|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1649-2858 |
0e+00 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 904.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1649 IRKESGKKSDNSLKGNGNTYNNNCNNS-----MREEYANQNGETCKFNETFWSKKKPSIEECDINAKERFQIQKYWDCNG 1723
Cdd:PTZ00176 28 DKRENESKYTDKLKGSLWEARFSDGLSssfgdVRSGYYDSCSLDHKFHTNINNGYPPARNPCDGRNQNRFDENGESYCNS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1724 -KTPDGKNTF----CIPPRRKDMCLKQLEEINSADVNNSKKLLQKIQDVAKKEGDDIIKKLLPKypcNEDVICKAMKYSF 1798
Cdd:PTZ00176 108 dKIRGNENNSnagaCAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDK---DKSSVCTALARSF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1799 ADLADIVRGIDKYKgPNGTNVLEKELKSVFETIYTKWKSENTnnKSKYTDVAS-----FRSAWWDANRKDIWNAMTCNAP 1873
Cdd:PTZ00176 185 ADIGDIVRGKDMFK-RNKHDNVENGLREVFKKIYEGLKNNGA--REHYKEVKNgnyikLREDWWTANRDQVWKAMTCVAP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1874 YDAKIYITK-EGGYISPLTFTKNKCGHNDDPPDYDYIPQPFRWLSEWSETYC-LAQKDLLETMKNCENC-MKKNKNADce 1950
Cdd:PTZ00176 262 ENAYFRKTEaDGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFCnVLNKEIDEMNNQCKDCeMSRRCNND-- 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1951 qTQYGACRDCKRKCEEYKKFIEIWKKQFETQNKAYQEIYRNATTTNRDNNNIV----------------DENTKNFVKKL 2014
Cdd:PTZ00176 340 -TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQNSSApergyrrnhrrrgyddDTNVQLFLKKV 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2015 QENcrtdrNE-SLDTADKYLENASVCRRFKFG--NKDSRHLNYAFHTDPPSYEEHCKCaKDFDPLDECPVDNNE--CKKY 2089
Cdd:PTZ00176 419 IEN-----NEcKVESLGKYLDKTSHCGNYNFNydNTPGSNRSNAFEITPEKFKKACKC-KIPNPLEKCPNEENKnvCTRF 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2090 G-IGSCPKKNFHKKLEEWTNYVLNNKSNKNKSAIVPPRRRQLCLQNLTRNLSRLNKEKSFKEGILISAASEAKMLTEQYR 2168
Cdd:PTZ00176 493 DkVYSCTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2169 ENPAKALQAIKYSFADIGNIIKGDDIIGNV--ISVQLNKLINGNKKINTST---LWWEANKEKIWNAMMCYYTGDEKTAT 2243
Cdd:PTZ00176 573 NYSNEAYEAMKFSYADYSDIVKGTDMMNDLkkLNKELNTLLKETEKGDISVdrkTWWDDNKNVVWNAMLCGYKTENENQQ 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2244 SCPSHGNI---DKEDQFLLWFQEWGENFCaRQKELYEHV-QAECSHVicVNGTGN------IDSKCTEACKNYSNFISET 2313
Cdd:PTZ00176 653 LNSSWCNVpddDNIDQFLRWLTEWAQQYC-KEKLIKAHIiNTKCKDI--VEGRKHksmvdiTDVECKRLFIDYEEWFRYR 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2314 KNVYQSLKKQY----NDNHNSIKVGGKE-VHHYMKEKCkDKCEC-------LSEKFNSDNNWEKPYDT---FDDTVLKNK 2378
Cdd:PTZ00176 730 YNQWKGLSEKYikikKSKNSGVNIPSEEcAASYVTKHC-NGCICnlrdmedIHKNINNQNELMKEMINiikFDTDQYRTQ 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2379 CQCKKPDSPILPVEPSVPAETEKE-----------------------KKKDSPLKPHTEPKPAPPKKPEVPppppvqppp 2435
Cdd:PTZ00176 809 LQNISNSMEINPKSVKTAVDTTKDivsyglagtmgvaaiglqagdflGKKIQDLYNEFMKPVEKKLDTSSK--------- 879
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2436 anqpfNRDILEK---TIPFGIALALGSIAFLF-IKKKPKSPVDLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYI 2511
Cdd:PTZ00176 880 -----NLNIYEDpniMVPAGIGVALTLGLLLFkMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYL 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2512 YMEGDSDSGHYY--EDTTDITSSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT----PSSDAPMNKFTDDEWNQL 2585
Cdd:PTZ00176 955 YVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTqndiPSDNTPSYKLTDEEWNQL 1034
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2586 KQDFISGILENEQkdlPKNNI-SGNTPMNTQPNTLYFNKPEEKPFITSIHDRDLYSGEEINYNINMSTNSMDDTSYVSNN 2664
Cdd:PTZ00176 1035 KDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEISYNINMSTNTMDDPKYVSNN 1111
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2665 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNYKKNTSNNNVAKLT-NSDPIMNQLDLLHKWLDRHRDMCEKWKSK 2743
Cdd:PTZ00176 1112 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKWENH 1191
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2744 EDILHKLNEQWNKDNDGGNVPIDNRSLNTDVWIEIDMDDPKGKKEFSNMDT-----ILDDIEDDIYYDVNDDEN----PS 2814
Cdd:PTZ00176 1192 HERLAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDInvdtpTMDNMEDDIYYDVNDNDDdndqPS 1271
|
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*.
gi 23499282 2815 VDNIPMDHNK--VDVPKKVHVEMKILNNTSNGSLEPEFPISDVWNI 2858
Cdd:PTZ00176 1272 VYDIPMDHNKvdVDVPKKVHIEMKILNNTSNGSLEQQFPISDVWNI 1317
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-404 |
8.45e-75 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 276.53 E-value: 8.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 12 SDVKNESHNSARNVFENIAEIIYNRVKEDAEKRGKsLKGDYKRAKFHQPLLEAAKYVWYAPSNPCNFDFRFDTNAPDKGS 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESKYTDK-LKGSLWEARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 92 YDRDPCHLRDTNRFSDKGDAICTNNKI--NCNNGGCGACAPYRRIQLCDYNLEYINEYNINSTHDLLGNLLVMAKREGDS 169
Cdd:PTZ00176 84 PARNPCDGRNQNRFDENGESYCNSDKIrgNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGES 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 170 IVNSHGHTGkgiyKSGICTSLARSFADIGDIIRGKDLFLGHNHkkkpllDNLEK-IFNRFQKIYEDINNLPIDD------ 242
Cdd:PTZ00176 164 IVNNHPDKD----KSSVCTALARSFADIGDIVRGKDMFKRNKH------DNVENgLREVFKKIYEGLKNNGAREhykevk 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 243 ------IREYWWALNRNDVWEALTCSAPYYAdYFKKKSGNTYNFT----TEGYCGRNEGAPPtnLDYVPQFLRWFDEWAE 312
Cdd:PTZ00176 234 ngnyikLREDWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISslilPYSKCGRDTDPPV--VDYIPQRLRWMSEWSE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 313 EFCRIKNIKIGNIKKSCTgesnnkhcsregyDCNKTNlRLNEIFMDLECPRCADDCKSYETWVENKKKEFNKQKEKYKEE 392
Cdd:PTZ00176 311 YFCNVLNKEIDEMNNQCK-------------DCEMSR-RCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMEL 376
|
410
....*....|..
gi 23499282 393 INESKPGVNSEH 404
Cdd:PTZ00176 377 YNKASTNITKQN 388
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
853-1567 |
1.39e-64 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 243.79 E-value: 1.39e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 853 GHRDYKGPCTGKDGHKKMFQVEKGWENGSKIGTEND----VFLPPRREHFCTSNVEHLYRsasglQGTTASHSLLGDVLL 928
Cdd:PTZ00176 81 GYPPARNPCDGRNQNRFDENGESYCNSDKIRGNENNsnagACAPFRRQNMCDKNLEYLIN-----KNTENTHDLLGNVLV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 929 AANKEAGFIKERYKTQKTSEgfkdeatVCRAIKYSFADIADIIKGTDLWKANSgKKNTQDKLVKIFQKIKDNLPVN-IKG 1007
Cdd:PTZ00176 156 TAKYEGESIVNNHPDKDKSS-------VCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNgARE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1008 KYNEDE--KHLELRKDWWFANRDKVWEAMKC-----------EQNGI----------TCSGPT--PLDDYIPQRLRWMTE 1062
Cdd:PTZ00176 228 HYKEVKngNYIKLREDWWTANRDQVWKAMTCvapenayfrktEADGIgisslilpysKCGRDTdpPVVDYIPQRLRWMSE 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1063 WAEWYCKAQKEAYDKLK-VCEKCMDNGKC---TQGnGECAKCKTACENYKKFINTWQPQWKQMEQKYESLYKEAQEN--- 1135
Cdd:PTZ00176 308 WSEYFCNVLNKEIDEMNnQCKDCEMSRRCnndTEG-EKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitk 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1136 GNSS---------HKSTTEQDKYMVEFLSQLQKANNGDKTgddkvystaagyvhqEATMNCEKQTQFCKNKNGVKAANDA 1206
Cdd:PTZ00176 387 QNSSapergyrrnHRRRGYDDDTNVQLFLKKVIENNECKV---------------ESLGKYLDKTSHCGNYNFNYDNTPG 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1207 EDVNYTFKDTPNGYDVVCKCK-DRPEQQIKKKEVEDACKIAQDIFkgkdenTTVGLCKKKDFGRTPYPDWKCEKNSKlvt 1285
Cdd:PTZ00176 452 SNRSNAFEITPEKFKKACKCKiPNPLEKCPNEENKNVCTRFDKVY------SCTSLSFKNDLSEWNNSGVKNKENDN--- 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1286 gNGECMPPRRQKLCLYFLAHKieTPNLNTQEDLRKAFIKCAAAETFFswyYFKKINDKLNKLDEKLKegeippqflrsmf 1365
Cdd:PTZ00176 523 -NGVLVPPRRRNLCINLFSKK--DYKMKDENDFKEDLLNAAFSQGKL---LGKKYSNYSNEAYEAMK------------- 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1366 YTFGDYKDICLDTDISlktenGDITKAKSNIDRIIPKKSAKNPDEERKIWWDGIKEDVWEGMLCGLSHAVSNNdkatvQK 1445
Cdd:PTZ00176 584 FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDISVDRKTWWDDNKNVVWNAMLCGYKTENENQ-----QL 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1446 TLTTKTIYDYDTVTfdgttkledfskrpQFLRWMTEWGEEFCKKRKEQLENLKDKCPD------YTCSFDTKKQECENHC 1519
Cdd:PTZ00176 654 NSSWCNVPDDDNID--------------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDivegrkHKSMVDITDVECKRLF 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 23499282 1520 KVYEEWLKGWKDQYKKQSEKFTtdKEKPEYKDDPDVASSENAHKYLSK 1567
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYI--KIKKSKNSGVNIPSEECAASYVTK 765
|
|
| PFEMP super family |
cl03834 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
566-706 |
2.56e-26 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
The actual alignment was detected with superfamily member pfam03011:
Pssm-ID: 281064 Cd Length: 154 Bit Score: 107.20 E-value: 2.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 566 FIKRWLESFLKDYNKLKENLNPCINNENQLPCIKDCLENCDCVEKWIKKKGEEWKKIKERYLKDYKIE-----DNNSSNS 640
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKgltgkTLDEYLD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23499282 641 LNKFLQQNQFHSDVVKAIKPFENLRAFEDSSGCTGTVPSGIEEC--KSNDVIKILLSKLKEKIELCKK 706
Cdd:pfam03011 81 LKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAKnnKNEDAIDKLLDKEEKKANNCKE 148
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
499-550 |
7.07e-15 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
:
Pssm-ID: 408346 Cd Length: 52 Bit Score: 70.76 E-value: 7.07e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 23499282 499 TFVIDILLNDNKKKVLSNDLNDYKECDLFKRLRRQNWNCKYKCNLHVCELNN 550
Cdd:pfam18562 1 TTTIDMLVSDNRGIKFENDLKECKEAGIFKGIRKDQWKCGKVCGYDVCKLKN 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1649-2858 |
0e+00 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 904.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1649 IRKESGKKSDNSLKGNGNTYNNNCNNS-----MREEYANQNGETCKFNETFWSKKKPSIEECDINAKERFQIQKYWDCNG 1723
Cdd:PTZ00176 28 DKRENESKYTDKLKGSLWEARFSDGLSssfgdVRSGYYDSCSLDHKFHTNINNGYPPARNPCDGRNQNRFDENGESYCNS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1724 -KTPDGKNTF----CIPPRRKDMCLKQLEEINSADVNNSKKLLQKIQDVAKKEGDDIIKKLLPKypcNEDVICKAMKYSF 1798
Cdd:PTZ00176 108 dKIRGNENNSnagaCAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDK---DKSSVCTALARSF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1799 ADLADIVRGIDKYKgPNGTNVLEKELKSVFETIYTKWKSENTnnKSKYTDVAS-----FRSAWWDANRKDIWNAMTCNAP 1873
Cdd:PTZ00176 185 ADIGDIVRGKDMFK-RNKHDNVENGLREVFKKIYEGLKNNGA--REHYKEVKNgnyikLREDWWTANRDQVWKAMTCVAP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1874 YDAKIYITK-EGGYISPLTFTKNKCGHNDDPPDYDYIPQPFRWLSEWSETYC-LAQKDLLETMKNCENC-MKKNKNADce 1950
Cdd:PTZ00176 262 ENAYFRKTEaDGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFCnVLNKEIDEMNNQCKDCeMSRRCNND-- 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1951 qTQYGACRDCKRKCEEYKKFIEIWKKQFETQNKAYQEIYRNATTTNRDNNNIV----------------DENTKNFVKKL 2014
Cdd:PTZ00176 340 -TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQNSSApergyrrnhrrrgyddDTNVQLFLKKV 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2015 QENcrtdrNE-SLDTADKYLENASVCRRFKFG--NKDSRHLNYAFHTDPPSYEEHCKCaKDFDPLDECPVDNNE--CKKY 2089
Cdd:PTZ00176 419 IEN-----NEcKVESLGKYLDKTSHCGNYNFNydNTPGSNRSNAFEITPEKFKKACKC-KIPNPLEKCPNEENKnvCTRF 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2090 G-IGSCPKKNFHKKLEEWTNYVLNNKSNKNKSAIVPPRRRQLCLQNLTRNLSRLNKEKSFKEGILISAASEAKMLTEQYR 2168
Cdd:PTZ00176 493 DkVYSCTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2169 ENPAKALQAIKYSFADIGNIIKGDDIIGNV--ISVQLNKLINGNKKINTST---LWWEANKEKIWNAMMCYYTGDEKTAT 2243
Cdd:PTZ00176 573 NYSNEAYEAMKFSYADYSDIVKGTDMMNDLkkLNKELNTLLKETEKGDISVdrkTWWDDNKNVVWNAMLCGYKTENENQQ 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2244 SCPSHGNI---DKEDQFLLWFQEWGENFCaRQKELYEHV-QAECSHVicVNGTGN------IDSKCTEACKNYSNFISET 2313
Cdd:PTZ00176 653 LNSSWCNVpddDNIDQFLRWLTEWAQQYC-KEKLIKAHIiNTKCKDI--VEGRKHksmvdiTDVECKRLFIDYEEWFRYR 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2314 KNVYQSLKKQY----NDNHNSIKVGGKE-VHHYMKEKCkDKCEC-------LSEKFNSDNNWEKPYDT---FDDTVLKNK 2378
Cdd:PTZ00176 730 YNQWKGLSEKYikikKSKNSGVNIPSEEcAASYVTKHC-NGCICnlrdmedIHKNINNQNELMKEMINiikFDTDQYRTQ 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2379 CQCKKPDSPILPVEPSVPAETEKE-----------------------KKKDSPLKPHTEPKPAPPKKPEVPppppvqppp 2435
Cdd:PTZ00176 809 LQNISNSMEINPKSVKTAVDTTKDivsyglagtmgvaaiglqagdflGKKIQDLYNEFMKPVEKKLDTSSK--------- 879
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2436 anqpfNRDILEK---TIPFGIALALGSIAFLF-IKKKPKSPVDLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYI 2511
Cdd:PTZ00176 880 -----NLNIYEDpniMVPAGIGVALTLGLLLFkMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYL 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2512 YMEGDSDSGHYY--EDTTDITSSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT----PSSDAPMNKFTDDEWNQL 2585
Cdd:PTZ00176 955 YVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTqndiPSDNTPSYKLTDEEWNQL 1034
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2586 KQDFISGILENEQkdlPKNNI-SGNTPMNTQPNTLYFNKPEEKPFITSIHDRDLYSGEEINYNINMSTNSMDDTSYVSNN 2664
Cdd:PTZ00176 1035 KDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEISYNINMSTNTMDDPKYVSNN 1111
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2665 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNYKKNTSNNNVAKLT-NSDPIMNQLDLLHKWLDRHRDMCEKWKSK 2743
Cdd:PTZ00176 1112 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKWENH 1191
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2744 EDILHKLNEQWNKDNDGGNVPIDNRSLNTDVWIEIDMDDPKGKKEFSNMDT-----ILDDIEDDIYYDVNDDEN----PS 2814
Cdd:PTZ00176 1192 HERLAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDInvdtpTMDNMEDDIYYDVNDNDDdndqPS 1271
|
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*.
gi 23499282 2815 VDNIPMDHNK--VDVPKKVHVEMKILNNTSNGSLEPEFPISDVWNI 2858
Cdd:PTZ00176 1272 VYDIPMDHNKvdVDVPKKVHIEMKILNNTSNGSLEQQFPISDVWNI 1317
|
|
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
2448-2858 |
0e+00 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 686.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2448 TIPFGIALALGSIAFLFIKKKPKSPV-DLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYIYMEGDSDSGH---YY 2523
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEkyaFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2524 EDTTDITSSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT----------PSSDAPM-NKFTDDEWNQLKQDFISG 2592
Cdd:pfam15445 81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTntpsdtqndiPSDDIPStNKITDEEWNTLKHDFISN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2593 ILENEQKDLPKNNISGNTPMNTQPNTLYFNKPEEKPFITSIHDRDLYSGEEINYNINMSTNSMDD-TSYVSNNVYSGIDL 2671
Cdd:pfam15445 161 MLQNTQNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNINMSTNSMDDiPKYVSNNVYSGIDL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2672 INDTLSGNQHIDIYDEVLKRKENELFGTNYKKNTSNNNVAKLTNSDPIMNQLDLLHKWLDRHRDMCEKWKSKEDILHKLN 2751
Cdd:pfam15445 241 INDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWKNKEERLDKLK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2752 EQWNKDNDGG-------NVPIDNRSLNTDVWIEIDMDDPKGKKEFSN---------MDTILDDIEDDIYY---------- 2805
Cdd:pfam15445 321 EEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNmdtnpdnstMDTILDDLEKYNEPyydiyeddiy 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 23499282 2806 -DVNDDenpsvDNIPMDHNKVDVPKKVHVEMKIlNNTsnGSLEPEFPISDVWNI 2858
Cdd:pfam15445 401 yDVNDH-----DASTVDSNNMDVPSKVQIEMDV-NNT--KLVEEKYPISDVWNI 446
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-404 |
8.45e-75 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 276.53 E-value: 8.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 12 SDVKNESHNSARNVFENIAEIIYNRVKEDAEKRGKsLKGDYKRAKFHQPLLEAAKYVWYAPSNPCNFDFRFDTNAPDKGS 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESKYTDK-LKGSLWEARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 92 YDRDPCHLRDTNRFSDKGDAICTNNKI--NCNNGGCGACAPYRRIQLCDYNLEYINEYNINSTHDLLGNLLVMAKREGDS 169
Cdd:PTZ00176 84 PARNPCDGRNQNRFDENGESYCNSDKIrgNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGES 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 170 IVNSHGHTGkgiyKSGICTSLARSFADIGDIIRGKDLFLGHNHkkkpllDNLEK-IFNRFQKIYEDINNLPIDD------ 242
Cdd:PTZ00176 164 IVNNHPDKD----KSSVCTALARSFADIGDIVRGKDMFKRNKH------DNVENgLREVFKKIYEGLKNNGAREhykevk 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 243 ------IREYWWALNRNDVWEALTCSAPYYAdYFKKKSGNTYNFT----TEGYCGRNEGAPPtnLDYVPQFLRWFDEWAE 312
Cdd:PTZ00176 234 ngnyikLREDWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISslilPYSKCGRDTDPPV--VDYIPQRLRWMSEWSE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 313 EFCRIKNIKIGNIKKSCTgesnnkhcsregyDCNKTNlRLNEIFMDLECPRCADDCKSYETWVENKKKEFNKQKEKYKEE 392
Cdd:PTZ00176 311 YFCNVLNKEIDEMNNQCK-------------DCEMSR-RCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMEL 376
|
410
....*....|..
gi 23499282 393 INESKPGVNSEH 404
Cdd:PTZ00176 377 YNKASTNITKQN 388
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
127-305 |
1.69e-67 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 226.00 E-value: 1.69e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 127 ACAPYRRIQLCDYNLEYINEYNINSTHDLLGNLLVMAKREGDSIVNSHGH--TGKGIYKSGICTSLARSFADIGDIIRGK 204
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKknTKYGDIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 205 DLFLGHNHKKKpLLDNLEKIfnrFQKIYEDINNLPIDD-----IREYWWALNRNDVWEALTCSAPYYADYFKKKSGNTYN 279
Cdd:pfam05424 81 DLYLGNNKKKK-LEENLKKI---FKKIYEKLTSKGKDDgnyyqLREDWWEANREDIWKAMTCALTYGAKYFRKTCGDGIS 156
|
170 180
....*....|....*....|....*.
gi 23499282 280 FTTEGycgrNEGAPPTNLDYVPQFLR 305
Cdd:pfam05424 157 PSTAG----CNDDVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
853-1567 |
1.39e-64 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 243.79 E-value: 1.39e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 853 GHRDYKGPCTGKDGHKKMFQVEKGWENGSKIGTEND----VFLPPRREHFCTSNVEHLYRsasglQGTTASHSLLGDVLL 928
Cdd:PTZ00176 81 GYPPARNPCDGRNQNRFDENGESYCNSDKIRGNENNsnagACAPFRRQNMCDKNLEYLIN-----KNTENTHDLLGNVLV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 929 AANKEAGFIKERYKTQKTSEgfkdeatVCRAIKYSFADIADIIKGTDLWKANSgKKNTQDKLVKIFQKIKDNLPVN-IKG 1007
Cdd:PTZ00176 156 TAKYEGESIVNNHPDKDKSS-------VCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNgARE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1008 KYNEDE--KHLELRKDWWFANRDKVWEAMKC-----------EQNGI----------TCSGPT--PLDDYIPQRLRWMTE 1062
Cdd:PTZ00176 228 HYKEVKngNYIKLREDWWTANRDQVWKAMTCvapenayfrktEADGIgisslilpysKCGRDTdpPVVDYIPQRLRWMSE 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1063 WAEWYCKAQKEAYDKLK-VCEKCMDNGKC---TQGnGECAKCKTACENYKKFINTWQPQWKQMEQKYESLYKEAQEN--- 1135
Cdd:PTZ00176 308 WSEYFCNVLNKEIDEMNnQCKDCEMSRRCnndTEG-EKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitk 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1136 GNSS---------HKSTTEQDKYMVEFLSQLQKANNGDKTgddkvystaagyvhqEATMNCEKQTQFCKNKNGVKAANDA 1206
Cdd:PTZ00176 387 QNSSapergyrrnHRRRGYDDDTNVQLFLKKVIENNECKV---------------ESLGKYLDKTSHCGNYNFNYDNTPG 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1207 EDVNYTFKDTPNGYDVVCKCK-DRPEQQIKKKEVEDACKIAQDIFkgkdenTTVGLCKKKDFGRTPYPDWKCEKNSKlvt 1285
Cdd:PTZ00176 452 SNRSNAFEITPEKFKKACKCKiPNPLEKCPNEENKNVCTRFDKVY------SCTSLSFKNDLSEWNNSGVKNKENDN--- 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1286 gNGECMPPRRQKLCLYFLAHKieTPNLNTQEDLRKAFIKCAAAETFFswyYFKKINDKLNKLDEKLKegeippqflrsmf 1365
Cdd:PTZ00176 523 -NGVLVPPRRRNLCINLFSKK--DYKMKDENDFKEDLLNAAFSQGKL---LGKKYSNYSNEAYEAMK------------- 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1366 YTFGDYKDICLDTDISlktenGDITKAKSNIDRIIPKKSAKNPDEERKIWWDGIKEDVWEGMLCGLSHAVSNNdkatvQK 1445
Cdd:PTZ00176 584 FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDISVDRKTWWDDNKNVVWNAMLCGYKTENENQ-----QL 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1446 TLTTKTIYDYDTVTfdgttkledfskrpQFLRWMTEWGEEFCKKRKEQLENLKDKCPD------YTCSFDTKKQECENHC 1519
Cdd:PTZ00176 654 NSSWCNVPDDDNID--------------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDivegrkHKSMVDITDVECKRLF 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 23499282 1520 KVYEEWLKGWKDQYKKQSEKFTtdKEKPEYKDDPDVASSENAHKYLSK 1567
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYI--KIKKSKNSGVNIPSEECAASYVTK 765
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1290-1477 |
1.79e-44 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 160.13 E-value: 1.79e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1290 CMPPRRQKLCLYFLaHKIETPNLNTQEDLRKAFIKCAAAETFFSWYYFKKINDKlnkldeklkEGEIPPQFLRSMFYTFG 1369
Cdd:pfam05424 2 CAPPRRLHLCVKNL-EKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTK---------YGDIPSEFCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1370 DYKDICLDTDISLKteNGDITKAKSNIDRIIPKKSAKNPDEE---------RKIWWDGIKEDVWEGMLCGLSHavsnNDK 1440
Cdd:pfam05424 72 DIGDIIRGKDLYLG--NNKKKKLEENLKKIFKKIYEKLTSKGkddgnyyqlREDWWEANREDIWKAMTCALTY----GAK 145
|
170 180 190
....*....|....*....|....*....|....*..
gi 23499282 1441 ATVQKTLTTKTIYDYDTVTFDGTtkleDFSKRPQFLR 1477
Cdd:pfam05424 146 YFRKTCGDGISPSTAGCNDDVPT----YFDYVPQFLR 178
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
566-706 |
2.56e-26 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 107.20 E-value: 2.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 566 FIKRWLESFLKDYNKLKENLNPCINNENQLPCIKDCLENCDCVEKWIKKKGEEWKKIKERYLKDYKIE-----DNNSSNS 640
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKgltgkTLDEYLD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23499282 641 LNKFLQQNQFHSDVVKAIKPFENLRAFEDSSGCTGTVPSGIEEC--KSNDVIKILLSKLKEKIELCKK 706
Cdd:pfam03011 81 LKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAKnnKNEDAIDKLLDKEEKKANNCKE 148
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
499-550 |
7.07e-15 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Pssm-ID: 408346 Cd Length: 52 Bit Score: 70.76 E-value: 7.07e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 23499282 499 TFVIDILLNDNKKKVLSNDLNDYKECDLFKRLRRQNWNCKYKCNLHVCELNN 550
Cdd:pfam18562 1 TTTIDMLVSDNRGIKFENDLKECKEAGIFKGIRKDQWKCGKVCGYDVCKLKN 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1649-2858 |
0e+00 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 904.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1649 IRKESGKKSDNSLKGNGNTYNNNCNNS-----MREEYANQNGETCKFNETFWSKKKPSIEECDINAKERFQIQKYWDCNG 1723
Cdd:PTZ00176 28 DKRENESKYTDKLKGSLWEARFSDGLSssfgdVRSGYYDSCSLDHKFHTNINNGYPPARNPCDGRNQNRFDENGESYCNS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1724 -KTPDGKNTF----CIPPRRKDMCLKQLEEINSADVNNSKKLLQKIQDVAKKEGDDIIKKLLPKypcNEDVICKAMKYSF 1798
Cdd:PTZ00176 108 dKIRGNENNSnagaCAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDK---DKSSVCTALARSF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1799 ADLADIVRGIDKYKgPNGTNVLEKELKSVFETIYTKWKSENTnnKSKYTDVAS-----FRSAWWDANRKDIWNAMTCNAP 1873
Cdd:PTZ00176 185 ADIGDIVRGKDMFK-RNKHDNVENGLREVFKKIYEGLKNNGA--REHYKEVKNgnyikLREDWWTANRDQVWKAMTCVAP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1874 YDAKIYITK-EGGYISPLTFTKNKCGHNDDPPDYDYIPQPFRWLSEWSETYC-LAQKDLLETMKNCENC-MKKNKNADce 1950
Cdd:PTZ00176 262 ENAYFRKTEaDGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFCnVLNKEIDEMNNQCKDCeMSRRCNND-- 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1951 qTQYGACRDCKRKCEEYKKFIEIWKKQFETQNKAYQEIYRNATTTNRDNNNIV----------------DENTKNFVKKL 2014
Cdd:PTZ00176 340 -TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQNSSApergyrrnhrrrgyddDTNVQLFLKKV 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2015 QENcrtdrNE-SLDTADKYLENASVCRRFKFG--NKDSRHLNYAFHTDPPSYEEHCKCaKDFDPLDECPVDNNE--CKKY 2089
Cdd:PTZ00176 419 IEN-----NEcKVESLGKYLDKTSHCGNYNFNydNTPGSNRSNAFEITPEKFKKACKC-KIPNPLEKCPNEENKnvCTRF 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2090 G-IGSCPKKNFHKKLEEWTNYVLNNKSNKNKSAIVPPRRRQLCLQNLTRNLSRLNKEKSFKEGILISAASEAKMLTEQYR 2168
Cdd:PTZ00176 493 DkVYSCTSLSFKNDLSEWNNSGVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2169 ENPAKALQAIKYSFADIGNIIKGDDIIGNV--ISVQLNKLINGNKKINTST---LWWEANKEKIWNAMMCYYTGDEKTAT 2243
Cdd:PTZ00176 573 NYSNEAYEAMKFSYADYSDIVKGTDMMNDLkkLNKELNTLLKETEKGDISVdrkTWWDDNKNVVWNAMLCGYKTENENQQ 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2244 SCPSHGNI---DKEDQFLLWFQEWGENFCaRQKELYEHV-QAECSHVicVNGTGN------IDSKCTEACKNYSNFISET 2313
Cdd:PTZ00176 653 LNSSWCNVpddDNIDQFLRWLTEWAQQYC-KEKLIKAHIiNTKCKDI--VEGRKHksmvdiTDVECKRLFIDYEEWFRYR 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2314 KNVYQSLKKQY----NDNHNSIKVGGKE-VHHYMKEKCkDKCEC-------LSEKFNSDNNWEKPYDT---FDDTVLKNK 2378
Cdd:PTZ00176 730 YNQWKGLSEKYikikKSKNSGVNIPSEEcAASYVTKHC-NGCICnlrdmedIHKNINNQNELMKEMINiikFDTDQYRTQ 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2379 CQCKKPDSPILPVEPSVPAETEKE-----------------------KKKDSPLKPHTEPKPAPPKKPEVPppppvqppp 2435
Cdd:PTZ00176 809 LQNISNSMEINPKSVKTAVDTTKDivsyglagtmgvaaiglqagdflGKKIQDLYNEFMKPVEKKLDTSSK--------- 879
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2436 anqpfNRDILEK---TIPFGIALALGSIAFLF-IKKKPKSPVDLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYI 2511
Cdd:PTZ00176 880 -----NLNIYEDpniMVPAGIGVALTLGLLLFkMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYL 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2512 YMEGDSDSGHYY--EDTTDITSSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT----PSSDAPMNKFTDDEWNQL 2585
Cdd:PTZ00176 955 YVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTqndiPSDNTPSYKLTDEEWNQL 1034
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2586 KQDFISGILENEQkdlPKNNI-SGNTPMNTQPNTLYFNKPEEKPFITSIHDRDLYSGEEINYNINMSTNSMDDTSYVSNN 2664
Cdd:PTZ00176 1035 KDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEISYNINMSTNTMDDPKYVSNN 1111
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2665 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNYKKNTSNNNVAKLT-NSDPIMNQLDLLHKWLDRHRDMCEKWKSK 2743
Cdd:PTZ00176 1112 VYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKWENH 1191
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2744 EDILHKLNEQWNKDNDGGNVPIDNRSLNTDVWIEIDMDDPKGKKEFSNMDT-----ILDDIEDDIYYDVNDDEN----PS 2814
Cdd:PTZ00176 1192 HERLAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDInvdtpTMDNMEDDIYYDVNDNDDdndqPS 1271
|
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*.
gi 23499282 2815 VDNIPMDHNK--VDVPKKVHVEMKILNNTSNGSLEPEFPISDVWNI 2858
Cdd:PTZ00176 1272 VYDIPMDHNKvdVDVPKKVHIEMKILNNTSNGSLEQQFPISDVWNI 1317
|
|
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
2448-2858 |
0e+00 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 686.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2448 TIPFGIALALGSIAFLFIKKKPKSPV-DLIRVLDIHKGDYGMPTLKSKNRYIPYASDTYKGKTYIYMEGDSDSGH---YY 2523
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEkyaFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2524 EDTTDITSSESEYEEMDINDIYVPDSPKYKTLIEVVLEPSKRDT----------PSSDAPM-NKFTDDEWNQLKQDFISG 2592
Cdd:pfam15445 81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTntpsdtqndiPSDDIPStNKITDEEWNTLKHDFISN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2593 ILENEQKDLPKNNISGNTPMNTQPNTLYFNKPEEKPFITSIHDRDLYSGEEINYNINMSTNSMDD-TSYVSNNVYSGIDL 2671
Cdd:pfam15445 161 MLQNTQNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNINMSTNSMDDiPKYVSNNVYSGIDL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2672 INDTLSGNQHIDIYDEVLKRKENELFGTNYKKNTSNNNVAKLTNSDPIMNQLDLLHKWLDRHRDMCEKWKSKEDILHKLN 2751
Cdd:pfam15445 241 INDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWKNKEERLDKLK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2752 EQWNKDNDGG-------NVPIDNRSLNTDVWIEIDMDDPKGKKEFSN---------MDTILDDIEDDIYY---------- 2805
Cdd:pfam15445 321 EEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNmdtnpdnstMDTILDDLEKYNEPyydiyeddiy 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 23499282 2806 -DVNDDenpsvDNIPMDHNKVDVPKKVHVEMKIlNNTsnGSLEPEFPISDVWNI 2858
Cdd:pfam15445 401 yDVNDH-----DASTVDSNNMDVPSKVQIEMDV-NNT--KLVEEKYPISDVWNI 446
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-404 |
8.45e-75 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 276.53 E-value: 8.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 12 SDVKNESHNSARNVFENIAEIIYNRVKEDAEKRGKsLKGDYKRAKFHQPLLEAAKYVWYAPSNPCNFDFRFDTNAPDKGS 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESKYTDK-LKGSLWEARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 92 YDRDPCHLRDTNRFSDKGDAICTNNKI--NCNNGGCGACAPYRRIQLCDYNLEYINEYNINSTHDLLGNLLVMAKREGDS 169
Cdd:PTZ00176 84 PARNPCDGRNQNRFDENGESYCNSDKIrgNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGES 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 170 IVNSHGHTGkgiyKSGICTSLARSFADIGDIIRGKDLFLGHNHkkkpllDNLEK-IFNRFQKIYEDINNLPIDD------ 242
Cdd:PTZ00176 164 IVNNHPDKD----KSSVCTALARSFADIGDIVRGKDMFKRNKH------DNVENgLREVFKKIYEGLKNNGAREhykevk 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 243 ------IREYWWALNRNDVWEALTCSAPYYAdYFKKKSGNTYNFT----TEGYCGRNEGAPPtnLDYVPQFLRWFDEWAE 312
Cdd:PTZ00176 234 ngnyikLREDWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISslilPYSKCGRDTDPPV--VDYIPQRLRWMSEWSE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 313 EFCRIKNIKIGNIKKSCTgesnnkhcsregyDCNKTNlRLNEIFMDLECPRCADDCKSYETWVENKKKEFNKQKEKYKEE 392
Cdd:PTZ00176 311 YFCNVLNKEIDEMNNQCK-------------DCEMSR-RCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMEL 376
|
410
....*....|..
gi 23499282 393 INESKPGVNSEH 404
Cdd:PTZ00176 377 YNKASTNITKQN 388
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
127-305 |
1.69e-67 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 226.00 E-value: 1.69e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 127 ACAPYRRIQLCDYNLEYINEYNINSTHDLLGNLLVMAKREGDSIVNSHGH--TGKGIYKSGICTSLARSFADIGDIIRGK 204
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKknTKYGDIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 205 DLFLGHNHKKKpLLDNLEKIfnrFQKIYEDINNLPIDD-----IREYWWALNRNDVWEALTCSAPYYADYFKKKSGNTYN 279
Cdd:pfam05424 81 DLYLGNNKKKK-LEENLKKI---FKKIYEKLTSKGKDDgnyyqLREDWWEANREDIWKAMTCALTYGAKYFRKTCGDGIS 156
|
170 180
....*....|....*....|....*.
gi 23499282 280 FTTEGycgrNEGAPPTNLDYVPQFLR 305
Cdd:pfam05424 157 PSTAG----CNDDVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
853-1567 |
1.39e-64 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 243.79 E-value: 1.39e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 853 GHRDYKGPCTGKDGHKKMFQVEKGWENGSKIGTEND----VFLPPRREHFCTSNVEHLYRsasglQGTTASHSLLGDVLL 928
Cdd:PTZ00176 81 GYPPARNPCDGRNQNRFDENGESYCNSDKIRGNENNsnagACAPFRRQNMCDKNLEYLIN-----KNTENTHDLLGNVLV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 929 AANKEAGFIKERYKTQKTSEgfkdeatVCRAIKYSFADIADIIKGTDLWKANSgKKNTQDKLVKIFQKIKDNLPVN-IKG 1007
Cdd:PTZ00176 156 TAKYEGESIVNNHPDKDKSS-------VCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNgARE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1008 KYNEDE--KHLELRKDWWFANRDKVWEAMKC-----------EQNGI----------TCSGPT--PLDDYIPQRLRWMTE 1062
Cdd:PTZ00176 228 HYKEVKngNYIKLREDWWTANRDQVWKAMTCvapenayfrktEADGIgisslilpysKCGRDTdpPVVDYIPQRLRWMSE 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1063 WAEWYCKAQKEAYDKLK-VCEKCMDNGKC---TQGnGECAKCKTACENYKKFINTWQPQWKQMEQKYESLYKEAQEN--- 1135
Cdd:PTZ00176 308 WSEYFCNVLNKEIDEMNnQCKDCEMSRRCnndTEG-EKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitk 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1136 GNSS---------HKSTTEQDKYMVEFLSQLQKANNGDKTgddkvystaagyvhqEATMNCEKQTQFCKNKNGVKAANDA 1206
Cdd:PTZ00176 387 QNSSapergyrrnHRRRGYDDDTNVQLFLKKVIENNECKV---------------ESLGKYLDKTSHCGNYNFNYDNTPG 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1207 EDVNYTFKDTPNGYDVVCKCK-DRPEQQIKKKEVEDACKIAQDIFkgkdenTTVGLCKKKDFGRTPYPDWKCEKNSKlvt 1285
Cdd:PTZ00176 452 SNRSNAFEITPEKFKKACKCKiPNPLEKCPNEENKNVCTRFDKVY------SCTSLSFKNDLSEWNNSGVKNKENDN--- 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1286 gNGECMPPRRQKLCLYFLAHKieTPNLNTQEDLRKAFIKCAAAETFFswyYFKKINDKLNKLDEKLKegeippqflrsmf 1365
Cdd:PTZ00176 523 -NGVLVPPRRRNLCINLFSKK--DYKMKDENDFKEDLLNAAFSQGKL---LGKKYSNYSNEAYEAMK------------- 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1366 YTFGDYKDICLDTDISlktenGDITKAKSNIDRIIPKKSAKNPDEERKIWWDGIKEDVWEGMLCGLSHAVSNNdkatvQK 1445
Cdd:PTZ00176 584 FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDISVDRKTWWDDNKNVVWNAMLCGYKTENENQ-----QL 653
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1446 TLTTKTIYDYDTVTfdgttkledfskrpQFLRWMTEWGEEFCKKRKEQLENLKDKCPD------YTCSFDTKKQECENHC 1519
Cdd:PTZ00176 654 NSSWCNVPDDDNID--------------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDivegrkHKSMVDITDVECKRLF 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 23499282 1520 KVYEEWLKGWKDQYKKQSEKFTtdKEKPEYKDDPDVASSENAHKYLSK 1567
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYI--KIKKSKNSGVNIPSEECAASYVTK 765
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1733-1914 |
8.74e-56 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 192.49 E-value: 8.74e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1733 CIPPRRKDMCLKQLEEINSADVNNSKKLLQKIQDVAKKEGDDII---KKLLPKYPCNEDVICKAMKYSFADLADIVRGID 1809
Cdd:pfam05424 2 CAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWhkyKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGKD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1810 KYKGPNGTNVLEKELKSVFETIYTKWKSENTNNKSKYTdvasFRSAWWDANRKDIWNAMTCNAPYDAKIYITKEGGYISP 1889
Cdd:pfam05424 82 LYLGNNKKKKLEENLKKIFKKIYEKLTSKGKDDGNYYQ----LREDWWEANREDIWKAMTCALTYGAKYFRKTCGDGISP 157
|
170 180
....*....|....*....|....*
gi 23499282 1890 LTFTKnkcgHNDDPPDYDYIPQPFR 1914
Cdd:pfam05424 158 STAGC----NDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1290-1477 |
1.79e-44 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 160.13 E-value: 1.79e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1290 CMPPRRQKLCLYFLaHKIETPNLNTQEDLRKAFIKCAAAETFFSWYYFKKINDKlnkldeklkEGEIPPQFLRSMFYTFG 1369
Cdd:pfam05424 2 CAPPRRLHLCVKNL-EKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTK---------YGDIPSEFCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1370 DYKDICLDTDISLKteNGDITKAKSNIDRIIPKKSAKNPDEE---------RKIWWDGIKEDVWEGMLCGLSHavsnNDK 1440
Cdd:pfam05424 72 DIGDIIRGKDLYLG--NNKKKKLEENLKKIFKKIYEKLTSKGkddgnyyqlREDWWEANREDIWKAMTCALTY----GAK 145
|
170 180 190
....*....|....*....|....*....|....*..
gi 23499282 1441 ATVQKTLTTKTIYDYDTVTFDGTtkleDFSKRPQFLR 1477
Cdd:pfam05424 146 YFRKTCGDGISPSTAGCNDDVPT----YFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
892-1058 |
1.20e-43 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 157.82 E-value: 1.20e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 892 PPRREHFCTSNVEHLyrsasGLQGTTASHSLLGDVLLAANKEAGFIKERYKTQKTSEGFKDEaTVCRAIKYSFADIADII 971
Cdd:pfam05424 4 PPRRLHLCVKNLEKI-----NSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPS-EFCRQMAYSFADIGDII 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 972 KGTDLWKANSGKKNTQDKLVKIFQKIKDNLPvnikGKYNEDEKHLELRKDWWFANRDKVWEAMKC------EQNGITCSG 1045
Cdd:pfam05424 78 RGKDLYLGNNKKKKLEENLKKIFKKIYEKLT----SKGKDDGNYYQLREDWWEANREDIWKAMTCaltygaKYFRKTCGD 153
|
170 180
....*....|....*....|....*
gi 23499282 1046 ------------PTPLDDYIPQRLR 1058
Cdd:pfam05424 154 gispstagcnddVPTYFDYVPQFLR 178
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
566-706 |
2.56e-26 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 107.20 E-value: 2.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 566 FIKRWLESFLKDYNKLKENLNPCINNENQLPCIKDCLENCDCVEKWIKKKGEEWKKIKERYLKDYKIE-----DNNSSNS 640
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKgltgkTLDEYLD 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23499282 641 LNKFLQQNQFHSDVVKAIKPFENLRAFEDSSGCTGTVPSGIEEC--KSNDVIKILLSKLKEKIELCKK 706
Cdd:pfam03011 81 LKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAKnnKNEDAIDKLLDKEEKKANNCKE 148
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1280-1924 |
4.51e-26 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 118.21 E-value: 4.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1280 NSKLVTGN------GECMPPRRQKLCLYFLAHKIETpNLNTQEDLRKAFIKCAAAETFFSwyyfkkINDKLNKldeklKE 1353
Cdd:PTZ00176 106 NSDKIRGNennsnaGACAPFRRQNMCDKNLEYLINK-NTENTHDLLGNVLVTAKYEGESI------VNNHPDK-----DK 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1354 GEIPPQFLRSmfytFGDYKDICLDTDISLKTENGDITKAKSNIDRII----PKKSAKNPDEE---------RKIWWDGIK 1420
Cdd:PTZ00176 174 SSVCTALARS----FADIGDIVRGKDMFKRNKHDNVENGLREVFKKIyeglKNNGAREHYKEvkngnyiklREDWWTANR 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1421 EDVWEGMLCglshavSNNDKATVQKTLT-----TKTIYDYDTVTFDGTTKLEDFSkrPQFLRWMTEWGEEFCKKRKEQLE 1495
Cdd:PTZ00176 250 DQVWKAMTC------VAPENAYFRKTEAdgigiSSLILPYSKCGRDTDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEID 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1496 NLKDKCPD----YTCSFDT---KKQECENHCKVYEEWLKGWKDQYKKQSEKF------------TTDKEKPE-------- 1548
Cdd:PTZ00176 322 EMNNQCKDcemsRRCNNDTegeKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastnitKQNSSAPErgyrrnhr 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1549 ---YKDDPDVA--------SSENAHKYLSKKLKQIFHNGSTTEKCDYTcmeyasrqpqtsacsqqqqqqnkssTQNHFPE 1617
Cdd:PTZ00176 402 rrgYDDDTNVQlflkkvieNNECKVESLGKYLDKTSHCGNYNFNYDNT-------------------------PGSNRSN 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1618 AFDYPPKEIGDRCTCpKLPEPkycVDKTAYDIRKESGKKSDNslkgngntYNNNCNNSMREEYANQNGETCKFNETfwsk 1697
Cdd:PTZ00176 457 AFEITPEKFKKACKC-KIPNP---LEKCPNEENKNVCTRFDK--------VYSCTSLSFKNDLSEWNNSGVKNKEN---- 520
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1698 kkpsieecdinakerfqiqkywDCNGktpdgkntFCIPPRRKDMCLKQL--EEINSADVNNSKkllQKIQDVAKKEGddi 1775
Cdd:PTZ00176 521 ----------------------DNNG--------VLVPPRRRNLCINLFskKDYKMKDENDFK---EDLLNAAFSQG--- 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 1776 iKKLLPKYPCNEDVICKAMKYSFADLADIVRGIDKYkgpNGTNVLEKELKSVFEtiytkwksentnnKSKYTDVASFRSA 1855
Cdd:PTZ00176 565 -KLLGKKYSNYSNEAYEAMKFSYADYSDIVKGTDMM---NDLKKLNKELNTLLK-------------ETEKGDISVDRKT 627
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23499282 1856 WWDANRKDIWNAMTCNapydakiYITKEGGYisplTFTKNKCghndDPPDYDYIPQPFRWLSEWSETYC 1924
Cdd:PTZ00176 628 WWDDNKNVVWNAMLCG-------YKTENENQ----QLNSSWC----NVPDDDNIDQFLRWLTEWAQQYC 681
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2121-2251 |
1.65e-16 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 79.62 E-value: 1.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 2121 AIVPPRRRQLCLQNLTR-NLSRLNKEKSFKEGILISAASEAKMLTEQYRE-------NPAKALQAIKYSFADIGNIIKGD 2192
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKiNSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKkntkygdIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23499282 2193 DI-IGNVISVQL------------NKLINGNKKINTSTL----WWEANKEKIWNAMMCYYT-GDEKTATSCPSHGNI 2251
Cdd:pfam05424 81 DLyLGNNKKKKLeenlkkifkkiyEKLTSKGKDDGNYYQlredWWEANREDIWKAMTCALTyGAKYFRKTCGDGISP 157
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
499-550 |
7.07e-15 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Pssm-ID: 408346 Cd Length: 52 Bit Score: 70.76 E-value: 7.07e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 23499282 499 TFVIDILLNDNKKKVLSNDLNDYKECDLFKRLRRQNWNCKYKCNLHVCELNN 550
Cdd:pfam18562 1 TTTIDMLVSDNRGIKFENDLKECKEAGIFKGIRKDQWKCGKVCGYDVCKLKN 52
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
116-401 |
1.51e-13 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 77.38 E-value: 1.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 116 NKINCNNGgcgACAPYRRIQLCdYNLEYINEYNINSTHDLLGNLLVMAKREGDSIVNSHGHTGKGIYKSgictsLARSFA 195
Cdd:PTZ00176 517 NKENDNNG---VLVPPRRRNLC-INLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEA-----MKFSYA 587
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 196 DIGDIIRGKDLflghnhkkkplLDNLEKIFNRFQKIYEDINNLPIDDIREYWWALNRNDVWEALTCSApyyadyfkkKSG 275
Cdd:PTZ00176 588 DYSDIVKGTDM-----------MNDLKKLNKELNTLLKETEKGDISVDRKTWWDDNKNVVWNAMLCGY---------KTE 647
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23499282 276 NTYNFTTEGYCGRNEGapptnlDYVPQFLRWFDEWAEEFCRIKNIKIGNIKKSCTG-ESNNKHCSREGydcnktnlrlne 354
Cdd:PTZ00176 648 NENQQLNSSWCNVPDD------DNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDiVEGRKHKSMVD------------ 709
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 23499282 355 iFMDLECPRCADDcksYETWVENKKKEFNKQKEKYKEEINESKPGVN 401
Cdd:PTZ00176 710 -ITDVECKRLFID---YEEWFRYRYNQWKGLSEKYIKIKKSKNSGVN 752
|
|
| NTS |
pfam15447 |
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ... |
21-56 |
1.19e-08 |
|
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.
Pssm-ID: 406013 [Multi-domain] Cd Length: 36 Bit Score: 52.79 E-value: 1.19e-08
10 20 30
....*....|....*....|....*....|....*.
gi 23499282 21 SARNVFENIAEIIYNRVKEDAEKRGKSLKGDYKRAK 56
Cdd:pfam15447 1 SAKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSKAK 36
|
|
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