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Conserved domains on  [gi|53829368|ref|NP_001005408|]
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neuralized-like protein 4 isoform 2 [Homo sapiens]

Protein Classification

SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)

SPRY_NHR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 718-880 1.59e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 279.01  E-value: 1.59e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  718 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 797
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  798 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 877
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  878 SIT 880
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 523-684 7.79e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 277.08  E-value: 7.79e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  523 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 602
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  603 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 682
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                 ..
gi 53829368  683 IV 684
Cdd:cd12887  160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 43-205 1.91e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.90  E-value: 1.91e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   43 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 122
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  123 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVNGRDCGVAATGLPPRVWAVVDLYGKCTQI 202
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  203 TVL 205
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 320-482 1.33e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.59  E-value: 1.33e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  320 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 399
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  400 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 479
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  480 TIV 482
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1131-1290 1.67e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1131 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACALK 1209
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1210 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1289
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 53829368 1290 V 1290
Cdd:cd12887  161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 913-1082 1.94e-50

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 175.77  E-value: 1.94e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  913 RFHSTCGKNVTLEEDGTRAVR-AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLAPGEMGPGAGGGgpg 991
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRvKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSAT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  992 lppslpELRTKTtWMVSSCEVRRDGQLQRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLD 1071
Cdd:cd12887   78 ------DLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVD 150

                        170
                 ....*....|.
gi 53829368 1072 LYGPVRGVSIV 1082
Cdd:cd12887  151 LYGQCEQVSIV 161
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 718-880 1.59e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 279.01  E-value: 1.59e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  718 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 797
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  798 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 877
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  878 SIT 880
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 523-684 7.79e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 277.08  E-value: 7.79e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  523 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 602
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  603 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 682
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                 ..
gi 53829368  683 IV 684
Cdd:cd12887  160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 43-205 1.91e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.90  E-value: 1.91e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   43 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 122
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  123 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVNGRDCGVAATGLPPRVWAVVDLYGKCTQI 202
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  203 TVL 205
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 320-482 1.33e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.59  E-value: 1.33e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  320 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 399
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  400 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 479
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  480 TIV 482
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1131-1290 1.67e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1131 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACALK 1209
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1210 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1289
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 53829368 1290 V 1290
Cdd:cd12887  161 V 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 719-881 3.42e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.90  E-value: 3.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    719 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 795
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    796 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 873
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 53829368    874 CVQVSITN 881
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 320-482 1.52e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.52e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    320 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 396
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    397 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVA---TPLTPPvVYGVVDLY 473
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVAlsgVPDSQP-LWAVFDLY 139


                   ....*....
gi 53829368    474 GMAVKVTIV 482
Cdd:pfam07177  140 GQTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 523-685 1.02e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.66  E-value: 1.02e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    523 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 599
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    600 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 677
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 53829368    678 AAQATIVD 685
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 45-205 1.34e-50

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 175.80  E-value: 1.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     45 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 121
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    122 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLGEGDRVGVERTVAGELRLWVNGRDCGVAATGLPPR--VWAVVDLYGKC 199
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQT 142


                   ....*.
gi 53829368    200 TQITVL 205
Cdd:pfam07177  143 TQVSIL 148
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 913-1082 1.94e-50

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 175.77  E-value: 1.94e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  913 RFHSTCGKNVTLEEDGTRAVR-AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLAPGEMGPGAGGGgpg 991
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRvKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSAT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  992 lppslpELRTKTtWMVSSCEVRRDGQLQRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLD 1071
Cdd:cd12887   78 ------DLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVD 150

                        170
                 ....*....|.
gi 53829368 1072 LYGPVRGVSIV 1082
Cdd:cd12887  151 LYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1132-1291 1.22e-45

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.55  E-value: 1.22e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   1132 FLENHGKNILLSNGNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLN---FPASACAL 1208
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   1209 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1286
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 53829368   1287 VTIVN 1291
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
316-437 1.31e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.31e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     316 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 395
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 53829368     396 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 437
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
520-642 5.47e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.29  E-value: 5.47e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     520 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 599
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 53829368     600 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 642
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
716-838 2.07e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.50  E-value: 2.07e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     716 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 795
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 53829368     796 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 838
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
45-163 1.75e-30

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 117.03  E-value: 1.75e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368      45 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 124
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 53829368     125 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLGEGDRVGVER 163
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 914-1083 3.54e-26

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 105.69  E-value: 3.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    914 FHSTCGKNVTLEEDGTRAVRAAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLApgemgpgAGGGGPGLP 993
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCD-------PATLRPKAL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    994 PSLPELRTKTTWMVSSCEvrrdgqlqrmnygrnlERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKN--VWAVLD 1071
Cdd:pfam07177   74 PDLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFD 137

                          170
                   ....*....|..
gi 53829368   1072 LYGPVRGVSIVS 1083
Cdd:pfam07177  138 LYGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
1130-1245 4.28e-15

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 73.11  E-value: 4.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    1130 LEFLENHGKNILLSNGNRTATRVAS-YNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACAL 1208
Cdd:smart00588    3 LRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNA 82

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 53829368    1209 KRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1245
Cdd:smart00588   83 CPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
913-1040 1.44e-09

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 57.32  E-value: 1.44e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     913 RFHSTCGKNVTLEEDGTRAVR-AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLApgemgpgaggggpg 991
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCD-------------- 69

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 53829368     992 lppsLPELRTKT--------TWMVSSCEVRRDG-QLQRMNYGRNLERLGVGSRVGVRR 1040
Cdd:smart00588   70 ----PATLRPASlptnacpdLVDMSGFWAKALGeGLAEQGGILGLDVLAEGEVVGVIN 123
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 718-880 1.59e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 279.01  E-value: 1.59e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  718 RFHQLHGSNAVITNGGRTALRhnCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTD 797
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  798 IDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPPEVYAVVDLYGQCVQV 877
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  878 SIT 880
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 523-684 7.79e-86

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 277.08  E-value: 7.79e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  523 FHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNL 602
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  603 RSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT 682
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVS 159


                 ..
gi 53829368  683 IV 684
Cdd:cd12887  160 IV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 43-205 1.91e-78

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 255.90  E-value: 1.91e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   43 ELHPRTGRLVSLSACGRTARRqqPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATG 122
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATR--VKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  123 LKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVNGRDCGVAATGLPPRVWAVVDLYGKCTQI 202
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  203 TVL 205
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 320-482 1.33e-77

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 253.59  E-value: 1.33e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  320 FHEKCGTLIKLSNNNKTAERRRplDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNL 399
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  400 QSGTIMMSGCGILTNGKGTRREYCeFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKV 479
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 53829368  480 TIV 482
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1131-1290 1.67e-73

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 241.64  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1131 EFLENHGKNILLSNGNRTATRVA-SYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACALK 1209
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368 1210 RAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1289
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 53829368 1290 V 1290
Cdd:cd12887  161 V 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 719-881 3.42e-55

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 188.90  E-value: 3.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    719 FHQLHGSNAVITNGGRTALRHNcrsEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLE---FPNTM 795
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    796 TDIDYDTWMLSgtaimQDGNTmrnnygcdldaLGTGARIGMMRTAKGDLHYFINGQDQGAACSGLPP--EVYAVVDLYGQ 873
Cdd:pfam07177   78 TDLRPGYWVVA-----LSGSY-----------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQ 141


                   ....*...
gi 53829368    874 CVQVSITN 881
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 320-482 1.52e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 186.97  E-value: 1.52e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    320 FHEKCGTLIKLSNNNKTAERRRpldEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLE---YPATM 396
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    397 TNLQSGTIMMSgcgiltngkgtrreyceFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVA---TPLTPPvVYGVVDLY 473
Cdd:pfam07177   78 TDLRPGYWVVA-----------------LSGSYLQEGDRLGFWVTSDGELHFSVNGEDQGVAlsgVPDSQP-LWAVFDLY 139


                   ....*....
gi 53829368    474 GMAVKVTIV 482
Cdd:pfam07177  140 GQTTQVSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 523-685 1.02e-53

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 184.66  E-value: 1.02e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    523 FHPNCGQKAAITHEGRTALRphaTDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQ---LPSTM 599
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    600 TNLRSGTWMMtgngvmhngttILDEYghnldRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPG--VYAVVDLYGQ 677
Cdd:pfam07177   78 TDLRPGYWVV-----------ALSGS-----YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 53829368    678 AAQATIVD 685
Cdd:pfam07177  142 TTQVSILG 149
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 45-205 1.34e-50

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 175.80  E-value: 1.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     45 HPRTGRLVSLSACGRTARRqqpGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVL---DFPSSAT 121
Cdd:pfam07177    2 HPVHGKNVRLSNDGRTARR---TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLAT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    122 GLKGGSWVVSgcsvlRDGRsvleeygqdldQLGEGDRVGVERTVAGELRLWVNGRDCGVAATGLPPR--VWAVVDLYGKC 199
Cdd:pfam07177   79 DLRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQT 142


                   ....*.
gi 53829368    200 TQITVL 205
Cdd:pfam07177  143 TQVSIL 148
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 913-1082 1.94e-50

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 175.77  E-value: 1.94e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  913 RFHSTCGKNVTLEEDGTRAVR-AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLAPGEMGPGAGGGgpg 991
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRvKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSAT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  992 lppslpELRTKTtWMVSSCEVRRDGQLQRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLD 1071
Cdd:cd12887   78 ------DLKSGT-WILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVD 150

                        170
                 ....*....|.
gi 53829368 1072 LYGPVRGVSIV 1082
Cdd:cd12887  151 LYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1132-1291 1.22e-45

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 161.55  E-value: 1.22e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   1132 FLENHGKNILLSNGNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLN---FPASACAL 1208
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRpkaLPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   1209 KRAAWLlrgrgvfhngLKICEKfgpnldTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVP--QPCHALVDLYGQCEQ 1286
Cdd:pfam07177   81 RPGYWV----------VALSGS------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTTQ 144


                   ....*
gi 53829368   1287 VTIVN 1291
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
316-437 1.31e-43

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 154.78  E-value: 1.31e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     316 DALLFHEKCGTLIKLSNNNKTAerRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPAT 395
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 53829368     396 MTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIG 437
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
520-642 5.47e-39

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 141.29  E-value: 5.47e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     520 RLLFHPNCGQKAAITHEGRTALRPHatDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTM 599
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 53829368     600 TNLRSGTWMMTGNGVMHNGTTILDEYG-HNLDRLKAGDTVGVVR 642
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
716-838 2.07e-33

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 125.50  E-value: 2.07e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     716 DLRFHQLHGSNAVITNGGRTALRHncRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTM 795
Cdd:smart00588    2 PLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLP 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 53829368     796 TDIDYDTWMLSGTAIMQDGNTMRNNYGC-DLDALGTGARIGMMR 838
Cdd:smart00588   80 TNACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
45-163 1.75e-30

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 117.03  E-value: 1.75e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368      45 HPRTGRLVSLSACGRTARRQQpgQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSATGLK 124
Cdd:smart00588    6 HHRHGSNIRLSDSGRVARRSA--SDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNAC 83

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 53829368     125 GGSWVVSGCSVLRDGRSVLEEYG-QDLDQLGEGDRVGVER 163
Cdd:smart00588   84 PDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 914-1083 3.54e-26

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 105.69  E-value: 3.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    914 FHSTCGKNVTLEEDGTRAVRAAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLApgemgpgAGGGGPGLP 993
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCD-------PATLRPKAL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    994 PSLPELRTKTTWMVSSCEvrrdgqlqrmnygrnlERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKN--VWAVLD 1071
Cdd:pfam07177   74 PDLATDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFD 137

                          170
                   ....*....|..
gi 53829368   1072 LYGPVRGVSIVS 1083
Cdd:pfam07177  138 LYGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
1130-1245 4.28e-15

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 73.11  E-value: 4.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368    1130 LEFLENHGKNILLSNGNRTATRVAS-YNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACAL 1208
Cdd:smart00588    3 LRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPTNA 82

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 53829368    1209 KRAAWLLRGRGVFHNGLKICEKFGP-NLDTCPEGTILG 1245
Cdd:smart00588   83 CPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVG 120
NEUZ smart00588
domain in neuralized proteins;
913-1040 1.44e-09

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 57.32  E-value: 1.44e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368     913 RFHSTCGKNVTLEEDGTRAVR-AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLRLGLTTLApgemgpgaggggpg 991
Cdd:smart00588    4 RFHHRHGSNIRLSDSGRVARRsASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCD-------------- 69

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 53829368     992 lppsLPELRTKT--------TWMVSSCEVRRDG-QLQRMNYGRNLERLGVGSRVGVRR 1040
Cdd:smart00588   70 ----PATLRPASlptnacpdLVDMSGFWAKALGeGLAEQGGILGLDVLAEGEVVGVIN 123
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 87-205 7.30e-09

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 55.13  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368   87 FTVRIDrkvNSWSGSIEIGVTalDPSVLDFPSSATGLKGGSWVVSGCSVlRDGRSVLEEYGQDldQLGEGDRVGVERTV- 165
Cdd:cd11709    5 WEVRVD---SGNGGLIQVGWA--TKSFSLDGEGGVGDDEESWGYDGSRL-RKGHGGSSGPGGR--PWKSGDVVGCLLDLd 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 53829368  166 AGELRLWVNGRDCGVAATGL---PPRVWAVVDLYGKCtQITVL 205
Cdd:cd11709   77 EGTLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQ-GVTIN 118
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 566-679 1.22e-04

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 43.19  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829368  566 FQVRIDKMVDkwaGSIEIGVTTHNPAYLQLPSTMTNLRSgtWMMTGNGVmHNGTTILDEYGhnLDRLKAGDTVGV-VRRE 644
Cdd:cd11709    5 WEVRVDSGNG---GLIQVGWATKSFSLDGEGGVGDDEES--WGYDGSRL-RKGHGGSSGPG--GRPWKSGDVVGClLDLD 76

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 53829368  645 DGTLHFFVNGMTQGPAAWNV---PPGVYAVVDLYGQAA 679
Cdd:cd11709   77 EGTLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQG 114
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 607-678 6.23e-03

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 39.36  E-value: 6.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53829368  607 WMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVV-RREDGTLHFFVNGMTQGPAAWNVP-----PGVYAVvdlYGQA 678
Cdd:cd12875   88 WDLGDNKLYHNGKKVIGSYPAKSENYQVPDRILVIlDMEDGTLAFEANGEYLGVAFRGLPgkllyPAVSAV---YGNC 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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