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Conserved domains on  [gi|110227589|ref|NP_001035975|]
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zinc finger protein 706 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
41-65 5.28e-03

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam18658:

Pssm-ID: 480613  Cd Length: 64  Bit Score: 31.86  E-value: 5.28e-03
                         10        20
                 ....*....|....*....|....*..
gi 110227589  41 CTVCRTQMPDPK--TFKQHFESKHPKT 65
Cdd:pfam18658 21 CMVCGESLASLKlsTIKRHILQKHPDT 47
 
Name Accession Description Interval E-value
zf-C2H2_12 pfam18658
Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 ...
 41-65 5.28e-03

Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.


Pssm-ID: 465831  Cd Length: 64  Bit Score: 31.86  E-value: 5.28e-03
                         10        20
                 ....*....|....*....|....*..
gi 110227589  41 CTVCRTQMPDPK--TFKQHFESKHPKT 65
Cdd:pfam18658 21 CMVCGESLASLKlsTIKRHILQKHPDT 47
 
Name Accession Description Interval E-value
zf-C2H2_12 pfam18658
Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 ...
 41-65 5.28e-03

Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.


Pssm-ID: 465831  Cd Length: 64  Bit Score: 31.86  E-value: 5.28e-03
                         10        20
                 ....*....|....*....|....*..
gi 110227589  41 CTVCRTQMPDPK--TFKQHFESKHPKT 65
Cdd:pfam18658 21 CMVCGESLASLKlsTIKRHILQKHPDT 47
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 39-61 7.38e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 30.93  E-value: 7.38e-03
                         10        20
                 ....*....|....*....|...
gi 110227589  39 YTCTVCRTQMPDPKTFKQHFESK 61
Cdd:pfam12874  1 FYCELCNVTFNSESQLKSHLQGK 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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