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Conserved domains on  [gi|73975942|ref|XP_851403|]
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ubiquitin-conjugating enzyme E2 N-like [Canis lupus familiaris]

Protein Classification

ubiquitin-conjugating enzyme family protein( domain architecture ID 439)

ubiquitin-conjugating enzyme family protein similar to ubiquitin-conjugating enzyme E2 that catalyzes the covalent attachment of ubiquitin to other proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UBCc super family cl00154
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ...
78-224 7.25e-81

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.


The actual alignment was detected with superfamily member PTZ00390:

Pssm-ID: 444715  Cd Length: 152  Bit Score: 238.17  E-value: 7.25e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942   78 LPRRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKL 157
Cdd:PTZ00390   3 ISKRIEKETQNLANDPPPGIKAEPDPGNYRHFKILMEGPDGTPYEGGYYKLELFLPEQYPMEPPKVRFLTKIYHPNIDKL 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 73975942  158 GRICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAMNN 224
Cdd:PTZ00390  83 GRICLDILKDKWSPALQIRTVLLSIQAlLSAPEPDDPLDTSVADHFKNNRADAEKVAREWNQKYAKHN 150
 
Name Accession Description Interval E-value
PTZ00390 PTZ00390
ubiquitin-conjugating enzyme; Provisional
78-224 7.25e-81

ubiquitin-conjugating enzyme; Provisional


Pssm-ID: 240397  Cd Length: 152  Bit Score: 238.17  E-value: 7.25e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942   78 LPRRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKL 157
Cdd:PTZ00390   3 ISKRIEKETQNLANDPPPGIKAEPDPGNYRHFKILMEGPDGTPYEGGYYKLELFLPEQYPMEPPKVRFLTKIYHPNIDKL 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 73975942  158 GRICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAMNN 224
Cdd:PTZ00390  83 GRICLDILKDKWSPALQIRTVLLSIQAlLSAPEPDDPLDTSVADHFKNNRADAEKVAREWNQKYAKHN 150
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
81-217 1.11e-60

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 395127  Cd Length: 139  Bit Score: 186.63  E-value: 1.11e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942    81 RIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLGRI 160
Cdd:pfam00179   1 RLQKELKELLKDPPPGISAGPVDDNLFEWKVTIIGPDGTPYEGGVFKLSVEFPEDYPFKPPKVKFTTKIYHPNVDSSGEV 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 73975942   161 CLDVLKDK-WSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWT 217
Cdd:pfam00179  81 CLDILKDErWSPALTLEQVLLSIQSlLSEPNPEDPLNAEAAKLYRKNREEFEKKVREYV 139
COG5078 COG5078
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
74-223 4.99e-60

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227410  Cd Length: 153  Bit Score: 185.54  E-value: 4.99e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942  74 KTAGLPRRIIKETQRLLAEPVPGIRAEP-DESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHP 152
Cdd:COG5078   2 SSPSALKRLLKELKKLQKDPPPGISAGPvDDDNLFHWEATITGPPDTPYEGGIFKLTLEFPEDYPFKPPKVRFTTKIFHP 81
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73975942 153 NVDKLGRICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAMN 223
Cdd:COG5078  82 NVDPSGNVCLDILKDRWSPVYTLETILLSLQSlLLSPNPDSPLNTEAATLYREDKEEYEKKVREWVKKYAEK 153
UBCc cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ...
79-217 1.43e-58

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.


Pssm-ID: 238117  Cd Length: 141  Bit Score: 181.25  E-value: 1.43e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942  79 PRRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLG 158
Cdd:cd00195   1 SKRLQKELKDLKKDPPSGISAEPVEENLLEWHGTIRGPPDTPYEGGIFKLDIEFPEDYPFKPPKVRFVTKIYHPNVDENG 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 73975942 159 RICLDVLKD-KWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWT 217
Cdd:cd00195  81 KICLSILKThGWSPAYTLRTVLLSLQSlLNEPNPSDPLNAEAAKLYKENREEFKKKAREWT 141
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
81-222 6.84e-56

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562  Cd Length: 145  Bit Score: 174.79  E-value: 6.84e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942     81 RIIKETQRLLAEPVPGIRAEP-DESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLGR 159
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYPvDDENLLEWTGTIVGPPGTPYEGGVFKLTIEFPEDYPFKPPKVKFITKIYHPNVDSSGE 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 73975942    160 ICLDVLK-DKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAM 222
Cdd:smart00212  81 ICLDILKqEKWSPALTLETVLLSLQSlLSEPNPDSPLNADAAELYKKNREEFKKKAREWTKKYAE 145
 
Name Accession Description Interval E-value
PTZ00390 PTZ00390
ubiquitin-conjugating enzyme; Provisional
78-224 7.25e-81

ubiquitin-conjugating enzyme; Provisional


Pssm-ID: 240397  Cd Length: 152  Bit Score: 238.17  E-value: 7.25e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942   78 LPRRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKL 157
Cdd:PTZ00390   3 ISKRIEKETQNLANDPPPGIKAEPDPGNYRHFKILMEGPDGTPYEGGYYKLELFLPEQYPMEPPKVRFLTKIYHPNIDKL 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 73975942  158 GRICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAMNN 224
Cdd:PTZ00390  83 GRICLDILKDKWSPALQIRTVLLSIQAlLSAPEPDDPLDTSVADHFKNNRADAEKVAREWNQKYAKHN 150
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
81-217 1.11e-60

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 395127  Cd Length: 139  Bit Score: 186.63  E-value: 1.11e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942    81 RIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLGRI 160
Cdd:pfam00179   1 RLQKELKELLKDPPPGISAGPVDDNLFEWKVTIIGPDGTPYEGGVFKLSVEFPEDYPFKPPKVKFTTKIYHPNVDSSGEV 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 73975942   161 CLDVLKDK-WSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWT 217
Cdd:pfam00179  81 CLDILKDErWSPALTLEQVLLSIQSlLSEPNPEDPLNAEAAKLYRKNREEFEKKVREYV 139
COG5078 COG5078
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
74-223 4.99e-60

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227410  Cd Length: 153  Bit Score: 185.54  E-value: 4.99e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942  74 KTAGLPRRIIKETQRLLAEPVPGIRAEP-DESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHP 152
Cdd:COG5078   2 SSPSALKRLLKELKKLQKDPPPGISAGPvDDDNLFHWEATITGPPDTPYEGGIFKLTLEFPEDYPFKPPKVRFTTKIFHP 81
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73975942 153 NVDKLGRICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAMN 223
Cdd:COG5078  82 NVDPSGNVCLDILKDRWSPVYTLETILLSLQSlLLSPNPDSPLNTEAATLYREDKEEYEKKVREWVKKYAEK 153
UBCc cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ...
79-217 1.43e-58

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.


Pssm-ID: 238117  Cd Length: 141  Bit Score: 181.25  E-value: 1.43e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942  79 PRRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLG 158
Cdd:cd00195   1 SKRLQKELKDLKKDPPSGISAEPVEENLLEWHGTIRGPPDTPYEGGIFKLDIEFPEDYPFKPPKVRFVTKIYHPNVDENG 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 73975942 159 RICLDVLKD-KWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWT 217
Cdd:cd00195  81 KICLSILKThGWSPAYTLRTVLLSLQSlLNEPNPSDPLNAEAAKLYKENREEFKKKAREWT 141
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
81-222 6.84e-56

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562  Cd Length: 145  Bit Score: 174.79  E-value: 6.84e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942     81 RIIKETQRLLAEPVPGIRAEP-DESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLGR 159
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYPvDDENLLEWTGTIVGPPGTPYEGGVFKLTIEFPEDYPFKPPKVKFITKIYHPNVDSSGE 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 73975942    160 ICLDVLK-DKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYAM 222
Cdd:smart00212  81 ICLDILKqEKWSPALTLETVLLSLQSlLSEPNPDSPLNADAAELYKKNREEFKKKAREWTKKYAE 145
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
80-221 2.08e-38

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 130.25  E-value: 2.08e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73975942   80 RRIIKETQRLLAEPVPGIRAEPDESNARYFHVVIAGPQGSPFEGGTFKLELFLPEECPMAAPKVRFMTKIYHPNVDKLGR 159
Cdd:PLN00172   4 KRIQKEHKDLLKDPPSNCSAGPSDENLFRWTASIIGPSDSPYAGGVFFLSILFPPDYPFKPPKVQFTTKIYHPNINSNGS 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 73975942  160 ICLDVLKDKWSPALQIRTVLLSIQA-LSAPNPDDPLANDEAEQWKTNDAQAIETARAWTRLYA 221
Cdd:PLN00172  84 ICLDILRDQWSPALTVSKVLLSISSlLTDPNPDDPLVPEIARVFKENRSRYEATAREWTQRYA 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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