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Conserved domains on  [gi|147905963|ref|NP_001081268|]
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G2/mitotic-specific cyclin-B2 [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 124-256 1.75e-94

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 278.67  E-value: 1.75e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRS 203
Cdd:cd20566    1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147905963 204 KLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20566   81 KLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 261-379 2.18e-77

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410273  Cd Length: 119  Bit Score: 234.78  E-value: 2.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 147905963 341 MKHMAKNITKVNQNLTKHVAVRNKYASSKLMKISTLPQL 379
Cdd:cd20570   81 MQHMAKNVVKVNEGLTKHVAVKNKYASSKLMKISTIPQL 119
 
Name Accession Description Interval E-value
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 124-256 1.75e-94

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 278.67  E-value: 1.75e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRS 203
Cdd:cd20566    1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147905963 204 KLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20566   81 KLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 261-379 2.18e-77

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 234.78  E-value: 2.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 147905963 341 MKHMAKNITKVNQNLTKHVAVRNKYASSKLMKISTLPQL 379
Cdd:cd20570   81 MQHMAKNVVKVNEGLTKHVAVKNKYASSKLMKISTIPQL 119
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
115-374 2.40e-71

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 230.05  E-value: 2.40e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 115 EDIDADDGGNPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINE-RMRAILVDWLVQVHSRFQLLQETLYMGVAIMDR 193
Cdd:COG5024  164 QDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEwSMRSILVDWLVEVHGKFGLLPETLFLAINIIDR 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 194 FLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFDLGRPLPLHFLRRASKS 273
Cdd:COG5024  244 FLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 274 CSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTW-GTTQHYYTGYTEGDLQLIMKHMAKNItkvN 352
Cdd:COG5024  324 SDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWdRTLIHYSGNYTNPDLKPLNESNKENL---Q 400

                        250       260
                 ....*....|....*....|..
gi 147905963 353 QNLTKHVAVRNKYASSKLMKIS 374
Cdd:COG5024  401 NPSVHHDAIFPKYPSPTFGKAS 422
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 134-259 6.29e-61

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 192.73  E-value: 6.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963  134 DIYNYLKQLEVQQSVHPCYLEG-KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTS 212
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 147905963  213 LLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFDLG 259
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 261-379 2.19e-44

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 149.70  E-value: 2.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963  261 PLPLHFLRRASKSCSA--DAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQ 338
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 147905963  339 LIMKHMAKNITKVNQNltKHVAVRNKYASSKLMKISTLPQL 379
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 168-252 2.09e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 87.26  E-value: 2.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963   168 DWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDnaYTASQIREME 247
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 147905963   248 MIILR 252
Cdd:smart00385  79 RLLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 265-346 7.38e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.85  E-value: 7.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963   265 HFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTT-QHYYTGYTEGDLQLIMKH 343
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKElVHYTGYFTEEEILRMERL 80


                   ...
gi 147905963   344 MAK 346
Cdd:smart00385  81 LLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 124-256 1.75e-94

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 278.67  E-value: 1.75e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRS 203
Cdd:cd20566    1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147905963 204 KLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20566   81 KLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 128-256 6.39e-83

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 248.98  E-value: 6.39e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 128 CSDYVMDIYNYLKQLEVQQSVHPCYLEG-KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQ 206
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGqPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 147905963 207 LVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20507   81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 261-379 2.18e-77

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 234.78  E-value: 2.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 147905963 341 MKHMAKNITKVNQNLTKHVAVRNKYASSKLMKISTLPQL 379
Cdd:cd20570   81 MQHMAKNVVKVNEGLTKHVAVKNKYASSKLMKISTIPQL 119
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
115-374 2.40e-71

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 230.05  E-value: 2.40e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 115 EDIDADDGGNPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINE-RMRAILVDWLVQVHSRFQLLQETLYMGVAIMDR 193
Cdd:COG5024  164 QDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEwSMRSILVDWLVEVHGKFGLLPETLFLAINIIDR 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 194 FLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFDLGRPLPLHFLRRASKS 273
Cdd:COG5024  244 FLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 274 CSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTW-GTTQHYYTGYTEGDLQLIMKHMAKNItkvN 352
Cdd:COG5024  324 SDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWdRTLIHYSGNYTNPDLKPLNESNKENL---Q 400

                        250       260
                 ....*....|....*....|..
gi 147905963 353 QNLTKHVAVRNKYASSKLMKIS 374
Cdd:COG5024  401 NPSVHHDAIFPKYPSPTFGKAS 422
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 128-256 1.17e-64

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 202.42  E-value: 1.17e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 128 CSDYVMDIYNYLKQLEVQQSVHPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQL 207
Cdd:cd20565    1 CSEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 147905963 208 VGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20565   81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 134-259 6.29e-61

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 192.73  E-value: 6.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963  134 DIYNYLKQLEVQQSVHPCYLEG-KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTS 212
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 147905963  213 LLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFDLG 259
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 113-256 2.68e-60

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 191.79  E-value: 2.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 113 SVEDIDADDGGNPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGK-EINERMRAILVDWLVQVHSRFQLLQETLYMGVAIM 191
Cdd:cd20567    3 PLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQpDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147905963 192 DRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20567   83 DRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 261-379 1.17e-58

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 186.63  E-value: 1.17e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 147905963 341 MKHMAKNITKVNQNLTKHVAVRNKYASSKLMKISTLPQL 379
Cdd:cd20569   81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQL 119
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 261-373 1.77e-56

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 180.50  E-value: 1.77e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 147905963 341 MKHMAKNITKVNQNltKHVAVRNKYASSKLMKI 373
Cdd:cd20509   81 VQKMAKLVVKSQTS--KYQAVKNKYSSSKFMRI 111
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 130-256 1.67e-54

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 176.28  E-value: 1.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 130 DYVMDIYNYLKQLEVQQSVHPCYLE-GKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLV 208
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDYMRkQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 147905963 209 GVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20504   81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 116-257 7.30e-54

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 175.13  E-value: 7.30e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 116 DIDADDGGNPQLCSDYVMDIYNYLKQLEVQQSVhPCYLEG-KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRF 194
Cdd:cd20508    1 DIDEENSDDPFQVSEYAKDIFDYMKEREEKFVV-PDYLEKqTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLY 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147905963 195 LQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20508   80 LSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 124-256 9.41e-54

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 174.41  E-value: 9.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLE-GKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSR 202
Cdd:cd20568    1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDdQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 147905963 203 SKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20568   81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 124-257 1.29e-48

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 161.42  E-value: 1.29e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLE--GKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVS 201
Cdd:cd20562    1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEkiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 147905963 202 RSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20562   81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 261-379 2.19e-44

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 149.70  E-value: 2.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963  261 PLPLHFLRRASKSCSA--DAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQ 338
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 147905963  339 LIMKHMAKNITKVNQNltKHVAVRNKYASSKLMKISTLPQL 379
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 129-257 1.58e-43

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 147.90  E-value: 1.58e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 129 SDYVMDIYNYLKQLEVQQSVHPCYLEGK-EINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQL 207
Cdd:cd20561    2 PDYHEDIHTYLREMEVKCKPKVGYMKKQpDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 147905963 208 VGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20561   82 VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 90-257 4.86e-41

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 142.29  E-value: 4.86e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963  90 SPVPMDVSLKEEELCQafsdaltSVEDIDAddggnpqLC-SDYVMDIYNYLKQLEVQQSVHPCYLEGK-EINERMRAILV 167
Cdd:cd20560    8 SPMLVDTSLQSQSEDD-------SAADVDV-------LAvPEYAEDIHQYLREAELKHRPKPGYMRKQpDITTGMRTILV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 168 DWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREME 247
Cdd:cd20560   74 DWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRME 153

                        170
                 ....*....|
gi 147905963 248 MIILRLLNFD 257
Cdd:cd20560  154 HLLLKVLAFD 163
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 162-254 3.48e-37

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 129.75  E-value: 3.48e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 162 MRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTAS 241
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 147905963 242 QIREMEMIILRLL 254
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 163-258 7.58e-37

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 128.98  E-value: 7.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 163 RAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQ 242
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 147905963 243 IREMEMIILRLLNFDL 258
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 149-256 7.02e-36

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 127.81  E-value: 7.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 149 HPCYLEGKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQP-VSRSKLQLVGVTSLLIASKYEEMYTPEV 227
Cdd:cd20519   23 RDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGITCLFIAAKLEEIYPPKL 102

                         90       100
                 ....*....|....*....|....*....
gi 147905963 228 ADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20519  103 SEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 263-376 3.40e-30

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 112.32  E-value: 3.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 263 PLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLIMK 342
Cdd:cd20512    2 PMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCAD 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 147905963 343 HMAKNITKvnqNLTKHVAVRNKYASSKLMKISTL 376
Cdd:cd20512   82 IMLEYLVK---PIKHHDAFFKKYSSKKFLKASIF 112
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 261-377 6.17e-28

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 106.21  E-value: 6.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLI 340
Cdd:cd20510    1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 147905963 341 MKHMAKNITKV-NQNLTkhvAVRNKYASSKLMKISTLP 377
Cdd:cd20510   81 VRKLNAMLTKPpNKKLK---TVRSKYSHKVFFEVAKIP 115
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 158-256 9.55e-27

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 103.77  E-value: 9.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 158 INERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQP-VSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDN 236
Cdd:cd20580   38 LQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDG 117

                         90       100
                 ....*....|....*....|
gi 147905963 237 AYTASQIREMEMIILRLLNF 256
Cdd:cd20580  118 ACSEDDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 138-256 1.88e-26

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 103.04  E-value: 1.88e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 138 YLKQLEVQQSvHPcylegkEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQP-VSRSKLQLVGVTSLLIA 216
Cdd:cd20579   25 YLRDKNFLQK-HP------LLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIA 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 147905963 217 SKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNF 256
Cdd:cd20579   98 AKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 261-346 7.32e-24

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 94.30  E-value: 7.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQH-YYTGYTEGDLQL 339
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLqLVTGYSENDLQE 80


                 ....*..
gi 147905963 340 IMKHMAK 346
Cdd:cd20537   81 CAKELLE 87
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 168-252 2.09e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 87.26  E-value: 2.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963   168 DWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDnaYTASQIREME 247
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 147905963   248 MIILR 252
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 160-246 1.80e-19

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 82.36  E-value: 1.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 160 ERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYT 239
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80


                 ....*..
gi 147905963 240 ASQIREM 246
Cdd:cd20521   81 YEDVVRM 87
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 266-369 3.25e-19

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 82.30  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 266 FLRR---ASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLIMK 342
Cdd:cd20506    6 FLRRflrAAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADLKPCVQ 85

                         90       100
                 ....*....|....*....|....*..
gi 147905963 343 HMAKNITKVNQNLTKhvAVRNKYASSK 369
Cdd:cd20506   86 ALHDLQLNASGSSLQ--AVREKYKQHK 110
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 261-377 6.84e-19

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 81.58  E-value: 6.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKIL-GQGTWGTTQHYYTGYTEGDLQL 339
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLnKTPEWTSTLEFHTGYSESQLME 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 147905963 340 IMKHMAKNITKV-NQNLTkhvAVRNKYASSKLMKISTLP 377
Cdd:cd20511   81 CARLMVRLHSKAgTGKLT---AVYKKYSSSKFGAVALLP 116
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 139-257 1.08e-17

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 79.27  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 139 LKQLEVQQSVHPCYLEG--KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIA 216
Cdd:cd20515   30 LLSLEERYLPSASYFKCvqTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLA 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 147905963 217 SKYEEMyTPEVAD-FVYITDNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20515  110 SKLKET-IPLTAEkLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 261-371 8.20e-17

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 75.41  E-value: 8.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 261 PLPLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEmVHIK--PSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQ 338
Cdd:cd20505    1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDAD-PYLKylPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLL 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 147905963 339 LIMKHMAKNITKVNQNltKHVAVRNKYASSKLM 371
Cdd:cd20505   80 PCLRDLHRTFLNAPSS--PQQAIREKYKSSKYH 110
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 162-256 2.16e-16

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 74.18  E-value: 2.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 162 MRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEE--MYTPEVADFVYITDN-AY 238
Cdd:cd20528    6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEEldDNIPKISDLNRYLCNsVY 85

                         90
                 ....*....|....*...
gi 147905963 239 TASQIREMEMIILRLLNF 256
Cdd:cd20528   86 SKQEYLQMELLILEFFQW 103
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 265-346 7.38e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.85  E-value: 7.38e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963   265 HFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTWGTT-QHYYTGYTEGDLQLIMKH 343
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKElVHYTGYFTEEEILRMERL 80


                   ...
gi 147905963   344 MAK 346
Cdd:smart00385  81 LLE 83
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 122-257 2.87e-15

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 72.71  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 122 GGNPQLCSDyvMDIYNYLKQLEVQQSVHPCYLE--GKEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQP 199
Cdd:cd20575   15 GPDPRLLGD--QRVLQNLLRLEERYVPRVSYFQcvQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVP 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147905963 200 VSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20575   93 TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 166-257 7.52e-15

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 69.72  E-value: 7.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 166 LVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEE--MYTPEVADFVYITDNAYTASQI 243
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWEskARVPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|....
gi 147905963 244 REMEMIILRLLNFD 257
Cdd:cd20559   82 IQMEMHILNTLNWD 95
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 156-257 1.22e-13

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 67.70  E-value: 1.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 156 KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMyTPEVADFVYI-T 234
Cdd:cd20573   48 KEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKET-IPLTAEKLCIyT 126

                         90       100
                 ....*....|....*....|...
gi 147905963 235 DNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20573  127 DNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 163-255 4.89e-13

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 64.65  E-value: 4.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 163 RAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSK---LQLVGVTSLLIASKYEEMYTPEVADF-VYITDNAY 238
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVF 81

                         90
                 ....*....|....*..
gi 147905963 239 TASQIREMEMIILRLLN 255
Cdd:cd20543   82 EAKTIQRMELLVLSTLE 98
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 167-258 1.31e-12

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 63.48  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 167 VDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKY--EEMYTPEVADFVYITDNAYTASQIR 244
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                         90
                 ....*....|....
gi 147905963 245 EMEMIILRLLNFDL 258
Cdd:cd20526   86 RMERIILDKLHWDL 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 166-249 2.34e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 59.35  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 166 LVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEmYTPEVADFVYITDnaYTASQIRE 245
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRK 78


                 ....
gi 147905963 246 MEMI 249
Cdd:cd00043   79 AEKE 82
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 156-257 8.68e-11

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 59.62  E-value: 8.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 156 KEINERMRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMyTPEVADFVYI-T 234
Cdd:cd20574   49 KDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKET-IPLTAEKLCIyT 127

                         90       100
                 ....*....|....*....|...
gi 147905963 235 DNAYTASQIREMEMIILRLLNFD 257
Cdd:cd20574  128 DNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 263-344 1.44e-07

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 49.29  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 263 PLHFLRR------ASKSCSADAEQHTL----------AKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILG-QGTWGTT 325
Cdd:cd20529    3 PAHFLEYylsqgvLFVDDHDGLPSELLekvkeyvrkyADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGlSPTWPEE 82

                         90
                 ....*....|....*....
gi 147905963 326 QHYYTGYTEGDLQLIMKHM 344
Cdd:cd20529   83 LEKLTGYSEDELEPCVELL 101
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 276-369 3.11e-07

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 48.67  E-value: 3.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 276 ADAEQHTLAKYLMELTLIDYE-MVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLIMKHMAKNITKVNQN 354
Cdd:cd20564   16 ANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKPCLMDLHQTYLKAPQH 95

                         90
                 ....*....|....*
gi 147905963 355 LTKhvAVRNKYASSK 369
Cdd:cd20564   96 AQQ--SIREKYKNSK 108
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 169-324 4.67e-07

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 50.89  E-value: 4.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 169 WLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADfVYITDNAYTA------SQ 242
Cdd:COG5333   51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIE-SFEARDLWSEepkssrER 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 243 IREMEMIILRLLNFDLGRPLPLHFLRRASKSCSAD--AEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQG 320
Cdd:COG5333  130 ILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKdkYKLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVLGMP 209


                 ....
gi 147905963 321 TWGT 324
Cdd:COG5333  210 IIKL 213
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 266-376 5.61e-07

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 48.27  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 266 FLRRASKSCSADAEQHTLAKYLMELTLIDYE-MVHIKPSEIAAAALCLSQKILGQGTWGTTQHYYTGYTEGDLQLIMKHM 344
Cdd:cd20563    6 FLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVPCLSDL 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 147905963 345 AKniTKVNQNLTKHVAVRNKYASSKLMKISTL 376
Cdd:cd20563   86 HK--ACLGAPHRPQQAIREKYKGSKYMQVSLL 115
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 177-255 1.30e-06

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 46.38  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 177 FQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKY--EEMYTPEVADFVYITDNAYTASQIREMEMIILRLL 254
Cdd:cd20584   16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95


                 .
gi 147905963 255 N 255
Cdd:cd20584   96 H 96
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 162-256 1.76e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 45.97  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 162 MRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKY--EEMYTPEVADFVYITDNAYT 239
Cdd:cd20583    1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                         90
                 ....*....|....*..
gi 147905963 240 ASQIREMEMIILRLLNF 256
Cdd:cd20583   81 VSDMMRMEKIILEKLCW 97
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 162-254 2.17e-06

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 45.63  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 162 MRAILVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKYEEMYTPEVADFVYITDNAYTAS 241
Cdd:cd20517    5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTNL 84

                         90
                 ....*....|...
gi 147905963 242 QIREMEMIILRLL 254
Cdd:cd20517   85 ELINQEKDILEAL 97
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 167-254 3.71e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 45.04  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 167 VDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVGVTSLLIASKY--EEMYTPEVADFVYITDNAYTASQIR 244
Cdd:cd20523    5 VDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLM 84

                         90
                 ....*....|
gi 147905963 245 EMEMIILRLL 254
Cdd:cd20523   85 RMEGIILEKL 94
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 283-377 4.59e-05

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 42.23  E-value: 4.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 283 LAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGT-WGTTQHYYTGYTEGDL-----QLIMKHMAKNITKVNQNlT 356
Cdd:cd20522    2 LASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALpWPSQLEEFTGFSLEDLlscvlHLHKKCFHEDSPKDYRN-V 80

                         90       100
                 ....*....|....*....|.
gi 147905963 357 KHVAVRNKYASSKLMKISTLP 377
Cdd:cd20522   81 SLTAVKQRYEDERFLSISKIK 101
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 210-258 5.26e-05

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 42.97  E-value: 5.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 147905963 210 VTSLLIASKYEEMYTPeVADFV-YITDNAYTASQIREMEMIILRLLNFDL 258
Cdd:cd20524  102 LTCLYLACKVEEFNIS-IDQFVgNIKESEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 263-322 5.05e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 38.55  E-value: 5.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 263 PLHFLRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKILGQGTW 322
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT 61
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 265-317 1.08e-03

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 38.10  E-value: 1.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147905963 265 HF----LRRASKSCSADAEQ-HTLAKYLMELTLIDYEMVHIKPSEIAAAALCLSQKIL 317
Cdd:cd20722    9 HFsslrLENRELSCAEEARKaRALARYLAELSLADYAFNQYPPSLLAICSLELADRML 66
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 267-313 8.94e-03

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 35.57  E-value: 8.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 147905963 267 LRRASKSCSADAEQHTLAKYLMELTLIDYEMVHIKPSEIAAAALCLS 313
Cdd:cd20721   14 LSLESGAAHASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLA 60
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 166-256 9.93e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 35.33  E-value: 9.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905963 166 LVDWLVQVHSRFQLLQETLYMGVAIMDRFLQVQPVSRSKLQLVG----VTSLLIASKYEEMYTPEVADFVYITDnaYTAS 241
Cdd:cd20557    2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGQEGSPyrlfLVALMLASKYLDDESYSNKSWAEISG--LPVR 79

                         90
                 ....*....|....*
gi 147905963 242 QIREMEMIILRLLNF 256
Cdd:cd20557   80 ELNAMEREFLEALDW 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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