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Conserved domains on  [gi|1813836565|ref|NP_000050|]
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breast cancer type 2 susceptibility protein isoform 1 [Homo sapiens]

Protein Classification

BRCA-2_helical and BRCA2DBD_OB2 domain-containing protein( domain architecture ID 11101627)

protein containing domains BRCA-2_helical, BRCA2DBD_OB1, BRCA2DBD_OB2, and BRCA2DBD_OB3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2481-2667 3.95e-112

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462700  Cd Length: 187  Bit Score: 354.34  E-value: 3.95e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2481 ITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESF 2560
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2561 QFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK 2640
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1813836565 2641 EFANRCLSPERVLLQLKYRYDTEIDRS 2667
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2804-3054 4.99e-107

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


:

Pssm-ID: 239940  Cd Length: 251  Bit Score: 342.89  E-value: 4.99e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2804 PLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKP 2883
Cdd:cd04494      1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2884 YLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLS 2963
Cdd:cd04494     81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2964 RDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDE 3043
Cdd:cd04494    161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                          250
                   ....*....|.
gi 1813836565 3044 ILFQIYQPREP 3054
Cdd:cd04494    241 ELFQPFQPRKA 251
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3052-3186 9.48e-72

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


:

Pssm-ID: 462679  Cd Length: 139  Bit Score: 236.79  E-value: 9.48e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 3052 REPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLN----EDIIKPHMLIAASNLQW 3127
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1813836565 3128 RPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHA 3186
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2670-2796 2.42e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462678  Cd Length: 123  Bit Score: 212.04  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2670 SAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSnktsSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQ 2749
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGS----GTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1813836565 2750 KIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP 2796
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1216-1243 3.73e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 48.60  E-value: 3.73e-07
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 1216 FRGFYSAHGTKLNVSTEALQKAVKLFSD 1243
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1974-2002 7.78e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.83  E-value: 7.78e-07
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1974 TCGIFSTASGKSVQVSDASLQNARQVFSE 2002
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1522-1548 2.62e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.62e-06
                           10        20
                   ....*....|....*....|....*..
gi 1813836565 1522 LGFHTASGKKVKIAKESLDKVKNLFDE 1548
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1424-1452 1.15e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1424 SDTFFQTASGKNISVAKESFNKIVNFFDQ 1452
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1005-1033 5.57e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.57e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1005 FGGSFRTASNKEIKLSEHNIKKSKMFFKD 1033
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1667-1695 2.01e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.01e-04
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1667 SALAFYTSCSRKTSVSQTSLLEAKKWLRE 1695
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2055-2082 8.28e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.97  E-value: 8.28e-04
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 2055 FSGFSTASGKQVSILESSLHKVKGVLEE 2082
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2481-2667 3.95e-112

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 354.34  E-value: 3.95e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2481 ITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESF 2560
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2561 QFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK 2640
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1813836565 2641 EFANRCLSPERVLLQLKYRYDTEIDRS 2667
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2804-3054 4.99e-107

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 342.89  E-value: 4.99e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2804 PLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKP 2883
Cdd:cd04494      1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2884 YLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLS 2963
Cdd:cd04494     81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2964 RDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDE 3043
Cdd:cd04494    161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                          250
                   ....*....|.
gi 1813836565 3044 ILFQIYQPREP 3054
Cdd:cd04494    241 ELFQPFQPRKA 251
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3052-3186 9.48e-72

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 236.79  E-value: 9.48e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 3052 REPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLN----EDIIKPHMLIAASNLQW 3127
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1813836565 3128 RPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHA 3186
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2670-2796 2.42e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 212.04  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2670 SAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSnktsSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQ 2749
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGS----GTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1813836565 2750 KIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP 2796
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2682-2794 6.79e-44

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 155.46  E-value: 6.79e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2682 AAKTLVLCVSDIISLsanisETSSNKTSsadtqkvaIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGS 2761
Cdd:cd04493      1 ASRLMVLCVSGINSE-----ERLSPHMP--------IIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1813836565 2762 PDACTPLEAPESLMLKISANSTRPARWYTKLGF 2794
Cdd:cd04493     68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3073-3167 5.79e-38

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 138.69  E-value: 5.79e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 3073 DLIGFVVSVVK-KTGLAPFVYLSDECYNLLAIKFWIDL----NEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFS 3147
Cdd:cd04495      1 DTVGVVISVGKpIEGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVVKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFS 80

                           90       100
                   ....*....|....*....|
gi 1813836565 3148 ASPKEGHFQETFNKMKNTVE 3167
Cdd:cd04495     81 ANPKESHLQEEFNNLKHLIE 100
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1216-1243 3.73e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 48.60  E-value: 3.73e-07
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 1216 FRGFYSAHGTKLNVSTEALQKAVKLFSD 1243
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1974-2002 7.78e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.83  E-value: 7.78e-07
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1974 TCGIFSTASGKSVQVSDASLQNARQVFSE 2002
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2831-2870 1.49e-06

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 47.36  E-value: 1.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1813836565 2831 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQ 2870
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQ 40
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1522-1548 2.62e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.62e-06
                           10        20
                   ....*....|....*....|....*..
gi 1813836565 1522 LGFHTASGKKVKIAKESLDKVKNLFDE 1548
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1424-1452 1.15e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1424 SDTFFQTASGKNISVAKESFNKIVNFFDQ 1452
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1005-1033 5.57e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.57e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1005 FGGSFRTASNKEIKLSEHNIKKSKMFFKD 1033
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1667-1695 2.01e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.01e-04
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1667 SALAFYTSCSRKTSVSQTSLLEAKKWLRE 1695
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2055-2082 8.28e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.97  E-value: 8.28e-04
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 2055 FSGFSTASGKQVSILESSLHKVKGVLEE 2082
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2481-2667 3.95e-112

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 354.34  E-value: 3.95e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2481 ITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESF 2560
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2561 QFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK 2640
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1813836565 2641 EFANRCLSPERVLLQLKYRYDTEIDRS 2667
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2804-3054 4.99e-107

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 342.89  E-value: 4.99e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2804 PLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKP 2883
Cdd:cd04494      1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2884 YLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLS 2963
Cdd:cd04494     81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2964 RDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDE 3043
Cdd:cd04494    161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                          250
                   ....*....|.
gi 1813836565 3044 ILFQIYQPREP 3054
Cdd:cd04494    241 ELFQPFQPRKA 251
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3052-3186 9.48e-72

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 236.79  E-value: 9.48e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 3052 REPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLN----EDIIKPHMLIAASNLQW 3127
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1813836565 3128 RPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHA 3186
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2670-2796 2.42e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 212.04  E-value: 2.42e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2670 SAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSnktsSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQ 2749
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGS----GTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1813836565 2750 KIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP 2796
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2682-2794 6.79e-44

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 155.46  E-value: 6.79e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 2682 AAKTLVLCVSDIISLsanisETSSNKTSsadtqkvaIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGS 2761
Cdd:cd04493      1 ASRLMVLCVSGINSE-----ERLSPHMP--------IIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1813836565 2762 PDACTPLEAPESLMLKISANSTRPARWYTKLGF 2794
Cdd:cd04493     68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3073-3167 5.79e-38

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 138.69  E-value: 5.79e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1813836565 3073 DLIGFVVSVVK-KTGLAPFVYLSDECYNLLAIKFWIDL----NEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFS 3147
Cdd:cd04495      1 DTVGVVISVGKpIEGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVVKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFS 80

                           90       100
                   ....*....|....*....|
gi 1813836565 3148 ASPKEGHFQETFNKMKNTVE 3167
Cdd:cd04495     81 ANPKESHLQEEFNNLKHLIE 100
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1216-1243 3.73e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 48.60  E-value: 3.73e-07
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 1216 FRGFYSAHGTKLNVSTEALQKAVKLFSD 1243
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1974-2002 7.78e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.83  E-value: 7.78e-07
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1974 TCGIFSTASGKSVQVSDASLQNARQVFSE 2002
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2831-2870 1.49e-06

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 47.36  E-value: 1.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1813836565 2831 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQ 2870
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQ 40
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1522-1548 2.62e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.62e-06
                           10        20
                   ....*....|....*....|....*..
gi 1813836565 1522 LGFHTASGKKVKIAKESLDKVKNLFDE 1548
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1424-1452 1.15e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1424 SDTFFQTASGKNISVAKESFNKIVNFFDQ 1452
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1005-1033 5.57e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.57e-05
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1005 FGGSFRTASNKEIKLSEHNIKKSKMFFKD 1033
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1667-1695 2.01e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.01e-04
                           10        20
                   ....*....|....*....|....*....
gi 1813836565 1667 SALAFYTSCSRKTSVSQTSLLEAKKWLRE 1695
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2055-2082 8.28e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.97  E-value: 8.28e-04
                           10        20
                   ....*....|....*....|....*...
gi 1813836565 2055 FSGFSTASGKQVSILESSLHKVKGVLEE 2082
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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