NCBI Conserved Domain Search

Conserved domains on [gi|52317261|ref|NP_001004741|]

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olfactory receptor 5M10 [Homo sapiens]

Protein Classification

7tmA_OR5M-like domain-containing protein( domain architecture ID 11607549)

7tmA_OR5M-like domain-containing protein

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-303

3.64e-173

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 480.74 E-value: 3.64e-173

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQ 303
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

Name

Accession

Description

Interval

E-value

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-303

3.64e-173

Pssm-ID: 320534 Cd Length: 279 Bit Score: 480.74 E-value: 3.64e-173

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQ 303
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-305

2.42e-40

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 142.26 E-value: 2.42e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261    31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEE 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52317261   271 --SKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMI 305
Cdd:pfam13853 241 llQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-303

3.64e-173

Pssm-ID: 320534 Cd Length: 279 Bit Score: 480.74 E-value: 3.64e-173

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQ 303
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-294

3.85e-146

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 411.90 E-value: 3.85e-146

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15230 242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-297

2.18e-135

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 385.52 E-value: 2.18e-135

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  12 FILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  92 ISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 172 LEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52317261 252 YGTLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-294

5.55e-133

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 378.36 E-value: 5.55e-133

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-297

5.86e-129

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 369.39 E-value: 5.86e-129

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  11 EFILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQK 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  91 TISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 171 SLEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTL 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52317261 251 FYGTLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEV 287

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-301

3.29e-127

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 364.08 E-value: 3.29e-127

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-305

6.63e-127

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 363.90 E-value: 6.63e-127

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  12 FILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKT 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  92 ISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGS 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 172 LEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 52317261 252 YGTLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMI 305
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-297

8.99e-126

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 360.48 E-value: 8.99e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15411  82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15411 162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15411 242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEV 273

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-297

1.07e-124

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 357.72 E-value: 1.07e-124

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEI 273

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-302

1.16e-124

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 357.79 E-value: 1.16e-124

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15413   2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15413  82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15413 162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQ 302
Cdd:cd15413 242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALK 278

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-297

5.45e-121

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 348.53 E-value: 5.45e-121

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDV 273

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-297

2.45e-120

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 346.90 E-value: 2.45e-120

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  24 EKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLL 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 104 FIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPP 183
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 184 LIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPP 263
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317261 264 SEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDV 274

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

27-301

2.23e-116

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 336.88 E-value: 2.23e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15229   3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15229  83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15229 163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15229 243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

27-301

1.12e-115

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 335.00 E-value: 1.12e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-301

2.79e-115

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 333.95 E-value: 2.79e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15416  82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15416 162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15416 242 YSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-305

3.92e-115

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 334.45 E-value: 3.92e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  12 FILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  92 ISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGS 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 172 LEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 52317261 252 YGTLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMI 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-294

1.70e-114

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 331.55 E-value: 1.70e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15237 241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-294

1.22e-113

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 329.45 E-value: 1.22e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-294

1.22e-112

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 327.13 E-value: 1.22e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15911 162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15911 242 TSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-308

1.75e-112

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 327.08 E-value: 1.75e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMIRGK 308
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-294

4.01e-112

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 325.72 E-value: 4.01e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-300

5.93e-112

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 325.66 E-value: 5.93e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILA 300
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-303

2.16e-111

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 324.78 E-value: 2.16e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  12 FILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  92 ISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 172 LEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317261 252 YGTLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQ 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-303

5.62e-111

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 323.21 E-value: 5.62e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQ 303
Cdd:cd15409 242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-305

3.32e-110

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 321.62 E-value: 3.32e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  16 GLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYA 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  96 GCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEIN 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 176 HFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTL 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52317261 256 FCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMI 305
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

27-297

6.74e-109

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 317.82 E-value: 6.74e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15415   3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15415  83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15415 243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDV 273

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-294

1.01e-108

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 316.86 E-value: 1.01e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQtLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-300

2.60e-104

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 306.25 E-value: 2.60e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILA 300
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-294

8.03e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 304.57 E-value: 8.03e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKmAMFVVAGFTLSSSLFI-ILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15232 162 LLSCSDTSLNE-IMAFVADVFFGVGNFLlTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15232 241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-297

9.51e-104

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 304.73 E-value: 9.51e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15407 243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEV 273

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

28-294

2.05e-101

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 298.60 E-value: 2.05e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  28 FGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIAL 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 108 VITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIML 187
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 188 ACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKS 267
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 52317261 268 VEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

27-297

2.12e-101

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 298.86 E-value: 2.12e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQV 273

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

26-297

2.96e-100

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 295.92 E-value: 2.96e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15418 243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDV 274

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

25-294

3.95e-100

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 295.30 E-value: 3.95e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-294

1.44e-96

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 286.10 E-value: 1.44e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                       250       260
                ....*....|....*....|....*...
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-297

6.74e-95

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 282.35 E-value: 6.74e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDV 273

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-294

4.07e-93

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 277.26 E-value: 4.07e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15915   2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15915  82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRI-RSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15915 162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15915 242 GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-294

5.20e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 274.63 E-value: 5.20e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15430 241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-297

1.49e-91

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 273.59 E-value: 1.49e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15432 241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDV 273

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

25-294

2.39e-91

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 272.93 E-value: 2.39e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIfRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 ekSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15939 240 --TFPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-297

1.46e-90

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 271.22 E-value: 1.46e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDV 273

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-301

4.94e-90

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 269.67 E-value: 4.94e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-297

7.92e-90

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 269.06 E-value: 7.92e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDM 273

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-294

3.05e-89

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 267.64 E-value: 3.05e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

27-301

3.27e-87

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 262.80 E-value: 3.27e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

27-294

1.41e-85

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 257.90 E-value: 1.41e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIfRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                       250       260
                ....*....|....*....|....*...
gi 52317261 267 SVEesKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15226 242 PVD--KFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-294

3.27e-85

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 257.41 E-value: 3.27e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-297

3.52e-85

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 257.38 E-value: 3.52e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQ-KTISYAGCFTQCLLFI 105
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEEskIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15916 243 EALDG--VIAVFYTVVTPLLNPLIYTLRNKEV 272

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-294

7.79e-85

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 256.14 E-value: 7.79e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-297

1.43e-84

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 255.87 E-value: 1.43e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDV 273

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-301

4.17e-83

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 252.00 E-value: 4.17e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317261 266 KSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-294

5.30e-80

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 243.89 E-value: 5.30e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIfRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSe 265
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSL-RKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST- 239

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 kSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15940 240 -SFSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

27-294

1.64e-79

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 242.62 E-value: 1.64e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15936   3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIfRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPpsEK 266
Cdd:cd15936 163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARP--FQ 239

                       250       260
                ....*....|....*....|....*...
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15936 240 TFPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-301

1.44e-76

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 235.40 E-value: 1.44e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15228   2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15228 162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317261 266 KSVeeSKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15228 242 PVL--VTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-297

2.09e-76

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 235.07 E-value: 2.09e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 52317261 265 EKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDV 273

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

27-294

2.45e-75

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 232.07 E-value: 2.45e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIfaaIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                       250       260
                ....*....|....*....|....*...
gi 52317261 267 SVEesKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15938 240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-301

4.18e-74

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 229.35 E-value: 4.18e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQT-PMYFFLGHLSFVDICYSSNVTPNMLHNFLS-EQKTISYAGCFTQCLL 103
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 104 FIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPP 183
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 184 LIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPP 263
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317261 264 SEKSveESKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15941 242 SSQA--GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-301

2.34e-73

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 227.32 E-value: 2.34e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIM 186
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEK 266
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 52317261 267 SVeeSKIIAVFYTFLSPMLNPLIYSLRNRDVILAI 301
Cdd:cd15942 243 PL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-294

3.75e-64

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 203.43 E-value: 3.75e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIfRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSE 265
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKL-RTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                       250       260
                ....*....|....*....|....*....
gi 52317261 266 KSVEesKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15937 241 FPMD--KVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-294

3.47e-63

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 200.76 E-value: 3.47e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQL-QTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFtLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPS 264
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGL-LSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 265 EKSVEesKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15935 241 SSSVD--KVASVFYTLITPALNPLIYTLRN 268

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

31-297

1.13e-58

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 189.81 E-value: 1.13e-58

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15223  87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV--RPPSEKSV 268
Cdd:cd15223 167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPP 246

                       250       260
                ....*....|....*....|....*....
gi 52317261 269 EESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15223 247 DVHVLLSVLYILIPPALNPIIYGVRTKEI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

31-295

1.45e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 181.72 E-value: 1.45e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV-------RPP 263
Cdd:cd15917 167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthrfghhVPP 246

                       250       260       270
                ....*....|....*....|....*....|..
gi 52317261 264 SEKSveeskIIAVFYTFLSPMLNPLIYSLRNR 295
Cdd:cd15917 247 HVHI-----LLANLYLLLPPMLNPIVYGVRTK 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-297

6.38e-54

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 177.22 E-value: 6.38e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNIC--ISLVTVPYMYGFLNGLsqTLLTFHLSFCGSLEINHFYCADPPLIMLA 188
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIaqIGLAIVLRALLFMTPL--TCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 189 CSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFY-GTLFCMYV-RPPSEK 266
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTqRFGQGV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15950 245 PPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

31-295

4.23e-49

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 164.98 E-value: 4.23e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQcLLFI-ALVI 109
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQ-MFFIhTFSF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 110 TEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLAC 189
Cdd:cd15222  86 MESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 190 SDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV--RPPSEKS 267
Cdd:cd15222 166 SDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMvhRFGKHAS 245

                       250       260
                ....*....|....*....|....*...
gi 52317261 268 VEESKIIAVFYTFLSPMLNPLIYSLRNR 295
Cdd:cd15222 246 PLVHVLMANVYLLVPPVLNPIIYSVKTK 273

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-295

2.35e-47

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 160.15 E-value: 2.35e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV--RPPSEKSV 268
Cdd:cd15221 167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHIPR 246

                       250       260
                ....*....|....*....|....*..
gi 52317261 269 EESKIIAVFYTFLSPMLNPLIYSLRNR 295
Cdd:cd15221 247 HVHILLANLYVLVPPMLNPIVYGVKTK 273

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-295

5.95e-47

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 159.35 E-value: 5.95e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYG-TLFCMYVRPPSEKSVE 269
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTpALFSFLTHRFGQGIAP 246

                       250       260
                ....*....|....*....|....*..
gi 52317261 270 ESKII-AVFYTFLSPMLNPLIYSLRNR 295
Cdd:cd15953 247 HIHIIlANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-297

6.05e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 159.43 E-value: 6.05e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEE 270
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPP 246

                       250       260
                ....*....|....*....|....*....
gi 52317261 271 SK--IIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15951 247 HVhiLIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-297

7.97e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 153.69 E-value: 7.97e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFtLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEE 270
Cdd:cd15952 167 SIRINIIYGLFAISV-LVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPR 245

                       250       260
                ....*....|....*....|....*....
gi 52317261 271 SKII--AVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15952 246 YIHIllANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

31-297

1.86e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 145.05 E-value: 1.86e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNIC--ISLVTVPYMYGFLNGLSQTLLTFHlsFCGSLEINHFYCADPPLIMLA 188
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVItkIGLAALARAVTLMTPLPFLLRRLP--YCRSHVIAHCYCEHMAVVKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 189 CSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV--RPPSEK 266
Cdd:cd15948 166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHV 245

                       250       260       270
                ....*....|....*....|....*....|.
gi 52317261 267 SVEESKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15948 246 APHVHILLANFYLLFPPMMNPIVYGVKTKQI 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-297

1.71e-40

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 142.70 E-value: 1.71e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVI 109
Cdd:cd15956   6 PFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 110 TEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLAC 189
Cdd:cd15956  86 MESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 190 SDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVE 269
Cdd:cd15956 166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 270 ESK--IIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15956 246 SAAhvLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-305

2.42e-40

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 142.26 E-value: 2.42e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261    31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEE 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 52317261   271 --SKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMI 305
Cdd:pfam13853 241 llQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-297

5.21e-38

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 136.45 E-value: 5.21e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  10 TEFILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQ 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  90 KTISYAGCFTQCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 170 GSLEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVT 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52317261 250 LFYGTL--------FCMYVRPPSEksveesKIIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15949 242 AFYVPIavsslihrFGQNVPPPTH------ILLANFYLLIPPMLNPIVYGVRTKQI 291

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-297

1.74e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 131.87 E-value: 1.74e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHL-TIVTLFYGTLFCMYVRPPSEKSVE 269
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHIcAIVITYTPAFFTFFAHRFGGHHIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 270 ESK--IIAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15954 247 PHIhiIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-297

1.02e-35

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 129.89 E-value: 1.02e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVIT 110
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYG-FLNGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLAC 189
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAvVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 190 SDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYG-TLFCMYVRPPSEKSV 268
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTlAFFSFFAHRFGHHVA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 52317261 269 EESKI-IAVFYTFLSPMLNPLIYSLRNRDV 297
Cdd:cd15955 247 PYVHIlLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-290

6.74e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 116.63 E-value: 6.74e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261    41 GNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTP-NMLHNFLSEQKTISYAGCFTQCLLFIALVITEFYFLASMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPfWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   120 LDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSleiNHFYCADPPLIMLACsdtRVKKMAM 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK---PVSYTLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261   200 FVVAGFTLssSLFIILLSYLFIFAAIFRIRSAEGR-------HKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEESK 272
Cdd:pfam00001 155 ISVLGFLL--PLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 52317261   273 II------AVFYTFLSPMLNPLIY 290
Cdd:pfam00001 233 LLdkalsvTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-294

4.25e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 88.11 E-value: 4.25e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGsleinhfycadPPLIM 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGG-----------YCCCC 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 187 LACSDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASH----------LTIVTLFYG--- 253
Cdd:cd00637 150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktLLIVVVVFLlcw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52317261 254 -----TLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd00637 230 lpyfiLLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-296

5.15e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 67.59 E-value: 5.15e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLngLSQTLLTFHLSFCGSLEINHFYCADPPLI 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL--ISLPPLVGWRDETQPSVVDCECEFTPNKI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSdtrvkkmamfVVAGFtlssslFIILLSYLFIFAAIFRIRSAEgrHKAFSTcashLTIVTL--------FYGTLFC 257
Cdd:cd14967 159 YVLVS----------SVISF------FIPLLIMIVLYARIFRVARRE--LKAAKT----LAIIVGafllcwlpFFIIYLV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 52317261 258 MYVRPPSEKSVEeskIIAVFYT--FLSPMLNPLIYSLRNRD 296
Cdd:cd14967 217 SAFCPPDCVPPI---LYAVFFWlgYLNSALNPIIYALFNRD 254

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

32-296

1.65e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 60.73 E-value: 1.65e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  32 LAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmLHNFLSEQKTISYAGC-FTQCLLFIALVIT 110
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGClFMACLVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLAsMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSqTLLTFHLSFcgSLEINHFYCadppliMLACS 190
Cdd:cd14968  86 IFSLLA-IAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLT-PMFGWNNGA--PLESGCGEG------GIQCL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 DTRVKKMAMFVVAGF--TLSSSLFIILLSYLFIFAAIFR--------IRSAEGRH---KAFSTCASHLTIVTLFYG---- 253
Cdd:cd14968 156 FEEVIPMDYMVYFNFfaCVLVPLLIMLVIYLRIFRVIRKqlrqieslLRSRRSRStlqKEVKAAKSLAIILFLFALcwlp 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52317261 254 -------TLFCmyvrpPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRD 296
Cdd:cd14968 236 lhiinciTLFC-----PECKVPKILTYIAILLSHANSAVNPIVYAYRIRK 280

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

32-296

1.95e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 54.55 E-value: 1.95e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  32 LAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLhnflseqkTISYAGC--FTQCLLF--IAL 107
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFCtdFHSCLFLacFVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 108 VITE--FYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTL-LTFHLSFCGSLEINHFYCADPPL 184
Cdd:cd15069  80 VLTQssIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLgWNKAMSATNNSTNPADHGTNHSC 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGF--TLSSSLFIILLSYLFIFAAIFRI--------RSAEGRHKAFSTCASHLTIVTLF--- 251
Cdd:cd15069 160 CLISCLFENVVPMSYMVYFNFfgCVLPPLLIMLVIYIKIFLVACRQlqrtelmdHSRTTLQREIHAAKSLAIIVGIFalc 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 52317261 252 ---YGTLFCMYVRPPSEKSVEESKII--AVFYTFLSPMLNPLIYSLRNRD 296
Cdd:cd15069 240 wlpVHILNCITLFQPEFSKSKPKWAMnvAILLSHANSVVNPIVYAYRNRD 289

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

25-132

2.51e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 54.16 E-value: 2.51e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLHNFlseqkTISYAGCFTQCLL 103
Cdd:cd15196   1 KVEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYGGDLLCRL 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 52317261 104 FIALVITEFY----FLASMALDRYVAICSPLHY 132
Cdd:cd15196  76 VKYLQVVGMYassyVLVATAIDRYIAICHPLSS 108

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

25-130

7.14e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 52.90 E-value: 7.14e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSS-NVTPNMLHNFlseqkTISYAGCFTQCLL 103
Cdd:cd15387   1 KVEVTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGPDFLCRL 75

                        90       100       110
                ....*....|....*....|....*....|.
gi 52317261 104 FIAL-VITEF---YFLASMALDRYVAICSPL 130
Cdd:cd15387  76 VKYLqVVGMFastYMLLLMSIDRCLAICQPL 106

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

26-153

2.65e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 51.20 E-value: 2.65e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlHNFLSEQKTISYAG---CFTQCL 102
Cdd:cd15312   2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMP---YSMVRSVESCWYFGdlfCKIHSS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52317261 103 LFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLV----TVPYMYGF 153
Cdd:cd15312  79 LDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLviswSVPCLFAF 133

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-175

3.65e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 50.63 E-value: 3.65e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlhnfLSEQKTIsyAGCF----TQC 101
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSI--ETCWyfgdTFC 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 102 LLF----IALVITEFYFLASMALDRYVAICSPLHYSSRMSKN---ICISLV-TVPYMYGFLnglsqtLLTFHLSFCGSLE 173
Cdd:cd15055  74 KLHssldYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRrvkICICLCwFVSALYSSV------LLYDNLNQPGLIR 147


                ..
gi 52317261 174 IN 175
Cdd:cd15055 148 YN 149

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

29-297

4.19e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 50.37 E-value: 4.19e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  29 GVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALV 108
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 109 ITeFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTlltfhlsfcgsLEINHFYCADPPLIMLA 188
Cdd:cd14972  83 AS-AYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPV-----------LGWNCVLCDQESCSPLG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 189 CSDTrvKKMAMFVVAGFTLssSLFIILLSYLFIFAAI----FRIR----SAEGRHKAFSTcASHLTIVTLF------YGT 254
Cdd:cd14972 151 PGLP--KSYLVLILVFFFI--ALVIIVFLYVRIFWCLwrhaNAIAarqeAAVPAQPSTSR-KLAKTVVIVLgvflvcWLP 225

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 52317261 255 LFCMYVRPPSEKSVEESKiiAVFYTFLSPML-----NPLIYSLRNRDV 297
Cdd:cd14972 226 LLILLVLDVLCPSVCDIQ--AVFYYFLVLALlnsaiNPIIYAFRLKEM 271

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

32-296

4.23e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 50.71 E-value: 4.23e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  32 LAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLhnFLSEQKTISYAGCFTQCLLFIALVITE 111
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 112 FYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSqTLLTFHLsfCGSLEINHFYCADPPLIMLACSD 191
Cdd:cd15068  86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLT-PMLGWNN--CGQPKEGKNHSQGCGEGQVACLF 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 192 TRVKKMAMFVVAGF--TLSSSLFIILLSYLFIFAAI--------------FRIRSAEGR--HKA---------FSTCASH 244
Cdd:cd15068 163 EDVVPMNYMVYFNFfaCVLVPLLLMLGVYLRIFLAArrqlkqmesqplpgERARSTLQKevHAAkslaiivglFALCWLP 242

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317261 245 LTIVTLFygTLFCmyvrPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRD 296
Cdd:cd15068 243 LHIINCF--TFFC----PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIRE 288

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

26-154

9.94e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 49.51 E-value: 9.94e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLIT-LAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd14969   1 YVLAVYLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLhYSSRMSKNICISLVTVPYMYGFL 154
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLF 129

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

26-296

1.44e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 48.82 E-value: 1.44e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFL-AIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYagcfTQCLLF 104
Cdd:cd15330   1 IITSLFLgTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQ----VTCDLF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVI----TEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLsqtlltfhlsfcgsleinhfyca 180
Cdd:cd15330  77 IALDVlcctSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI----------------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 181 dPPLIMLACSDTRVKKMAMFVVA--GFTLSSSL---FIILLSYLFIFAAIFRIRSAEgrHKAFSTCASHLTIVTLFYGTL 255
Cdd:cd15330 134 -PPMLGWRTPEDRSDPDACTISKdpGYTIYSTFgafYIPLILMLVLYGRIFKAAARE--RKTVKTLGIIMGTFILCWLPF 210

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52317261 256 FCM-YVRPPSEKSVEESKIIAVFYTFL---SPMLNPLIYSLRNRD 296
Cdd:cd15330 211 FIVaLVLPFCESTCHMPELLGAIINWLgysNSLLNPIIYAYFNKD 255

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

30-135

2.20e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 48.53 E-value: 2.20e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLHNFLSEQ-------KTISYAGCFTqc 101
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWvagdvlcRIVKYLQVVG-- 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 52317261 102 llfialVITEFYFLASMALDRYVAICSPLHYSSR 135
Cdd:cd14986  84 ------LFASTYILVSMSLDRYQAIVKPMSSLKP 111

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

25-159

4.69e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 47.49 E-value: 4.69e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSS-NVTPNMLHNFlseqkTISYAG----CFT 99
Cdd:cd15386   1 KVEIGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEI-----TYRFQGpdllCRA 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 100 QCLLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICIsLVTVPYMYGFLNGLSQ 159
Cdd:cd15386  76 VKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYL-MIGATWLLSCILSLPQ 134

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

29-147

4.87e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 47.10 E-value: 4.87e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  29 GVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLhNFLSEQKTISYAGCFTQCL----- 102
Cdd:cd15103   5 EVFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvSNALETIV-IILLNNGYLVPRDSFEQHIdnvid 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 52317261 103 -LFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTV 147
Cdd:cd15103  84 sMICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITA 129

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

34-147

1.32e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 46.30 E-value: 1.32e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  34 IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTI-SYAGCFTQCLLFIALVITEF 112
Cdd:cd15005  10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSA 89

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52317261 113 YFLASMALDRYVAICSPLHYSSRMSKNICISLVTV 147
Cdd:cd15005  90 FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICM 124

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

26-154

1.50e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 45.90 E-value: 1.50e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlHNFLSEQKTISYAG---CFTQCL 102
Cdd:cd15317   2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHTG 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52317261 103 LFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTV----PYMYGFL 154
Cdd:cd15317  79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIgwlvPGIYTFG 134

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-296

2.39e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 45.01 E-value: 2.39e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLA-IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlhnfLSEQKTISYAGCFTQ--CL 102
Cdd:cd15064   1 VLISVLLSlIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP------LSAVYELTGRWILGQvlCD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 103 LFIALVIT----EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTvpymygflnglsqtlLTFHLSFCGSLeinhfy 178
Cdd:cd15064  75 IWISLDVTcctaSILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIA---------------LVWTLSICISL------ 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 179 cadPPLIMLACSDTRVKKMAM----FVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEgrHKAFSTCASHLTIVTLFYGT 254
Cdd:cd15064 134 ---PPLFGWRTPDSEDPSECLisqdIGYTIFSTFGAFYIPLLLMLILYWKIYRAAARE--RKAAKTLGIILGAFIVCWLP 208

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 52317261 255 LFCMYVRPPSEKSVEESKIIAVFYTFL---SPMLNPLIYSLRNRD 296
Cdd:cd15064 209 FFLVALIVPLCSHCWIPLALKSFFLWLgyfNSLINPLIYTFFNKD 253

7tmA_SKR_NK2R

cd16004

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-130

2.81e-05

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.

Pssm-ID: 320670 [Multi-domain] Cd Length: 285 Bit Score: 44.83 E-value: 2.81e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNvtpNMLHNFLSEQKTISYAG---CFTQCLLFIAL 107
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAF---NTAFNFVYASHNDWYFGlefCRFQNFFPITA 83

                        90       100
                ....*....|....*....|...
gi 52317261 108 VITEFYFLASMALDRYVAICSPL 130
Cdd:cd16004  84 MFVSIYSMTAIAADRYMAIIHPF 106

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

34-139

3.43e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 44.75 E-value: 3.43e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  34 IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVITEFY 113
Cdd:cd15058  10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89

                        90       100
                ....*....|....*....|....*.
gi 52317261 114 FLASMALDRYVAICSPLHYSSRMSKN 139
Cdd:cd15058  90 TLCVIAVDRYIAITRPLRYQVLLTKR 115

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

26-300

4.94e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 44.02 E-value: 4.94e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSqtlltfhlSFCGSLEINHFYCADPPLI 185
Cdd:cd15063  82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFP--------PLVGWNDGKDGIMDYSGSS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 MLACSDTRVKKMAMFVvagFTLSSSLFIILLSYLFIFAAIFRIRSAEGrhKAFSTCASHLTIVTLFYGTLFCMY-VRPPS 264
Cdd:cd15063 154 SLPCTCELTNGRGYVI---YSALGSFYIPMLVMLFFYFRIYRAARMET--KAAKTVAIIVGCFIFCWLPFFTVYlVRAFC 228

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 52317261 265 EKSVEESKIIAVFYT-FLSPMLNPLIYSLRNRDVILA 300
Cdd:cd15063 229 EDCIPPLLFSVFFWLgYCNSALNPCIYALFSRDFRFA 265

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-134

1.71e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 42.41 E-value: 1.71e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  28 FGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLHNFLSEQkTISYAGCFTQCLLFIA 106
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEW-RAGDFACKVIRYLQVV 82

                        90       100
                ....*....|....*....|....*...
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSS 134
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNFSQ 110

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

29-293

1.90e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 42.53 E-value: 1.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  29 GVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlhnfLSEQKTISYAGCFTQCLLF--IA 106
Cdd:cd15071   5 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP------LAIIINIGPQTEFYSCLMVacPV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLA--SMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSfcgSLEINHFYCADPPL 184
Cdd:cd15071  79 LILTQSSILAllAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLN---AVERAWAANSSMGE 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 185 IMLACSDTRVKKMAMFVVAGFT--LSSSLFIILLSYLFIFAAIFR------IRSAEGRHKAFS---TCASHLTIVTLFYG 253
Cdd:cd15071 156 LVIKCQFETVISMEYMVYFNFFvwVLPPLLLMLLIYLEVFYLIRKqlnkkvSSSSSDPQKYYGkelKIAKSLALILFLFA 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 52317261 254 -------TLFCMYVRPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLR 293
Cdd:cd15071 236 lswlplhILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFR 282

7tmA_NKR_NK3R

cd16003

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...

23-169

1.91e-04

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320669 [Multi-domain] Cd Length: 282 Bit Score: 42.22 E-value: 1.91e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  23 LEKILFGVFLAIYLItlaGNLCMILLIRTNSQLQTPMYFFLGHLSFVDicySSNVTPNMLHNFLSEQKTISYAG---CFT 99
Cdd:cd16003   2 LWSLAYGFVVAVAVF---GNLIVIWIILAHKRMRTVTNYFLVNLAFSD---ASMAAFNTLINFIYALHSEWYFGeayCRF 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52317261 100 QCLLFIALVITEFYFLASMALDRYVAICSPL--HYSSRMSKNICISLVTVPYMYGFLNGL-SQTLLTFHLSFC 169
Cdd:cd16003  76 HNFFPITSVFASIYSMTAIAVDRYMAIIDPLkpRLSATATKVVIGSIWILAFLLAFPQCLySKTKVMPGRTLC 148

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

27-138

2.05e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 42.20 E-value: 2.05e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAI-YLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15959   2 LAGALLSLaILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSK 138
Cdd:cd15959  82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTK 114

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

32-306

3.03e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 41.81 E-value: 3.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  32 LAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQK-TISYAGCFTQCLLFIALVIT 110
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 111 EFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFlnGLSQTLLTFHLSFCGSLEINHFYCADPPLIMLACS 190
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISI--GISMPIPVIGLQDDEKVFVNGTCVLNDENFVLIGS 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 191 dtrvkKMAMFVvagftlssSLFIILLSYLFIFAAIFRIRSAEGRHKAfstcASHLTIVTLFYGTLFC-------MYV--- 260
Cdd:cd15305 166 -----FVAFFI--------PLIIMVITYCLTIQVLQRQQAINNERRA----SKVLGIVFFLFLIMWCpffitniLSVlck 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 52317261 261 RPPSEKSVEESKIIAVFYTFLSPMLNPLIYSLRNRDVILAIQQMIR 306
Cdd:cd15305 229 EACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIR 274

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

30-296

3.68e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 41.26 E-value: 3.68e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVI 109
Cdd:cd15060   6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 110 TEFYFLASMALDRYVAICSPLHYS-SRMSKNICIS---------LVTVPYMYGFLNGLSQtlltfhlsfcgsleinhFYC 179
Cdd:cd15060  86 ASILNLCAIALDRYWAIHDPINYAqKRTLKRVLLMivvvwalsaLISVPPLIGWNDWPEN-----------------FTE 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 180 ADPplimlaCSDTRVKkmaMFVVagFTLSSSLFIILLSYLFIFAAIFRIRSAEGRhkAFSTCASHLTIVTLFYGTLFCMY 259
Cdd:cd15060 149 TTP------CTLTEEK---GYVI--YSSSGSFFIPLLIMTIVYVKIFIATSKERR--AARTLGIIMGVFVVCWLPFFLMY 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 52317261 260 VRPPSEKSVEESKIIAVFYTFL---SPMLNPLIYSLRNRD 296
Cdd:cd15060 216 VILPFCETCSPSAKVVNFITWLgyvNSALNPVIYTIFNLD 255

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

26-227

5.04e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 41.16 E-value: 5.04e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIY-LITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGC----FTQ 100
Cdd:cd15083   1 YVLGIFILIIgLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCdmygFSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 101 CLLFIALVITefyfLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGF------LNGLSQTLLTFHLSFCGslei 174
Cdd:cd15083  81 GLFGIMSINT----LAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLlwvlppLFGWSRYVLEGLLTSCS---- 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 52317261 175 nhF-YCADPPLimlacsdTRVKKMAMFVVaGFTLSssLFIILLSYLFIFAAIFR 227
Cdd:cd15083 153 --FdYLSRDDA-------NRSYVICLLIF-GFVLP--LLIIIYCYSFIFRAVRR 194

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

30-295

5.26e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 41.09 E-value: 5.26e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVI 109
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 110 TEFYFLASMALDRYVAicspLHYSSRMSKNICISLVTVpymygflnglsQTLLTFHLSFCGSLEINHFYCADPPLIMLAC 189
Cdd:cd15307  86 ASIMHLCTISVDRYLS----LRYPMRFGRNKTRRRVTL-----------KIVFVWLLSIAMSLPLSLMYSKDHASVLVNG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 190 SDTRVKKMAMFVVAGFTLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLF-----YGTLFCMYVRP-- 262
Cdd:cd15307 151 TCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPtv 230

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 52317261 263 --PSEKSVEESKI-IAVFYTFLSPMLNPLIYSLRNR 295
Cdd:cd15307 231 caECEERISHWVFdVVTWLGYASSMVNPIFYTIFNK 266

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

22-145

5.28e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 40.85 E-value: 5.28e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  22 VLEKILFGVflaIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGC---- 97
Cdd:cd15393   1 VLLSILYGI---ISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCpfcp 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 52317261  98 FTQCLLFIALVITefyfLASMALDRYVAICSPLhySSRMSK---NICISLV 145
Cdd:cd15393  78 FVQVLSVNVSVFT----LTVIAVDRYRAVIHPL--KARCSKksaKIIILII 122

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-137

7.52e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 40.31 E-value: 7.52e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCL------L 103
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsL 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 52317261 104 FIALVITEFYFLASMALDRYVAICSPLHYSSRMS 137
Cdd:cd15354  86 ICISVVASMCSLLAIAVDRYVTIFYALRYHNIMT 119

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-166

8.33e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 40.30 E-value: 8.33e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTP-NMLHNFlseqKTISYAG---CFTQC 101
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPpSMVRSV----ETCWYFGdlfCKIHS 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52317261 102 LLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHL 166
Cdd:cd15314  78 SFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNI 142

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

26-147

1.04e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 40.28 E-value: 1.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGC----FTQC 101
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCkavpYLQG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 52317261 102 LLFIALVITefyfLASMALDRYVAICSPLHYSSRMSK-NICISLVTV 147
Cdd:cd14993  82 VSVSASVLT----LVAISIDRYLAICYPLKARRVSTKrRARIIIVAI 124

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

36-145

1.19e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 39.91 E-value: 1.19e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  36 LITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVITEFYFL 115
Cdd:cd15321  18 LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHL 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 52317261 116 ASMALDRYVAICSPLHYSS-RMSKNI-CISLV 145
Cdd:cd15321  98 CAISLDRYWSVSRAIEYNSkRTPRRIkCIILI 129

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-130

1.26e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 39.80 E-value: 1.26e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100
                ....*....|....*....|....*
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPL 130
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPL 106

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

30-138

1.56e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 39.65 E-value: 1.56e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQK-TISYAGCFTQCLLFIALV 108
Cdd:cd14979   6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACT 85

                        90       100       110
                ....*....|....*....|....*....|
gi 52317261 109 ITEFYFLASMALDRYVAICSPLHYSSRMSK 138
Cdd:cd14979  86 YATVLTIVALSVERYVAICHPLKAKTLVTK 115

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

32-133

1.74e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 39.53 E-value: 1.74e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  32 LAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQK-TISYAGCFTQCLLFIALVIT 110
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFSTA 87

                        90       100
                ....*....|....*....|...
gi 52317261 111 EFYFLASMALDRYVAICSPLHYS 133
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHS 110

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

34-145

2.34e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 39.16 E-value: 2.34e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  34 IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQK-TISYAGCFTQCLLFIALVITEF 112
Cdd:cd15217  10 IICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHAA 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 52317261 113 YFLASMALDRYVAICSPLHYSSRMSKNICISLV 145
Cdd:cd15217  90 FMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVI 122

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

31-170

2.42e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 38.95 E-value: 2.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  31 FLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNML-HNFLSEQKTISYAGCFTQCLLFIALVI 109
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLaYAFEPRGWVFGRFMCYFVFLMQPVTVY 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52317261 110 TEFYFLASMALDRYVAICSPLHysSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCG 170
Cdd:cd15394  87 VSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG 145

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

30-137

2.43e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 38.99 E-value: 2.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCL------L 103
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGPFETKLddimdsL 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 52317261 104 FIALVITEFYFLASMALDRYVAICSPLHYSSRMS 137
Cdd:cd15350  86 FCLSLLGSIFSILAIAADRYITIFHALRYHNIMT 119

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-137

2.62e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 39.01 E-value: 2.62e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  29 GVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLHNFLSEQKTISYAGCFTQC-----L 102
Cdd:cd15351   5 GLFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSvSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidT 84

                        90       100       110
                ....*....|....*....|....*....|....*
gi 52317261 103 LFIALVITEFYFLASMALDRYVAICSPLHYSSRMS 137
Cdd:cd15351  85 MICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMT 119

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

26-151

3.71e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 38.43 E-value: 3.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSnVTPNMLHNFLSEQKTisyagcFTQCLLFI 105
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWP------FGEVMCKI 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52317261 106 ALVI------TEFYFLASMALDRYVAICSPL----HYSSRMSKNICIS------LVTVPYMY 151
Cdd:cd14970  75 VLSVdaynmfTSIFCLTVMSVDRYLAVVHPVkslrFRTPRKAKLVSLCvwalslVLGLPVII 136

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

27-145

3.89e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 38.22 E-value: 3.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYSSRMS-KNICISLV 145
Cdd:cd15209  83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSlRNTCCYLC 122

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-296

4.50e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 38.11 E-value: 4.50e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTP----NMLHNFLSEQKTIsyagCFTQC 101
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPlaiiRQLLGYWPLGSHL----CDFWI 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 102 LLFIALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFLNGLSQTLLTFHLSFCGSLEinhfycad 181
Cdd:cd15061  77 SLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGS-------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 182 pplimlaCSDTRVKKMAMFVVAGftlssSLFIILLSYLFIFAAIFRIRSAEgrHKAFSTCASHLTIVTLFYGTLFCMYVR 261
Cdd:cd15061 149 -------CYYTYDKGYRIYSSMG-----SFFLPLLLMLFVYLRIFRVIAKE--RKTAKTLAIVVGCFIVCWLPFFIMYLI 214

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 52317261 262 PPSeKSVEESKIIAVFYTFL---SPMLNPLIYSLRNRD 296
Cdd:cd15061 215 EPF-CDCQFSEALSTAFTWLgyfNSVINPFIYAFYNKD 251

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

26-294

4.69e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 38.18 E-value: 4.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLA-IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLF 104
Cdd:cd15050   1 APLGIALStISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVtvpymygflnglsqtLLTFHLSFCGSLEI---NHFYCAD 181
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMI---------------SGAWLLSFLWVIPIlgwHHFARGG 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 182 PPLIMLACSDTRVKKMAMFVVAGFTLSSSL--FIILLSYLFIFAAIFRIRSAEGR----HKAFSTCasHLTIVTLFYGTL 255
Cdd:cd15050 146 ERVVLEDKCETDFHDVTWFKVLTAILNFYIpsLLMLWFYAKIFKAVNRERKAAKQlgfiMAAFILC--WIPYFILFMVIA 223

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317261 256 FCMYVRPPSeksveeSKIIAVFYTFLSPMLNPLIYSLRN 294
Cdd:cd15050 224 FCKNCCNEN------LHMFTIWLGYINSTLNPFIYPLCN 256

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

25-297

5.01e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 37.83 E-value: 5.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLhnfLSEQKT--ISYAGCFT-QC 101
Cdd:cd15102   1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL---LSGARTlrLSPAQWFLrEG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 102 LLFIALVITEFYFLAsMALDRYVAICSPLHY----SSRMSKNICISLVtVPYMYGFLNGLSQTLLTfHLSFCGSLEinhf 177
Cdd:cd15102  78 SMFVALSASVFSLLA-IAIERHLTMAKMKPYgaskTSRVLLLIGACWL-ISLLLGGLPILGWNCLG-ALDACSTVL---- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 178 ycadpPLImlacsdtrVKKMAMFVVAGFTlssslfIILLSYLFIFAAIFRIRSAEGRHKAFSTCASH-------LTIVTL 250
Cdd:cd15102 151 -----PLY--------SKHYVLFCVTIFA------GILAAIVALYARIYCLVRASGRKATRASASPRslallktVLIVLL 211

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 52317261 251 FY----GTLFCMYVRPPSEKSVEESKIIAVFYTF----LSPMLNPLIYSLRNRDV 297
Cdd:cd15102 212 VFiacwGPLFILLLLDVACPVKTCPILYKADWFLalavLNSALNPIIYTLRSREL 266

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

27-154

5.30e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 38.10 E-value: 5.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLA-IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFI 105
Cdd:cd15065   1 LIGIFLSlIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52317261 106 ALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGFL 154
Cdd:cd15065  81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

30-225

6.15e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 37.77 E-value: 6.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGC----FTQCLLFI 105
Cdd:cd15336   6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCelyaFCGALFGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 106 ALVITefyfLASMALDRYVAICSPLHYSSRMSKN---ICISLV-------TVPYMYGFLNGLSQTLLTF----HLSFCGS 171
Cdd:cd15336  86 TSMIT----LLAISLDRYLVITKPLASIRWVSKKramIIILLVwlyslawSLPPLFGWSAYVPEGLLTSctwdYMTFTPS 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 52317261 172 leiNHFYCadpplIMLACsdtrvkkmamfvvagFTLSSSLFIILLSYLFIFAAI 225
Cdd:cd15336 162 ---VRAYT-----MLLFC---------------FVFFIPLGIIIYCYLFIFLAI 192

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

29-79

7.14e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 37.58 E-value: 7.14e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 52317261  29 GVFLAIY-LITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTP 79
Cdd:cd15327   4 GVFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP 55

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

30-138

7.67e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 37.27 E-value: 7.67e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSS-NVTPNMLHNFLSEQKtISYAGCFTQCLLFIALV 108
Cdd:cd15390   6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAfNTVFNFTYLLYNDWP-FGLFYCKFSNFVAITTV 84

                        90       100       110
                ....*....|....*....|....*....|
gi 52317261 109 ITEFYFLASMALDRYVAICSPLHysSRMSK 138
Cdd:cd15390  85 AASVFTLMAISIDRYIAIVHPLR--PRLSR 112

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

27-296

8.18e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 37.22 E-value: 8.18e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIA 106
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 107 LVITEFYFLASMALDRYVAICSPLHYS-SRMSKNICISLVTVpymygflnglsqTLLTFHLSFcgsleinhfycadPPLI 185
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNlKRTPRRVKAIIVTV------------WLISAVISF-------------PPLI 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261 186 ML--ACSDTRVKKMAMFVVAGFTLSS---SLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYV 260
Cdd:cd15323 138 SMyrDPEGDVYPQCKLNDETWYILSScigSFFAPCLIMILVYIRIYRVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSL 217

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 52317261 261 RPPSEKSVEESKIIAVFYTFL---SPMLNPLIYSLRNRD 296
Cdd:cd15323 218 YGICREACEVPEPLFKFFFWIgycNSSLNPVIYTIFNQD 256

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

26-153

8.23e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 37.12 E-value: 8.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  26 ILFGVFLAiyLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHN-FLSEQKTISYAGCFTQCLLF 104
Cdd:cd15308   4 LVGGVLLI--LAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSeFQGGVWTLSPVLCDALMTMD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 52317261 105 IALVITEFYFLASMALDRYVAICSPLHYSSRMSKNICISLVTVPYMYGF 153
Cdd:cd15308  82 VMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSF 130

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

30-134

9.04e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 37.23 E-value: 9.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLcMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVI 109
Cdd:cd14978   6 VLPVICIFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPLA 84

                        90       100       110
                ....*....|....*....|....*....|
gi 52317261 110 TEF-----YFLASMALDRYVAICSPLHYSS 134
Cdd:cd14978  85 NTFqtasvWLTVALTVERYIAVCHPLKART 114

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

25-135

9.06e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 37.08 E-value: 9.06e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  25 KILFGVFLA-IYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYSSNVTPnmlhnfLSEQKTISYAGCFTQ--C 101
Cdd:cd15333   4 KISLAVLLAlITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP------ISIVYTVTGTWTLGQvvC 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 52317261 102 LLFIALVIT----EFYFLASMALDRYVAICSPLHYSSR 135
Cdd:cd15333  78 DIWLSSDITcctaSILHLCVIALDRYWAITDAVEYSKK 115

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-147

9.83e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 37.18 E-value: 9.83e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  30 VFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICYS-SNVTPNMLHNFLS------EQKTISYAGCFTQCL 102
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvSNSLETIMIAVLNsgylviSDQFIQHMDNVFDSM 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 52317261 103 LFIALVITEFYFLAsMALDRYVAICSPLHYSSRMSKNICISLVTV 147
Cdd:cd15352  86 ICISLVASICNLLA-IAVDRYVTIFYALRYHSIMTVRKALVLIAV 129

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

27-134

9.97e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 37.04 E-value: 9.97e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317261  27 LFGVFLAIYLITLAGNLCMILLIRTNSQLQTPMYFFLGHLSFVDICySSNVTPNMLHnfLSEQKTISYAGCFtqcllfIA 106
Cdd:cd15905   1 IFWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLL-TGVALPFIPG--MSNESRRGYHSCL------FV 71

                        90       100       110
                ....*....|....*....|....*....|....
gi 52317261 107 LVITEFYFLASMA------LDRYVAICSPLHYSS 134
Cdd:cd15905  72 YVAPNFLFLSFLAnllmvhYERYLCIVYPLQYHN 105

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01