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NCBI's Conserved Domain Database (CDD) is now available as a preview version, providing protein domain family models and corresponding RPS-BLAST search databases that are not yet part of a versioned public release. Find more details on the CDD News Page if you want to scan protein or nucleotide query sequences against the NCBI_Preview set.

Query Exception:
[2025-06-18T00:00:07.141645] The service has encountered an internal error. If the problem persists, please contact NIH helpdesk.
RID = 4BCJSP7801R
Search for Conserved Domains within a protein or coding nucleotide sequence

Enter protein or nucleotide query as accession, gi, or sequence in FASTA format. For multiple protein queries, use Batch CD-Search.

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References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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