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Conserved domains on  [gi|6981308|ref|NP_036749|]
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delta-type opioid receptor [Rattus norvegicus]

Protein Classification

7tmA_Delta_opioid_R domain-containing protein (domain architecture ID 11606794)

7tmA_Delta_opioid_R domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
50-329 7.76e-177

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


:

Pssm-ID: 320217  Cd Length: 281  Bit Score: 497.17  E-value: 7.76e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKVVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQ-PRDGAVVCTLQFPSPSWY 208
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKtPRDGTVVCMLQFPDPSWY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVD 288
Cdd:cd15089 161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 INRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15089 241 IDKRNPLVVASLHLCIALGYTNSSLNPVLYAFLDENFKRCF 281
 
Name Accession Description Interval E-value
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
50-329 7.76e-177

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217  Cd Length: 281  Bit Score: 497.17  E-value: 7.76e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKVVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQ-PRDGAVVCTLQFPSPSWY 208
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKtPRDGTVVCMLQFPDPSWY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVD 288
Cdd:cd15089 161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 INRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15089 241 IDKRNPLVVASLHLCIALGYTNSSLNPVLYAFLDENFKRCF 281
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
66-318 2.54e-66

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 278431  Cd Length: 254  Bit Score: 213.71  E-value: 2.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308     66 GNVLVMFGIVRYTKLKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSV 144
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfLLLTLPFWLVYALFGTWPFGSALCKLVTALDVVNGYASILLLTAISI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    145 DRYIAVCHPVKALdfRTPAKAKLINICIWVLASGVGVPIMVMA--VTQPRDGAVVCTLQFpsPSWYWDTVTKICVFLFAF 222
Cdd:pfam00001  81 DRYLAIVHPLRYR--RIMRRAKAIILLIWVLALLLSLPPLLGWntLDIPSNGVTSCLITF--PESLWPVSYLLFSTVVGF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    223 VVPILIITVCYGlmLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVV----A 298
Cdd:pfam00001 157 LLPLLVILVCYT--RIIRTLRKQARSRRRSVRSERKALKTLLVVVVVFILCWLPYHILNLLDSLCDLLIIISCVVtpprT 234
                         250       260
                  ....*....|....*....|
gi 6981308    299 ALHLCIALGYANSSLNPVLY 318
Cdd:pfam00001 235 LLQLTVWLAYSNSCLNPIIY 254
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
48-334 3.25e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976  Cd Length: 335  Bit Score: 149.93  E-value: 3.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    48 LAIAITALYSAVCAVGLLGNVLVMFgIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSI 127
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   128 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSW 207
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   208 YWDTVTKICVFLFAFVVPILIITVCYglmllrLRSVRLLSGSKEKDRSLRRItRMVLVVVGAFVVCWAPIHIFVIVWTLV 287
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCY------SKILITLKGINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6981308   288 DINRRD-----PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR 334
Cdd:PHA03087 271 ILHFKSgckavKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
 
Name Accession Description Interval E-value
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
50-329 7.76e-177

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217  Cd Length: 281  Bit Score: 497.17  E-value: 7.76e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKVVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQ-PRDGAVVCTLQFPSPSWY 208
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKtPRDGTVVCMLQFPDPSWY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVD 288
Cdd:cd15089 161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 INRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15089 241 IDKRNPLVVASLHLCIALGYTNSSLNPVLYAFLDENFKRCF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
50-329 1.65e-135

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101  Cd Length: 282  Bit Score: 392.04  E-value: 1.65e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQP-RDGAVVCTLQFPSPSWY 208
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQeEGGTISCNLQWPDPPDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLL--RLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd14970 161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRrlRSSRNLSTSGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6981308  287 VDINrRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14970 241 IDPP-ETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
50-329 2.27e-135

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218  Cd Length: 279  Bit Score: 391.66  E-value: 2.27e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYW 209
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  210 DTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDI 289
Cdd:cd15090 161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6981308  290 NrRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15090 241 P-ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
50-329 2.82e-133

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219  Cd Length: 282  Bit Score: 386.62  E-value: 2.82e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR--DGAVVCTLQFPSPS- 206
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRedVDSTECSLQFPDDDy 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd15091 161 SWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6981308  287 VDINRRDPlVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15091 241 GSVSHSTA-AVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
50-329 2.39e-124

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220  Cd Length: 279  Bit Score: 363.42  E-value: 2.39e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVIVRYTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKIVIAIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYW 209
Cdd:cd15092  81 YNMFTSTFTLTMMSVDRYVAICHPIKALDIRTPHKAKVVNVCIWALASVIGVPVMVMGSAQVENEEIECLVEIPTPQDYW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  210 DTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLvDI 289
Cdd:cd15092 161 DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRVLSGSKEKDRNLRRITRLVLVVVAVFVICWTPIQIFVLAQSL-GA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6981308  290 NRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15092 240 KPSSELAVAILHFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-329 1.94e-84

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221  Cd Length: 280  Bit Score: 261.24  E-value: 1.94e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR-DGAVVCTLQFPSPSWY 208
Cdd:cd15093  81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENqDGSSACNMQWPEPAAA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVwTLVD 288
Cdd:cd15093 161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLV-NVFV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 INRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15093 240 QLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
50-329 2.12e-76

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636  Cd Length: 276  Bit Score: 240.58  E-value: 2.12e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15970   1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR-DGAVVCTLQFPSPSWY 208
Cdd:cd15970  81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNsDGSVACNMQMPEPSQR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVd 288
Cdd:cd15970 161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFV- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 inRRDPLVVAalHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15970 240 --GQHDATVS--QLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
50-329 5.38e-76

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639  Cd Length: 274  Bit Score: 239.37  E-value: 5.38e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR-DGAVVCTLQFPSPSwy 208
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRkGQAVACNLIWPHPA-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVd 288
Cdd:cd15973 159 WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFL- 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  289 iNRRDPLVVaalHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15973 238 -PRLDATVN---HASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
52-329 1.74e-70

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637  Cd Length: 279  Bit Score: 225.49  E-value: 1.74e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYN 131
Cdd:cd15971   3 LTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  132 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDT 211
Cdd:cd15971  83 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSAWYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  212 VTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDInR 291
Cdd:cd15971 163 GFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSI-S 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6981308  292 RDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15971 242 PTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
66-318 2.54e-66

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 278431  Cd Length: 254  Bit Score: 213.71  E-value: 2.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308     66 GNVLVMFGIVRYTKLKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSV 144
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfLLLTLPFWLVYALFGTWPFGSALCKLVTALDVVNGYASILLLTAISI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    145 DRYIAVCHPVKALdfRTPAKAKLINICIWVLASGVGVPIMVMA--VTQPRDGAVVCTLQFpsPSWYWDTVTKICVFLFAF 222
Cdd:pfam00001  81 DRYLAIVHPLRYR--RIMRRAKAIILLIWVLALLLSLPPLLGWntLDIPSNGVTSCLITF--PESLWPVSYLLFSTVVGF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    223 VVPILIITVCYGlmLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVV----A 298
Cdd:pfam00001 157 LLPLLVILVCYT--RIIRTLRKQARSRRRSVRSERKALKTLLVVVVVFILCWLPYHILNLLDSLCDLLIIISCVVtpprT 234
                         250       260
                  ....*....|....*....|
gi 6981308    299 ALHLCIALGYANSSLNPVLY 318
Cdd:pfam00001 235 LLQLTVWLAYSNSCLNPIIY 254
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
55-329 6.74e-66

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222  Cd Length: 282  Bit Score: 213.49  E-value: 6.74e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   55 LYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFT 134
Cdd:cd15094   6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  135 SIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFP-SPSWYWDTVT 213
Cdd:cd15094  86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPdSSAVNGQKAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  214 KICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRD 293
Cdd:cd15094 166 TLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDM 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6981308  294 P-LVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15094 246 PkWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
50-329 1.05e-64

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215  Cd Length: 282  Bit Score: 210.37  E-value: 1.05e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPV--KALDFRTPAKAKLINICIWVLASGVGVPIMVMA-VTQPRDGAVVCTLQFPSPS 206
Cdd:cd15087  81 YNIFSSIYFLTVMSVDRYLVVLATVrsRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAgVYSNELGRKSCVLSFPSPE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd15087 161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6981308  287 VDInRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15087 241 TDL-PQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
50-329 1.70e-63

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640  Cd Length: 277  Bit Score: 207.35  E-value: 1.70e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPrdGAVVCTLQFPSPSWYW 209
Cdd:cd15974  81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQP--DLNTCNISWPEPVSVW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  210 DTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVwTLVDI 289
Cdd:cd15974 159 STAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIV-NLIVI 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6981308  290 NRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15974 238 LPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
52-322 2.11e-63

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 320095  Cd Length: 270  Bit Score: 206.49  E-value: 2.11e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd14964   1 LFVLLLLIFLLGLLGNLLVLLVILRSRRLRTPTNLFLLNLALADLLFSLVvVPFLLLGLLSGEWSFGFAGCKLVLFFFYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWD 210
Cdd:cd14964  81 FGFASIFLLTAMAIDRYLAICHPLKYTVLMTPRRARLLILGIWVLSLLLSLPPLLGWGTLPFCGPNVPLLTLSCSDTAWN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  211 TVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSK-EKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVdi 289
Cdd:cd14964 161 IAYTLGLLILGFLLPLLLILVSYARIVRALLRRKRITRSAiSSARRERKAFKTLLIVVLVFLLCWLPYHIVYLLPALL-- 238
                       250       260       270
                ....*....|....*....|....*....|...
gi 6981308  290 nRRDPLVVAALHLCIALGYANSSLNPVLYAFLD 322
Cdd:cd14964 239 -QLSNSLPLLLLLSVLLAVLNSCLNPLIYSLRN 270
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
50-327 5.40e-63

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216  Cd Length: 278  Bit Score: 205.76  E-value: 5.40e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLM-ETWPFGELLCKAVLSID 128
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIdGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV-MAVTQPRDGAVVCTLQFPSPS- 206
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVySSLIYFPDGTTFCYVSLPSPDd 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTvtkICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHifVIVWTL 286
Cdd:cd15088 161 LYWFT---IYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFH--VVQLVN 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6981308  287 VDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKR 327
Cdd:cd15088 236 LAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
50-329 5.08e-57

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638  Cd Length: 279  Bit Score: 190.40  E-value: 5.08e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTqPRDGAvVCTLQFPSPSWYW 209
Cdd:cd15972  81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGV-PGGMG-TCHIAWPEPAQVW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  210 DTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVR--LLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLV 287
Cdd:cd15972 159 RAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGrrVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVC 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 6981308  288 DINrRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15972 239 PLP-EEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
52-321 5.18e-55

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 320086  Cd Length: 274  Bit Score: 184.79  E-value: 5.18e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLvGLLVIPFSLVSLLLGGWWFGDALCKLLGFLQTV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTlqFPSPSWYWD 210
Cdd:cd00637  81 SLTASILTLTAISVDRYLAIVHPLRYRRRFTKRRAKLVIALIWLLSLLLALPPLLGWKVYEYGGYCCCC--LCWPDLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  211 TVTKICVFLFAFVVPILIITVCYGL------MLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVW 284
Cdd:cd00637 159 KAYTIFLFVLLFLLPLLVIIVCYVRifrklrRHRKRISSSSNSSRRRRRRRERKVTKMLLIVVVVFLLCWLPYFILFLLD 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6981308  285 TLVDINRRDPLVVaaLHLCIALGYANSSLNPVLYAFL 321
Cdd:cd00637 239 VFGPDPSPLPRIL--YFLALLLAYLNSAINPIIYAFF 273
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-329 5.35e-54

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226  Cd Length: 282  Bit Score: 182.62  E-value: 5.35e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLK--TATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLS 126
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADlFFLLFCVPFQATIYSLPEWVFGAFMCKFVHY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  127 IDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAV---TQPRDGAVVCTLQFP 203
Cdd:cd15098  81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDlvhHWTASNQTFCWENWP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  204 SPSWYwdTVTKICVFLFAFVVPILIITVCYgLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIfVIV 283
Cdd:cd15098 161 EKQQK--PVYVVCTFVFGYLLPLLLITFCY-AKVLNHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHI-IHL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6981308  284 WtlvdINRRD-PLVVAALHLCIA---LGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15098 237 W----VEFGDfPLTQASFVLRITahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
50-329 6.14e-54

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223  Cd Length: 288  Bit Score: 182.48  E-value: 6.14e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVlsid 128
Cdd:cd15095   1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDlAFLVCCVPFTAALYATPSWVFGDFMCKFV---- 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSI----FTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR--DGAVV-CTLQ 201
Cdd:cd15095  77 NYMMQVTVqatcLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGywYGPQTyCREV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  202 FPSPSWYwdTVTKICVFLFAFVVPILIITVCYGL------MLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWA 275
Cdd:cd15095 157 WPSKAFQ--KAYMIYTVLLTYVIPLAIIAVCYGLilrrlwRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6981308  276 PIHIFViVWTLVDINRRDPLVVAALH-LCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15095 235 PNHVLN-LWQRFDPNFPETYATYALKiAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
52-327 1.08e-53

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320115  Cd Length: 278  Bit Score: 181.65  E-value: 1.08e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMEtWPFGELLCKAVLSIDYYN 131
Cdd:cd14984   3 LPVLYSLVFVLGLVGNSLVLLVLLYYKKLRSMTDVYLLNLALSDLLFVLTLPFWAVYAAHG-WVFGSFLCKLVSALYTIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  132 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWY-WD 210
Cdd:cd14984  82 FYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLAVWALALLLSLPEFIFSQVYEENGSSRCSYIYPEDTATtWK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  211 TVTKICVFLFAFVVPILIITVCYGlmllRLRSVRLLSGSKEKDRSLRRItrmvLVVVGAFVVCWAPIHIFVIVWTLVDIN 290
Cdd:cd14984 162 TLLRLLQNILGFLLPLLVMLFCYS----RIIRTLLRARNHKKHRALRLI----FAVVVVFFLCWLPYNIVLLLDTLQRLG 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6981308  291 RRDP------LVVAALHLCIALGYANSSLNPVLYAFLDENFKR 327
Cdd:cd14984 234 VIIRscelskRLDYALQVTETLAFSHCCLNPVLYAFVGEKFRK 276
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
50-329 1.61e-53

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124  Cd Length: 296  Bit Score: 181.64  E-value: 1.61e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSID 128
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDG-------AVVCTLQ 201
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYICTED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  202 FPSPSW--YWDtvtkICVFLFAFVVPILIITVCYG-------LMLLRLRSVRLLSGSKEK-DRSLRRITRMVLVVVGAFV 271
Cdd:cd14993 161 WPSPELrkAYN----VALFVVLYVLPLLIISVAYSligrrlwRRKPPGDRGSANSTSSRRiLRSKKKVARMLIVVVVLFA 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981308  272 VCWAPIHifvIVWTLVD----INRRDPLVVAALHLCIA-LGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14993 237 LSWLPYY---VLSILLDfgplSSEESDENFLLILPFAQlLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
50-327 7.42e-53

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320113  Cd Length: 283  Bit Score: 179.38  E-value: 7.42e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLM-ETWPFGELLCKAVLSID 128
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNgGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWY 208
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLAASVPLLLLRSTIAKENNSTTCFEFLSEWLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLlsgSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVD 288
Cdd:cd14982 161 SAAPLVLIALVVGFLIPLLIILVCYSLIIRALRRRSK---QSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVR 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6981308  289 IN-----RRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKR 327
Cdd:cd14982 238 LSviadcSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
52-329 8.13e-51

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102  Cd Length: 281  Bit Score: 174.19  E-value: 8.13e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd14971   3 VPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADlTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIM-VMAVTQPRDGAV-VCTLQFPSPswY 208
Cdd:cd14971  83 SMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLaLHRLRNYTPGNRtVCSEAWPSR--A 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 WDTVTKICVFLFAFVVPILIITVCYGLMLLRL-RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFvIVWTLV 287
Cdd:cd14971 161 HRRAFALCTFLFGYLLPLLLICVCYAAMLRHLwRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAI-LLLVAL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 6981308  288 DINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14971 240 GPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
50-327 1.62e-48

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 320116  Cd Length: 284  Bit Score: 167.95  E-value: 1.62e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSID 128
Cdd:cd14985   1 VVIPAFYIAIFLVGLLGNLFVVWLFLLPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQyDWPFGDFLCKVSSYAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQ--PRDGAVVCTLQFpsPS 206
Cdd:cd14985  81 TVNMFASVFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQalPDLNKTACIELY--PH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGskEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd14985 159 EAWHVGLSLVLNILGFVLPLVIILTCYCHIARTLRTHYERTG--KGGRKRRKSLKIIFAVVVAFLVCWLPFHVFKFLDFL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6981308  287 VDINRRDP-----LVVAALHLCIALGYANSSLNPVLYAFLDENFKR 327
Cdd:cd14985 237 AQLGAIRPcfweaFLDLGLPIATCLAFTNSCLNPFIYVFFDRRFRQ 282
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
50-329 3.54e-48

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105  Cd Length: 274  Bit Score: 166.71  E-value: 3.54e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFgIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLM-ETWPFGELLCKAVLSID 128
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIW-VAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMgHHWPFGSVLCKLNSFVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQ---FPSP 205
Cdd:cd14974  80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTcveDYDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  206 SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLrlrsvrllsgsKEKDRSLRRITR---MVLVVVGAFVVCWAPIHIFVI 282
Cdd:cd14974 160 RRSRHKALTVIRFLCGFLLPLLIIAICYSVIAV-----------KLRRKRLAKSSKplrVLLAVVVAFFLCWLPYHVFAL 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6981308  283 vWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14974 229 -LELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
50-329 1.78e-47

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224  Cd Length: 284  Bit Score: 165.16  E-value: 1.78e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSID 128
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMA-------VTQPRDGAVVCTLQ 201
Cdd:cd15096  81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHgvvsygfSSEAYSYCTFLTEV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  202 FPSPSWYWdtvtkICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG--SKEKDRSLRRITRMVLVVVGAFVVCWAPIHI 279
Cdd:cd15096 161 GTAAQTFF-----TSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGrrSAESQRGKRRVTRLVVVVVVVFAICWLPIHI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6981308  280 FVIVWTLVDINRRDPLVVAALhLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15096 236 ILLLKYYGVLPETVLYVVIQI-LSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
50-329 4.26e-47

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331  Cd Length: 293  Bit Score: 164.70  E-value: 4.26e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATS-TLPFQSAKYLMETWPFGELLCKAVLSID 128
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLvSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKalDFRTPAKAKLINICIWVLASGVGVPIMVM------AVTQPRDGAVVCTLQF 202
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFqelsdvPIEILPYCGYFCTESW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  203 psPSWYWDTVTKICVFLFAFVVPILIITVCYGL--------MLLRLRSVRLLSGSKEKDRS-LRRITRMVLVVVGAFVVC 273
Cdd:cd15203 159 --PSSSSRLIYTISVLVLQFVIPLLIISFCYFRislklrkrVKKKRGKRTLSSRRRRSELRrKRRTNRLLIAMVVVFAVC 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981308  274 WAPIHIFVIV----WTLVDINRRDPLVVAALHLCialgyANSS--LNPVLYAFLDENFKRCF 329
Cdd:cd15203 237 WLPLNLFNLLrdfePLPQIDGRHFYLIFLICHLI-----AMSSacVNPLLYGWLNDNFRKEF 293
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-329 1.96e-46

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098  Cd Length: 259  Bit Score: 161.58  E-value: 1.96e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLvALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWd 210
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYV- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  211 tvtkICVFLFAFVVPILIITVCYGLMLLRLrsvrllsgSKEkdrslRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIN 290
Cdd:cd14967 161 ----LVSSVISFFIPLLIMIVLYARIFRVA--------RRE-----LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPD 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6981308  291 RRDPLVVAAlhlCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14967 224 CVPPILYAV---FFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-329 2.76e-43

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320  Cd Length: 285  Bit Score: 154.13  E-value: 2.76e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSID 128
Cdd:cd15192   1 IMIPTVYSIIFVIGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMGyHWPFGNFLCKISSTLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVM--AVTQPRDGAVVCTLQFPSPS 206
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRIRRTLVVARVTCIVIWLLAGVASLPAIIFrdVFFYENWNKTVCAFHYPNQN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSlrrITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd15192 161 KQLLVGMGLMKNLLGFLIPFLIILTCYTLIGKTLKQAYQIQRSKSRNDE---IFKMIMAVVLFFFFCWIPHQVFTFLDVL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6981308  287 VDIN-----RRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15192 238 IQLKviqncHILEIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
52-329 6.42e-42

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132  Cd Length: 266  Bit Score: 150.12  E-value: 6.42e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQP---RDGAVVCTLQFPSPSW 207
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRyesENGVTVYHCQKAWPST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  208 YWDTVTKICVFLFAFVVPILIITVCYGlmllrlrsvrllsgskeKDRSLrRITRMVLVVVGAFVVCWAPIHIFVIVWTLV 287
Cdd:cd15001 162 LYSRLYVVYLAIVIFFIPLIVMTFAYA-----------------RDTRK-QVIKMLISVVVLFAVCWGPLLIDNLLVSFD 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6981308  288 DINRRDPLVVAALHLCI-ALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15001 224 VISTLHTQALKYMRIAFhLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-328 9.59e-42

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 320318  Cd Length: 292  Bit Score: 150.29  E-value: 9.59e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   52 ITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSA-KYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd15190   3 IPVIYMLVFVLGLSGNGLVIWTVFRSKAKRRSADTFIANLALADLTFVVTLPLWAVyTALGYHWPFGSFLCKLSSYLVFV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGA--VVCTLQFPSPS-- 206
Cdd:cd15190  83 NMYASVFCLTCLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAGLLALPALILRTTRELDGSnkTICDMDFSGVVsn 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 ---WYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSgsKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIV 283
Cdd:cd15190 163 eaeLFWIAGLGLSSTVLGFLLPFLVMLTCYFFIGRTVARHFSKE--RKELKKKRRLLKIIITLVVTFALCWLPFHLVKTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 6981308  284 WTLVDIN------RRDPLVVAALHLCIALGYANSSLNPVLYAFLDENF-KRC 328
Cdd:cd15190 241 YALMYLGilpfscGFDQFLVNAHPYATCLAYVNSCLNPFLYAFFDPRFrQQC 292
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
50-329 2.74e-41

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107  Cd Length: 290  Bit Score: 148.80  E-value: 2.74e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTA--TNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLS 126
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDfVWPFGTAMCKVVRY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  127 IDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAV-VCTLQFPSP 205
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHtLCLLRFPKN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  206 S-----WYWDTVTKICVFLFAFVVPILIITVCYglMLLRLRSVRLLSGSKekdRSLRRITRMVLVVVGAFVVCWAPIHIF 280
Cdd:cd14976 161 SsvtrwYNWLGMYQLQKVVLGFFLPLGIITLSY--LLLLRFLQRKRGGSK---RRKSRVTKSVFIVVLSFFICWLPNQAL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6981308  281 VIVWTLVDINrrDPLVVAALHLC--------IALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd14976 236 SLWSALIKFD--DVPFSDAFFAFqtyafpvaICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-326 3.01e-41

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130  Cd Length: 282  Bit Score: 148.74  E-value: 3.01e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   51 AITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 130
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  131 NMFTSIFTLTMMSVDRYIAVCHPVKALDfRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRD----GAVVCTLQFPSPS 206
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEdksgGSKRICLPTWSEE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTkiCVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSL-RRITRMVLVVVGAFVVCWAPIHIfvivWT 285
Cdd:cd14999 160 SYKVYLT--LLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPkQKVLKMIFTIVLVFWACFLPFWI----WQ 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6981308  286 LVDINRRDPLVVAALHLCI-----ALGYANSSLNPVLYAFLDENFK 326
Cdd:cd14999 234 LLYLYSPSLSLSPRTTTYVnylltCLTYSNSCINPFLYTLLTKNYK 279
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
48-334 3.25e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976  Cd Length: 335  Bit Score: 149.93  E-value: 3.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308    48 LAIAITALYSAVCAVGLLGNVLVMFgIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSI 127
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   128 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSW 207
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   208 YWDTVTKICVFLFAFVVPILIITVCYglmllrLRSVRLLSGSKEKDRSLRRItRMVLVVVGAFVVCWAPIHIFVIVWTLV 287
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCY------SKILITLKGINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6981308   288 DINRRD-----PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR 334
Cdd:PHA03087 271 ILHFKSgckavKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
51-326 1.79e-40

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320319  Cd Length: 286  Bit Score: 146.44  E-value: 1.79e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   51 AITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKY-LMETWPFGELLCKAVLSIDY 129
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVLCHQSGPKTVANIYILNLAVADLLFLATLPLWAVYYsLGYNWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRD--GAVVCTLQFP-SPS 206
Cdd:cd15191  82 LNLYASIFFITCMSVDRYLAIVYPLRSQRRRSPRQARLVCLLVWVLACLSSLPTFYFRDTYYIEelGVTACIMDYPnEEY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  207 WYWDTVTKICVFLFAFVVPILIITVCYglmLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd15191 162 AQWSAGLALMKNTLGFLLPLIVIATCY---CGIGRHLLATKGFGLNKQRRDKVLKLVAAVVLAFLICWFPFHVLTFLDAL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6981308  287 VDINRRDPLVV-----AALHLCIALGYANSSLNPVLYAFLDENFK 326
Cdd:cd15191 239 ARMGVINNCWVitvidKALPFAICLGFSNSCINPFLYCFVGNHFR 283
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
54-327 3.06e-40

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461  Cd Length: 283  Bit Score: 146.11  E-value: 3.06e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   54 ALYSAVCAVGLLGNVLVMFGIVRyTKLKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSIDYYNM 132
Cdd:cd15339   5 SFIGILCSTGLVGNILVLFTIIR-SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  133 FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMA-VTQPRDGAVVCTLQFPSPS---WY 208
Cdd:cd15339  84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAkVIKFRDGLESCAFNLTSPDdvlWY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  209 --WDTVTkicvflfAFVVPILIITVCYGLMLLRL-------RSVRLLSGSKEKDRsLRRITRMVLVVVGAFVVCWAPIHI 279
Cdd:cd15339 164 tlYQTIT-------TFFFPLPLILICYILILCYTwemyrknKKAGRYNTSIPRQR-VMRLTKMVLVLVGVFLVSAAPYHV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6981308  280 FvivwTLVDINRRDPLV--VAALHLCIALGYANSSLNPVLYAFLDENFKR 327
Cdd:cd15339 236 I----QLVNLSVSQPTLafYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
50-329 1.30e-39

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320306  Cd Length: 279  Bit Score: 143.95  E-value: 1.30e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFqSAKYLMETWPFGELLCKAVLSIDY 129
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPF-WAVSVVKGWIFGTFMCKLVSLLQE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  130 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAkAKLINICIWVLASGVGVPIMVM--AVTQPRDGAVVCTLQFPSPSW 207
Cdd:cd15178  80 ANFYSGILLLACISVDRYLAIVHATRALTQKRHL-VKFVCAGVWLLSLLLSLPALLNrdAFKPPNSGRTVCYENLGNESA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  208 Y-WDTVTKICVFLFAFVVPILIITVCYGlmllRLRSVRLLSGSKEKDRSLRRItrmvLVVVGAFVVCWAPIHIFVIVWTL 286
Cdd:cd15178 159 DkWRVVLRILRHTLGFLLPLVVMLFCYG----FTIKTLLQTRSFQKHRAMRVI----FAVVLAFLLCWLPYNVTVLIDTL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6981308  287 V-------DINRRDPlVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15178 231 MrtkliteTCELRNH-VDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
50-329 1.61e-39

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460  Cd Length: 282  Bit Score: 143.80  E-value: 1.61e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFGIVRYTKLK---TATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVL 125
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNgVWHFGETMCTLIT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  126 SIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQP-RDGAVVCTLQFPS 204
Cdd:cd15338  81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPlPDGSVGCALLLPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  205 PS--WYWDTVTKicvFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVI 282
Cdd:cd15338 161 PEtdTYWFTLYQ---FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6981308  283 VWTLVDinRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15338 238 AHLSID--RPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
54-329 2.01e-39

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 320296  Cd Length: 283  Bit Score: 143.61  E-value: 2.01e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   54 ALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDYYNM 132
Cdd:cd15168   5 IVYGVVFLVGLLLNAVVLYRFIFSLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  133 FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCtLQFPSPSWYWDTV 212
Cdd:cd15168  85 YCSILFLTCISVHRYLGICHPMRSLRKLKKRHAVAVCVAVWILVLLQLLPILFFATTGRPNNRTTC-YDTTSPEELNDYV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  213 T-KICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKekdRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVdinR 291
Cdd:cd15168 164 PySMVLTGLGFLLPLLIILACYGLIARTLLRSLGSGVTS---ALRRKSIRLVIVVLALFAVCFLPFHVTRTIYLAA---R 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6981308  292 RDPLVVAALHLCIALGY--------ANSSLNPVLYAFLDENFKRCF 329
Cdd:cd15168 238 LLSGTSCATLNGIYVAYkvtrplasLNSCLNPLLYFLTGDKFRRRL 283
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
50-327 2.62e-39

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244  Cd Length: 284  Bit Score: 143.37  E-value: 2.62e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308   50 IAITALYSAVCAVGLLGNVLVMFgIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSID 128
Cdd:cd15116   1 ILSMVIYSVVFVLGVLGNGLVIF-ITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  129 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPR--DGAVVCTLQFP--- 203
Cdd:cd15116  80 FLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSqnNNKIICFNNFSlsg 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981308  204