|
Name |
Accession |
Description |
Interval |
E-value |
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
138-509 |
1.00e-154 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 448.41 E-value: 1.00e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 138 PNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLL 216
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 217 EYVTLKKMREIIGWP----GGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALP-----RLIAFTSEHSHFSLKK 287
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaeflGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSsgilaKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 288 GAAALGIGtdsVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAW 367
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 368 GGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFqqdkHYDLSYDTGDKALQCG 447
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLG----HTDSAYDTGHKQIPLS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503875 448 RHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFdgKPQHTNVCFWYI 509
Cdd:pfam00282 314 RRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICA--EVGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
178-581 |
3.19e-145 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 423.15 E-value: 3.19e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 178 YFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFK 257
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 258 MFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIgtdSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAG 337
Cdd:cd06450 81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 338 TTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVReeglmqn 417
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 418 cnqmhasylfqqdkhydlsydtgdkalqcgrhvdVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdG 497
Cdd:cd06450 231 ----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL--G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 498 KPQHTNVCFWYIPPslrtledneermSRLSKVAPVIKARMMEYGTTMVSYQPLGDKvNFFRMVISNPAATHQDIDFLIEE 577
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLED 341
|
....
gi 4503875 578 IERL 581
Cdd:cd06450 342 IERA 345
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
111-584 |
1.09e-141 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 418.47 E-value: 1.09e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 111 LQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEIL--MHcQTTLKYAIKTGHPRYFNQLSTGLDM 188
Cdd:COG0076 2 FRALLHQALDLAADYLAGLDRPVFGPSPEELRAALDEPLPEEGLPPEEALaeLE-DLVLPGSVDWNHPRFLAFVTGGTTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 189 VGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSgDGIFSPGGAISNMYAMMIARFKMFPE-VKEKGM 267
Cdd:COG0076 81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA-GGVFTSGGTEANLLALLAARDRALARrVRAEGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 268 AALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPL 347
Cdd:COG0076 160 PGAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 348 LAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLF 427
Cdd:COG0076 240 AEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 428 QQDkhyDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdGKPQHTNVCFW 507
Cdd:COG0076 320 PAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELL--APPELNIVCFR 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503875 508 YIPPSLRTL-EDNEErmsrlskvapvIKARMMEYGTTMVSYQPLGDKVNfFRMVISNPAATHQDIDFLIEEIERLGQD 584
Cdd:COG0076 395 YKPAGLDEEdALNYA-----------LRDRLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
151-571 |
1.67e-41 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 157.56 E-value: 1.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 151 DQPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIG 229
Cdd:PLN02590 105 ERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQ 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 230 WPG-----GSGDGIFSPGGAISNMYAMMIARFKMFPEVkekGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKC 304
Cdd:PLN02590 185 LPDhflstGNGGGVIQGTGCEAVLVVVLAARDRILKKV---GKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKT 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 305 DERGK--MIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLS 382
Cdd:PLN02590 262 DSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFID 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 383 GVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAK 462
Cdd:PLN02590 342 GIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLY 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 463 GTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdGKPQHTNVCFWYIPpslrtLEDNEERMSRLSKvapVIKARMMEYGT 542
Cdd:PLN02590 422 GSENLRNFIRDHVNLAKHFEDYVAQDPSFEVV--TTRYFSLVCFRLAP-----VDGDEDQCNERNR---ELLAAVNSTGK 491
|
410 420
....*....|....*....|....*....
gi 4503875 543 TMVSYQPLGDKVnFFRMVISNPAATHQDI 571
Cdd:PLN02590 492 IFISHTALSGKF-VLRFAVGAPLTEEKHV 519
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
138-509 |
1.00e-154 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 448.41 E-value: 1.00e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 138 PNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLL 216
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 217 EYVTLKKMREIIGWP----GGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALP-----RLIAFTSEHSHFSLKK 287
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaeflGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSsgilaKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 288 GAAALGIGtdsVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAW 367
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 368 GGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFqqdkHYDLSYDTGDKALQCG 447
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLG----HTDSAYDTGHKQIPLS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4503875 448 RHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFdgKPQHTNVCFWYI 509
Cdd:pfam00282 314 RRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICA--EVGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
178-581 |
3.19e-145 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 423.15 E-value: 3.19e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 178 YFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFK 257
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 258 MFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIgtdSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAG 337
Cdd:cd06450 81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 338 TTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVReeglmqn 417
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 418 cnqmhasylfqqdkhydlsydtgdkalqcgrhvdVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdG 497
Cdd:cd06450 231 ----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL--G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 498 KPQHTNVCFWYIPPslrtledneermSRLSKVAPVIKARMMEYGTTMVSYQPLGDKvNFFRMVISNPAATHQDIDFLIEE 577
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLED 341
|
....
gi 4503875 578 IERL 581
Cdd:cd06450 342 IERA 345
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
111-584 |
1.09e-141 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 418.47 E-value: 1.09e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 111 LQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEIL--MHcQTTLKYAIKTGHPRYFNQLSTGLDM 188
Cdd:COG0076 2 FRALLHQALDLAADYLAGLDRPVFGPSPEELRAALDEPLPEEGLPPEEALaeLE-DLVLPGSVDWNHPRFLAFVTGGTTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 189 VGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSgDGIFSPGGAISNMYAMMIARFKMFPE-VKEKGM 267
Cdd:COG0076 81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA-GGVFTSGGTEANLLALLAARDRALARrVRAEGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 268 AALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPL 347
Cdd:COG0076 160 PGAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 348 LAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLF 427
Cdd:COG0076 240 AEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 428 QQDkhyDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdGKPQHTNVCFW 507
Cdd:COG0076 320 PAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELL--APPELNIVCFR 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503875 508 YIPPSLRTL-EDNEErmsrlskvapvIKARMMEYGTTMVSYQPLGDKVNfFRMVISNPAATHQDIDFLIEEIERLGQD 584
Cdd:COG0076 395 YKPAGLDEEdALNYA-----------LRDRLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
151-571 |
1.67e-41 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 157.56 E-value: 1.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 151 DQPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIG 229
Cdd:PLN02590 105 ERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQ 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 230 WPG-----GSGDGIFSPGGAISNMYAMMIARFKMFPEVkekGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKC 304
Cdd:PLN02590 185 LPDhflstGNGGGVIQGTGCEAVLVVVLAARDRILKKV---GKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKT 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 305 DERGK--MIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLS 382
Cdd:PLN02590 262 DSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFID 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 383 GVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAK 462
Cdd:PLN02590 342 GIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLY 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 463 GTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdGKPQHTNVCFWYIPpslrtLEDNEERMSRLSKvapVIKARMMEYGT 542
Cdd:PLN02590 422 GSENLRNFIRDHVNLAKHFEDYVAQDPSFEVV--TTRYFSLVCFRLAP-----VDGDEDQCNERNR---ELLAAVNSTGK 491
|
410 420
....*....|....*....|....*....
gi 4503875 543 TMVSYQPLGDKVnFFRMVISNPAATHQDI 571
Cdd:PLN02590 492 IFISHTALSGKF-VLRFAVGAPLTEEKHV 519
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
151-527 |
6.93e-35 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 137.73 E-value: 6.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 151 DQPQNLEEILMHCQTTLKYAIKTGH-PRYF--------------NQLSTGLDMVGLAadWLTSTANTNmftyeiapvfvl 215
Cdd:PLN02880 57 NQPETLDQVLDDVQAKILPGVTHWQsPNYFayypsnssvagflgEMLSAGLNIVGFS--WITSPAATE------------ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 216 LEYVTLKKMREIIGWP-----GGSGDGIFSPGGAISNMYAMMIARFKMfpeVKEKGMAALPRLIAFTSEHSHFSLKKGAA 290
Cdd:PLN02880 123 LEMIVLDWLAKLLNLPeqflsTGNGGGVIQGTASEAVLVVLLAARDRV---LRKVGKNALEKLVVYASDQTHSALQKACQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 291 ALGIGTDSVILIK--CDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWG 368
Cdd:PLN02880 200 IAGIHPENCRLLKtdSSTNYALAPELLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 369 GGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGR 448
Cdd:PLN02880 280 GSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503875 449 HVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVfdGKPQHTNVCFWYIPPSlrtleDNEERMSRLS 527
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV--TPRIFSLVCFRLVPPK-----NNEDNGNKLN 431
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
237-489 |
6.15e-21 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 95.11 E-value: 6.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 237 GIFSPGGAISNMYAMMIARfKMFPEVkekgmaalprlIAFTSEHSHFSLKKGAAALGIGTDsviLIKCDERGKMIPSDLE 316
Cdd:PRK02769 87 GYITNGGTEGNLYGCYLAR-ELFPDG-----------TLYYSKDTHYSVSKIARLLRIKSR---VITSLPNGEIDYDDLI 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 317 RRILEAKQKgfvPFLVSATAGTTVYGAFDPLLAVADICKKYKI---WMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWN 393
Cdd:PRK02769 152 SKIKENKNQ---PPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSGMILPFVNNPPPFSFADGIDSIAIS 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 394 PHKMMGVPLQCSALLVREEGLMQNcnqmhasylfqqdkHYDLSY-DTGDKALQCGR--HVDVFkLWLMWRAKGTTGFEAH 470
Cdd:PRK02769 229 GHKFIGSPMPCGIVLAKKKYVERI--------------SVDVDYiGSRDQTISGSRngHTALL-LWAAIRSLGSKGLRQR 293
|
250
....*....|....*....
gi 4503875 471 VDKCLELAEYLYNIIKNRE 489
Cdd:PRK02769 294 VQHCLDMAQYAVDRLQANG 312
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
266-481 |
3.54e-13 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 71.40 E-value: 3.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 266 GMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIkcdERGKMIPSDLERRILEAKQKgfvPFLVSATAGTTVYGAFD 345
Cdd:PLN03032 105 GREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTL---PSGEIDYDDLERALAKNRDK---PAILNVNIGTTVKGAVD 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 346 PLLAVADICKKYKI-----WMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQncnq 420
Cdd:PLN03032 179 DLDRILRILKELGYtedrfYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRKKHVKA---- 254
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503875 421 mhasylFQQDKHYDLSYDTGDKALQCGrHVDVFkLWLMWRAKGTTGFEAHVDKCLELAEYL 481
Cdd:PLN03032 255 ------LSQNVEYLNSRDATIMGSRNG-HAPLY-LWYTLRRKGYRGIKRDVQHCMRNAHYL 307
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
266-481 |
9.17e-12 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 67.53 E-value: 9.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 266 GMAALPRLIAFTSEHSHFSLKKGAAALGIGtdsVILIKCDERGKMIPSDLERRILEAKQKgfvPFLVSATAGTTVYGAFD 345
Cdd:PLN02263 172 GREVFPDGILYASRESHYSVFKAARMYRME---CVKVDTLVSGEIDCADFKAKLLANKDK---PAIINVNIGTTVKGAVD 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 346 PLLAVADICKKY-----KIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEglmqncnq 420
Cdd:PLN02263 246 DLDLVIKTLEECgfsqdRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRME-------- 317
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503875 421 mHASYLfQQDKHYDLSYDTGDKALQCGrHVDVFkLWLMWRAKGTTGFEAHVDKCLELAEYL 481
Cdd:PLN02263 318 -HINVL-SSNVEYLASRDATIMGSRNG-HAPIF-LWYTLNRKGYRGFQKEVQKCLRNAHYL 374
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
309-410 |
3.71e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.01 E-value: 3.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 309 KMIPSD------LERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGllmSRKHKWKLS 382
Cdd:cd01494 67 VPVPVDdagyggLDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGG---ASPAPGVLI 143
|
90 100
....*....|....*....|....*...
gi 4503875 383 GVERANSVTWNPHKMMGVPlQCSALLVR 410
Cdd:cd01494 144 PEGGADVVTFSLHKNLGGE-GGGVVIVK 170
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
280-366 |
2.02e-04 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 43.36 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 280 HSHFSLKKGAAALGIGTdsVILIKCDERGKMIPSDLERRILEAKQKGFVPF-LVSAT-----AGTTVYgAFDPLLAVADI 353
Cdd:pfam01212 81 HIHFDETGGHAELGGVQ--PRPLDGDEAGNMDLEDLEAAIREVGADIFPPTgLISLEnthnsAGGQVV-SLENLREIAAL 157
|
90
....*....|...
gi 4503875 354 CKKYKIWMHVDAA 366
Cdd:pfam01212 158 AREHGIPVHLDGA 170
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
302-506 |
1.77e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 41.08 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 302 IKCDERGKMIPSDLERRILEaKQKgfvpfLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGgglLMSRKHKWKL 381
Cdd:pfam00266 119 LPLDEDGLLDLDELEKLITP-KTK-----LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQA---IGHRPIDVQK 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 382 SGVERANSVTwnpHKMMGvPLQCSALLVREEGLmqncNQMH-----ASYLFQQDKHYDLSYDTGDK----------ALQC 446
Cdd:pfam00266 190 LGVDFLAFSG---HKLYG-PTGIGVLYGRRDLL----EKMPpllggGGMIETVSLQESTFADAPWKfeagtpniagIIGL 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 447 GRHVDvfklWLMwrakgTTGFEAHVDKCLELAEYLYNIIKNREGYEmVFDGKPQHTNVCF 506
Cdd:pfam00266 262 GAALE----YLS-----EIGLEAIEKHEHELAQYLYERLLSLPGIR-LYGPERRASIISF 311
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
339-424 |
3.28e-03 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 39.92 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503875 339 TVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMS---RKHKWKLSGVERANSVtwnpHKMMGVPLQCSALLVREEGL- 414
Cdd:cd00615 164 TYYGICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHpilPSSAAMAGADIVVQST----HKTLPALTQGSMIHVKGDLVn 239
|
90
....*....|...
gi 4503875 415 ---MQNCNQMHAS 424
Cdd:cd00615 240 pdrVNEALNLHQS 252
|
|
| |
