|
Name |
Accession |
Description |
Interval |
E-value |
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
3018-3467 |
0e+00 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
:
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 775.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3018 TIPFGIALALTSIALLFLKKKPKSPV-DLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTSGDDdKYMF 3096
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDE-KYAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3097 LSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTPSkGDGNTLGDDMIPTTNTFTDEEWNELKHDFI 3176
Cdd:pfam15445 80 MSDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS-DTQNDIPSDDIPSTNKITDEEWNTLKHDFI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3177 SQYIQSRlPMDVPQYDVSTELPMNITEVNVLDVGINEKPFITSIHDRDLYSGEEINYNINMSTNTNNDIPKYVSNNVYSG 3256
Cdd:pfam15445 159 SNMLQNT-QNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNINMSTNSMDDIPKYVSNNVYSG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3257 IDLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKNTSNNSVAKNTNSDSIMNQLDLLHKWLDRRRNMCEKWEkhNKEEL 3336
Cdd:pfam15445 238 IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWK--NKEER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3337 LDKLNEQWNKDNDGI-------NVPSDNRSLNTDVSIQIDMDENKGKKEFSNMDTNVDTPTMDNILDDLETCNEPFYDIY 3409
Cdd:pfam15445 316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNMDTNPDNSTMDTILDDLEKYNEPYYDIY 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 23498129 3410 EDDIYYDVNDEnpsvDDIPMDHNKVDVPKKVHVEMKIlNNTsnGSLEPEFPISDVWNI 3467
Cdd:pfam15445 396 EDDIYYDVNDH----DASTVDSNNMDVPSKVQIEMDV-NNT--KLVEEKYPISDVWNI 446
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-418 |
2.42e-115 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 401.72 E-value: 2.42e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 12 KDVKNESHNSARNVLENIGIEIYNEEKKKVNgYTSQLRGDLSRARFHDGLRKAARLgVIPGPANSCDLDHKFYTNINNGY 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSSFGD-VRSGYYDSCSLDHKFHTNINNGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 92 PPARNPCDLRNQNRFGENAEAYCNSDKIRVTGKKSAGGACAPFRRQNMCDKNLEYLDNTNTDDTDDLLGNVLVTAKYEGE 171
Cdd:PTZ00176 83 PPARNPCDGRNQNRFDENGESYCNSDKIRGNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 172 SIVAKHPHKENSEVCTALARSFADIGDIVRGKDMFKRNEEDAVQKGLRAVFKKINDNLKEKEISDY---DNDPNYYKLRE 248
Cdd:PTZ00176 163 SIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIYEGLKNNGAREHykeVKNGNYIKLRE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 249 DWWTANRDQVWRAITCYIPYYVnYFKKTSDDTIVFTN----DGKCGHyEGAPPTnLDYVPQFLRWFDEWAEEFCRIRNHK 324
Cdd:PTZ00176 243 DWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISSlilpYSKCGR-DTDPPV-VDYIPQRLRWMSEWSEYFCNVLNKE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 325 LRKIKDACRNDKERLYCSQNgydctkriekgsscSRENKCTGCSNKCVDYDFWLEKQQNEFKIQKDKYdkeIETYVN-KT 403
Cdd:PTZ00176 320 IDEMNNQCKDCEMSRRCNND--------------TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY---MELYNKaST 382
|
410
....*....|....*
gi 23498129 404 PISNSNSNTKKEYYK 418
Cdd:PTZ00176 383 NITKQNSSAPERGYR 397
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
743-1534 |
5.91e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 267.67 E-value: 5.91e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 743 NGGKLVRVKRlaemmqRRARKQLEKRGGEINlKADASQGKYIRGGKEKKLNGQICNIDTSYSNDSRNGNNGG--PCTGKN 820
Cdd:PTZ00176 21 NIGNEIKDKR------ENESKYTDKLKGSLW-EARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYPPArnPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 821 DKRFKIGTEwSYGEHEKKRTHPEVY-----MPPRREHMCISNLEKLdvvsVIKNGNASHSLLGDVLLAAKYEAKNIkely 895
Cdd:PTZ00176 94 QNRFDENGE-SYCNSDKIRGNENNSnagacAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYEGESI---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 896 qQNNSKNgvidqNDKETICRAMKYSFADIGDIIRGKDMWVQNtDATKLQAYLAKIFDKIKDNHKDIKGKLQYN--GDTDH 973
Cdd:PTZ00176 165 -VNNHPD-----KDKSSVCTALARSFADIGDIVRGKDMFKRN-KHDNVENGLREVFKKIYEGLKNNGAREHYKevKNGNY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 974 KLLREDWWEANRHQVWRAMKC-AIEND--KDMKCNGI------------------PIEDYIPQRLRWMTEWAEWYCKEQS 1032
Cdd:PTZ00176 238 IKLREDWWTANRDQVWKAMTCvAPENAyfRKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSEWSEYFCNVLN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1033 RLYGELLEKCQSCKGKQKC---TEGDvDCGKCKAACDKYKDEINKWREQWTKIKGKYKTLYKKATKpGVTTSNNPK---- 1105
Cdd:PTZ00176 318 KEIDEMNNQCKDCEMSRRCnndTEGE-KCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKAST-NITKQNSSAperg 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1106 -----------DEKDVVDFLKQLLprkSKNTPGVTAMTpntlyssaagyihQELGKTVGCNTQKEFCDNKKGK---YAFK 1171
Cdd:PTZ00176 396 yrrnhrrrgydDDTNVQLFLKKVI---ENNECKVESLG-------------KYLDKTSHCGNYNFNYDNTPGSnrsNAFE 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1172 HPPKEYEEACICdtrqKAQKPIEK------KNDCngikTLLDRsnggtggIDGCNPKI--GNYPSWNCERNESKA-ENKG 1242
Cdd:PTZ00176 460 ITPEKFKKACKC----KIPNPLEKcpneenKNVC----TRFDK-------VYSCTSLSfkNDLSEWNNSGVKNKEnDNNG 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1243 ACVPPRREKFCVSLLAKEGiFKNKGE-DIRETFVKSAALETYFAWKRYNDDNKKAEEELKsgtipenfkrqmyYTFADYR 1321
Cdd:PTZ00176 525 VLVPPRRRNLCINLFSKKD-YKMKDEnDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK-------------FSYADYS 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1322 DIFFGTDITshDHILDVSKNAKNKLKEKngeQKSVIIIDDEKlladWWKEHGHEIWEGMLCALTheiDEEEKNKIKSTYS 1401
Cdd:PTZ00176 591 DIVKGTDMM--NDLKKLNKELNTLLKET---EKGDISVDRKT----WWDDNKNVVWNAMLCGYK---TENENQQLNSSWC 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1402 ydqlkkttngTTPLEKFAErpQFLRWFTEWSDEFCREREKKEEVVEKKCKKDHEGCNKPNTKG--NHGCVSACKDYEEYI 1479
Cdd:PTZ00176 659 ----------NVPDDDNID--QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSMVDitDVECKRLFIDYEEWF 726
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 23498129 1480 STKKKQYNTQKEKFDIDKNKGNEEYENYKDKEAHDYLKDKCFPGTCDY--MEKVKNN 1534
Cdd:PTZ00176 727 RYRYNQWKGLSEKYIKIKKSKNSGVNIPSEECAASYVTKHCNGCICNLrdMEDIHKN 783
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1616-1795 |
1.72e-53 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
:
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 186.32 E-value: 1.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1616 ACMPPRRQKLCVINLQYFKGK---TTVDLREAFIKCAAVETFFLWHKYKEDNNGGedlqnqlesGIIPDDFKRQMFYTFG 1692
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGnttTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY---------GDIPSEFCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1693 DYRDFLFGTDISKGHGIGSELAKKIDSLFKNIGGKNPGDLS--------RKDWWNENGPYIWKGMLCSLekawGKDTIKN 1764
Cdd:pfam05424 72 DIGDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKddgnyyqlREDWWEANREDIWKAMTCAL----TYGAKYF 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1765 KSNYNYHNVKFSDNRNGPDLETFAKRPQFLR 1795
Cdd:pfam05424 148 RKTCGDGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2168-2390 |
2.40e-39 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
:
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 145.49 E-value: 2.40e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2168 ICVPPRRRRLYVGKLTQWASqrtqggtssqivGKTASQPNshptlspssnprddgLRDAFIQSAAVETFFLWDRYKKLNT 2247
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINS------------GNTTTTHD---------------LLKAVILAAKYEGFSLWHKYKKKNT 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2248 KkpdatlgglpqiplamgaingyvpsgddnnpqkkleEGEIPEEFKRQMFYTLGDYRDILFGKnDIVIGNTgsgasdkem 2327
Cdd:pfam05424 54 K------------------------------------YGDIPSEFCRQMAYSFADIGDIIRGK-DLYLGNN--------- 87
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2328 kaKEEKIKETIDKVFPNSVSTPPPTPATKPSDEK-RKTWWEANGEHIWKGMIYALTYKDNGEKK 2390
Cdd:pfam05424 88 --KKKKLEENLKKIFKKIYEKLTSKGKDDGNYYQlREDWWEANREDIWKAMTCALTYGAKYFRK 149
|
|
| PFEMP super family |
cl03834 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
581-726 |
7.13e-18 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
The actual alignment was detected with superfamily member pfam03011:
Pssm-ID: 281064 Cd Length: 154 Bit Score: 83.32 E-value: 7.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 581 FHSWAKNLLIDTIRWEHQLKNCINNTNVTDCTSKCIKNCECYEAWIERKKDEWEKLKEVLNKKDETSHNYYNKLKDVFD- 659
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLDl 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23498129 660 -----RFLFQVMFALDQDEKGKWDQFTEDLKK-KFGPSVESAGTANSQDAIEFLLDHLKDNALTCRDNNSIKP 726
Cdd:pfam03011 82 ksfleTFLFYIDIKEAYGDVKELKKLEEILDEeGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
|
|
| PFEMP super family |
cl03834 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
2738-2884 |
3.49e-12 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
The actual alignment was detected with superfamily member pfam03011:
Pssm-ID: 281064 Cd Length: 154 Bit Score: 66.75 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2738 FLEYWLQDFIEGYyiLKKRKIIEQCKENG-GETCNENSKNDCACVKGWVAQKTTEWNQIKDHYNKKEYGNG--YDMSHKV 2814
Cdd:pfam03011 1 LFKRWVEYFLEDS--IKWRKKLKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGltGKTLDEY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23498129 2815 KNYFEKNENELRKWI-----DNYDVLKNNEEYEVCNNGDKNCNFEGKKRKKDMVTLLLSRLQNEIKTCQNPPPSD 2884
Cdd:pfam03011 79 LDLKSFLETFLFYIDikeayGDVKELKKLEEILDEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
2659-2722 |
8.58e-11 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
:
Pssm-ID: 408346 Cd Length: 52 Bit Score: 59.59 E-value: 8.58e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2659 STEITVEMIDRREpliKNYSKILEEsgnssdslFKTSRLFKSVRDQQWECRYkDEKTDICKLKN 2722
Cdd:pfam18562 1 TTTIDMLVSDNRG---IKFENDLKE--------CKEAGIFKGIRKDQWKCGK-VCGYDVCKLKN 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
3018-3467 |
0e+00 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 775.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3018 TIPFGIALALTSIALLFLKKKPKSPV-DLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTSGDDdKYMF 3096
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDE-KYAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3097 LSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTPSkGDGNTLGDDMIPTTNTFTDEEWNELKHDFI 3176
Cdd:pfam15445 80 MSDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS-DTQNDIPSDDIPSTNKITDEEWNTLKHDFI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3177 SQYIQSRlPMDVPQYDVSTELPMNITEVNVLDVGINEKPFITSIHDRDLYSGEEINYNINMSTNTNNDIPKYVSNNVYSG 3256
Cdd:pfam15445 159 SNMLQNT-QNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNINMSTNSMDDIPKYVSNNVYSG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3257 IDLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKNTSNNSVAKNTNSDSIMNQLDLLHKWLDRRRNMCEKWEkhNKEEL 3336
Cdd:pfam15445 238 IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWK--NKEER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3337 LDKLNEQWNKDNDGI-------NVPSDNRSLNTDVSIQIDMDENKGKKEFSNMDTNVDTPTMDNILDDLETCNEPFYDIY 3409
Cdd:pfam15445 316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNMDTNPDNSTMDTILDDLEKYNEPYYDIY 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 23498129 3410 EDDIYYDVNDEnpsvDDIPMDHNKVDVPKKVHVEMKIlNNTsnGSLEPEFPISDVWNI 3467
Cdd:pfam15445 396 EDDIYYDVNDH----DASTVDSNNMDVPSKVQIEMDV-NNT--KLVEEKYPISDVWNI 446
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
3019-3467 |
0e+00 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 627.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3019 IPFGIALALTSIALLF-LKKKPKSPVDLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTsgDDDKYMFL 3097
Cdd:PTZ00176 891 VPAGIGVALTLGLLLFkMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYLYVEGDT--DEEKYMFM 968
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3098 SDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTPSKGDGNTlgddmiptTNTFTDEEWNELKHDFIS 3177
Cdd:PTZ00176 969 SDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTQNDIPSDNTP--------SYKLTDEEWNQLKDDFIS 1040
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3178 QYIQSRLPMDVPQydvSTELPMNITEVNVLDVGINEKPFITSIHDRDLYSGEEINYNINMSTNTNNDiPKYVSNNVYSGI 3257
Cdd:PTZ00176 1041 QYLPNTEPNNNYR---SGNSPTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEISYNINMSTNTMDD-PKYVSNNVYSGI 1116
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3258 DLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKNTSNNSVAKNT-NSDSIMNQLDLLHKWLDRRRNMCEKWEkhNKEEL 3336
Cdd:PTZ00176 1117 DLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKWE--NHHER 1194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3337 LDKLNEQWNKDNDGINVPSDNRSLNTDVSIQIDMDENKGKKEFSNMDTNVDTPTMDNIlddletcnepfydiyEDDIYYD 3416
Cdd:PTZ00176 1195 LAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDINVDTPTMDNM---------------EDDIYYD 1259
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 23498129 3417 VND-----ENPSVDDIPMDHNK--VDVPKKVHVEMKILNNTSNGSLEPEFPISDVWNI 3467
Cdd:PTZ00176 1260 VNDndddnDQPSVYDIPMDHNKvdVDVPKKVHIEMKILNNTSNGSLEQQFPISDVWNI 1317
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-418 |
2.42e-115 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 401.72 E-value: 2.42e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 12 KDVKNESHNSARNVLENIGIEIYNEEKKKVNgYTSQLRGDLSRARFHDGLRKAARLgVIPGPANSCDLDHKFYTNINNGY 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSSFGD-VRSGYYDSCSLDHKFHTNINNGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 92 PPARNPCDLRNQNRFGENAEAYCNSDKIRVTGKKSAGGACAPFRRQNMCDKNLEYLDNTNTDDTDDLLGNVLVTAKYEGE 171
Cdd:PTZ00176 83 PPARNPCDGRNQNRFDENGESYCNSDKIRGNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 172 SIVAKHPHKENSEVCTALARSFADIGDIVRGKDMFKRNEEDAVQKGLRAVFKKINDNLKEKEISDY---DNDPNYYKLRE 248
Cdd:PTZ00176 163 SIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIYEGLKNNGAREHykeVKNGNYIKLRE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 249 DWWTANRDQVWRAITCYIPYYVnYFKKTSDDTIVFTN----DGKCGHyEGAPPTnLDYVPQFLRWFDEWAEEFCRIRNHK 324
Cdd:PTZ00176 243 DWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISSlilpYSKCGR-DTDPPV-VDYIPQRLRWMSEWSEYFCNVLNKE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 325 LRKIKDACRNDKERLYCSQNgydctkriekgsscSRENKCTGCSNKCVDYDFWLEKQQNEFKIQKDKYdkeIETYVN-KT 403
Cdd:PTZ00176 320 IDEMNNQCKDCEMSRRCNND--------------TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY---MELYNKaST 382
|
410
....*....|....*
gi 23498129 404 PISNSNSNTKKEYYK 418
Cdd:PTZ00176 383 NITKQNSSAPERGYR 397
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
743-1534 |
5.91e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 267.67 E-value: 5.91e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 743 NGGKLVRVKRlaemmqRRARKQLEKRGGEINlKADASQGKYIRGGKEKKLNGQICNIDTSYSNDSRNGNNGG--PCTGKN 820
Cdd:PTZ00176 21 NIGNEIKDKR------ENESKYTDKLKGSLW-EARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYPPArnPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 821 DKRFKIGTEwSYGEHEKKRTHPEVY-----MPPRREHMCISNLEKLdvvsVIKNGNASHSLLGDVLLAAKYEAKNIkely 895
Cdd:PTZ00176 94 QNRFDENGE-SYCNSDKIRGNENNSnagacAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYEGESI---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 896 qQNNSKNgvidqNDKETICRAMKYSFADIGDIIRGKDMWVQNtDATKLQAYLAKIFDKIKDNHKDIKGKLQYN--GDTDH 973
Cdd:PTZ00176 165 -VNNHPD-----KDKSSVCTALARSFADIGDIVRGKDMFKRN-KHDNVENGLREVFKKIYEGLKNNGAREHYKevKNGNY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 974 KLLREDWWEANRHQVWRAMKC-AIEND--KDMKCNGI------------------PIEDYIPQRLRWMTEWAEWYCKEQS 1032
Cdd:PTZ00176 238 IKLREDWWTANRDQVWKAMTCvAPENAyfRKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSEWSEYFCNVLN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1033 RLYGELLEKCQSCKGKQKC---TEGDvDCGKCKAACDKYKDEINKWREQWTKIKGKYKTLYKKATKpGVTTSNNPK---- 1105
Cdd:PTZ00176 318 KEIDEMNNQCKDCEMSRRCnndTEGE-KCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKAST-NITKQNSSAperg 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1106 -----------DEKDVVDFLKQLLprkSKNTPGVTAMTpntlyssaagyihQELGKTVGCNTQKEFCDNKKGK---YAFK 1171
Cdd:PTZ00176 396 yrrnhrrrgydDDTNVQLFLKKVI---ENNECKVESLG-------------KYLDKTSHCGNYNFNYDNTPGSnrsNAFE 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1172 HPPKEYEEACICdtrqKAQKPIEK------KNDCngikTLLDRsnggtggIDGCNPKI--GNYPSWNCERNESKA-ENKG 1242
Cdd:PTZ00176 460 ITPEKFKKACKC----KIPNPLEKcpneenKNVC----TRFDK-------VYSCTSLSfkNDLSEWNNSGVKNKEnDNNG 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1243 ACVPPRREKFCVSLLAKEGiFKNKGE-DIRETFVKSAALETYFAWKRYNDDNKKAEEELKsgtipenfkrqmyYTFADYR 1321
Cdd:PTZ00176 525 VLVPPRRRNLCINLFSKKD-YKMKDEnDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK-------------FSYADYS 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1322 DIFFGTDITshDHILDVSKNAKNKLKEKngeQKSVIIIDDEKlladWWKEHGHEIWEGMLCALTheiDEEEKNKIKSTYS 1401
Cdd:PTZ00176 591 DIVKGTDMM--NDLKKLNKELNTLLKET---EKGDISVDRKT----WWDDNKNVVWNAMLCGYK---TENENQQLNSSWC 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1402 ydqlkkttngTTPLEKFAErpQFLRWFTEWSDEFCREREKKEEVVEKKCKKDHEGCNKPNTKG--NHGCVSACKDYEEYI 1479
Cdd:PTZ00176 659 ----------NVPDDDNID--QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSMVDitDVECKRLFIDYEEWF 726
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 23498129 1480 STKKKQYNTQKEKFDIDKNKGNEEYENYKDKEAHDYLKDKCFPGTCDY--MEKVKNN 1534
Cdd:PTZ00176 727 RYRYNQWKGLSEKYIKIKKSKNSGVNIPSEECAASYVTKHCNGCICNLrdMEDIHKN 783
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
130-308 |
2.19e-65 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 220.22 E-value: 2.19e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 130 ACAPFRRQNMCDKNLEYLDNTNTDDTDDLLGNVLVTAKYEGESIVAKHPHKEN------SEVCTALARSFADIGDIVRGK 203
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTkygdipSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 204 DMFKRN-EEDAVQKGLRAVFKKINDNLKEKEisdyDNDPNYYKLREDWWTANRDQVWRAITCYIPYYVNYFKKTSDDTIV 282
Cdd:pfam05424 81 DLYLGNnKKKKLEENLKKIFKKIYEKLTSKG----KDDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTCGDGIS 156
|
170 180
....*....|....*....|....*.
gi 23498129 283 FTNDGKcghyEGAPPTNLDYVPQFLR 308
Cdd:pfam05424 157 PSTAGC----NDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1616-1795 |
1.72e-53 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 186.32 E-value: 1.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1616 ACMPPRRQKLCVINLQYFKGK---TTVDLREAFIKCAAVETFFLWHKYKEDNNGGedlqnqlesGIIPDDFKRQMFYTFG 1692
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGnttTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY---------GDIPSEFCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1693 DYRDFLFGTDISKGHGIGSELAKKIDSLFKNIGGKNPGDLS--------RKDWWNENGPYIWKGMLCSLekawGKDTIKN 1764
Cdd:pfam05424 72 DIGDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKddgnyyqlREDWWEANREDIWKAMTCAL----TYGAKYF 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1765 KSNYNYHNVKFSDNRNGPDLETFAKRPQFLR 1795
Cdd:pfam05424 148 RKTCGDGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
844-1018 |
5.93e-52 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 181.70 E-value: 5.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 844 VYMPPRREHMCISNLEKLDvvsvIKNGNASHSLLGDVLLAAKYEAKNIKELYQQNNSKNGVIdqndKETICRAMKYSFAD 923
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKIN----SGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDI----PSEFCRQMAYSFAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 924 IGDIIRGKDMWVQNTDATKLQAYLAKIFDKIKDNHKDIKGKlqyngDTDHKLLREDWWEANRHQVWRAMKCAIENDKD-- 1001
Cdd:pfam05424 73 IGDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKD-----DGNYYQLREDWWEANREDIWKAMTCALTYGAKyf 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1002 ------------MKCNGIPIE--DYIPQRLR 1018
Cdd:pfam05424 148 rktcgdgispstAGCNDDVPTyfDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2168-2390 |
2.40e-39 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 145.49 E-value: 2.40e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2168 ICVPPRRRRLYVGKLTQWASqrtqggtssqivGKTASQPNshptlspssnprddgLRDAFIQSAAVETFFLWDRYKKLNT 2247
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINS------------GNTTTTHD---------------LLKAVILAAKYEGFSLWHKYKKKNT 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2248 KkpdatlgglpqiplamgaingyvpsgddnnpqkkleEGEIPEEFKRQMFYTLGDYRDILFGKnDIVIGNTgsgasdkem 2327
Cdd:pfam05424 54 K------------------------------------YGDIPSEFCRQMAYSFADIGDIIRGK-DLYLGNN--------- 87
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2328 kaKEEKIKETIDKVFPNSVSTPPPTPATKPSDEK-RKTWWEANGEHIWKGMIYALTYKDNGEKK 2390
Cdd:pfam05424 88 --KKKKLEENLKKIFKKIYEKLTSKGKDDGNYYQlREDWWEANREDIWKAMTCALTYGAKYFRK 149
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
581-726 |
7.13e-18 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 83.32 E-value: 7.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 581 FHSWAKNLLIDTIRWEHQLKNCINNTNVTDCTSKCIKNCECYEAWIERKKDEWEKLKEVLNKKDETSHNYYNKLKDVFD- 659
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLDl 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23498129 660 -----RFLFQVMFALDQDEKGKWDQFTEDLKK-KFGPSVESAGTANSQDAIEFLLDHLKDNALTCRDNNSIKP 726
Cdd:pfam03011 82 ksfleTFLFYIDIKEAYGDVKELKKLEEILDEeGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
2738-2884 |
3.49e-12 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 66.75 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2738 FLEYWLQDFIEGYyiLKKRKIIEQCKENG-GETCNENSKNDCACVKGWVAQKTTEWNQIKDHYNKKEYGNG--YDMSHKV 2814
Cdd:pfam03011 1 LFKRWVEYFLEDS--IKWRKKLKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGltGKTLDEY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23498129 2815 KNYFEKNENELRKWI-----DNYDVLKNNEEYEVCNNGDKNCNFEGKKRKKDMVTLLLSRLQNEIKTCQNPPPSD 2884
Cdd:pfam03011 79 LDLKSFLETFLFYIDikeayGDVKELKKLEEILDEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
2659-2722 |
8.58e-11 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Pssm-ID: 408346 Cd Length: 52 Bit Score: 59.59 E-value: 8.58e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2659 STEITVEMIDRREpliKNYSKILEEsgnssdslFKTSRLFKSVRDQQWECRYkDEKTDICKLKN 2722
Cdd:pfam18562 1 TTTIDMLVSDNRG---IKFENDLKE--------CKEAGIFKGIRKDQWKCGK-VCGYDVCKLKN 52
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
3018-3467 |
0e+00 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 775.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3018 TIPFGIALALTSIALLFLKKKPKSPV-DLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTSGDDdKYMF 3096
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDE-KYAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3097 LSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTPSkGDGNTLGDDMIPTTNTFTDEEWNELKHDFI 3176
Cdd:pfam15445 80 MSDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS-DTQNDIPSDDIPSTNKITDEEWNTLKHDFI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3177 SQYIQSRlPMDVPQYDVSTELPMNITEVNVLDVGINEKPFITSIHDRDLYSGEEINYNINMSTNTNNDIPKYVSNNVYSG 3256
Cdd:pfam15445 159 SNMLQNT-QNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNINMSTNSMDDIPKYVSNNVYSG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3257 IDLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKNTSNNSVAKNTNSDSIMNQLDLLHKWLDRRRNMCEKWEkhNKEEL 3336
Cdd:pfam15445 238 IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWK--NKEER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3337 LDKLNEQWNKDNDGI-------NVPSDNRSLNTDVSIQIDMDENKGKKEFSNMDTNVDTPTMDNILDDLETCNEPFYDIY 3409
Cdd:pfam15445 316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNMDTNPDNSTMDTILDDLEKYNEPYYDIY 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 23498129 3410 EDDIYYDVNDEnpsvDDIPMDHNKVDVPKKVHVEMKIlNNTsnGSLEPEFPISDVWNI 3467
Cdd:pfam15445 396 EDDIYYDVNDH----DASTVDSNNMDVPSKVQIEMDV-NNT--KLVEEKYPISDVWNI 446
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
3019-3467 |
0e+00 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 627.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3019 IPFGIALALTSIALLF-LKKKPKSPVDLIRVLDVHKGDYGMPTLESKNRYIPYRSGTYKGKTYIYMEGDTsgDDDKYMFL 3097
Cdd:PTZ00176 891 VPAGIGVALTLGLLLFkMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYLYVEGDT--DEEKYMFM 968
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3098 SDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKSNGNTPSKGDGNTlgddmiptTNTFTDEEWNELKHDFIS 3177
Cdd:PTZ00176 969 SDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTQNDIPSDNTP--------SYKLTDEEWNQLKDDFIS 1040
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3178 QYIQSRLPMDVPQydvSTELPMNITEVNVLDVGINEKPFITSIHDRDLYSGEEINYNINMSTNTNNDiPKYVSNNVYSGI 3257
Cdd:PTZ00176 1041 QYLPNTEPNNNYR---SGNSPTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEISYNINMSTNTMDD-PKYVSNNVYSGI 1116
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3258 DLINDTLSGNKHIDIYDEVLKRKENELFGTNHTKNTSNNSVAKNT-NSDSIMNQLDLLHKWLDRRRNMCEKWEkhNKEEL 3336
Cdd:PTZ00176 1117 DLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHRDMCEKWE--NHHER 1194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 3337 LDKLNEQWNKDNDGINVPSDNRSLNTDVSIQIDMDENKGKKEFSNMDTNVDTPTMDNIlddletcnepfydiyEDDIYYD 3416
Cdd:PTZ00176 1195 LAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDINVDTPTMDNM---------------EDDIYYD 1259
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 23498129 3417 VND-----ENPSVDDIPMDHNK--VDVPKKVHVEMKILNNTSNGSLEPEFPISDVWNI 3467
Cdd:PTZ00176 1260 VNDndddnDQPSVYDIPMDHNKvdVDVPKKVHIEMKILNNTSNGSLEQQFPISDVWNI 1317
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
12-418 |
2.42e-115 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 401.72 E-value: 2.42e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 12 KDVKNESHNSARNVLENIGIEIYNEEKKKVNgYTSQLRGDLSRARFHDGLRKAARLgVIPGPANSCDLDHKFYTNINNGY 91
Cdd:PTZ00176 5 KGVINESKLSARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSSFGD-VRSGYYDSCSLDHKFHTNINNGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 92 PPARNPCDLRNQNRFGENAEAYCNSDKIRVTGKKSAGGACAPFRRQNMCDKNLEYLDNTNTDDTDDLLGNVLVTAKYEGE 171
Cdd:PTZ00176 83 PPARNPCDGRNQNRFDENGESYCNSDKIRGNENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 172 SIVAKHPHKENSEVCTALARSFADIGDIVRGKDMFKRNEEDAVQKGLRAVFKKINDNLKEKEISDY---DNDPNYYKLRE 248
Cdd:PTZ00176 163 SIVNNHPDKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIYEGLKNNGAREHykeVKNGNYIKLRE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 249 DWWTANRDQVWRAITCYIPYYVnYFKKTSDDTIVFTN----DGKCGHyEGAPPTnLDYVPQFLRWFDEWAEEFCRIRNHK 324
Cdd:PTZ00176 243 DWWTANRDQVWKAMTCVAPENA-YFRKTEADGIGISSlilpYSKCGR-DTDPPV-VDYIPQRLRWMSEWSEYFCNVLNKE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 325 LRKIKDACRNDKERLYCSQNgydctkriekgsscSRENKCTGCSNKCVDYDFWLEKQQNEFKIQKDKYdkeIETYVN-KT 403
Cdd:PTZ00176 320 IDEMNNQCKDCEMSRRCNND--------------TEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY---MELYNKaST 382
|
410
....*....|....*
gi 23498129 404 PISNSNSNTKKEYYK 418
Cdd:PTZ00176 383 NITKQNSSAPERGYR 397
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
743-1534 |
5.91e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 267.67 E-value: 5.91e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 743 NGGKLVRVKRlaemmqRRARKQLEKRGGEINlKADASQGKYIRGGKEKKLNGQICNIDTSYSNDSRNGNNGG--PCTGKN 820
Cdd:PTZ00176 21 NIGNEIKDKR------ENESKYTDKLKGSLW-EARFSDGLSSSFGDVRSGYYDSCSLDHKFHTNINNGYPPArnPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 821 DKRFKIGTEwSYGEHEKKRTHPEVY-----MPPRREHMCISNLEKLdvvsVIKNGNASHSLLGDVLLAAKYEAKNIkely 895
Cdd:PTZ00176 94 QNRFDENGE-SYCNSDKIRGNENNSnagacAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYEGESI---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 896 qQNNSKNgvidqNDKETICRAMKYSFADIGDIIRGKDMWVQNtDATKLQAYLAKIFDKIKDNHKDIKGKLQYN--GDTDH 973
Cdd:PTZ00176 165 -VNNHPD-----KDKSSVCTALARSFADIGDIVRGKDMFKRN-KHDNVENGLREVFKKIYEGLKNNGAREHYKevKNGNY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 974 KLLREDWWEANRHQVWRAMKC-AIEND--KDMKCNGI------------------PIEDYIPQRLRWMTEWAEWYCKEQS 1032
Cdd:PTZ00176 238 IKLREDWWTANRDQVWKAMTCvAPENAyfRKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSEWSEYFCNVLN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1033 RLYGELLEKCQSCKGKQKC---TEGDvDCGKCKAACDKYKDEINKWREQWTKIKGKYKTLYKKATKpGVTTSNNPK---- 1105
Cdd:PTZ00176 318 KEIDEMNNQCKDCEMSRRCnndTEGE-KCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKAST-NITKQNSSAperg 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1106 -----------DEKDVVDFLKQLLprkSKNTPGVTAMTpntlyssaagyihQELGKTVGCNTQKEFCDNKKGK---YAFK 1171
Cdd:PTZ00176 396 yrrnhrrrgydDDTNVQLFLKKVI---ENNECKVESLG-------------KYLDKTSHCGNYNFNYDNTPGSnrsNAFE 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1172 HPPKEYEEACICdtrqKAQKPIEK------KNDCngikTLLDRsnggtggIDGCNPKI--GNYPSWNCERNESKA-ENKG 1242
Cdd:PTZ00176 460 ITPEKFKKACKC----KIPNPLEKcpneenKNVC----TRFDK-------VYSCTSLSfkNDLSEWNNSGVKNKEnDNNG 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1243 ACVPPRREKFCVSLLAKEGiFKNKGE-DIRETFVKSAALETYFAWKRYNDDNKKAEEELKsgtipenfkrqmyYTFADYR 1321
Cdd:PTZ00176 525 VLVPPRRRNLCINLFSKKD-YKMKDEnDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK-------------FSYADYS 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1322 DIFFGTDITshDHILDVSKNAKNKLKEKngeQKSVIIIDDEKlladWWKEHGHEIWEGMLCALTheiDEEEKNKIKSTYS 1401
Cdd:PTZ00176 591 DIVKGTDMM--NDLKKLNKELNTLLKET---EKGDISVDRKT----WWDDNKNVVWNAMLCGYK---TENENQQLNSSWC 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1402 ydqlkkttngTTPLEKFAErpQFLRWFTEWSDEFCREREKKEEVVEKKCKKDHEGCNKPNTKG--NHGCVSACKDYEEYI 1479
Cdd:PTZ00176 659 ----------NVPDDDNID--QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSMVDitDVECKRLFIDYEEWF 726
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 23498129 1480 STKKKQYNTQKEKFDIDKNKGNEEYENYKDKEAHDYLKDKCFPGTCDY--MEKVKNN 1534
Cdd:PTZ00176 727 RYRYNQWKGLSEKYIKIKKSKNSGVNIPSEECAASYVTKHCNGCICNLrdMEDIHKN 783
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
130-308 |
2.19e-65 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 220.22 E-value: 2.19e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 130 ACAPFRRQNMCDKNLEYLDNTNTDDTDDLLGNVLVTAKYEGESIVAKHPHKEN------SEVCTALARSFADIGDIVRGK 203
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTkygdipSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 204 DMFKRN-EEDAVQKGLRAVFKKINDNLKEKEisdyDNDPNYYKLREDWWTANRDQVWRAITCYIPYYVNYFKKTSDDTIV 282
Cdd:pfam05424 81 DLYLGNnKKKKLEENLKKIFKKIYEKLTSKG----KDDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTCGDGIS 156
|
170 180
....*....|....*....|....*.
gi 23498129 283 FTNDGKcghyEGAPPTNLDYVPQFLR 308
Cdd:pfam05424 157 PSTAGC----NDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1616-1795 |
1.72e-53 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 186.32 E-value: 1.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1616 ACMPPRRQKLCVINLQYFKGK---TTVDLREAFIKCAAVETFFLWHKYKEDNNGGedlqnqlesGIIPDDFKRQMFYTFG 1692
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGnttTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY---------GDIPSEFCRQMAYSFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1693 DYRDFLFGTDISKGHGIGSELAKKIDSLFKNIGGKNPGDLS--------RKDWWNENGPYIWKGMLCSLekawGKDTIKN 1764
Cdd:pfam05424 72 DIGDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKddgnyyqlREDWWEANREDIWKAMTCAL----TYGAKYF 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1765 KSNYNYHNVKFSDNRNGPDLETFAKRPQFLR 1795
Cdd:pfam05424 148 RKTCGDGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
844-1018 |
5.93e-52 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 181.70 E-value: 5.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 844 VYMPPRREHMCISNLEKLDvvsvIKNGNASHSLLGDVLLAAKYEAKNIKELYQQNNSKNGVIdqndKETICRAMKYSFAD 923
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKIN----SGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDI----PSEFCRQMAYSFAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 924 IGDIIRGKDMWVQNTDATKLQAYLAKIFDKIKDNHKDIKGKlqyngDTDHKLLREDWWEANRHQVWRAMKCAIENDKD-- 1001
Cdd:pfam05424 73 IGDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKD-----DGNYYQLREDWWEANREDIWKAMTCALTYGAKyf 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1002 ------------MKCNGIPIE--DYIPQRLR 1018
Cdd:pfam05424 148 rktcgdgispstAGCNDDVPTyfDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1243-1426 |
6.72e-42 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 152.81 E-value: 6.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1243 ACVPPRREKFCVSLLAKEGIFK-NKGEDIRETFVKSAALETYFAWKRYNDDNKKAeeelksGTIPENFKRQMYYTFADYR 1321
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNtTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY------GDIPSEFCRQMAYSFADIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1322 DIFFGTDITSHDhilDVSKNAKNKLK---EKNGEQ---KSVIIIDDEKLLADWWKEHGHEIWEGMLCALTHeideEEKNK 1395
Cdd:pfam05424 75 DIIRGKDLYLGN---NKKKKLEENLKkifKKIYEKltsKGKDDGNYYQLREDWWEANREDIWKAMTCALTY----GAKYF 147
|
170 180 190
....*....|....*....|....*....|.
gi 23498129 1396 IKSTYSYDQLKKTTNGTTPLEKFAERPQFLR 1426
Cdd:pfam05424 148 RKTCGDGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
2168-2390 |
2.40e-39 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 145.49 E-value: 2.40e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2168 ICVPPRRRRLYVGKLTQWASqrtqggtssqivGKTASQPNshptlspssnprddgLRDAFIQSAAVETFFLWDRYKKLNT 2247
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINS------------GNTTTTHD---------------LLKAVILAAKYEGFSLWHKYKKKNT 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2248 KkpdatlgglpqiplamgaingyvpsgddnnpqkkleEGEIPEEFKRQMFYTLGDYRDILFGKnDIVIGNTgsgasdkem 2327
Cdd:pfam05424 54 K------------------------------------YGDIPSEFCRQMAYSFADIGDIIRGK-DLYLGNN--------- 87
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2328 kaKEEKIKETIDKVFPNSVSTPPPTPATKPSDEK-RKTWWEANGEHIWKGMIYALTYKDNGEKK 2390
Cdd:pfam05424 88 --KKKKLEENLKKIFKKIYEKLTSKGKDDGNYYQlREDWWEANREDIWKAMTCALTYGAKYFRK 149
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1233-1869 |
2.90e-29 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 129.38 E-value: 2.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1233 RNESKAENKGACVPPRREKFCVSLLakEGIFKNKGEDIRETFVKSAALETYFAWKRYNDDNKKAEEELKSGtipenfkrq 1312
Cdd:PTZ00176 111 RGNENNSNAGACAPFRRQNMCDKNL--EYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKSSVCTA--------- 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1313 MYYTFADYRDIFFGTDI---TSHDHILD-------------VSKNAKNKLKE-KNGEQKsviiiddeKLLADWWKEHGHE 1375
Cdd:PTZ00176 180 LARSFADIGDIVRGKDMfkrNKHDNVENglrevfkkiyeglKNNGAREHYKEvKNGNYI--------KLREDWWTANRDQ 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1376 IWEGMLCA-------LTHEIDEEEKNKIKSTYSydqlKKTTNGTTPLEKFAerPQFLRWFTEWSDEFCREREKKEEVVEK 1448
Cdd:PTZ00176 252 VWKAMTCVapenayfRKTEADGIGISSLILPYS----KCGRDTDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNN 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1449 KCKkDHEGCNKPNTKGNHG----CVSACKDYEEYISTKKKQYNTQKEKF---------DIDKNKGNEEYENYK------- 1508
Cdd:PTZ00176 326 QCK-DCEMSRRCNNDTEGEkckkCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastNITKQNSSAPERGYRrnhrrrg 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1509 ---DKEAHDYLKDKCFPGTCD------YMEKVKN----NSEYWDKPNKTYTNS------DLEKKCECKPQPPPPAPAPTQ 1569
Cdd:PTZ00176 405 yddDTNVQLFLKKVIENNECKveslgkYLDKTSHcgnyNFNYDNTPGSNRSNAfeitpeKFKKACKCKIPNPLEKCPNEE 484
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1570 SAceivddilNGKSATDYIEKCNGKYKYGRYPEWNcNSQI---HRTHNGACMPPRRQKLCvINL---QYFKGKTTVDLRE 1643
Cdd:PTZ00176 485 NK--------NVCTRFDKVYSCTSLSFKNDLSEWN-NSGVknkENDNNGVLVPPRRRNLC-INLfskKDYKMKDENDFKE 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1644 AFIKCAAVETFFLWHKYKEDNNGGEDlqnqlesgiipddfkrQMFYTFGDYRDFLFGTDISKGHgigSELAKKIDSLFKN 1723
Cdd:PTZ00176 555 DLLNAAFSQGKLLGKKYSNYSNEAYE----------------AMKFSYADYSDIVKGTDMMNDL---KKLNKELNTLLKE 615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1724 iggKNPGDLS--RKDWWNENGPYIWKGMLCslekAWGKDTIKNKSNYNYHNVKFSDNRNgpdletfakrpQFLRWFTEWG 1801
Cdd:PTZ00176 616 ---TEKGDISvdRKTWWDDNKNVVWNAMLC----GYKTENENQQLNSSWCNVPDDDNID-----------QFLRWLTEWA 677
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 1802 DEFCREQKKQLDILKKKCPKETctnEGKKK---------ECSDACKAYKEWLQ----TWKEHYEKQkIKYENDKDSYTND 1868
Cdd:PTZ00176 678 QQYCKEKLIKAHIINTKCKDIV---EGRKHksmvditdvECKRLFIDYEEWFRyrynQWKGLSEKY-IKIKKSKNSGVNI 753
|
.
gi 23498129 1869 P 1869
Cdd:PTZ00176 754 P 754
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
581-726 |
7.13e-18 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 83.32 E-value: 7.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 581 FHSWAKNLLIDTIRWEHQLKNCINNTNVTDCTSKCIKNCECYEAWIERKKDEWEKLKEVLNKKDETSHNYYNKLKDVFD- 659
Cdd:pfam03011 2 FKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLDl 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23498129 660 -----RFLFQVMFALDQDEKGKWDQFTEDLKK-KFGPSVESAGTANSQDAIEFLLDHLKDNALTCRDNNSIKP 726
Cdd:pfam03011 82 ksfleTFLFYIDIKEAYGDVKELKKLEEILDEeGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
129-394 |
1.49e-12 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 74.30 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 129 GACAPFRRQNMCdKNLEYLDNTNTDDTDDLLGNVLVTAKYEGESIVAKHPHKENsEVCTALARSFADIGDIVRGKDMFkr 208
Cdd:PTZ00176 524 GVLVPPRRRNLC-INLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSN-EAYEAMKFSYADYSDIVKGTDMM-- 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 209 needavqKGLRAVFKKINDNLKEKEISDYDNDpnyyklREDWWTANRDQVWRAITCyipyyvNYFKKTSDDTIvftNDGK 288
Cdd:PTZ00176 600 -------NDLKKLNKELNTLLKETEKGDISVD------RKTWWDDNKNVVWNAMLC------GYKTENENQQL---NSSW 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 289 CGhyegaPPTNlDYVPQFLRWFDEWAEEFCR---IRNHKLR-KIKDACRNDKERLYCSQNGYDCtKRIekgsscsrenkc 364
Cdd:PTZ00176 658 CN-----VPDD-DNIDQFLRWLTEWAQQYCKeklIKAHIINtKCKDIVEGRKHKSMVDITDVEC-KRL------------ 718
|
250 260 270
....*....|....*....|....*....|
gi 23498129 365 tgcsnkCVDYDFWLEKQQNEFKIQKDKYDK 394
Cdd:PTZ00176 719 ------FIDYEEWFRYRYNQWKGLSEKYIK 742
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
2738-2884 |
3.49e-12 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 66.75 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23498129 2738 FLEYWLQDFIEGYyiLKKRKIIEQCKENG-GETCNENSKNDCACVKGWVAQKTTEWNQIKDHYNKKEYGNG--YDMSHKV 2814
Cdd:pfam03011 1 LFKRWVEYFLEDS--IKWRKKLKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGltGKTLDEY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23498129 2815 KNYFEKNENELRKWI-----DNYDVLKNNEEYEVCNNGDKNCNFEGKKRKKDMVTLLLSRLQNEIKTCQNPPPSD 2884
Cdd:pfam03011 79 LDLKSFLETFLFYIDikeayGDVKELKKLEEILDEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
2659-2722 |
8.58e-11 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Pssm-ID: 408346 Cd Length: 52 Bit Score: 59.59 E-value: 8.58e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23498129 2659 STEITVEMIDRREpliKNYSKILEEsgnssdslFKTSRLFKSVRDQQWECRYkDEKTDICKLKN 2722
Cdd:pfam18562 1 TTTIDMLVSDNRG---IKFENDLKE--------CKEAGIFKGIRKDQWKCGK-VCGYDVCKLKN 52
|
|
| NTS |
pfam15447 |
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ... |
21-56 |
5.48e-09 |
|
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.
Pssm-ID: 406013 [Multi-domain] Cd Length: 36 Bit Score: 53.94 E-value: 5.48e-09
10 20 30
....*....|....*....|....*....|....*.
gi 23498129 21 SARNVLENIGIEIYNEEKKKVNGYTSQLRGDLSRAR 56
Cdd:pfam15447 1 SAKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSKAK 36
|
|
| |
