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Conserved domains on  [gi|268607540|ref|NP_001005248|]
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BLOC-2 complex member HPS5 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
38-150 5.83e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607540   38 TSIAVSR--KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIAcCSHDDDYVAVATSQGLVVVWELNQerrgkPERI 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607540  116 HVSSEHKGRkVTALC-------------------WDTA---VLRVFVGdHVGKVSAI 150
Cdd:COG2319   324 RTLTGHTGA-VRSVAfspdgktlasgsddgtvrlWDLAtgeLLRTLTG-HTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-150 5.83e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607540   38 TSIAVSR--KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIAcCSHDDDYVAVATSQGLVVVWELNQerrgkPERI 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607540  116 HVSSEHKGRkVTALC-------------------WDTA---VLRVFVGdHVGKVSAI 150
Cdd:COG2319   324 RTLTGHTGA-VRSVAfspdgktlasgsddgtvrlWDLAtgeLLRTLTG-HTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-150 5.83e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607540   38 TSIAVSR--KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIAcCSHDDDYVAVATSQGLVVVWELNQerrgkPERI 115
Cdd:COG2319   250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 268607540  116 HVSSEHKGRkVTALC-------------------WDTA---VLRVFVGdHVGKVSAI 150
Cdd:COG2319   324 RTLTGHTGA-VRSVAfspdgktlasgsddgtvrlWDLAtgeLLRTLTG-HTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
38-131 1.06e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607540   38 TSIAVSR--KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIACcSHDDDYVAVATSQGLVVVWELNQerrgkPERI 115
Cdd:COG2319   292 NSVAFSPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLAT-----GELL 365

                          90
                  ....*....|....*.
gi 268607540  116 HVSSEHKGRkVTALCW 131
Cdd:COG2319   366 RTLTGHTGA-VTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
38-150 1.30e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268607540   38 TSIAVSR--KWLALGSTGGGLNLIQKDGWKQRLFLSHREGAISQIACcSHDDDYVAVATSQGLVVVWELNQERRGKPERI 115
Cdd:COG2319   166 TSVAFSPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKLLASGSADGTVRLWDLATGKLLRTLTG 244

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 268607540  116 H---VSS---EHKGRKV-------TALCWD--TAVLRVFVGDHVGKVSAI 150
Cdd:COG2319   245 HsgsVRSvafSPDGRLLasgsadgTVRLWDlaTGELLRTLTGHSGGVNSV 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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