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Conserved domains on  [gi|6320063|ref|NP_010143|]
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glucose sensor [Saccharomyces cerevisiae S288C]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 11489872)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
76-555 2.02e-160

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


:

Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 473.36  E-value: 2.02e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063     76 GDGAIETTSILLSQPLPLRSN-VMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPNHS-YFTTSQIAILVSFLS 153
Cdd:TIGR00879   2 SDANLADASELLVTPAGLGSTyWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSdSYSSSLWGLVVSIFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    154 LGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQVASG---GLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNL 230
Cdd:TIGR00879  82 VGGFIGALFAGWLSDRFGRKKSLLII-ALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    231 RGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLR 310
Cdd:TIGR00879 161 RGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    311 GLPIEDPRLLEELVEIKATYDYEASFGPSTLLdCFKTSENRpkQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD 390
Cdd:TIGR00879 241 GTSGEDKELLDELELIDIKRSIEKRSVQPSWG-SLFSSTRR--IRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    391 N--SYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTV--VASKIMIAFICLFIAAFS 466
Cdd:TIGR00879 318 TdhAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSskSSGNVAIVFILLFIAFFA 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    467 ATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:TIGR00879 398 MGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLE-----SIGVGGVFIFFGGLNVLGLIFVYFFLPE 472

                  ....*....
gi 6320063    547 TRGLTLEEI 555
Cdd:TIGR00879 473 TKGRTLEEI 481
 
Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
76-555 2.02e-160

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 473.36  E-value: 2.02e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063     76 GDGAIETTSILLSQPLPLRSN-VMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPNHS-YFTTSQIAILVSFLS 153
Cdd:TIGR00879   2 SDANLADASELLVTPAGLGSTyWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSdSYSSSLWGLVVSIFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    154 LGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQVASG---GLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNL 230
Cdd:TIGR00879  82 VGGFIGALFAGWLSDRFGRKKSLLII-ALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    231 RGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLR 310
Cdd:TIGR00879 161 RGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    311 GLPIEDPRLLEELVEIKATYDYEASFGPSTLLdCFKTSENRpkQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD 390
Cdd:TIGR00879 241 GTSGEDKELLDELELIDIKRSIEKRSVQPSWG-SLFSSTRR--IRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    391 N--SYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTV--VASKIMIAFICLFIAAFS 466
Cdd:TIGR00879 318 TdhAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSskSSGNVAIVFILLFIAFFA 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    467 ATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:TIGR00879 398 MGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLE-----SIGVGGVFIFFGGLNVLGLIFVYFFLPE 472

                  ....*....
gi 6320063    547 TRGLTLEEI 555
Cdd:TIGR00879 473 TKGRTLEEI 481
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
101-559 2.15e-154

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 454.79  E-value: 2.15e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  101 LVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIA--PNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMF 178
Cdd:cd17356   1 LLCAFVSLGGFLFGYDTGSISGILNMKSFQKYFAdnTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  179 STaVIFSIGNSLQVAS-GGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTH 257
Cdd:cd17356  81 GC-VIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  258 SKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYvlkdelnkaakslsflrglpiedprlleelveikatydyeasfg 337
Cdd:cd17356 160 KLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL-------------------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  338 pstlldcfktsenrpkqiLRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD--NSYLVSFISYAVNVAFSIPGMYLVD 415
Cdd:cd17356 196 ------------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTgsSPLLTSIILYIVNFVSTIPGLFFVD 257
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  416 RIGRRPVLLAGGVIMAIANLVIAIVGVSEG--------KTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRS 487
Cdd:cd17356 258 KFGRRTCLLIGAAGMSICLFIYAAVGVRYLipnpqsgtSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRS 337
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320063  488 KCTAICAAANWLVNFTCALITPYIVDvgshtsSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELF 559
Cdd:cd17356 338 KGMALATAFNWLWNFLISFFTPFIIG------SIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
Sugar_tr pfam00083
Sugar (and other) transporter;
102-559 1.21e-139

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 418.98  E-value: 1.21e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    102 VGIFVAVGGFLFGYDTGLINSITDMP-YVKTYIAPNHS---YFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIM 177
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdFFKNFGLSKSVsslAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    178 FStAVIFSIGNSLQVASGGLV---LLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQ 254
Cdd:pfam00083  81 IA-NVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    255 GTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPrlleELVEIKATYDYEA 334
Cdd:pfam00083 160 GLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDR----ELDEIKDSLEAGQ 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    335 SFGPSTlLDCFKTSENRPKqilRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLV 414
Cdd:pfam00083 236 EAEKAS-WKELFSTKTRRQ---RLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLV 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    415 DRIGRRPVLLAGGVIMAIANLVIAIVG-VSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAIC 493
Cdd:pfam00083 312 DRFGRRPLLLLGAAGMAICFVILGIVAlLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALA 391
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320063    494 AAANWLVNFTCALITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELF 559
Cdd:pfam00083 392 TAANWLANFLIGFLFPIITD-----AIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
xylE PRK10077
D-xylose transporter XylE; Provisional
101-562 6.61e-55

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 196.45  E-value: 6.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   101 LVGI-FVAV-GGFLFGYDTGLInSITDMPYVKTYIAPNHSYF--TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTI 176
Cdd:PRK10077  10 IFSItLVATlGGLLFGYDTAVI-SGTVESLNTVFVAPQNLSEsaANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   177 MFStAVIF---SIGNS------LQVASGGLVLLI---VGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITI 244
Cdd:PRK10077  89 KIA-AVLFfisALGSAwpefgfTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   245 GLLVSSAVSQGThSKNGPSSYRIPIGLQYVWSS------ILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDpr 318
Cdd:PRK10077 168 GQLVVYFVNYFI-ARSGDASWLNTDGWRYMFASeaipalLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLAT-- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   319 llEELVEIKATYDYEA-------SFGpstlldcfktsenrpkqILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV-- 389
Cdd:PRK10077 245 --QALQEIKHSLDHGRktggkllMFG-----------------VGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAst 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   390 DNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVAskimIAFICLFIAAFSATW 469
Cdd:PRK10077 306 DIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQAPGIVA----LLSMLFYVAAFAMSW 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   470 GGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKI-FFIWGGLNVVAVIVVYFAVYETR 548
Cdd:PRK10077 382 GPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHFHNGFsYWIYGCMGVLAALFMWKFVPETK 461
                        490
                 ....*....|....
gi 6320063   549 GLTLEEIDELFRKA 562
Cdd:PRK10077 462 GKTLEEMEALWEPE 475
ProP COG0477
MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and ...
104-458 5.20e-09

MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 223553 [Multi-domain]  Cd Length: 338  Bit Score: 58.55  E-value: 5.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGGFLFGYDTGLINsitdmPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAV- 182
Cdd:COG0477   5 LALALAALLLGLDLGLLS-----PALPLLLSTLSLSSGRLLYGLLLSAFFLGYAIGSLLAGPLGDRYGRRKVLIIGLLLf 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  183 IFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAA-QKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNG 261
Cdd:COG0477  80 LLGTLLLALAPNVGLALLLILRLLQGLGGGGLLPVASALLSEWFpEATERGLAVGLVTLGAGALGLALGPLLAGLLLGAL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  262 PSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPiedprlleelveikatydYEASFGPSTL 341
Cdd:COG0477 160 LWGWRAAFLLAALLGLLLLILVLLLDLLLAAPRLPLAVGLALIELGKLLLLL------------------LILLLGGLVL 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  342 LDCFKTSENRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRP 421
Cdd:COG0477 222 LLLGLYLSAAGFGLRALLLGLGLALLALFVGALILLVLLPILLGAAGGLSALVGAAGGLLALILLGLAGLLGTLVGGSLL 301
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6320063  422 VLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFI 458
Cdd:COG0477 302 VDRLGRSLGLRAILLAGALLLAILLLVLLLALVLTIL 338
 
Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
76-555 2.02e-160

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 473.36  E-value: 2.02e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063     76 GDGAIETTSILLSQPLPLRSN-VMSVLVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIAPNHS-YFTTSQIAILVSFLS 153
Cdd:TIGR00879   2 SDANLADASELLVTPAGLGSTyWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSdSYSSSLWGLVVSIFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    154 LGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQVASG---GLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNL 230
Cdd:TIGR00879  82 VGGFIGALFAGWLSDRFGRKKSLLII-ALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    231 RGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLR 310
Cdd:TIGR00879 161 RGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    311 GLPIEDPRLLEELVEIKATYDYEASFGPSTLLdCFKTSENRpkQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD 390
Cdd:TIGR00879 241 GTSGEDKELLDELELIDIKRSIEKRSVQPSWG-SLFSSTRR--IRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    391 N--SYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTV--VASKIMIAFICLFIAAFS 466
Cdd:TIGR00879 318 TdhAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSskSSGNVAIVFILLFIAFFA 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    467 ATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:TIGR00879 398 MGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLE-----SIGVGGVFIFFGGLNVLGLIFVYFFLPE 472

                  ....*....
gi 6320063    547 TRGLTLEEI 555
Cdd:TIGR00879 473 TKGRTLEEI 481
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
101-559 2.15e-154

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 454.79  E-value: 2.15e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  101 LVGIFVAVGGFLFGYDTGLINSITDMPYVKTYIA--PNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMF 178
Cdd:cd17356   1 LLCAFVSLGGFLFGYDTGSISGILNMKSFQKYFAdnTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  179 STaVIFSIGNSLQVAS-GGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTH 257
Cdd:cd17356  81 GC-VIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  258 SKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYvlkdelnkaakslsflrglpiedprlleelveikatydyeasfg 337
Cdd:cd17356 160 KLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL-------------------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  338 pstlldcfktsenrpkqiLRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD--NSYLVSFISYAVNVAFSIPGMYLVD 415
Cdd:cd17356 196 ------------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTgsSPLLTSIILYIVNFVSTIPGLFFVD 257
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  416 RIGRRPVLLAGGVIMAIANLVIAIVGVSEG--------KTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRS 487
Cdd:cd17356 258 KFGRRTCLLIGAAGMSICLFIYAAVGVRYLipnpqsgtSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRS 337
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320063  488 KCTAICAAANWLVNFTCALITPYIVDvgshtsSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELF 559
Cdd:cd17356 338 KGMALATAFNWLWNFLISFFTPFIIG------SIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
Sugar_tr pfam00083
Sugar (and other) transporter;
102-559 1.21e-139

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 418.98  E-value: 1.21e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    102 VGIFVAVGGFLFGYDTGLINSITDMP-YVKTYIAPNHS---YFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIM 177
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdFFKNFGLSKSVsslAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    178 FStAVIFSIGNSLQVASGGLV---LLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQ 254
Cdd:pfam00083  81 IA-NVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    255 GTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPrlleELVEIKATYDYEA 334
Cdd:pfam00083 160 GLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDR----ELDEIKDSLEAGQ 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    335 SFGPSTlLDCFKTSENRPKqilRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLV 414
Cdd:pfam00083 236 EAEKAS-WKELFSTKTRRQ---RLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLV 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    415 DRIGRRPVLLAGGVIMAIANLVIAIVG-VSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAIC 493
Cdd:pfam00083 312 DRFGRRPLLLLGAAGMAICFVILGIVAlLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALA 391
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320063    494 AAANWLVNFTCALITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEIDELF 559
Cdd:pfam00083 392 TAANWLANFLIGFLFPIITD-----AIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
107-546 2.27e-76

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 250.95  E-value: 2.27e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  107 AVGGFLFGYDTGLINsitdmPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFSI 186
Cdd:cd17315   3 ALGGLLFGYDLGVIN-----GALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIA-AVLYVI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  187 GNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGThSKNGPSSYR 266
Cdd:cd17315  77 GALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL-SLSPPGWWR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  267 IPIGLQYVWSSILAVGMIFLPESPRyyvlkdelnkaakslsflrglpiedprlleelveikatydyeasfgpstlldcfk 346
Cdd:cd17315 156 LMFALAAVPALLQLLLMFFLPESRA------------------------------------------------------- 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  347 tsenrpkqilrIFTGIAIQAFQQASGINFIFYYGVNFFNNTG-VDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLA 425
Cdd:cd17315 181 -----------LLVGVGLQLLQQLTGINAVMYYAPTIFKSAGgGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLI 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  426 GGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCA 505
Cdd:cd17315 250 GFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVG 329
                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 6320063  506 LITPYIVDvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:cd17315 330 LTFLIMVS-----TIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
101-546 6.43e-74

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 245.17  E-value: 6.43e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  101 LVGIFVAVGGFLFGYDTGLINSItdMPYVKTYIApnhsyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSt 180
Cdd:cd17359   1 LISLVAALGGLLFGYDTGVINGA--LPFLQTDFN-----LTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLIS- 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  181 AVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAV-----SQG 255
Cdd:cd17359  73 AVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnyliaNAG 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  256 THSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKdelnkaakslsflrGLPIedprlleelveikatydyeas 335
Cdd:cd17359 153 GADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSK--------------GKPI--------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  336 fgpstlldcfktsenrpkqilrIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDN--SYLVSFISYAVNVAFSIPGMYL 413
Cdd:cd17359 198 ----------------------LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSEnaALLQTIGIGVVNVIFTIIAILL 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  414 VDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAIC 493
Cdd:cd17359 256 VDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIA 335
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320063  494 AAANWLVNFTCALITPYIVDvgshTSSMGPkIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:cd17359 336 VFFLWIANFLVSLTFPILLA----AFGLAF-TFLIFAVICVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
105-546 5.30e-66

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 222.92  E-value: 5.30e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  105 FVAVGGFLFGYDTGLINSItdMPYVKTyiAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAvIF 184
Cdd:cd17360   1 FAGIGGFLFGYDTGVISGA--LLYIKD--DLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADA-LF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  185 SIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQG-THSKNGps 263
Cdd:cd17360  76 TIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAfSYLPGG-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  264 sYRIPIGLQYVWSSILAVGMIFLPESPRYyvlkdelnkaakslsflrglpiedprlleelveikatydyeasfgpstlld 343
Cdd:cd17360 154 -WRWMLGLAAVPAVLQFIGLLFLPESPRW--------------------------------------------------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  344 cfktsenrPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV---DNSYLVSFISYAVNVAFSIPGMYLVDRIGRR 420
Cdd:cd17360 182 --------PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFkdnQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRR 253
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  421 PVLLAGGVIMAIANLVIAIVgvsegktvvaskIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLV 500
Cdd:cd17360 254 KLLLISLFGVIVALVVLAVW------------LALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVF 321
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 6320063  501 NFTCAL----ITPYIVDVGShtssmgpkiFFIWGGLNVVAVIVVYFAVYE 546
Cdd:cd17360 322 NLLVSQtfltLTQAIGPYGT---------FLLFAGLAVLGLIFIYFCVPE 362
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
104-549 1.96e-65

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 224.06  E-value: 1.96e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGG-FLFGYDTGLINS---ITDMPYVKTYIAPNHSYFTTSQIAIL----VSFLSLGTFFGALIAPYISDSYGRKpt 175
Cdd:cd17357   2 VIVAFGGsFQFGYNIGVVNApqeVFKEFINDTLVDRYGLNLSDSELDLLwsliVSIFFIGGAIGSFISAFLANRFGRK-- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  176 imfstaVIFSIGNSLQVASGGLV----------LLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIG 245
Cdd:cd17357  80 ------NGLLISNALLVVSSLLMflsksakspeLLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  246 LLVSSAVSQgthskngpssyRIPIGLQYVWSSILAVGMI----------FLPESPRYYVL-KDELNKAAKSLSFLRGlpi 314
Cdd:cd17357 154 ILLGQVFGL-----------PSVLGTETLWPYLLFFPGIpallqlaalpFFPESPKFLLIsKGDEEEAEKSLKFLRG--- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  315 EDPRLLEELVEIKATYDYEASFGPSTLLDCFKTSENRpkqiLRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV--DNS 392
Cdd:cd17357 220 IEDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLR----LPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFspQLA 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  393 YLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGV 472
Cdd:cd17357 296 EWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPI 375
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320063  473 VWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGshtssmGPKIFFIWGGLNVVAVIVVYFAVYETRG 549
Cdd:cd17357 376 PWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIG------GGFVFIIFAIPCALFLLYLYRYLPETKG 446
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
97-554 7.01e-65

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 222.45  E-value: 7.01e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   97 VMSVLVGIFVAvgGFLFGYDTGLINSITDmpyvktyiapNHSYF---TTSQIAILVSFLSLGTFFGALIAPYISDSYGRK 173
Cdd:cd17358   4 TFVANLGSFSF--GIAVGWSSPALPSLMS----------DNSLSlplTVAQFSWFGSLLTLGALIGALLSGKLADRIGRK 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  174 PTIMFStAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVs 253
Cdd:cd17358  72 RTLLIS-AIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVL- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  254 qGTHskngpSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPRLLEELVEikATYDYE 333
Cdd:cd17358 150 -GSF-----LPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQE--ELAELE 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  334 ASFGPSTLLDCFktsenRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVD-NSYLVSFISYAVNVAFSIPGMY 412
Cdd:cd17358 222 KEAKESSFSDLF-----QRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGlDPNTATIIIGVVQVVGTLVATL 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  413 LVDRIGRRPVLLAGGVIMAIANLVIA----IVGVSEGKTVVaSKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSK 488
Cdd:cd17358 297 LVDRLGRRPLLLVSAIGMGIGLLALGlyfyLQEHGALLSSV-SWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGL 375
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320063  489 CTAICAAANWLVNFTCALITPYIVDV-GSHTSsmgpkiFFIWGGLNVVAVIVVYFAVYETRGLTLEE 554
Cdd:cd17358 376 AGSLVTLVNWLFAFIVTKTFPFLTLAwGASGT------FWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
106-546 6.39e-60

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 207.49  E-value: 6.39e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  106 VAVGGFLFGYDTGLINSITDMP----------YVKTYIAPNHSY--FTTSQIAILVSFLSLGTFFGALIAPYISDSYGRK 173
Cdd:cd17361   2 AALGGLIFGYDIGISGGVTSMDpflekffpsvYEKKKGASENNYckYDDQLLQLFTSSLYLAGLVASLLASYVTRKWGRK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  174 PTIMFStAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVS 253
Cdd:cd17361  82 PSMLIG-GVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  254 QGTHsKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPryyvlkdelnkaakslsflrglpiedprlleelveikatydye 333
Cdd:cd17361 161 YGTS-KIKPNGWRLSLGLAAVPALILLLGSLFLPETP------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  334 asfgpstlldcfktseNRPKQILriftGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSY--LVSFISYAVNVAFSIPGM 411
Cdd:cd17361 197 ----------------NSPQLVI----AILIPFFQQLTGINVIMFYAPVLFQTLGFGSDAslISAVITGAVNVVSTLVSI 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  412 YLVDRIGRRPVLLAGGVIMAIANLVIAIV-GVSEGKTVVASK----IMIAFICLFIAAFSATWGGVVWVVSAELYPLGVR 486
Cdd:cd17361 257 YLVDRFGRRFLLLEGGVQMLASQVAIGILlAVKFGDGGELPKayaiAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETR 336
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  487 SKCTAICAAANWLVNFtcaLITPYIVdvgSHTSSMGPKIFFIWGGLNVVAVIVVYFAVYE 546
Cdd:cd17361 337 SAGQSLTVAVNFLFTF---VIAQAFL---SMLCAMKFGIFLFFAGWVVVMSLFVYFLLPE 390
xylE PRK10077
D-xylose transporter XylE; Provisional
101-562 6.61e-55

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 196.45  E-value: 6.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   101 LVGI-FVAV-GGFLFGYDTGLInSITDMPYVKTYIAPNHSYF--TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTI 176
Cdd:PRK10077  10 IFSItLVATlGGLLFGYDTAVI-SGTVESLNTVFVAPQNLSEsaANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   177 MFStAVIF---SIGNS------LQVASGGLVLLI---VGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITI 244
Cdd:PRK10077  89 KIA-AVLFfisALGSAwpefgfTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   245 GLLVSSAVSQGThSKNGPSSYRIPIGLQYVWSS------ILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDpr 318
Cdd:PRK10077 168 GQLVVYFVNYFI-ARSGDASWLNTDGWRYMFASeaipalLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLAT-- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   319 llEELVEIKATYDYEA-------SFGpstlldcfktsenrpkqILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV-- 389
Cdd:PRK10077 245 --QALQEIKHSLDHGRktggkllMFG-----------------VGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAst 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   390 DNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVAskimIAFICLFIAAFSATW 469
Cdd:PRK10077 306 DIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQAPGIVA----LLSMLFYVAAFAMSW 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   470 GGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKI-FFIWGGLNVVAVIVVYFAVYETR 548
Cdd:PRK10077 382 GPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHFHNGFsYWIYGCMGVLAALFMWKFVPETK 461
                        490
                 ....*....|....
gi 6320063   549 GLTLEEIDELFRKA 562
Cdd:PRK10077 462 GKTLEEMEALWEPE 475
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
105-555 2.10e-54

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 192.57  E-value: 2.10e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  105 FVAVGGFLFGYDTGLIN----SITDMPYVKTyiapNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSt 180
Cdd:cd17362   1 FPALGGLLFGYDIGATSgallSITSPALSGT----DWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILA- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  181 AVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGThsKN 260
Cdd:cd17362  76 ALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAF--AD 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  261 GPSSYRIPIGLQYVWSSILAVGMIFLPESPRYyvlkdelnkaakslsflrglpiedprlleelveikatydyeasfgpst 340
Cdd:cd17362 154 VVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW------------------------------------------------ 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  341 lldcfktsenRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGV---DNSYLVSFISYAVNVAFSIPGMYLVDRI 417
Cdd:cd17362 186 ----------QGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsaaSDATLVSVGLGVFKLLMTIVAVLLVDKL 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  418 GRRPVLLAGGVIMAIANLVIAIVGVS-EGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAA 496
Cdd:cd17362 256 GRRPLLLGGVSGMVVSLFLLAAYNLFvQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLV 335
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  497 NWLVNFTCALITPYIVDVgshtssMG-PKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555
Cdd:cd17362 336 NFGSNALVSLAFLPLQEL------IGlPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
104-549 1.48e-53

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 191.78  E-value: 1.48e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAV-GGFLFGYDTGLINS----ITDMpYVKTYIAPN----HSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKP 174
Cdd:cd17431   3 VFVAVlGSLQFGYNTGVINApqkvIEEF-YNKTLGDRYgepiSPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  175 TIMFST--AVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAV 252
Cdd:cd17431  82 SMLYNNllAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  253 sqGTHSKNG-PSSYRIPIGLQYVWSSILAVGMIFLPESPRY-YVLKDELNKAAKSLSFLRGlpIEDPRllEELVEIKATY 330
Cdd:cd17431 162 --GLEFILGtEELWPLLLGFTIVPAILQLALLPFCPESPRYlLINRNEEEEAKSVLKKLRG--TTDVS--EDIQEMKEES 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  331 DYEASFGPSTLLDCFKTSENRPKqilrIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPG 410
Cdd:cd17431 236 RQMMREKKVTILELFRSSSYRQP----IIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVS 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  411 MYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCT 490
Cdd:cd17431 312 LFLVERAGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM 391
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6320063  491 AICAAANWLVNFTCALITPYIVDVgshtssMGPKIFFIWGGLNVVAVIVVYFAVYETRG 549
Cdd:cd17431 392 AVAGFSNWTSNFIVGMCFQYIANL------CGPYVFIIFTVFLLTFFIFTYFKVPETKG 444
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
107-555 4.43e-48

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 176.65  E-value: 4.43e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  107 AVGG-FLFGYDTGLINSITdmPYVK-----TYIAPNHSYFTTSQIAIL----VSFLSLGTFFGALIAPYISDSYGRKPTI 176
Cdd:cd17432   6 AFGSsFQYGYNLSVVNSPT--PYIQnfyneTWTERYGTPLEESTLTLLwsltVSIFPLGGLFGSLLVGPLVIRLGRKGTL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  177 MFST--AVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVsq 254
Cdd:cd17432  84 LLNNifAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVL-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  255 GTHSKNGPSSyripiGLQYVWSSILAVGMI------FLPESPRYYVL--KDElNKAAKSLSFLRGLpIEDPRLLEELVEI 326
Cdd:cd17432 162 GLRELLGNEE-----GWPLLLALTGVPALLqlltlpFFPESPRYLLIekGDE-EAARKALQRLRGK-EDVDDEMEEMLEE 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  327 KATydyEASFGPSTLLDCFKTSENRpKQILRIftgIAIQAFQQASGINFIFYYGVNFFNNTGV--DNSYLVSFISYAVNV 404
Cdd:cd17432 235 QRA---EKGVGTVSVLELFRDRSVR-WQLISI---IVLMAGQQLCGINAIYFYADSIFLEAGIpeDKIQYVTVGTGACEV 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  405 AFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLG 484
Cdd:cd17432 308 LATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQS 387
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320063  485 VRSKCTAICAAANWLVNFTCALITPYIVdvgshtSSMGPKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555
Cdd:cd17432 388 SRPAAFMVAGSLNWLSNFLVGLLFPFIQ------EGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
112-555 1.20e-45

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 167.96  E-value: 1.20e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  112 LFGYDTGLINSItdMPYVKTYIAPNHSyfttsQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQ 191
Cdd:cd17437   8 LLGYDIGVMSGA--VIFIKEDLKISDV-----QEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALA-ALIFFVGALLM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  192 VASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSSYRIPIGL 271
Cdd:cd17437  80 GVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLHVGWRLMLGV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  272 QYVWSSILAVGMIFLPESPRYyvlkdelnkaakslsflrglpiedprlleelveikatydyeasfgpstlldcfktsenR 351
Cdd:cd17437 160 GAVPSLFLAIGVLAMPESPRW----------------------------------------------------------T 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  352 PKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVA---FSIPGMYLVDRIGRRPVLL--AG 426
Cdd:cd17437 182 PAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTktlFILVATFLLDKVGRRPLLLtsTG 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  427 GVIMAIANLVIA--IVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTC 504
Cdd:cd17437 262 GMTLSLTALATSltFIDRNGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTV 341
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320063  505 ALitpyivDVGSHTSSMG-PKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555
Cdd:cd17437 342 SM------TFLSMSKAITtGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
110-554 1.71e-45

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 168.13  E-value: 1.71e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  110 GFLFGYDTGLINSITDmpyvktyIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNS 189
Cdd:cd17433  15 GFVLGYSSPAIPSLQR-------IADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLC-SVPFIAGFT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  190 LQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLvssavsqGTHSKNGPSSYRIPI 269
Cdd:cd17433  87 VITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIM-------GAYLAGLVLDWRWLA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  270 GLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRG--LPIEDPrlleeLVEIKATYDYEASfgpstlldCFKT 347
Cdd:cd17433 160 VLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGpdQGWEWE-----CIGIEQSFHLEEQ--------SFSL 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  348 SENRPKQILRIF-TGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAG 426
Cdd:cd17433 227 ALLKQPGIYKPLiIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLS 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  427 GVIMAIANLVIAIVGVSEgktvvaskimiafICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFtcaL 506
Cdd:cd17433 307 GVVMVFSTAAFGWLAVGS-------------MGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAF---L 370
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 6320063  507 ITPYIVDVGSHTSSMGpkIFFIWGGLNVVAVIVVYFAVYETRGLTLEE 554
Cdd:cd17433 371 VTKEFSSLMEVLSSYG--TFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
107-555 8.06e-35

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 136.47  E-value: 8.06e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  107 AVGGFLFGYDTGLINSItdMPYVKTYIApnhsyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFsTAVIFSI 186
Cdd:cd17435   7 AVSGLLVGYELGIISGA--LLQLRTLLA-----LSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIIL-TSCLLVL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  187 GNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGThsKNGPSSYR 266
Cdd:cd17435  79 GSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAF--ANVSNGWK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  267 IPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKaakslsflrglpiedprlleelveikatydyeasfgpstlldcfk 346
Cdd:cd17435 157 YMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRA--------------------------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  347 tsenrpkqilRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVA---FSIPGMYLVDRIGRRPVL 423
Cdd:cd17435 192 ----------RLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVkvvSTIPAIFLVDKVGSKTFL 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  424 LAGGVIMAIANLVIAIVgvsegktvvaskIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFt 503
Cdd:cd17435 262 CIGSSVMAVSLVTMGLW------------LSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINL- 328
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320063  504 caLITPYIVDVgshTSSMG-PKIFFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555
Cdd:cd17435 329 --LISLTFLTV---TELIGlPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
108-555 7.15e-33

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 131.08  E-value: 7.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  108 VGGFLFGYDTGLINSItdMPYVKTyiapnHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAVIFSiG 187
Cdd:cd17436   8 LGGLTFGYELGIISGA--LLQLQT-----DFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLA-G 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  188 NSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGThsKNGPSSYRI 267
Cdd:cd17436  80 SLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFF--SNVLTGWRY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  268 PIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKaakslsflrglpiedprlleelveikatydyeasfgpstlldcfkt 347
Cdd:cd17436 158 MFGLAIIPAAIQFASILLLPKKPEVLNIKDNMRR---------------------------------------------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  348 senrpkqilRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDN---SYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLL 424
Cdd:cd17436 192 ---------RTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSnssAVLASVGLGVVKVIATLLAMLFADRAGRRSLLI 262
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  425 AGGVIMAIAnlviaivgvsegktVVASKIMIAFICL--FIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNF 502
Cdd:cd17436 263 AGCSVMAVS--------------VSGIGLWITLLCLmaFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANL 328
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320063  503 TCALITPYIVDVGSHTSsmgpkIFFIWGGLNVVAVIVVYFAVYETRGLTLEEI 555
Cdd:cd17436 329 LITLSFLDLIDVIGLSW-----TFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
104-554 1.28e-29

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 122.25  E-value: 1.28e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAV-GGFLFGYdtGLINSITDMPYVKTYIAPNhSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAV 182
Cdd:cd17434   4 VFSAVlGNFSFGY--ALVYTSPVIPALEQGDDPR-LHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFS-AV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  183 IFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAvsqgthskngp 262
Cdd:cd17434  80 PSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYA----------- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  263 ssyripIGLQYVWSSILAVG------MI----FLPESPRYYVLKDELNKAAKSLSFLRGlpiEDPRLLEELVEIKATYDY 332
Cdd:cd17434 149 ------LGLLLPWRWLAVAGevpvviMIlllcFMPNSPRFLISKGKDEKALKALAWLRG---PNTDYMTEFEQIKDNIRK 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  333 EASfgpstlldCFKTSENRPKQILR-IFTGIAIQAFQQASGINFIFYYGVNFFNNTGV-----DNSYLVSFISYaVNVAF 406
Cdd:cd17434 220 QSS--------RLSWAELKTPSYYKpILIAVVMRFLQQLTGITPILVYLEPIFHLTAVilepkYDAALVGAVRL-LSVAI 290
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  407 SIPGMylvDRIGRRPVLLAGGVIMAIANLVIAIvgvsegktvvaskIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVR 486
Cdd:cd17434 291 AASLM---DKAGRKILLFTSAFLMFAANLSMGL-------------IPLIAAMLFIMGYAMGWGPITWLLMSEILPLKAR 354
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320063  487 SKCTAICAAANWLVNFTCA-LITPYIVDVGSHTSsmgpkiFFIWGGLNVVAVIVVYFAVYETRGLTLEE 554
Cdd:cd17434 355 GVASGLCVVVSWITAFVLTqLFLPVVVTFGLQVP------FLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
104-539 1.62e-23

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 102.68  E-value: 1.62e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGGFLFGYDTGLINSItdMPYVKTYIAPNhsyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFsTAVI 183
Cdd:cd17316   2 LLAGLGWFFDAYDFFLIGFV--APVLAAEFSLG---LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALIL-TLLL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  184 FSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRG----AIISSYQWAITIGLLVSSAVSQGTHSK 259
Cdd:cd17316  76 FGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGfalgLLQSGWALGALLAALVASLLIPLLSGD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  260 NGpssYRIPiglqYVWSSILAVGMIFLpespRYYVLKdelnkaakslsflrglpiedprlleelveikatydyeasfgps 339
Cdd:cd17316 156 WG---WRIL----FLIGALPALLALLL----RRRTLL------------------------------------------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  340 tlldcfktsenrpkqilriftgIAIQAFQQASGINFIFYYGVNFFNNTG---VDNSYLVSFISYAVNVAFSIPGMYLVDR 416
Cdd:cd17316 182 ----------------------LILLWFFISFGYYGLTTFLPTYLQTVLglsPATSSLYLLLISLGALVGALIAGLLSDR 239
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  417 IGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFiclfiaaFSATWGGVVWVVSAELYPLGVRSKCTAICAAA 496
Cdd:cd17316 240 IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF-------FVGGVWGALYAYLAELFPTEVRATGVGLSYNL 312
                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 6320063  497 NWLVNFTCALITPYIVDVGSHTSSMgpkiFFIWGGLNVVAVIV 539
Cdd:cd17316 313 GRLGGGGAPPLIALLLASTGGTGVP----ALILALLAIVALIV 351
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
106-541 2.07e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 102.89  E-value: 2.07e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  106 VAVGGFLFGYDTGLINSItdMPYVKTYIApnhsyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFS 185
Cdd:cd06174   1 LLLGFFLTGLARGLISPL--LPALLQSFG-----LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLG-LLLFA 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  186 IGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGpSSY 265
Cdd:cd06174  73 LGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGW 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  266 RIPIGLQYVWSSILAVGMIFLPESPRYYVLKDelNKAAKSLSFLRGLPiedprlleelveikatydyeasfgpstlldcf 345
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAK--NEEASSKSVLKLLK-------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  346 ktsenRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTG--VDNSYLVSFISYAVNVAFSIPGMYLVDR-IGRRPV 422
Cdd:cd06174 198 -----RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlsVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPL 272
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  423 LLAGGVIMAIANLVIAIvgvsegktvVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNF 502
Cdd:cd06174 273 LLIGLLLMALGLALLLL---------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGA 343
                       410       420       430
                ....*....|....*....|....*....|....*....
gi 6320063  503 TCALITPYIVDVGSHTSSMgpkiFFIWGGLNVVAVIVVY 541
Cdd:cd06174 344 IGPLLAGFLLAATFGLTGA----FLVLAVLLLLAAILLL 378
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
144-554 2.43e-21

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 98.16  E-value: 2.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    144 QIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAVIfSIGNSLQVASGGLVLLIVGRVIS-GIGIGIISAVVPLYq 222
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVT-AVSGVLTAFSPNYTVFLVFRLLVgMGIGGIWVQAVVLN- 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    223 AEAAQKNLRGAIISSYQWAITIGLLVSSAVsqgthskngpsSYRIP--IGLQyVWSS----ILAVGMIFLPESPRYYVLK 296
Cdd:TIGR00898 206 TEFLPKKQRAIVGTLIQVFFSLGLVLLPLV-----------AYFIPdwRWLQ-LAVSlptfLFFLLSWFVPESPRWLISQ 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    297 DELNKAAKSLSFLR-----GLPIE--DPRLLEELVEIKATYdyeasfgpsTLLDCFKTSenrpkqILRIFTGIAIQAfqq 369
Cdd:TIGR00898 274 GRIEEALKILQRIAkingkKLPAEvlSLSLEKDLSSSKKQY---------SFLDLFRTP------NLRKTTLCLMML--- 335
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    370 ASGINFIFYYGVNFFNNTGVdNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVgVSEGKTVV 449
Cdd:TIGR00898 336 WFTTAFSYYGLVLDLGNLGG-NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV-PVDLYFLR 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    450 ASKIMIAFICLfIAAFSAtwggvVWVVSAELYPLGVRSKCTAICAAANWLvnftCALITPYIVDVGSHTSSMgPKIFFiw 529
Cdd:TIGR00898 414 TALAVLGKFGI-TSAFQM-----VYLYTAELYPTVVRNLGVGVCSTMARV----GSIISPFLVYLGEKWLFL-PLVLF-- 480
                         410       420
                  ....*....|....*....|....*
gi 6320063    530 GGLNVVAVIVVYFaVYETRGLTLEE 554
Cdd:TIGR00898 481 GGLALLAGILTLF-LPETKGVPLPE 504
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
104-547 5.00e-16

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 80.78  E-value: 5.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGGFLFGYDTGLINSITDMpYVKTYIAPNHSYFTTSQIAILVSFLsLGTFFGALIAPYISDSYGRKpTIMFSTAVI 183
Cdd:cd17364   2 IIAGMGFFTDAYDLFSISLVTKI-LGRLYYGGKGSLPSGVSGLVNAAAL-VGTIIGQLFFGFLGDRFGRK-RVYGVELII 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  184 FSIGNSLQVAS------GGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTH 257
Cdd:cd17364  79 MIIGTILSALSpgstplGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  258 SK-NGPSSYRIPIGLQYVWSSILAVGMIflPESPRYYVLKDELnkAAKSLSFLrglpiedprlleelveikatYDYeASF 336
Cdd:cd17364 159 AIfEHPLPAGTYHHADLVWRIVLGLGAI--PALSVLYFRKHLL--GTAGTWFL--------------------LDI-AFY 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  337 GPStlldcfktsenrpkqilrIFTGIAIQAFQQASGINFIfyygvnffnntgvDNSYLVSFISYAVNVAFSIPG----MY 412
Cdd:cd17364 214 GQN------------------LFQSTIISAIGFSKTMNAY-------------QELFNIAVGQLIIALAGTVPGywftVF 262
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  413 LVDRIGRRPVLLAGGVIMAIANLVIAIVgVSEGKTVVASKIMIAFICLFIAAFSAtwGGVVWVVSAELYPLGVRSKCTAI 492
Cdd:cd17364 263 LIDRIGRKKIQMMGFFGMTIFLLILAGP-YDHWKISTIGFFVLYGLTFFFSNFGP--NTTTFIVPAEVFPARVRSTCHGI 339
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6320063  493 CAAANWLVNFTCALITPYIVDvgshtsSMG-PKIFFIWGGLNVVAVIVVYFAVYET 547
Cdd:cd17364 340 SAASGKIGAIVGSFLFLSLTQ------NIGvRNVLIILAGVALLGIILTLLFPEEK 389
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
106-544 1.01e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 79.54  E-value: 1.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  106 VAVGGFLFGYDTGLINSItdMP-YVKTYIApnhsyfTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTaVIF 184
Cdd:cd17325   1 LSLALFLDMLGYGIIIPI--LPlYAESLGA------SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL-LLL 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  185 SIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGpss 264
Cdd:cd17325  72 AVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG--- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  265 YRIPIglqYVWSSILAVGMIFlpespRYYVLKDELNKAAKSlsflrglPIEDPRLLEELVEIKatydyeasfgpstlldc 344
Cdd:cd17325 149 YRAPF---LVCAALALLALVL-----ALLLLPEPRPPPNKR-------AVSAARLRSGLRLLL----------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  345 fktsenRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISyAVNVAFSIPGMYLVDRIGRRPVLL 424
Cdd:cd17325 197 ------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG-LASALSQPPAGKLSDRIGRKPLIL 269
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  425 AGGVIMAIANLVIAIVGvsegkTVVASKIMIAFICLFIAAFSATWGGVVwvvsAELYPLGVRSKCTAICAAANWLVNFTC 504
Cdd:cd17325 270 IGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLALL----ADIVPPEGRGTAMGLFNTAFSLGMVLG 340
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 6320063  505 ALITPYIVDVGSHTSSmgpkiFFIWGGLNVVAVIVVYFAV 544
Cdd:cd17325 341 PLLGGFLYDAFGFATP-----FLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
106-492 2.54e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.15  E-value: 2.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    106 VAVGGFLFGYDTGLInsitdMPYVKTYIAPNHSyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTaVIFS 185
Cdd:pfam07690   1 LFLAAFLAALGRSLL-----GPALPLLLAEDLG-ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL-LLFA 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    186 IGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNG-PSS 264
Cdd:pfam07690  74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwRAA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    265 YRIPIGLqyvwsSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPIEDPRLLeelveikatydyeasfgpstlldc 344
Cdd:pfam07690 154 FLILAIL-----SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW------------------------ 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    345 fktsenrpkqilrIFTGIAIQAFQQASGINFIFYYGVNFfnNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLL 424
Cdd:pfam07690 205 -------------LLLALLLFGFAFFGLLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320063    425 AGGVIMAIANLVIAIVGVSEgktvvaSKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAI 492
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTL------SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
104-556 4.57e-13

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 72.07  E-value: 4.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    104 IFVA-VGGFLFGYDTGLINSITDMPYVKTYIAPNHsYFTTSQIAILVSfLSLGTFFGALIAPYISDSYGRKpTIMFSTAV 182
Cdd:TIGR00887  18 IVIAgVGFFTDSYDLFCISLVTKMLGYVYYHGKGP-LPSSVSAAVNGS-ASIGTLAGQLFFGWLADKLGRK-RVYGMELI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    183 IFSIGNSLQVASGG------LVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISS---YQ-WAITIGLLVSSAV 252
Cdd:TIGR00887  95 IMIIATVASGLSPGsspksvMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAvfaMQgFGILAGAIVALIV 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    253 SQG-THSKNGPSSYRIPIG-----LQYVWSSILAVGMIF----------LPESPRYYVL-KDELNKAAKSLS-FLRGLPI 314
Cdd:TIGR00887 175 LAGfKHSLEAAADEASCTGscvpaVDYMWRILIGFGAVPallalyfrltIPETPRYTADvAKDVEQAASDMSaVLQVKIE 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    315 EDPRLLEELVEIKATYDyEASFGpstlldcFKTSENRPKQILRIFtGIAIQAFQQAsginfIFYYGVNFFN--------- 385
Cdd:TIGR00887 255 AEPDEVEKASTAVEVPK-ASWSD-------FFTHFFKWRHGKHLL-GTAGSWFLLD-----IAFYGVNLNQkvilsaigy 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    386 -NTGVDNSYLVSFISYAVN-----VAFSIPG----MYLVDRIGRRPVLLAGGVIMAIANLVIAIV--GVSEGktvvaski 453
Cdd:TIGR00887 321 sPPAATNNAYEELYKTAVGnliiaLAGTVPGywvtVFLVDIIGRKPIQLMGFFILTVLFFVLGFAynHLSTH-------- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    454 miAFICLF-IAAFSATWG--GVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKIFF--- 527
Cdd:TIGR00887 393 --GFLAIYvLAQFFANFGpnATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGDPTKGYPTGIWMghv 470
                         490       500       510
                  ....*....|....*....|....*....|.
gi 6320063    528 --IWGGLNVVAvIVVYFAVYETRGLTLEEID 556
Cdd:TIGR00887 471 leIFALFMFLG-ILFTLLIPETKGKSLEELS 500
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
92-512 1.19e-12

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 70.46  E-value: 1.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063     92 PLRSNVMSVLVGIFVAVggFLFGYDTGLInsitdmpyvkTYIAPNHSY---FTTSQIAILVSFLSLGTFFGALIAPYISD 168
Cdd:TIGR00895  10 PLSRYQWRAIILSFLIM--LMDGYDLAAM----------GFAAPAISAewgLDPVQLGFLFSAGLIGMAFGALFFGPLAD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    169 SYGRKPTIMFSTaVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLV 248
Cdd:TIGR00895  78 RIGRRRVLLWSI-LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    249 SSAVsqgthskngpSSYRIPiglQYVWSSILAVG-----------MIFLPESPRYYVLKdelnkaakslsflrglpiEDP 317
Cdd:TIGR00895 157 GGFL----------AGWLIP---VFGWRSLFYVGgiaplllllllMRFLPESIDFLVSK------------------RPE 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    318 RLLEELVEIKATYDYEASFGPSTLldcfKTSENRPKQILR-IFTGI---AIQAFQQASGINFIFYYGVN-----FFNNTG 388
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQSALPEQ----KSTQGTKRSVFKaLFQGKtarITVLLWLLYFMLLVGVYFLTnwlpkLMVELG 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    389 VDNSY--LVSFISYAVNVAFSIPGMYLVDRIGRRPvllaggviMAIANLVIAIVGVSEGKTVVASKIMIAFICLFiAAFS 466
Cdd:TIGR00895 282 FSLSLaaTGGALFNFGGVIGSIIFGWLADRLGPRV--------TALLLLLGAVFAVLVGSTLFSPTLLLLLGAIA-GFFV 352
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 6320063    467 ATWGGVVWVVSAELYPLGVRSkcTAIcaaaNWLVNF--TCALITPYIV 512
Cdd:TIGR00895 353 NGGQSGLYALMALFYPTAIRA--TGV----GWAIGIgrLGAIIGPILA 394
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
141-478 4.08e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.18  E-value: 4.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  141 TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAvIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPL 220
Cdd:cd17324  32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLL-LFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAA 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  221 YQAEAAQKNLRGAIISSYQWAITIGLLV----SSAVSQGThskngpsSYRIPIGLQYVWSSILAVGMIF-LPESPRyyvl 295
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLgrplGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRlLPSLPP---- 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  296 kdelnKAAKSLSFLRGLpiedPRLLeelveikatydyeasfgpstlldcfktsenRPKQILRIFtgiAIQAFQQASGINF 375
Cdd:cd17324 180 -----KKPGSLGLLSSL----LLLL------------------------------RNPRLRLAY---LITFLLFGGFFAL 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  376 IFYYGVNFFNNTGVDNSYLVS--FISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGktvvaskI 453
Cdd:cd17324 218 YTYLAPFLTDVPGFSSSAIIGllLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLL-------L 290
                       330       340
                ....*....|....*....|....*
gi 6320063  454 MIAFICLFIAAFSATWGGVVWVVSA 478
Cdd:cd17324 291 LVGLVLWGLGFFAAHSALQTRVLRL 315
MFS_1 pfam07690
Major Facilitator Superfamily;
394-560 9.87e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 9.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    394 LVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEgktvvaskIMIAFICLFIAAFSATWGGVV 473
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAAL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    474 wVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSsmgpkIFFIWGGLNVVAVIVVYFAVYETRGLTLE 553
Cdd:pfam07690 108 -ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-----AFLILAILSLLAAVLLLLPRPPPESKRPK 181

                  ....*..
gi 6320063    554 EIDELFR 560
Cdd:pfam07690 182 PAEEARL 188
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
362-582 2.74e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 59.75  E-value: 2.74e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  362 IAIQAFQQASGINFIFYYGVNFFNNTGVDNSY--LVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAi 439
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQlgLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  440 vgvsegktVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTS 519
Cdd:cd06174  80 --------FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW 151
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320063  520 SMgpkIFFIWGGLNVVAVIVVYFAVYETRGLTLEEiDELFRKAPNSVISSKWNKKIRKRCLAF 582
Cdd:cd06174 152 RA---VFLIAAALALLAAILLLLVVPDPPESARAK-NEEASSKSVLKLLKRVLKNPGLWLLLL 210
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
106-541 4.59e-09

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 59.31  E-value: 4.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  106 VAVGGFLFGYDTGLINSITdmPYVKTYIAPNHSYFTtsqiAILVSFLSLGTFF-----GALIAPYISDSYGRKPTIMFST 180
Cdd:cd17368   4 ATSGNALEFFDFGVYGFFA--VYIGRLFFPSGSEFA----SLLLTFATFGVGFfmrpiGAIVLGAYADRIGRKPAMTLTL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  181 AvIFSIGNSL--------QVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIIS----SYQWAITIGLLV 248
Cdd:cd17368  78 A-IMALGTLLialaptyaTIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSwqsaSQQVAIVAGALV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  249 SSAVSQG-THSKNGPSSYRIPiglqyvwssiLAVGMIFLPespryyvlkdelnkaakSLSFLRGLPIEDPRLLEELVEIK 327
Cdd:cd17368 157 GYLLSLTlTAEALAEWGWRIP----------FFIGLLIIP-----------------LGLWLRRSLEETEAFLERKARPT 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  328 ATydyeasfgpstllDCFKTSENrPKQILRIFTGIAIqafqqASGINF--IFYYGVNFFN---NTGVDNSYLVSFISYAV 402
Cdd:cd17368 210 RR-------------ELFALLAN-NRRIILLGMLLVA-----GSTVTFyfTTVYTPTYAKtvlGLSARDSFLVTLLAGVA 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  403 NVAFSIPGMYLVDRIGRRPVLLaGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFsatwGGVVWVVSAELYP 482
Cdd:cd17368 271 NFIWAPLGGALSDRIGRRPVLL-VITLAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMY----GGAMVVALVELFP 345
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320063  483 LGVRSKCTAICAAANWLV--NFTCALITPYIVDVGSHTSSmgpkIFFIWGG--LNVVAVIVVY 541
Cdd:cd17368 346 VRVRSTGFSLVYALAVAIfgGFAQFIVTWLIELTGSPLAP----AWYLMGAalLGLLATLMLR 404
ProP COG0477
MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and ...
104-458 5.20e-09

MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 223553 [Multi-domain]  Cd Length: 338  Bit Score: 58.55  E-value: 5.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGGFLFGYDTGLINsitdmPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAV- 182
Cdd:COG0477   5 LALALAALLLGLDLGLLS-----PALPLLLSTLSLSSGRLLYGLLLSAFFLGYAIGSLLAGPLGDRYGRRKVLIIGLLLf 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  183 IFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAA-QKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNG 261
Cdd:COG0477  80 LLGTLLLALAPNVGLALLLILRLLQGLGGGGLLPVASALLSEWFpEATERGLAVGLVTLGAGALGLALGPLLAGLLLGAL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  262 PSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELNKAAKSLSFLRGLPiedprlleelveikatydYEASFGPSTL 341
Cdd:COG0477 160 LWGWRAAFLLAALLGLLLLILVLLLDLLLAAPRLPLAVGLALIELGKLLLLL------------------LILLLGGLVL 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  342 LDCFKTSENRPKQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRP 421
Cdd:COG0477 222 LLLGLYLSAAGFGLRALLLGLGLALLALFVGALILLVLLPILLGAAGGLSALVGAAGGLLALILLGLAGLLGTLVGGSLL 301
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6320063  422 VLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFI 458
Cdd:COG0477 302 VDRLGRSLGLRAILLAGALLLAILLLVLLLALVLTIL 338
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
141-547 9.31e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 58.08  E-value: 9.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  141 TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFsTAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPL 220
Cdd:cd17371  32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVI-TILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAA 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  221 YQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSsyripIGLQYV-WSSILAVGMI-----FLPESPRYyv 294
Cdd:cd17371 111 LMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPE-----IAWRVLfLLGALPALLVlfirrFVKEPPQW-- 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  295 lkdeLNKAAKSLSFlrglpiedprlleelveikatydyEASFGPSTLLDcfktsenrpkqilRIFTGIAIQAFQQASGIN 374
Cdd:cd17371 184 ----QAARAARRHF------------------------ADRPSLRELFS-------------PPLLRTTLLASLLATGAL 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  375 FIfYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMY--------LVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGK 446
Cdd:cd17371 223 GG-YYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFlgylaggfLADRIGRRNNFALFALGSAISILLYFFLPLSPTL 301
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  447 TVVAskimiAFICLF--IAAFSAtWGGVVwvvsAELYPLGVRSKCTAICAAANWLVnftcALITPYIVDVGSHTSSMGPK 524
Cdd:cd17371 302 ILIL-----GFPLGFfaSGPFSG-MGAYL----TELFPTAVRATAQGFCYNVGRII----GALFPFLVGFLATSGSLGTA 367
                       410       420
                ....*....|....*....|....
gi 6320063  525 I-FFIWGGlnVVAVIVVYFAVYET 547
Cdd:cd17371 368 IaVFAAVY--YIAGLVLALLLPET 389
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
145-486 9.73e-09

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 58.31  E-value: 9.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  145 IAILVSFLSLG-TFF----GALIAPYISDSYGRKPTIMFSTAVI----FSIG---NSLQVASGGLVLLIVGRVISGIGIG 212
Cdd:cd17369  41 AGTLAAFATFGvGFLarplGGVVFGHFGDRIGRKKTLVLTLLLMgiatFLIGllpTYAQIGILAPILLVLLRLLQGLALG 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  213 IISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPSS-----YRIPIglqyvWSSI--LAVGMIF 285
Cdd:cd17369 121 GEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAflswgWRIPF-----LLSAvlVAVGLYI 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  286 ---LPESPryyVLKDELNKAAKSLSFLRGLPIEDPRLLeelveikatydyeasfgpstlldcfktsenrpkqILRIFTGI 362
Cdd:cd17369 196 rlrLEETP---VFRRAKEAGQVVRAPLVEVLRRHWRAL----------------------------------LLAIGLRL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  363 AIQAFQQASGInFIFYYGVNFFnntGVDNS--YLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIAnLVIAIV 440
Cdd:cd17369 239 AENVLFYLFTT-FALSYATQTL---GVDRStvLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALF-AFPFFW 313
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*.
gi 6320063  441 GVSEGKTVVaskIMIAFICLFIAAFSATWgGVVWVVSAELYPLGVR 486
Cdd:cd17369 314 LLDTGSTWL---IVLAAVVVLGVLHGMMY-GPQAAFLAELFPTRVR 355
2_A_01_02 TIGR00880
Multidrug resistance protein;
397-547 1.64e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 53.81  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    397 FISYAVNVAF-SIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAivgvsegktvVASKIMIAFICLFIAAFSAtwgGVVWV 475
Cdd:TIGR00880   4 LAGYALGQLIySPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFA----------LSSNITVLIIARFLQGFGA---AFALV 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320063    476 VS----AELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHtssmgPKIFFIWGGLNVVAVIVVYFAVYET 547
Cdd:TIGR00880  71 AGaaliADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGW-----RAPFLFLAILALAAFILLAFLLPET 141
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
159-545 4.48e-07

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 52.68  E-value: 4.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  159 GALIAPYISDSYGRKPTIMFSTAVI----FSIGNSLQVASGGL---VLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLR 231
Cdd:cd17367  56 GGWLFGRLADRIGRRAALTLSVSLMaagsLVIAVTPTYATIGIwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  232 GaIISSYQWAITI-GLLVSSAVSQGTHSKNGPS-----SYRIPIGLqyvwSSILAVGMIFLpespRyyvlkdelNKAAKS 305
Cdd:cd17367 136 G-FYSSFQYVTLIgGQLLALGVLLVLQHTLGEDqmaawGWRIPFLL----GGVLAVVVLWL----R--------RGLEET 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  306 LSFLR--GLPIEDPRLLEELVeikatydyeasfgpstlldcfktseNRPKQILRIFtGIAiqafqqaSGINFIFY----Y 379
Cdd:cd17367 199 ESFEAiaESNEASAGTLRELR-------------------------RHPRELLLVV-GLT-------AGGTLAFYtwttY 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  380 GVNFFNNTGVDNSYLVSFISYAVNVAFSI--P--GMyLVDRIGRRPVLLAGGVIMAIANLVI-AIVGVSEGKTVVASKIM 454
Cdd:cd17367 246 LQKFLVNTAGFSKGDATWITTAALLVFMLlqPlgGR-LSDRIGRRPLLLFFGIGGTLATVPLlSALDHTDSPYTAFALVL 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  455 IAFicLFIAAFSATWGgvvwVVSAELYPLGVRSKCTAIC-AAANWLVNFTCALITPYIVDVGshtssmGPKIFFIWggln 533
Cdd:cd17367 325 VGL--VFLSGYTSINA----VVKAELFPTHVRALGVGLPyALAVAIFGGTAPYVALWLKSIG------HEWVFFWY---- 388
                       410
                ....*....|..
gi 6320063  534 VVAVIVVYFAVY 545
Cdd:cd17367 389 VAGLIAISLVVY 400
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
104-485 5.90e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.18  E-value: 5.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  104 IFVAVGGFLFGYdtGLInsitdMPYVKTYIAPNHsyFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVI 183
Cdd:cd17477   1 LLLSVALLGLGS--GLL-----LPLLSLRLEREG--VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAG-AAI 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  184 FSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQWAITIGLLVssavsqgthsknGPs 263
Cdd:cd17477  71 TAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL------------GP- 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  264 syripiglqyvwssilAVGMIFLPESPRYYVLkdelnkaAKSLSFLRGLPIedprlleelveikatydyeaSFGPSTLLD 343
Cdd:cd17477 138 ----------------LLLALVGTAGALPFLI-------AAVLLLLALVPL--------------------LLTRRAAPE 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  344 CFKTSENRPKQILRI----FTGIAIQAFQQASGINFIFYYGVNFfnntGVDNSYLVSFIS--YAVNVAFSIPGMYLVDRI 417
Cdd:cd17477 175 IEEAESISLRRLLRIaplaLLGAFVAGFLEGAFYSLLPLYGLRL----GLSVAQAALLLAafVLGGLLLQWPLGWLADRF 250
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320063  418 GRRPVLLAGGVIMAIANLVIAIVGVSEGktvvaskimIAFICLFIaafsatWGGvvwvVSAELYPLGV 485
Cdd:cd17477 251 DRRRVLLGCALLGALAALLLPLVPGLPL---------ALLVLLFL------WGG----AAGPLYTLAL 299
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
397-548 1.30e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 1.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  397 FISYAV-NVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAivgvsegktVVASKIMIAFICLFIAAFSATWGGVVWV 475
Cdd:cd17325  37 VAAYALaQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA---------FATSYWQLLLARFLQGLASAAVWPAAMA 107
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320063  476 VSAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSsmgpkIFFIWGGLNVVAVIVVYFAVYETR 548
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA-----PFLVCAALALLALVLALLLLPEPR 175
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
144-542 1.65e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 50.66  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  144 QIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFstavifsignslqvasgGLVLLIVGRVISgigigiisAVVPLYQA 223
Cdd:cd17317  26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLL-----------------GLVLQIVCGVLS--------AFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  224 EAAQKNLRGAIISS-YQWAITIGL-LVSSavsqgthskngpsSYR--IPIGLQYVWssilAVGMIFLPesPRYYVLKDel 299
Cdd:cd17317  81 FLVLRFLVGVTSAGiFTVGFVLGMeIVGP-------------KYRsfVGILFGLFW----ALGYMLLA--LLAYLIRD-- 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  300 nkaAKSLSFLRGLPIedprLLeelveikatydyeasfgpsTLLDCFKTsenrPKQILRI-FTGIAiqafqqasgiNFIFY 378
Cdd:cd17317 140 ---WRWLQLAISLPG----LL-------------------FLLLLWWL----PRRTIIVgLIWFV----------TSLVY 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  379 YGVNFF-NNTGVdNSYLVSFISYAVnvafSIPG----MYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASkI 453
Cdd:cd17317 180 YGLSLNsSNLGG-NLYLNFFLSGLV----EIPAyflaLLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL-A 253
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  454 MIAFICLfiaafSATWgGVVWVVSAELYPLGVRSKCTAICAAANWLvnftCALITPYIVDVGSHtssmGPKI-FFIWGGL 532
Cdd:cd17317 254 LVGKFAI-----SAAF-SVIYLYTAELYPTVVRNTGVGLCSTVARV----GAILAPFIVLLGKI----GPLLpLIIFGVL 319
                       410
                ....*....|
gi 6320063  533 NVVAVIVVYF 542
Cdd:cd17317 320 ALLGGLLTLL 329
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
355-542 2.19e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 50.65  E-value: 2.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  355 ILRIFTGIAIQAFqqasGINFIFYyGVNFF------NNTGVDNSY--LVSFISYAVNVAFSIPGMYLVDRI---GRRPVL 423
Cdd:cd17319 177 YLRQVWGLALGYF----GINYALY-GLLTWlptylkQARGFSLKQvgLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVI 251
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  424 LAGGVIMAIANLVIAIVgvsegktvvaSKIMIAFICLFIAAFSA-TWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNF 502
Cdd:cd17319 252 IIGLLLAAVGLLLAYLT----------TSPVVAVILLSLAGFGIgAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGF 321
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6320063  503 TCALITPYIVDV-GSHTSSmgpkiFFIWGGLNVVAVIVVYF 542
Cdd:cd17319 322 VAPLLIGYLVDAtGSYTAA-----FLFLAAVALLAALLVLL 357
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
412-545 3.25e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 3.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  412 YLVDRIGRRPVLLAGGVIMAIANLVIAIVGVsegktvvaskIMIAFICLFIAAFSAtwGG---VVWVVSAELYPLGVRSK 488
Cdd:cd17316  58 YLGDRIGRKKALILTLLLFGLATLLIGLLPT----------PILLLVLRFLQGIGI--GGeypGASTYVAEFAPSKRRGF 125
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320063  489 CTAICAAANWLVNFTCALITPYIVDVGSHTSsmGPKIFFIWGGL----------NVVAVIVVYFAVY 545
Cdd:cd17316 126 ALGLLQSGWALGALLAALVASLLIPLLSGDW--GWRILFLIGALpallalllrrRTLLLILLWFFIS 190
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
91-254 3.39e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   91 LPLRSNVMSVLVGIFVAVGGFlFGYDTglinsitdmpYVKTYIAPNHSyFTTSQIAILVSFLSLGTFFGALIAPYISDSY 170
Cdd:cd17316 173 LLLRRRTLLLILLWFFISFGY-YGLTT----------FLPTYLQTVLG-LSPATSSLYLLLISLGALVGALIAGLLSDRI 240
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  171 GRKPTIMFST--AVIFSIGnSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIIS-SYQWAITIGLL 247
Cdd:cd17316 241 GRKKTLVIGLilSGILALP-LFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGlSYNLGRLGGGG 319

                ....*..
gi 6320063  248 VSSAVSQ 254
Cdd:cd17316 320 APPLIAL 326
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
413-548 3.87e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 49.88  E-value: 3.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  413 LVDRIGRRPVLLAGGVIMAIANLVIAivgvsegktvVASKIMIAFICLFIAAFSATWGGVVW-VVSAELYPLGVRSKCTA 491
Cdd:cd17320  57 LSDRFGRRPVLLAGLLLFILASLLCA----------LASSIEQLLIARFLQGLGAAAGSVVArAIVRDLYSGAELAKIFS 126
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6320063  492 ICAAAnWLVNFTCA-LITPYIVDVGSHTSsmgpkIFFIWGGLNVVAVIVVYFAVYETR 548
Cdd:cd17320 127 LLMMI-LAIAPALApLLGGLLLLFFGWRA-----IFVFLALLGLLLLLLVLLFLPETL 178
AraJ COG2814
Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];
141-476 4.10e-06

Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 225371 [Multi-domain]  Cd Length: 394  Bit Score: 49.92  E-value: 4.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  141 TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAvIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPL 220
Cdd:COG2814  46 SEGAAGQLITAYALGVALGAPLLALLTGRLERRRLLLGLLA-LFIVSNLLSALAPSFAVLLLARALAGLAHGVFWSIAAA 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  221 YQAEAAQKNLRGAIISSyqwaITIGLLVSS--AVSQGTHskngpssyripIGLQYVWSS----ILAVGMIFLpespryyv 294
Cdd:COG2814 125 LAARLVPPGKRGRALAL----VFTGLTLATvlGVPLGTF-----------LGQLFGWRAtflaIAVLALLAL-------- 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  295 lkdelnkaaksLSFLRGLPIEDPRLLeelveikatydyeasfGPSTLLDCFKTSenRPKQILRIFTGIAIQAfqqasGIN 374
Cdd:COG2814 182 -----------LLLWKLLPPSEISGS----------------LPGPLRTLLRLL--RRPGVLLGLLATFLFM-----TGH 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  375 FIFY-YGVNFF-NNTGVDNSyLVSFISYAVNVAF---SIPGMYLVDRiGRRPVLLAGGVIMAIANLVIAIVGVSEGktvv 449
Cdd:COG2814 228 FALYtYIRPFLeSVAGFSVS-AVSLVLLAFGIAGfigNLLGGRLADR-GPRRALIAALLLLALALLALTFTGASPA---- 301
                       330       340
                ....*....|....*....|....*..
gi 6320063  450 askimIAFICLFIAAFSATWGGVVWVV 476
Cdd:COG2814 302 -----LALALLFLWGFAFSPALQGLQT 323
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
140-543 5.29e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.13  E-value: 5.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  140 FTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVP 219
Cdd:cd17489  28 GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIG-LLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAA 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  220 LYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGpssyripiglqYVWSSILAVGMIFlpespryyvlkdel 299
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-----------FAVLFIVAAVLAL-------------- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  300 nkaaksLSFLRGLPIEDPrlleelVEIKATYDYEASFGPSTLLDcfktsenrpKQILRIFTGIAIQAFQQASGINFIFYY 379
Cdd:cd17489 162 ------LALLLVFLVKDP------PPVAAEEAEAGTRAFRRLVE---------KKVLPPALILFLASIAYGAISTFLPLY 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  380 GvnffNNTGVDNSYLVsFISYAVNVAFSIP--GMyLVDRIGRRPVLLAGGVIMAIANLVIAIvgvsegkTVVASKIMIAF 457
Cdd:cd17489 221 A----AERGISNAGLF-FTVYAIALLLSRPfsGK-LSDRKGPKTVIIPGLLLLALGLLLLSF-------AGSPWMLLLAA 287
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  458 ICL---FIAAFSAtwgGVVWVVSaeLYPLGVRSKCTAIcaaanWLVNFTCAL-ITPYIvdVGSHTSSMGPKIFFIWGGLN 533
Cdd:cd17489 288 VLYglgFGLLFPA---LQALAVD--LVPPHRRGAANGT-----FFIFFDLGIgLGGLL--LGLVAELFGYRAMFLLAAVV 355
                       410
                ....*....|
gi 6320063  534 VVAVIVVYFA 543
Cdd:cd17489 356 VLLALVLYIF 365
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
376-532 1.72e-05

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 47.74  E-value: 1.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  376 IFYYGVNFfNNTGVD-NSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGvsegktvVASKIM 454
Cdd:cd17378 187 MVYYGIPL-AVGNLKfNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLS-------IGGTTS 258
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320063  455 IAFICLFIAAFSATWG-GVVWVVSAELYPLGVRSkcTAICAAANWLVnfTCALITPYIVDVGSHTSSMGPKIFFIWGGL 532
Cdd:cd17378 259 LQIALELVGFFGAAGAfNLLYIYTVELFPTCVRN--AALGMLRQALV--VGGIFAPFIVSLGRKNAALSFGVFGVAILL 333
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
74-286 2.16e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 2.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   74 PAGDGAIETTSILLSQPLPLRSN--VMSVLVGIFVAVGGFLFGYdtglinsitdmpyvkTYIAP---NHSYFTTSQIAIL 148
Cdd:cd17324 175 PSLPPKKPGSLGLLSSLLLLLRNprLRLAYLITFLLFGGFFALY---------------TYLAPfltDVPGFSSSAIIGL 239
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  149 VSFLSLGTFFGALIAPYISDSYGRKPT------IMFSTAVIFSIGNSLQVASGGLVLLIVGrvisgigigiISAVVPLYQ 222
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALlialllLAAALLLLTLLGPSPLLLLVGLVLWGLG----------FFAAHSALQ 309
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  223 ------AEAAQKNLRGAIISSYQWAITIGLLVSSAVSQgthskngpssyripiglQYVWSSILAVGMIFL 286
Cdd:cd17324 310 trvlrlAPEARGLASSLYLAAYNLGGALGAALGGLVLD-----------------HGGWAGVGWVGAALL 362
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
141-502 2.48e-05

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 47.48  E-value: 2.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  141 TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAV--IFSIGNSLQVASGglvLLIVGRVISGIGIGIISAVV 218
Cdd:cd17363  32 SNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVngVFAFLSSFVQGYG---FFLFCRLLSGIGIGGSIPIV 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  219 PLYQAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQGTHSKNGPS----------SYRIPIGLQYVWSSILAVGMIFLPE 288
Cdd:cd17363 109 FSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWGfsmgtayqfhSWRVFVIVCALPSVASVVALTFMPE 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  289 SPRYY-----------VLKD--ELNKAAK-------------------------SLSF-LRGLPIEDPRLLEELvEIKAT 329
Cdd:cd17363 189 SPRFLlevgkhdeawmILKQvhDTNMRAKghpervftvshikrmntlflaivwfTMSFsYYGLTVWFPDMIKYL-QFEDS 267
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  330 YDYEASFGPSTLLDCFktsenrpkqilriftgiaiqaFQQASGINFIFY----YGVNFFNNTGVDNS------------- 392
Cdd:cd17363 268 LFEECYFEDVTSTNTF---------------------FENCTFINTVFYntdlFEYKFIDSRFLNSTfflkekcgchlnd 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  393 --------YLVSFISYAVNVAFSIPGMYLVDRIGRRpVLLAGGVIMAIANLVIAIVGVSEGktvvaskIMIAFICLFIAA 464
Cdd:cd17363 327 deenayliYLVSFLGSLSVLPGNIVSALLMDKIGRL-KMIGGSMLLSAVCCFFLFFGNSES-------AMIGLQCLFCGV 398
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 6320063  465 FSATWGGVVwVVSAELYPLGVRSKC----TAICAAANWLVNF 502
Cdd:cd17363 399 SIAAWNALD-VVTVELYPTDKRATAfgflNGLCKLAAILGNS 439
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
394-566 3.13e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 3.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  394 LVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGvsegktvvaskiMIAFICLFIAAFSATWGGVV 473
Cdd:cd17329  39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH------------SPWLFAIALVLTGFGGGLFE 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  474 WVVSAELYPLGVRSKCTAICAAANWLVNFTcALITPYIvdvGSHTSSMGPK-IFFIWGGLNVVAVIVVYFAVYETRGLTL 552
Cdd:cd17329 107 PASEAMIADVTTPENRTRAFSLLYWAINLG-VAIGPLL---GGLLLLYSFRlLFLAAAVLFLLAALVLLFLLPETRPKRR 182
                       170
                ....*....|....
gi 6320063  553 EEIDELFRKAPNSV 566
Cdd:cd17329 183 AAEKTEILRGYKIV 196
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
372-486 4.36e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 46.26  E-value: 4.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  372 GINFIfYYGVNFfNNTGVD-NSYLVSFISYAVNVAFSIPGMYLVDRIGRRpvLLAGGVIMAIANLVIAIVGVSEGKTVVA 450
Cdd:cd17447 184 GVAFT-YYGISF-NISGFGlNVYLTQFIYGAIELPAKLLAYLLLDRIGRR--LTQAGSLILTGLSIGINILIPSEFTVVR 259
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6320063  451 SKIMIaficlFIAAFSATWGGVVWVVSAELYPLGVR 486
Cdd:cd17447 260 TVIAV-----LGKGFSEAAFTTVFLYTSELYPTVLR 290
AraJ COG2814
Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];
393-544 6.11e-05

Predicted arabinose efflux permease, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 225371 [Multi-domain]  Cd Length: 394  Bit Score: 46.07  E-value: 6.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  393 YLVSFisYAVNVAF-SIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIvgvsegktvvASKIMIAFICLFIAAFSAtwgG 471
Cdd:COG2814  52 QLITA--YALGVALgAPLLALLTGRLERRRLLLGLLALFIVSNLLSAL----------APSFAVLLLARALAGLAH---G 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  472 VVWVVS----AELYPLGVRSKCTAICAAAnwlvnFTCALIT--P---YIVD-VGSHTssmgpkIFFIWGGLNVVAVIVVY 541
Cdd:COG2814 117 VFWSIAaalaARLVPPGKRGRALALVFTG-----LTLATVLgvPlgtFLGQlFGWRA------TFLAIAVLALLALLLLW 185

                ...
gi 6320063  542 FAV 544
Cdd:COG2814 186 KLL 188
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
143-312 1.15e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 45.34  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   143 SQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAV--IFSIG-------NSLQVA--------SGGLVLLIvgrv 205
Cdd:PRK11551  50 AQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALfgLFSLAtaqawdfPSLLVArlltgvglGGALPNLI---- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063   206 isgigigiisAVVplyqAEAAQKNLRGAIISSYQWAITIGLLVSSAVSQgthSKNGPSSyripiglqyvWSSILAVG--- 282
Cdd:PRK11551 126 ----------ALT----SEAVGPRLRGTAVSLMYCGVPFGGALASVIGV---LAAGDAA----------WRHIFYVGgvg 178
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 6320063   283 --------MIFLPESPRYyvlKDELNKAAKSLSFLRGL 312
Cdd:PRK11551 179 plllvpllMRWLPESRAF---AQAAGAGKQRAPVLRAL 213
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
381-483 2.24e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.11  E-value: 2.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  381 VNFFNNTGvDNSYLVSFISYAVNVAFSIPGM---YLVDRIGRRPVLLAGGVIMAIANLVIA-------------IVGV-S 443
Cdd:cd17317  14 VTEWDLVC-DRDWLVALVQTIFFLGVLIGSLlfgYLADRFGRRPVLLLGLVLQIVCGVLSAfspsyelflvlrfLVGVtS 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6320063  444 EGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAELYPL 483
Cdd:cd17317  93 AGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLAL 132
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
384-501 2.27e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063    384 FNNTGvDNSYLVSFISYAVNVAFsIPG----MYLVDRIGRRpVLLAGGVIMAIANLVIAIVGVSEgktvvasKIMIAFIC 459
Cdd:TIGR01299 587 FDGDD-EGAYMIYFVNFLGTLAV-LPGnivsALLMDKIGRL-RMLAGSMVLSCISCFFLSFGNSE-------SAMIALLC 656
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6320063    460 LFIAAFSATWGGVVwVVSAELYPLGVRSKC----TAICAAANWLVN 501
Cdd:TIGR01299 657 LFGGLSIAAWNALD-VLTVELYPSDKRATAfgflNALCKAAAVLGI 701
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
390-496 2.38e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 44.25  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  390 DNSYLVSFISYAVNVAFsIPG----MYLVDRIGRRPvLLAGGVIMAIANLVIAIVGVSEGKtvvaskiMIAFICLFIAAF 465
Cdd:cd17439 333 NNAYMIYFVSFLGTLAV-LPGnivsALLMDKIGRLR-MLAGSSVMSCVSCFFLSFGNSESA-------MIALLCLFGGVS 403
                        90       100       110
                ....*....|....*....|....*....|....*
gi 6320063  466 SATWGGVVwVVSAELYPLGVRSKC----TAICAAA 496
Cdd:cd17439 404 IASWNALD-VLTVELYPSDKRTTAfgflNALCKLA 437
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
141-544 2.43e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.10  E-value: 2.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  141 TTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFStAVIFSIGNSLQVASGGLVLLIVGRV-----ISGIGIGIIS 215
Cdd:cd17474  32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG-LLLFGIGGLLCGLSDSFALLLAGRAlqgigAAGLGPLALT 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  216 AVVPLYQAEAaqknlRGAIISSYQWAITIGLLVSSAVSqgthSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRyyvl 295
Cdd:cd17474 111 LIGDLFEGGE-----RAKAMGLYEAALGLGIAVGPLLG----GLLAAISWRYPFFLLAALIPVAFLAILFLLPEPK---- 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  296 kdelNKAAKSLSFLRGLPIedprlleelveikatydyeasfgpstlldcfktsenrpkqilRIFTGIAIQAFQQASGINF 375
Cdd:cd17474 178 ----EKAKSSSATKLRDLK------------------------------------------KALRGRGLLTFLVSAFLYF 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  376 IFYYGVNFFNNTGVDNSYLVSfiSYAVNVAFSIPGM-----------YLVDRIGRRPVLLAGGVIMAIANLVIAIVGvse 444
Cdd:cd17474 212 FLYFAFLTYLPFLLELLYGIS--PIIIGLLFAGWSVllalgslfvgrLLKKRFGARRILVIGLLLYALSLLLLGFVP--- 286
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  445 gktvvaskiMIAFICLFIAAFSATWGGVVWVVS---AELYPLGVRSKCTAICAAANWLVNFTCALITPYIVdvgshtSSM 521
Cdd:cd17474 287 ---------SLALLLIAIVLFGLGLGLNLPLLTtlvTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL------EIF 351
                       410       420
                ....*....|....*....|...
gi 6320063  522 GPKIFFIWGGLNVVAVIVVYFAV 544
Cdd:cd17474 352 GLSAPFLVGAAIALAAAVLLALL 374
ProP COG0477
MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and ...
353-542 2.81e-04

MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 223553 [Multi-domain]  Cd Length: 338  Bit Score: 43.91  E-value: 2.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  353 KQILRIFTGIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAI 432
Cdd:COG0477   2 RSLLALALAALLLGLDLGLLSPALPLLLSTLSLSSGRLLYGLLLSAFFLGYAIGSLLAGPLGDRYGRRKVLIIGLLLFLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  433 ANLVIAIVGVSegktvvASKIMIAFICLFIAAFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFtcaLITPYIV 512
Cdd:COG0477  82 GTLLLALAPNV------GLALLLILRLLQGLGGGGLLPVASALLSEWFPEATERGLAVGLVTLGAGALGL---ALGPLLA 152
                       170       180       190
                ....*....|....*....|....*....|
gi 6320063  513 DVGSHTSSMGPKIFFIWGGLNVVAVIVVYF 542
Cdd:COG0477 153 GLLLGALLWGWRAAFLLAALLGLLLLILVL 182
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
126-205 2.84e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.72  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  126 MPYVKTYIAP-NHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTAvIFSIGNSLQVASGGLVLLIVGR 204
Cdd:cd17330  16 FPVLPFYVREfNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA-GSAVSYVLLGLSRNLWLLFLAR 94

                .
gi 6320063  205 V 205
Cdd:cd17330  95 F 95
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
378-542 3.36e-04

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 43.61  E-value: 3.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  378 YYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPV----LLAGGVIMAIANLVIAIVGVSEGKTVVASKI 453
Cdd:cd17376 190 YFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSiaatLVLGGGVLLFIQLVPTDLQVLATALVMLGKF 269
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  454 MIAficlfiAAFSatwggVVWVVSAELYPLGVRSKCTAICAAANWLvnftCALITPYIVDVGSHTSSMGpkiFFIWGGLN 533
Cdd:cd17376 270 GIT------AAFS-----MVYVYTAELYPTVVRNMGVGVCSTASRI----GSIISPYFVYLGAYDRYLP---YILMGSLT 331

                ....*....
gi 6320063  534 VVAVIVVYF 542
Cdd:cd17376 332 VLIGILTLF 340
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
345-542 3.37e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 3.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  345 FKTSENRPKQILRIFTGI-AIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVnvaFSIPGMYLVDRIGRRPVL 423
Cdd:cd17370 191 KKTSLKKLPKAFWLYLLAvALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYAL---AAYPAGRLSDRIGRKKLL 267
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  424 LAGGVIMAIANLVIAIVGVSEGktvvaskIMIAFICLFIaaFSATWGGVVWVVSAELYPLGVRSKCTAICAAANWLVNFT 503
Cdd:cd17370 268 ILGYLSLALAYLGFALGSSLWL-------LLLGFILWGL--YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLL 338
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6320063  504 CALITPYIVDvgshtsSMGPKIFFIWGGLNVVAVIVVYF 542
Cdd:cd17370 339 ASLIAGYLWD------LISPSAAFLFSAVLALIALLLLL 371
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
392-544 4.54e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 4.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  392 SYLVSFisYAVNVAF-SIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIvgvsegktvvASKIMIAFICLFIAAFSAtwg 470
Cdd:cd17324  37 GLLVSA--YALGYALgALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL----------APSFALLLLARALAGLAH--- 101
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320063  471 GVVWVVS----AELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGS-HTSsmgpkiFFIWGGLNVVAVIVVYFAV 544
Cdd:cd17324 102 GGFWAIAaayaADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGwRAA------FLAIAVLALLAALLLWRLL 174
PRK12307 PRK12307
MFS transporter;
155-231 5.34e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 42.99  E-value: 5.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320063   155 GTFFGALiapyiSDSYGRKPTIMFSTaVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLR 231
Cdd:PRK12307  70 GALFGLL-----ADKFGRKPLMMWSI-VAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLK 140
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
390-512 5.37e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 42.72  E-value: 5.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  390 DNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIV--GVSEGKTVVAS----KIMIAFiclfia 463
Cdd:cd17379 199 GNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIppDLHWLKTTIACvgrlGITMAF------ 272
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320063  464 afsatwgGVVWVVSAELYPLGVR----SKCTAICAAAnwlvnftcALITPYIV 512
Cdd:cd17379 273 -------EIVCLVNTELYPTFLRnlgvSVCSSLCDIG--------GIIAPFLL 310
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
350-480 6.62e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 225121 [Multi-domain]  Cd Length: 467  Bit Score: 43.01  E-value: 6.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  350 NRPKQILRIFTGIAIQAFQQASGInfIFYYGVNFFNNTGVDnSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVI 429
Cdd:COG2211 235 NRPLLLLLLMNLLLFIAFNIRGSI--MVYYVTYVLGDPELF-AYLLLLASGAGLLIGLILWPRLVKKFGKKKLFLIGLLL 311
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320063  430 MAIANLVIAIVGvsegktvvASKIMIAFICLFIAAF-SATWGGVVWVVSAEL 480
Cdd:COG2211 312 LAVGYLLLYFTP--------AGSVVLIVVALIIAGVgTGIANPLPWAMVADT 355
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
144-543 1.13e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  144 QIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFSTaVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVP---- 219
Cdd:cd17473  36 LVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGL-LLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATalig 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  220 -LYQAEAAQK--NLRGAIISsyqWAITIGLLVSSAVSQgthskngpSSYRIPIGLqYVWSSILAVG-MIFLPESPRyyvl 295
Cdd:cd17473 115 dYFEGEERAKmlGLQSAAMS---LGGVVFLLLGGALAE--------IGWRAPFLV-YLLALPVLILvLLFLPEPAR---- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  296 kdelnkaakslsflrglpiedprlleelveikatydyeasfgPSTLLDCFKTSENRPKQILRIFtGIAIQAFqqasgINF 375
Cdd:cd17473 179 ------------------------------------------KSKSAASPGAATAAALPWKRVL-PIYFLAF-----LAM 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  376 IFYYGVN-----FFNNTGVDNSYLVSFISYAVNVAFSIPGM---YLVDRIGRRPVLLAGGVIMAIANLVIAIvgvsegkt 447
Cdd:cd17473 211 LLFYVIPiqlpfLLQERGGGSAALIGLALAIASLAGAIGALlfgRLKRRLGKRRLLAIGFALMALGFLLLAL-------- 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  448 vvASKIMIAFICLFIAAFSATWGG---VVWVVSaeLYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMgpk 524
Cdd:cd17473 283 --ASGLWVVLLGAILAGLGFGLLLptlNSWAMS--LVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGA--- 355
                       410
                ....*....|....*....
gi 6320063  525 iFFIWGGLNVVAVIVVYFA 543
Cdd:cd17473 356 -FLILGVLALVLAIVLLLL 373
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
397-552 1.30e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.79  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  397 FISYAVnvaFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGktvvaskiMIAFICLFIAAFSATWGGVVwVV 476
Cdd:cd17319  48 FLGYAL---FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFPGAI-KA 115
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320063  477 SAELYPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSmgpkiFFIWGGLNVVAVIVVYFAVYETRGLTL 552
Cdd:cd17319 116 LAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA-----FIIEGLLGLLLAVLWWFYLRQVWGLAL 186
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
413-474 2.66e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 40.65  E-value: 2.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320063   413 LVDRIGRRPVLLAGGVIMAIANLVIAIVgvsegktvvaSKIMIAFICLFIAAFSATWGGVVW 474
Cdd:PRK11043  64 LSDRYGRKPVLLAGLSLFALGSLGMLWV----------ESAAQLLVLRFVQAVGVCSAAVIW 115
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
374-542 2.85e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.74  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  374 NFIFYYGVNF-FNNTGVdNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIAnlVIAIVGVSEGKTVVasK 452
Cdd:cd17374 185 NSFSYYGLSLdLQHLGL-NVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLC--ILANIFVPQEMQTL--R 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  453 IMIAfiCLFIAAFSATWGgVVWVVSAELYPLGVRSKCTAICAAANWLvnftCALITPYIVDVGSHTSSMgPKIffIWGGL 532
Cdd:cd17374 260 TVLA--VLGKGSSAAAFT-ISYVYTAELFPTVLRQTGMGLNSMFARI----GGILAPLIMLLGVYSPLL-PMI--IYGVL 329
                       170
                ....*....|
gi 6320063  533 NVVAVIVVYF 542
Cdd:cd17374 330 PILAGLLALL 339
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
404-466 4.67e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 4.67e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320063  404 VAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFS 466
Cdd:cd17313 295 LIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYP 357
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
394-474 4.74e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 4.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  394 LVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVIMAIANLVIAIVGVSEGKTVVaskimIAFICLFIAAFSATWGGVV 473
Cdd:cd06173  38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLW-----LLLVLAFLLGIASAFFGPA 112

                .
gi 6320063  474 W 474
Cdd:cd06173 113 R 113
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
350-497 5.81e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.90  E-value: 5.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  350 NRPKQILRIFTGIAIQAFQQASGInFIFYYgvnFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRRPVLLAGGVI 429
Cdd:cd17332 220 NRPFLILLLAYLLYFLAFNIVNTV-LVYYF---KYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLL 295
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320063  430 MAIANLVIAIvgVSEGKTVVaskiMIAFICLFIAAFSATWgGVVWVVSAEL-----YPLGVRskCTAICAAAN 497
Cdd:cd17332 296 AILGLLLLFF--LPPGNLVL----ILVLAVLAGIGYGGAN-LLPWAMLADVidygeLKTGKR--REGIFYSVM 359
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
393-502 7.77e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 39.51  E-value: 7.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  393 YLVSFISYAVNVAFSIPGMYLVDRIGRRpVLLAGGVIMAIANLVIAIVGVSEGktvvaskIMIAFICLFIAAFSATWGGV 472
Cdd:cd17440 340 YFVNFLGTLAVLPGNIVSALLMDRIGRL-TMLGGSMVLSGISCFFLWFGTSES-------MMIGMLCLYNGLTISAWNSL 411
                        90       100       110
                ....*....|....*....|....*....|....
gi 6320063  473 VwVVSAELYPLGVRSK----CTAICAAANWLVNF 502
Cdd:cd17440 412 D-VVTVELYPTDRRATgfgfLNALCKAAAVLGNL 444
MFS_MFSD5_like cd17487
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ...
127-205 8.58e-03

Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341040  Cd Length: 385  Bit Score: 39.12  E-value: 8.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320063  127 PYVktYIAPNHSYFTTSQIAIL--VSFLSLGTFfgALIAPYISDSYGRKPT-IMFStaVIFSIGNSLQvASGGLVLLIVG 203
Cdd:cd17487  24 PYL--YALYESYGFSEEQIAILfvTGFGSSVVF--GTFVGSLADKFGRKRAcLLFC--VLYSLSCLTK-HSPNFGVLLLG 96

                ..
gi 6320063  204 RV 205
Cdd:cd17487  97 RV 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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