPGNLHLfINAYNSRR 154
Cdd:PLN02894 245 -----PQKIIRGLGPWGPNL-VRRYTTAR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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