|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
907-1194 |
4.06e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 457.04 E-value: 4.06e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 986
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 987 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 1066
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1067 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1143
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1144 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1210 |
1.81e-53 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 206.47 E-value: 1.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 127 KRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYK-TSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWS 205
Cdd:COG2373 367 GGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAgLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 206 IQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLYcsmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkk 277
Cdd:COG2373 447 LELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---- 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 278 knitkTFKinGSANFSFNDEEMKN---VMDSSNG-------------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVS 339
Cdd:COG2373 520 -----AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSAT 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 340 TNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK- 417
Cdd:COG2373 592 VPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKe 665
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 418 -----------------INYTVPQSGTFKIEfpiLEDSSELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIK 478
Cdd:COG2373 666 epvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYK 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 479 VG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIIS 544
Cdd:COG2373 737 PGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDM 806
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 545 D-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvh 612
Cdd:COG2373 807 ParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVKGAAgkaAEVTLAAVDEGIlNLTG------------ 871
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 613 elelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPH 685
Cdd:COG2373 872 ----YKTpdplDFF----------YGKRALGVETRDLY--GRLIGAFGGAAGALRSggdGALGRG----------GNPKP 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 686 VRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSWVATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRG 761
Cdd:COG2373 926 PRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPG 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 762 EEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsneinATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTA 841
Cdd:COG2373 1000 DRFELPVDVFNLTGKAGTVTVTLEASGGLTL--------EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGE 1071
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 842 SDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRM 917
Cdd:COG2373 1072 SDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRY 1141
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 918 PYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFL 997
Cdd:COG2373 1142 PYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLL 1219
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 998 EADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLE 1076
Cdd:COG2373 1220 EAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRR 1286
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1077 SEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHF 1153
Cdd:COG2373 1287 KDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELG 1353
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*..
gi 227430301 1154 LQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlMNTERTNIQVTVT 1210
Cdd:COG2373 1354 PDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLT 1406
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1292-1379 |
3.85e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.85e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1292 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1367
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430301 1368 YEPRRQAVRSYN 1379
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
907-1194 |
4.06e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 457.04 E-value: 4.06e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 986
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 987 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 1066
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1067 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1143
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1144 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
897-1194 |
2.52e-108 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.44 E-value: 2.52e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 897 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 972
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 973 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 1052
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1053 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 1124
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1125 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1210 |
1.81e-53 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 206.47 E-value: 1.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 127 KRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYK-TSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWS 205
Cdd:COG2373 367 GGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAgLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 206 IQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLYcsmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkk 277
Cdd:COG2373 447 LELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---- 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 278 knitkTFKinGSANFSFNDEEMKN---VMDSSNG-------------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVS 339
Cdd:COG2373 520 -----AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSAT 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 340 TNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK- 417
Cdd:COG2373 592 VPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKe 665
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 418 -----------------INYTVPQSGTFKIEfpiLEDSSELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIK 478
Cdd:COG2373 666 epvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYK 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 479 VG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIIS 544
Cdd:COG2373 737 PGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDM 806
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 545 D-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvh 612
Cdd:COG2373 807 ParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVKGAAgkaAEVTLAAVDEGIlNLTG------------ 871
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 613 elelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPH 685
Cdd:COG2373 872 ----YKTpdplDFF----------YGKRALGVETRDLY--GRLIGAFGGAAGALRSggdGALGRG----------GNPKP 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 686 VRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSWVATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRG 761
Cdd:COG2373 926 PRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPG 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 762 EEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsneinATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTA 841
Cdd:COG2373 1000 DRFELPVDVFNLTGKAGTVTVTLEASGGLTL--------EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGE 1071
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 842 SDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRM 917
Cdd:COG2373 1072 SDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRY 1141
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 918 PYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFL 997
Cdd:COG2373 1142 PYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLL 1219
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 998 EADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLE 1076
Cdd:COG2373 1220 EAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRR 1286
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1077 SEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHF 1153
Cdd:COG2373 1287 KDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELG 1353
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*..
gi 227430301 1154 LQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlMNTERTNIQVTVT 1210
Cdd:COG2373 1354 PDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLT 1406
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
693-784 |
6.62e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 128.47 E-value: 6.62e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 693 TWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 772
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 227430301 773 YLKDATEVKVII 784
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1292-1379 |
3.85e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.85e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1292 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1367
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430301 1368 YEPRRQAVRSYN 1379
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
907-1194 |
4.06e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 457.04 E-value: 4.06e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 986
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 987 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 1066
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1067 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1143
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1144 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
907-1194 |
4.10e-109 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 346.30 E-value: 4.10e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPsGST 986
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 987 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 1066
Cdd:cd02891 80 WLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACDAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1067 dVQESIHFLESEFSrGISDNYTLALITYALSSVG-SPKAKEALNMLTWRAEQEGGMQFWVSSesklSDSWQPRSLDIEVA 1145
Cdd:cd02891 160 -IEKALAYLETQLD-GLLDPYALAILAYALALAGdSTRADEALKKLLEAAREKGGTAHWSLS----WPGDYGSSLRVEAT 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 227430301 1146 AYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:cd02891 234 AYALLALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
897-1194 |
2.52e-108 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.44 E-value: 2.52e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 897 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 972
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 973 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 1052
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1053 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 1124
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1125 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
907-1194 |
3.85e-85 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 280.31 E-value: 3.85e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQ---LTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPS 983
Cdd:cd02896 1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 984 gsTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGG---NKSPVTLTAYIVTSLLGYR 1060
Cdd:cd02896 81 --TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGvegSEGDVSLTAFVLIALQEAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1061 KYQPNI--DVQESIH----FLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDS 1134
Cdd:cd02896 159 SICPPEvqNLDQSIRkaisYLENQLP-NLQRPYALAITAYALALADSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYWPV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1135 WQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1194
Cdd:cd02896 238 PGPSAITVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
907-1194 |
5.81e-68 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 231.29 E-value: 5.81e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 907 SINGLASLIRMPYG--------CGEQNMINFAPNIYILDYLTkkkqlTDNLKEKALSFMRQGYQRELLYQREDGSFSAFG 978
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLA-----ATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 979 NYDpSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSelQGGNKSPVTLTAYIVTSLLG 1058
Cdd:cd00688 76 GND-YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1059 YRKYQPNIDVQESIHFLESEF-------SRGISDNYTLALITYALSSVGS---PKAKEALNMLTWRAEQEGGMQFWVSSE 1128
Cdd:cd00688 153 LGKLDPDPLIEKALDYLLSCQnydggfgPGGESHGYGTACAAAALALLGDldsPDAKKALRWLLSRQRPDGGWGEGRDRT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430301 1129 SKLSDswqprSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFAS-------TQDTTVALKALSEF 1194
Cdd:cd00688 233 NKLSD-----SCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1210 |
1.81e-53 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 206.47 E-value: 1.81e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 127 KRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYK-TSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWS 205
Cdd:COG2373 367 GGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAgLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 206 IQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLYcsmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkk 277
Cdd:COG2373 447 LELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---- 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 278 knitkTFKinGSANFSFNDEEMKN---VMDSSNG-------------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVS 339
Cdd:COG2373 520 -----AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSAT 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 340 TNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK- 417
Cdd:COG2373 592 VPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKe 665
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 418 -----------------INYTVPQSGTFKIEfpiLEDSSELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIK 478
Cdd:COG2373 666 epvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYK 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 479 VG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIIS 544
Cdd:COG2373 737 PGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDM 806
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 545 D-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvh 612
Cdd:COG2373 807 ParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVKGAAgkaAEVTLAAVDEGIlNLTG------------ 871
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 613 elelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPH 685
Cdd:COG2373 872 ----YKTpdplDFF----------YGKRALGVETRDLY--GRLIGAFGGAAGALRSggdGALGRG----------GNPKP 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 686 VRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSWVATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRG 761
Cdd:COG2373 926 PRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPG 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 762 EEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsneinATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTA 841
Cdd:COG2373 1000 DRFELPVDVFNLTGKAGTVTVTLEASGGLTL--------EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGE 1071
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 842 SDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRM 917
Cdd:COG2373 1072 SDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRY 1141
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 918 PYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFL 997
Cdd:COG2373 1142 PYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLL 1219
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 998 EADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLE 1076
Cdd:COG2373 1220 EAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRR 1286
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1077 SEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHF 1153
Cdd:COG2373 1287 KDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELG 1353
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*..
gi 227430301 1154 LQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlMNTERTNIQVTVT 1210
Cdd:COG2373 1354 PDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLT 1406
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
693-784 |
6.62e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 128.47 E-value: 6.62e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 693 TWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 772
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 227430301 773 YLKDATEVKVII 784
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1292-1379 |
3.85e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.85e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 1292 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1367
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430301 1368 YEPRRQAVRSYN 1379
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
468-599 |
6.94e-24 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 98.58 E-value: 6.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 468 IQLKTRDENIKVGSPFELVV----SGNKRLKELSYMVVSRGQLVAVG-KQNSTMFSLTPENSWTPKACVIVYYI---EDD 539
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVkspfDGTVERDGFTYLVLSKGQIVVVGrGGVTTSFSLPVTAEMAPSARVVAYYVrvdLSK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 540 GEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVtQPDSIVGIVAVDKSVNLM 599
Cdd:pfam07703 81 PEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKA-DPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
223-301 |
3.73e-21 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 88.87 E-value: 3.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 223 EYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKN--ITKTFKING--SANFSFNDEE 298
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFesFSKELDKDGcgSASLSTEEFQ 80
|
...
gi 227430301 299 MKN 301
Cdd:pfam17791 81 LTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
130-221 |
1.10e-12 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 65.41 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430301 130 SVFIQTDKALYKPKQEVKFRIVTLFSDFKPYK-TSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQV 208
Cdd:pfam01835 1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAgLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVL 80
|
90
....*....|....*
gi 227430301 209 QVNDQT--YYQSFQV 221
Cdd:pfam01835 81 RDGAGGslGSGSFRV 95
|
|
| |
