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Conserved domains on  [gi|654690915|ref|WP_028149553|]
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MULTISPECIES: SMP-30/gluconolactonase/LRE family protein [Bradyrhizobium]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 1000408)

SMP-30/gluconolactonase/LRE family protein similar to vertebrate senescence marker protein 30 (SMP-30) and to Pseudomonas putida 6-deoxy-6-sulfogluconolactonase, which catalyzes the hydrolysis of 6-deoxy-6-sulfo-D-glucono-1,5-lactone to form 6-deoxy-6-sulfo-D-gluconate

CATH:  2.120.10.30

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SGL super family cl37778
SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in ...
73-287 6.50e-27

SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


The actual alignment was detected with superfamily member pfam08450:

Pssm-ID: 430002 [Multi-domain]  Cd Length: 246  Bit Score: 105.81  E-value: 6.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915   73 PAGGaasEQFTALPAGSVGNAIRFARDGTMFIADYKKHnIFAIAKGTREPVVWFHSDEM--NQPNDITVARDGTIYASDP 150
Cdd:pfam08450  29 PATG---KETVWDTPGPVGAIAPRDDGGLIVALKDGLA-LLDLATGELTPLADLEDDDWplNRFNDGKVDPDGRFWAGTM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  151 NW----KGREGHIWRIakSADGTVQGQVmsapRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTV--RGNELTGAKLVKA 224
Cdd:pfam08450 105 GDdeapGGDPGALYRL--DPDGKLVRLL----DGLTISNGLAWSPDGRTFYFADSPARKIWAYDYdlDGGLLSNRRVFAD 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654690915  225 FQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAFGGSDGKTVFVT 287
Cdd:pfam08450 179 FKDGLGrpDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLRTLYVT 243
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in ...
73-287 6.50e-27

SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 430002 [Multi-domain]  Cd Length: 246  Bit Score: 105.81  E-value: 6.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915   73 PAGGaasEQFTALPAGSVGNAIRFARDGTMFIADYKKHnIFAIAKGTREPVVWFHSDEM--NQPNDITVARDGTIYASDP 150
Cdd:pfam08450  29 PATG---KETVWDTPGPVGAIAPRDDGGLIVALKDGLA-LLDLATGELTPLADLEDDDWplNRFNDGKVDPDGRFWAGTM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  151 NW----KGREGHIWRIakSADGTVQGQVmsapRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTV--RGNELTGAKLVKA 224
Cdd:pfam08450 105 GDdeapGGDPGALYRL--DPDGKLVRLL----DGLTISNGLAWSPDGRTFYFADSPARKIWAYDYdlDGGLLSNRRVFAD 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654690915  225 FQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAFGGSDGKTVFVT 287
Cdd:pfam08450 179 FKDGLGrpDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLRTLYVT 243
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism];
48-287 1.87e-22

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism];


Pssm-ID: 225921 [Multi-domain]  Cd Length: 307  Bit Score: 95.14  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  48 EGPAADLDGN-LFVVNFGKpGTIGKLPAGGAASEQFTALPAGSVGNAIRfaRDGTMFIADykkHNIFAIAKGTREPVVWF 126
Cdd:COG3386   28 EGPVWDPDRGaLLWVDILG-GRIHRLDPETGKKRVFPSPGGFSSGALID--AGGRLIACE---HGVRLLDPDTGGKITLL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 127 HSDE----MNQPNDITVARDGTIYASDPNWKGRE-------GHIWRIakSADGTVQGQVmsaPRAMGTTNGIDLSPDGKT 195
Cdd:COG3386  102 AEPEdglpLNRPNDGVVDPDGRIWFGDMGYFDLGkseerptGSLYRV--DPDGGVVRLL---DDDLTIPNGLAFSPDGKT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 196 LYVGESSSGEIWSY-TVRGNELTGAKLVKAF---QPDTVDGLRTDVAGRLYVARILKGT-IALMKPNGAVEREIALKGKE 270
Cdd:COG3386  177 LYVADTPANRIHRYdLDPATGPIGGRRGFVDfdeEPGLPDGMAVDADGNLWVAAVWGGGrVVRFNPDGKLLGEIKLPVKR 256
                        250
                 ....*....|....*..
gi 654690915 271 PTNLAFGGSDGKTVFVT 287
Cdd:COG3386  257 PTNPAFGGPDLNTLYIT 273
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
51-248 8.92e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 64.26  E-value: 8.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  51 AADLDGNLFVVNFGK---------PGTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTRE 121
Cdd:cd05819   61 AVDSDGNLYVADTGNhriqkfdpdGNFLASFGGSGDGDGEFNG-PRG-----IAVDSSGNIYVADTGNHRIQKFDPDGEF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 122 PVVW----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQ---GQVMSAPRAMGTTNGIDLSPDG 193
Cdd:cd05819  135 LTTFgsggSGPGQFNGPTGVAVDSDGNIYVAD-----TGNH--RIQVfDPDGNFLttfGSTGTGPGQFNYPTGIAVDSDG 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654690915 194 kTLYVGESSSGEIWSYTVRGNEL--TGAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILK 248
Cdd:cd05819  208 -NIYVADSGNNRVQVFDPDGAGFggNGNFLGSDGQFNRPSGLAVDSDGNLYVAdtgnnRIQV 268
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in ...
73-287 6.50e-27

SMP-30/Gluconolaconase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 430002 [Multi-domain]  Cd Length: 246  Bit Score: 105.81  E-value: 6.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915   73 PAGGaasEQFTALPAGSVGNAIRFARDGTMFIADYKKHnIFAIAKGTREPVVWFHSDEM--NQPNDITVARDGTIYASDP 150
Cdd:pfam08450  29 PATG---KETVWDTPGPVGAIAPRDDGGLIVALKDGLA-LLDLATGELTPLADLEDDDWplNRFNDGKVDPDGRFWAGTM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  151 NW----KGREGHIWRIakSADGTVQGQVmsapRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTV--RGNELTGAKLVKA 224
Cdd:pfam08450 105 GDdeapGGDPGALYRL--DPDGKLVRLL----DGLTISNGLAWSPDGRTFYFADSPARKIWAYDYdlDGGLLSNRRVFAD 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654690915  225 FQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAFGGSDGKTVFVT 287
Cdd:pfam08450 179 FKDGLGrpDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLRTLYVT 243
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism];
48-287 1.87e-22

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism];


Pssm-ID: 225921 [Multi-domain]  Cd Length: 307  Bit Score: 95.14  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  48 EGPAADLDGN-LFVVNFGKpGTIGKLPAGGAASEQFTALPAGSVGNAIRfaRDGTMFIADykkHNIFAIAKGTREPVVWF 126
Cdd:COG3386   28 EGPVWDPDRGaLLWVDILG-GRIHRLDPETGKKRVFPSPGGFSSGALID--AGGRLIACE---HGVRLLDPDTGGKITLL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 127 HSDE----MNQPNDITVARDGTIYASDPNWKGRE-------GHIWRIakSADGTVQGQVmsaPRAMGTTNGIDLSPDGKT 195
Cdd:COG3386  102 AEPEdglpLNRPNDGVVDPDGRIWFGDMGYFDLGkseerptGSLYRV--DPDGGVVRLL---DDDLTIPNGLAFSPDGKT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 196 LYVGESSSGEIWSY-TVRGNELTGAKLVKAF---QPDTVDGLRTDVAGRLYVARILKGT-IALMKPNGAVEREIALKGKE 270
Cdd:COG3386  177 LYVADTPANRIHRYdLDPATGPIGGRRGFVDfdeEPGLPDGMAVDADGNLWVAAVWGGGrVVRFNPDGKLLGEIKLPVKR 256
                        250
                 ....*....|....*..
gi 654690915 271 PTNLAFGGSDGKTVFVT 287
Cdd:COG3386  257 PTNPAFGGPDLNTLYIT 273
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
51-248 8.92e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 64.26  E-value: 8.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  51 AADLDGNLFVVNFGK---------PGTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTRE 121
Cdd:cd05819   61 AVDSDGNLYVADTGNhriqkfdpdGNFLASFGGSGDGDGEFNG-PRG-----IAVDSSGNIYVADTGNHRIQKFDPDGEF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 122 PVVW----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQ---GQVMSAPRAMGTTNGIDLSPDG 193
Cdd:cd05819  135 LTTFgsggSGPGQFNGPTGVAVDSDGNIYVAD-----TGNH--RIQVfDPDGNFLttfGSTGTGPGQFNYPTGIAVDSDG 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654690915 194 kTLYVGESSSGEIWSYTVRGNEL--TGAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILK 248
Cdd:cd05819  208 -NIYVADSGNNRVQVFDPDGAGFggNGNFLGSDGQFNRPSGLAVDSDGNLYVAdtgnnRIQV 268
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
49-287 1.23e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.88  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGKpGTIGKLPAGGAASEQFTALPAGSVG----NAIRFARDGTMFIADYKKHNIFAIAKGTREPVV 124
Cdd:cd05819   12 GIAVDSSGNIYVADTGN-NRIQVFDPDGNFITSFGSFGSGDGQfnepAGVAVDSDGNLYVADTGNHRIQKFDPDGNFLAS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 125 W----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQGQVMSAPRAMGTTN---GIDLSPDGkTL 196
Cdd:cd05819   91 FggsgDGDGEFNGPRGIAVDSSGNIYVAD-----TGNH--RIQKfDPDGEFLTTFGSGGSGPGQFNgptGVAVDSDG-NI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 197 YVGESSSGEIWSYTVRGNELT--GAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILKGTIALMKPNGAVEREIALKG- 268
Cdd:cd05819  163 YVADTGNHRIQVFDPDGNFLTtfGSTGTGPGQFNYPTGIAVDSDGNIYVAdsgnnRVQVFDPDGAGFGGNGNFLGSDGQf 242
                        250
                 ....*....|....*....
gi 654690915 269 KEPTNLAFgGSDGKtVFVT 287
Cdd:cd05819  243 NRPSGLAV-DSDGN-LYVA 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
45-209 1.24e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  45 FGIEGPAADLDGNLFVVNFGK-------P--GTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAI 115
Cdd:cd05819  102 NGPRGIAVDSSGNIYVADTGNhriqkfdPdgEFLTTFGSGGSGPGQFNG-PTG-----VAVDSDGNIYVADTGNHRIQVF 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 116 AKGTREPVVW----FHSDEMNQPNDITVARDGTIYASDPNWKgreghiwRI----AKSADGTVQGQVMSAPRAMGTTNGI 187
Cdd:cd05819  176 DPDGNFLTTFgstgTGPGQFNYPTGIAVDSDGNIYVADSGNN-------RVqvfdPDGAGFGGNGNFLGSDGQFNRPSGL 248
                        170       180
                 ....*....|....*....|..
gi 654690915 188 DLSPDGKtLYVGESSSGEIWSY 209
Cdd:cd05819  249 AVDSDGN-LYVADTGNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
76-303 2.58e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.78  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  76 GAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTREPVVW----FHSDEMNQPNDITVARDGTIYASDpN 151
Cdd:cd05819    1 GTGPGELNN-PQG-----IAVDSSGNIYVADTGNNRIQVFDPDGNFITSFgsfgSGDGQFNEPAGVAVDSDGNLYVAD-T 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 152 WKGReghIWRIakSADGTVQGQV---------MSAPRamgttnGIDLSPDGkTLYVGESSSGEIWSYTVRGNELT--GAK 220
Cdd:cd05819   74 GNHR---IQKF--DPDGNFLASFggsgdgdgeFNGPR------GIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTtfGSG 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 221 LVKAFQPDTVDGLRTDVAGRLYVA-----RILKgtialMKPNGAVEREIALKG------KEPTNLAFGGSDgkTVFVTQR 289
Cdd:cd05819  142 GSGPGQFNGPTGVAVDSDGNIYVAdtgnhRIQV-----FDPDGNFLTTFGSTGtgpgqfNYPTGIAVDSDG--NIYVADS 214
                        250
                 ....*....|....
gi 654690915 290 QGGFVESFRTDQQG 303
Cdd:cd05819  215 GNNRVQVFDPDGAG 228
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
53-244 9.54e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 49.21  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  53 DLDGNlFVVNFGKPGTI-GKL--PAGGAASEQ---------------FTA-------LPAGSVGNAIR-----FARDGTM 102
Cdd:cd14963   36 DYEGK-FKKSFGGPGTGpGEFkyPYGIAVDSDgniyvadlyngriqvFDPdgkflkyFPEKKDRVKLIspaglAIDDGKL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 103 FIADYKKHNI----------FAIAKGTREPvvwfhsDEMNQPNDITVARDGTIYASDPNwKGR-------EGHIWRIAKS 165
Cdd:cd14963  115 YVSDVKKHKVivfdlegkllLEFGKPGSEP------GELSYPNGIAVDEDGNIYVADSG-NGRiqvfdknGKFIKELNGS 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 166 ADGTvqgQVMSAPRamgttnGIDLSPDGKtLYVGESSSG----------EIWSYTVRGNELTGAKLvkafqPdtvDGLRT 235
Cdd:cd14963  188 PDGK---SGFVNPR------GIAVDPDGN-LYVVDNLSHrvyvfdeqgkELFTFGGRGKDDGQFNL-----P---NGLFI 249

                 ....*....
gi 654690915 236 DVAGRLYVA 244
Cdd:cd14963  250 DDDGRLYVT 258
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
129-276 1.91e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.36  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 129 DEMNQPNDITVArDGTIYASDP-NWK----GREG-HIWRIAKSadGTVQGQvMSAPramgttNGIDLSPDGKtLYVGESS 202
Cdd:cd14963    7 DPLNKPMGVAVS-DGRIYVADTnNHRvqvfDYEGkFKKSFGGP--GTGPGE-FKYP------YGIAVDSDGN-IYVADLY 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654690915 203 SGEIWSYTVRGNEL----TGAKLVKAFQPDtvdGLRTDvAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAF 276
Cdd:cd14963   76 NGRIQVFDPDGKFLkyfpEKKDRVKLISPA---GLAID-DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPGELSY 149
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
35-300 3.81e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 225926 [Multi-domain]  Cd Length: 381  Bit Score: 44.90  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  35 VQVTPPGEYTFGIegpAADLDG-NLFVVNFGkPGTIGKLPAGGAASEQFTALPAGSVGNAIRFARDGTMFIADYKKHNIF 113
Cdd:COG3391   24 TAAISLGRGPGGV---AVNPDGtQVYVANSG-SNDVSVIDATSNTVTQSLSVGGVYPAGVAVNPAGNKVYVTTGDSNTVS 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 114 AIA-----KGTREPVVWfhsdemnQPNDITVARDG-TIYASDPNwkGREGHIWRIAKSADGTVQ-GQVMSAPRamgttnG 186
Cdd:COG3391  100 VIDtatntVLGSIPVGL-------GPVGLAVDPDGkYVYVANAG--NGNNTVSVIDAATNKVTAtIPVGNTPT------G 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 187 IDLSPDGKTLYVGESSSGEIWSYTVRGNELTGAKLVKAFQPDTVD-GLRTDVAG-RLYVA-------RILKGTIAlmkPN 257
Cdd:COG3391  165 VAVDPDGNKVYVTNSDDNTVSVIDTSGNSVVRGSVGSLVGVGTGPaGIAVDPDGnRVYVAndgsgsnNVLKIDTA---TG 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 654690915 258 GAVEREIALKGKEPTNLAFgGSDGKTVFVTQRQGGFVESFRTD 300
Cdd:COG3391  242 NVTATDLPVGSGAPRGVAV-DPAGKAAYVANSQGGTVSVIDGA 283
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
48-151 1.00e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  48 EGPAADLDGNLFVVNFGKpGTIGKLPAGGAAseqFTALPAGSVGNAIRFARD--GTMFIADYKKHNIFAIAKGTREPVVW 125
Cdd:cd14952   97 TGVAVDAAGNVYVADTGN-NRVLKLAAGSNT---QTVLPFTGLSNPDGVAVDgaGNVYVTDTGNNRVLKLAAGSTTQTVL 172
                         90       100
                 ....*....|....*....|....*..
gi 654690915 126 -FHsdEMNQPNDITVARDGTIYASDPN 151
Cdd:cd14952  173 pFT--GLNSPSGVAVDTAGNVYVTDHG 197
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
38-271 1.46e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 42.65  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  38 TPPGEYTfGIEGPAADLDGNLFVVN--------FGKPGT-IGKLPAGGAASEQFTALpagsvgNAIRFARDGTMFIADYK 108
Cdd:cd14956    7 SGPGQFK-DPRGIAVDADDNVYVADarngriqvFDKDGTfLRRFGTTGDGPGQFGRP------RGLAVDKDGWLYVADYW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 109 KHNIFAIAKGTREPVVWFHS----DEMNQPNDITVARDGTIYASD-PNwkgreghiWRIAK-SADGTVQGQVMSAPRAMG 182
Cdd:cd14956   80 GDRIQVFTLTGELQTIGGSSgsgpGQFNAPRGVAVDADGNLYVADfGN--------QRIQKfDPDGSFLRQWGGTGIEPG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 183 TTN---GIDLSPDGkTLYVGESSSGEIWSYTVRGNELT--GAKLVKAFQPDTVDGLRTDVAGRLYVARILKGTIALMKPN 257
Cdd:cd14956  152 SFNyprGVAVDPDG-TLYVADTYNDRIQVFDNDGAFLRkwGGRGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTAD 230
                        250
                 ....*....|....
gi 654690915 258 GAVEREIALKGKEP 271
Cdd:cd14956  231 GTFLTSWGSPGTGP 244
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
49-149 2.35e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGkPGTIGKLPAGgaASEQfTALP--AGSVGNAIRFARDGTMFIADYKKHNIFAIAKGTREPVVwF 126
Cdd:cd14952  140 GVAVDGAGNVYVTDTG-NNRVLKLAAG--STTQ-TVLPftGLNSPSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTV-L 214
                         90       100
                 ....*....|....*....|...
gi 654690915 127 HSDEMNQPNDITVARDGTIYASD 149
Cdd:cd14952  215 PFTGLNGPLGVAVDAAGNVYVAD 237
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
131-287 1.61e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.49  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 131 MNQPNDITVARDGTIYASDP--------NWKGREGHIWRIAKsadgtvqGQVMSAPRamgttnGIDLSPDGkTLYVGESS 202
Cdd:cd14962   11 LTRPYGVAADGRGRIYVADTgrgavfvfDLPNGKVFVIGNAG-------PNRFVSPI------GVAIDANG-NLYVSDAE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 203 SGEIWSYTVRGNELtgAKLVKAFQPDTVDGLRTDVAG-RLYVARILKGTIALMKPNGAVEREIALKGKE------PTNLA 275
Cdd:cd14962   77 LGKVFVFDRDGKFL--RAIGAGALFKRPTGIAVDPAGkRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGpgefnlPTDLA 154
                        170
                 ....*....|..
gi 654690915 276 FGGSDgkTVFVT 287
Cdd:cd14962  155 VDRDG--NLYVT 164
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
49-248 4.88e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.96  E-value: 4.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGkPGTIGKLPAGgaaSEQFTALPAGSVGN--AIRFARDGTMFIADYKKHNIFAIAKGTREPVVWF 126
Cdd:cd14952   56 GVAVDAAGTVYVTDFG-NNRVLKLAAG---STTQTVLPFTGLNDptGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVLP 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 127 HSDeMNQPNDITVARDGTIYASDPnwkGREghiwRIAKSADGTvqgqvmSAPRAMGTT-----NGIDLSPDGkTLYVGES 201
Cdd:cd14952  132 FTG-LSNPDGVAVDGAGNVYVTDT---GNN----RVLKLAAGS------TTQTVLPFTglnspSGVAVDTAG-NVYVTDH 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 654690915 202 SSGEIWSYTVRGNELTGAKLVKAFQPdtvDGLRTDVAGRLYVA-----RILK 248
Cdd:cd14952  197 GNNRVLKLAAGSTTPTVLPFTGLNGP---LGVAVDAAGNVYVAdrgndRVVK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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