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Conserved domains on  [gi|206597541|ref|NP_001128667|]
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zinc transporter ZIP5 precursor [Homo sapiens]

Protein Classification

ZIP family metal transporter( domain architecture ID 10495033)

ZIP family metal transporter mediates zinc uptake, but may also transport other divalent cations such as copper and cadmium ions

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653
TCDB:  2.A.5

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
248-504 1.15e-35

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


:

Pssm-ID: 396884  Cd Length: 325  Bit Score: 135.97  E-value: 1.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  248 FLGALAVGTLCGDALLHLLPHAQEG-RHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNle 326
Cdd:pfam02535  40 LLLAFASGVLLGTAFLHLLPEALEAlESLCLSDHGWHFPFAGLIVLLGFLLVLLVEKLLTYYKHRPTPGPADNSHSHL-- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  327 tRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTD------ITWMVLLGDGLHNLTDGL 400
Cdd:pfam02535 118 -ATVKSVSNVEVTESEEGEDHGHLHGHDDDSDELLHKGHQGPSDSIHEQSDEDGEPlasqrvRAILLELGIILHSFFEGL 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  401 AIGaaFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGL-----GGAVLGVGLSLGPVPLTP 475
Cdd:pfam02535 197 ALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPlgiliGIGVSSIGNSPGADITSG 274
                         250       260       270
                  ....*....|....*....|....*....|
gi 206597541  476 WVFGVTAGVFLYVALVDMLPA-LLRPPEPL 504
Cdd:pfam02535 275 ILLAFSAGTFLYVALVELLPHeLLRNKSSE 304
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
248-504 1.15e-35

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884  Cd Length: 325  Bit Score: 135.97  E-value: 1.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  248 FLGALAVGTLCGDALLHLLPHAQEG-RHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNle 326
Cdd:pfam02535  40 LLLAFASGVLLGTAFLHLLPEALEAlESLCLSDHGWHFPFAGLIVLLGFLLVLLVEKLLTYYKHRPTPGPADNSHSHL-- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  327 tRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTD------ITWMVLLGDGLHNLTDGL 400
Cdd:pfam02535 118 -ATVKSVSNVEVTESEEGEDHGHLHGHDDDSDELLHKGHQGPSDSIHEQSDEDGEPlasqrvRAILLELGIILHSFFEGL 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  401 AIGaaFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGL-----GGAVLGVGLSLGPVPLTP 475
Cdd:pfam02535 197 ALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPlgiliGIGVSSIGNSPGADITSG 274
                         250       260       270
                  ....*....|....*....|....*....|
gi 206597541  476 WVFGVTAGVFLYVALVDMLPA-LLRPPEPL 504
Cdd:pfam02535 275 ILLAFSAGTFLYVALVELLPHeLLRNKSSE 304
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
366-501 2.33e-13

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 223505 [Multi-domain]  Cd Length: 266  Bit Score: 70.08  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541 366 APPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRL 445
Cdd:COG0428  103 EGKSVEGLEGLRKPNLRRGFLLALAISLHNFPEGLAIGVAFLSNPSLGIALALAIAIHNIPEGLAVALPLAGAGRSRLKA 182
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 206597541 446 -LLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPP 501
Cdd:COG0428  183 lLVAVLSGLAEPLGAVIGAYLLGISSPLVLPFALAFAAGAMVYVVVDELLPEAKRHG 239
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
248-504 1.15e-35

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884  Cd Length: 325  Bit Score: 135.97  E-value: 1.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  248 FLGALAVGTLCGDALLHLLPHAQEG-RHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNle 326
Cdd:pfam02535  40 LLLAFASGVLLGTAFLHLLPEALEAlESLCLSDHGWHFPFAGLIVLLGFLLVLLVEKLLTYYKHRPTPGPADNSHSHL-- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  327 tRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTD------ITWMVLLGDGLHNLTDGL 400
Cdd:pfam02535 118 -ATVKSVSNVEVTESEEGEDHGHLHGHDDDSDELLHKGHQGPSDSIHEQSDEDGEPlasqrvRAILLELGIILHSFFEGL 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541  401 AIGaaFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGL-----GGAVLGVGLSLGPVPLTP 475
Cdd:pfam02535 197 ALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPlgiliGIGVSSIGNSPGADITSG 274
                         250       260       270
                  ....*....|....*....|....*....|
gi 206597541  476 WVFGVTAGVFLYVALVDMLPA-LLRPPEPL 504
Cdd:pfam02535 275 ILLAFSAGTFLYVALVELLPHeLLRNKSSE 304
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
366-501 2.33e-13

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 223505 [Multi-domain]  Cd Length: 266  Bit Score: 70.08  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206597541 366 APPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRL 445
Cdd:COG0428  103 EGKSVEGLEGLRKPNLRRGFLLALAISLHNFPEGLAIGVAFLSNPSLGIALALAIAIHNIPEGLAVALPLAGAGRSRLKA 182
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 206597541 446 -LLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPP 501
Cdd:COG0428  183 lLVAVLSGLAEPLGAVIGAYLLGISSPLVLPFALAFAAGAMVYVVVDELLPEAKRHG 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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