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Conserved domains on  [gi|1890346159|ref|NP_001186611|]
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RWD domain-containing protein 3 isoform c [Homo sapiens]

Protein Classification

RWD domain-containing protein( domain architecture ID 10651873)

RWD domain-containing protein such as RWD domain-containing protein 3 (RWDD3), also known as RSUME, a RWD-containing protein that enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favours sumoylation of specific targets

CATH:  3.10.110.10
Gene Ontology:  GO:0005515
PubMed:  26276859|25918163

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
8-114 1.43e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


:

Pssm-ID: 214735  Cd Length: 107  Bit Score: 84.72  E-value: 1.43e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890346159    8 ELSVLAAIFCRPHEWEVLSRSETDgTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQ-LTRAQCVTVKEN 86
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPE-ITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNSEgLSDEQLAELLKK 79
                           90       100
                   ....*....|....*....|....*...
gi 1890346159   87 LLEQAESLLSEPMVHELVLWIQQNLRHI 114
Cdd:smart00591  80 LEEIAEENLGEVMIFELVEKLQEFLSEF 107
 
Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
8-114 1.43e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 84.72  E-value: 1.43e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890346159    8 ELSVLAAIFCRPHEWEVLSRSETDgTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQ-LTRAQCVTVKEN 86
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPE-ITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNSEgLSDEQLAELLKK 79
                           90       100
                   ....*....|....*....|....*...
gi 1890346159   87 LLEQAESLLSEPMVHELVLWIQQNLRHI 114
Cdd:smart00591  80 LEEIAEENLGEVMIFELVEKLQEFLSEF 107
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
3-111 2.51e-19

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 78.90  E-value: 2.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890346159   3 EPVQEELSVLAAIFcrPHEWEVLSRSETDGTVFRIHTK---AEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQ-LTRA 78
Cdd:pfam05773   1 EEQEEELEALESIY--PDEFEVISDSPYESLEIEIKLSldsDESDSSHLPPLVLKFTLPEDYPDEPPKISLSSPWnLSDE 78
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1890346159  79 QCVTVKENLLEQAESLLSEPMVHELVLWIQQNL 111
Cdd:pfam05773  79 QVLSLLEELEELAEENLGEVMIFELIEWLQENL 111
 
Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
8-114 1.43e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 84.72  E-value: 1.43e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890346159    8 ELSVLAAIFCRPHEWEVLSRSETDgTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQ-LTRAQCVTVKEN 86
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPE-ITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNSEgLSDEQLAELLKK 79
                           90       100
                   ....*....|....*....|....*...
gi 1890346159   87 LLEQAESLLSEPMVHELVLWIQQNLRHI 114
Cdd:smart00591  80 LEEIAEENLGEVMIFELVEKLQEFLSEF 107
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
3-111 2.51e-19

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 78.90  E-value: 2.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890346159   3 EPVQEELSVLAAIFcrPHEWEVLSRSETDGTVFRIHTK---AEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQ-LTRA 78
Cdd:pfam05773   1 EEQEEELEALESIY--PDEFEVISDSPYESLEIEIKLSldsDESDSSHLPPLVLKFTLPEDYPDEPPKISLSSPWnLSDE 78
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1890346159  79 QCVTVKENLLEQAESLLSEPMVHELVLWIQQNL 111
Cdd:pfam05773  79 QVLSLLEELEELAEENLGEVMIFELIEWLQENL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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