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Conserved domains on  [gi|307219238|ref|NP_001182534|]
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zinc finger protein 865 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-421 6.90e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 6.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 307219238  349 PFACPLCWKVFKKPSHLHQHQIIHTGEKPFSCSV--CSKSFNRRESLKRHVKTHSADLLRLPCGICGKAFRDASY 421
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-587 6.99e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.99e-06
                           10        20
                   ....*....|....*....|...
gi 307219238   565 LKRHERIHTGEKPHQCPVCGKRF 587
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-421 6.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 6.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 307219238  349 PFACPLCWKVFKKPSHLHQHQIIHTGEKPFSCSV--CSKSFNRRESLKRHVKTHSADLLRLPCGICGKAFRDASY 421
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-587 6.99e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.99e-06
                           10        20
                   ....*....|....*....|...
gi 307219238   565 LKRHERIHTGEKPHQCPVCGKRF 587
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-389 2.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.86e-03
                           10        20
                   ....*....|....*....|...
gi 307219238   367 QHQIIHTGEKPFSCSVCSKSFNR 389
Cdd:pfam13465    4 RHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 349-401 4.22e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 4.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 307219238  349 PFACPLCWKVFKKPSHLHQHqiIHTGEKPFSCSVCSKSFNRRESLKRHV-KTHS 401
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHVcKKHN 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
349-421 6.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 6.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 307219238  349 PFACPLCWKVFKKPSHLHQHQIIHTGEKPFSCSV--CSKSFNRRESLKRHVKTHSADLLRLPCGICGKAFRDASY 421
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-587 6.99e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.99e-06
                           10        20
                   ....*....|....*....|...
gi 307219238   565 LKRHERIHTGEKPHQCPVCGKRF 587
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
552-597 1.14e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 307219238  552 CGICGRGFGRRETLKRHERIHTGEKPHQCPVCGKRFRES------FHLSKHH 597
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-389 2.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.86e-03
                           10        20
                   ....*....|....*....|...
gi 307219238   367 QHQIIHTGEKPFSCSVCSKSFNR 389
Cdd:pfam13465    4 RHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 349-401 4.22e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 4.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 307219238  349 PFACPLCWKVFKKPSHLHQHqiIHTGEKPFSCSVCSKSFNRRESLKRHV-KTHS 401
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHVcKKHN 124
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 9.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 9.88e-03
                           10        20
                   ....*....|....*....|...
gi 307219238   378 FSCSVCSKSFNRRESLKRHVKTH 400
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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