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Conserved domains on  [gi|490593739|ref|WP_004458759|]
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MULTISPECIES: OmpA family protein [Leptospira]

Protein Classification

OmpA family protein( domain architecture ID 10163224)

OmpA family protein may have porin activity and function in peptidoglycan binding

CATH:  3.30.1330.60
Gene Ontology:  GO:0042834|GO:0015288
SCOP:  4001470

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 79-189 7.26e-22

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


:

Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 85.30  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  79 FSYKKADVNPGdfsewSKANVSVIKEGLGKLPdNYALEITGHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPA 158
Cdd:cd07185    6 FDFGSAELTPE-----AKPLLDKLAEVLKKNP-DAKIRIEGHTDSRGSDAY------NQELSERRAEAVADYLVSKGVDA 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490593739 159 NRIISKGAGSSEPVS--GLDAKDAKNRRVTFRF 189
Cdd:cd07185   74 SRITAVGYGESRPIAsnDTEEGRAKNRRVEIVI 106
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 79-189 7.26e-22

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 85.30  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  79 FSYKKADVNPGdfsewSKANVSVIKEGLGKLPdNYALEITGHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPA 158
Cdd:cd07185    6 FDFGSAELTPE-----AKPLLDKLAEVLKKNP-DAKIRIEGHTDSRGSDAY------NQELSERRAEAVADYLVSKGVDA 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490593739 159 NRIISKGAGSSEPVS--GLDAKDAKNRRVTFRF 189
Cdd:cd07185   74 SRITAVGYGESRPIAsnDTEEGRAKNRRVEIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 23-189 3.36e-20

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 85.60  E-value: 3.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  23 SAEKKEESAAPEPSAQEQSASAANRSVDVNSPEAIADSLNEKLKDFRYPDGITrpgFSYKKADVNPGdfsewSKANVSVI 102
Cdd:COG2885  138 SAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVY---FDFDSAELTPE-----AKAALDEL 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739 103 KEGLGKLPdNYALEITGHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPANRIISKGAGSSEPVSGLD--AKDA 180
Cdd:COG2885  210 AALLKENP-DLRIEIEGHTDSRGSDAY------NLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDteEGRA 282


                 ....*....
gi 490593739 181 KNRRVTFRF 189
Cdd:COG2885  283 KNRRVEIVV 291
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 85-184 1.44e-11

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 58.14  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739   85 DVNPGDFSEWSKANVSVIKEGLGKLPDNYALEITGHTDAIGPEqaegakKGNIFYSELRANAVKQALIKQGIPANRIISK 164
Cdd:pfam00691   2 DPGSSQLTPKAKATLDEIADLLKFPELKNTITIEGHTDTVGSA------AYNWELSQRRAEAVRRYLVNFGVPPSRISVV 75

                          90       100
                  ....*....|....*....|
gi 490593739  165 GAGSSEPVSGLDAKDAKNRR 184
Cdd:pfam00691  76 GYGATKPITDNKTPEGRARN 95
motB PRK08457
flagellar motor protein MotB; Reviewed
 16-194 3.10e-10

flagellar motor protein MotB; Reviewed


Pssm-ID: 181435 [Multi-domain]  Cd Length: 257  Bit Score: 57.80  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  16 FSFTLCSSAEKKEESAAPEPSAQE--------QSASAANRSVDVNSPEAIADSLNEKLKD--FRYPDGITrpgFSYKKAD 85
Cdd:PRK08457  56 FDYTAKPEVKQPVKVIPPDSGDAEeemdelksLKASQNTQQETIERRKGEGGALDQIDNGiaLKLPSKLL---FENGSAE 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  86 VNPGDFSEWSKANVSVIKeglgKLPDNYALEITGHTDAIGPEQAEGakKGNIFYSELRANAVKQALIKQGIPANRIISKG 165
Cdd:PRK08457 133 IINADMMDYLKRIAKIIT----KLPKQVKINVRGYTDNSPLNKSRY--KDHYELAAARAYNVMKVLIQYGINPNRLSFSS 206

                        170       180       190
                 ....*....|....*....|....*....|.
gi 490593739 166 AGSSEPVSGLD--AKDAKNRRVTFRFATSAP 194
Cdd:PRK08457 207 YGSNNPIAPNDslENRLKNNRVEIFFKVDAN 237
 
Name Accession Description Interval E-value
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 79-189 7.26e-22

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 85.30  E-value: 7.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  79 FSYKKADVNPGdfsewSKANVSVIKEGLGKLPdNYALEITGHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPA 158
Cdd:cd07185    6 FDFGSAELTPE-----AKPLLDKLAEVLKKNP-DAKIRIEGHTDSRGSDAY------NQELSERRAEAVADYLVSKGVDA 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490593739 159 NRIISKGAGSSEPVS--GLDAKDAKNRRVTFRF 189
Cdd:cd07185   74 SRITAVGYGESRPIAsnDTEEGRAKNRRVEIVI 106
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 23-189 3.36e-20

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 85.60  E-value: 3.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  23 SAEKKEESAAPEPSAQEQSASAANRSVDVNSPEAIADSLNEKLKDFRYPDGITrpgFSYKKADVNPGdfsewSKANVSVI 102
Cdd:COG2885  138 SAAAAAAALAAAKALGDSAAAALDAAAKAEAAAAAAALLPAAVAEVVLLSNVY---FDFDSAELTPE-----AKAALDEL 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739 103 KEGLGKLPdNYALEITGHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPANRIISKGAGSSEPVSGLD--AKDA 180
Cdd:COG2885  210 AALLKENP-DLRIEIEGHTDSRGSDAY------NLALSERRAEAVKDYLVSKGIPASRITAVGYGESRPVASNDteEGRA 282


                 ....*....
gi 490593739 181 KNRRVTFRF 189
Cdd:COG2885  283 KNRRVEIVV 291
MotB COG1360
Flagellar motor protein MotB [Cell motility];
112-196 1.27e-13

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 65.64  E-value: 1.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739 112 NYALEITGHTDAIGPeqaegakKGNIFYS--EL---RANAVKQALIKQGIPANRIISKGAGSSEPV--SGLDAKDAKNRR 184
Cdd:COG1360   89 PNRIRVEGHTDNVPI-------STARFPSnwELsaaRAAAVVRYLIEGGVPPERLSAVGYGDTRPLapNDTPEGRARNRR 161

                         90
                 ....*....|..
gi 490593739 185 VTFRFATSAPQQ 196
Cdd:COG1360  162 VEIVILRRAAEE 173
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 85-184 1.44e-11

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 58.14  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739   85 DVNPGDFSEWSKANVSVIKEGLGKLPDNYALEITGHTDAIGPEqaegakKGNIFYSELRANAVKQALIKQGIPANRIISK 164
Cdd:pfam00691   2 DPGSSQLTPKAKATLDEIADLLKFPELKNTITIEGHTDTVGSA------AYNWELSQRRAEAVRRYLVNFGVPPSRISVV 75

                          90       100
                  ....*....|....*....|
gi 490593739  165 GAGSSEPVSGLDAKDAKNRR 184
Cdd:pfam00691  76 GYGATKPITDNKTPEGRARN 95
motB PRK08457
flagellar motor protein MotB; Reviewed
 16-194 3.10e-10

flagellar motor protein MotB; Reviewed


Pssm-ID: 181435 [Multi-domain]  Cd Length: 257  Bit Score: 57.80  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  16 FSFTLCSSAEKKEESAAPEPSAQE--------QSASAANRSVDVNSPEAIADSLNEKLKD--FRYPDGITrpgFSYKKAD 85
Cdd:PRK08457  56 FDYTAKPEVKQPVKVIPPDSGDAEeemdelksLKASQNTQQETIERRKGEGGALDQIDNGiaLKLPSKLL---FENGSAE 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  86 VNPGDFSEWSKANVSVIKeglgKLPDNYALEITGHTDAIGPEQAEGakKGNIFYSELRANAVKQALIKQGIPANRIISKG 165
Cdd:PRK08457 133 IINADMMDYLKRIAKIIT----KLPKQVKINVRGYTDNSPLNKSRY--KDHYELAAARAYNVMKVLIQYGINPNRLSFSS 206

                        170       180       190
                 ....*....|....*....|....*....|.
gi 490593739 166 AGSSEPVSGLD--AKDAKNRRVTFRFATSAP 194
Cdd:PRK08457 207 YGSNNPIAPNDslENRLKNNRVEIFFKVDAN 237
PRK10510 PRK10510
OmpA family lipoprotein;
111-186 1.74e-09

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 55.27  E-value: 1.74e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490593739 111 DNYALEITGHTDAIGpeqaegAKKGNIFYSELRANAVKQALIKQGIPANRIISKGAGSSEPVS--GLDAKDAKNRRVT 186
Cdd:PRK10510 142 PKTAVNVVGYTDSTG------SHDLNMRLSQQRADSVASALITQGVDASRIRTQGMGPANPIAsnSTAEGKAQNRRVE 213
PRK09039 PRK09039
peptidoglycan -binding protein;
84-189 5.86e-08

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 51.51  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  84 ADVNPGDFSEWSKAnVSVIKEGLGKLPD--NYALEITGHTDAIgPEQAEGAKKGNIFYSELRANAVKQALIKQGIPANRI 161
Cdd:PRK09039 233 AELNPEGQAEIAKL-AAALIELAKEIPPeiNWVLRVDGHTDNV-PLSGTGRFRDNWELSSARAISVVKFLIALGVPADRL 310

                         90       100       110
                 ....*....|....*....|....*....|
gi 490593739 162 ISKGAGSSEPVSGLDAKDA--KNRRVTFRF 189
Cdd:PRK09039 311 AAAGFGEFQPLDPGDTPEAraRNRRIELKL 340
PRK08126 PRK08126
hypothetical protein; Provisional
 117-185 2.82e-07

hypothetical protein; Provisional


Pssm-ID: 236157 [Multi-domain]  Cd Length: 432  Bit Score: 49.69  E-value: 2.82e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490593739 117 ITGHTDAIGPEQAEGAKkgNIFYSELRANAVKQALIKQGIPANRIISKGAGSSEPV--SGLDAKDAKNRRV 185
Cdd:PRK08126 358 VTGHTDNQPIRSAQFAS--NLVLSEKRAAQVAQMLQSAGVPASRLEAVGKGDAQPVadNRTPQGRAQNRRV 426
PRK10808 PRK10808
outer membrane protein A; Reviewed
 119-174 4.54e-07

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 48.92  E-value: 4.54e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490593739 119 GHTDAIGPEQAegakkgNIFYSELRANAVKQALIKQGIPANRIISKGAGSSEPVSG 174
Cdd:PRK10808 264 GYTDRIGSDAY------NQGLSEKRAQSVVDYLVSKGIPADKISARGMGKSNPVTG 313
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
79-184 8.85e-05

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 41.39  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490593739  79 FSYKKADVNPgDFSEWSKANVSVIKEGlgklpDNYALEITGHTDAIG-PEQaegakkgNIFYSELRANAVKQALIKQGIP 157
Cdd:PRK10802  73 FDLDKYDIRS-DFAQMLDAHANFLRSN-----PSYKVTVEGHADERGtPEY-------NIALGERRANAVKMYLQGKGVS 139

                         90       100
                 ....*....|....*....|....*....
gi 490593739 158 ANRIISKGAGSSEP-VSGLD-AKDAKNRR 184
Cdd:PRK10802 140 ADQISIVSYGKEKPaVLGHDeAAYAKNRR 168
PRK09040 PRK09040
hypothetical protein; Provisional
 140-185 1.23e-04

hypothetical protein; Provisional


Pssm-ID: 181620 [Multi-domain]  Cd Length: 214  Bit Score: 41.16  E-value: 1.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 490593739 140 SELRANAVKQALIKQGIPANRIISKGAGSSEPVSGLDAKD--AKNRRV 185
Cdd:PRK09040 150 SAQRALTVTRALIDAGVPASSVFAAAFGSEQPVASNADDEgrAKNRRV 197
motB PRK08944
flagellar motor protein MotB; Reviewed
 115-185 1.31e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 236356 [Multi-domain]  Cd Length: 302  Bit Score: 38.45  E-value: 1.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490593739 115 LEITGHTDAIgPEQAEgakkgnIFYSE-----LRANAVKQALIK-QGIPANRIISKGAGSSEPVSGLDAKD--AKNRRV 185
Cdd:PRK08944 212 ITVSGHTDNV-PISSE------LYRSNwdlssARAVAVAHELLKvKGFDPQRLKVVGMADTQPLVPNDTAEnrARNRRV 283
motB PRK09041
motility protein MotB;
117-185 8.61e-03

motility protein MotB;


Pssm-ID: 236365 [Multi-domain]  Cd Length: 317  Bit Score: 36.07  E-value: 8.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490593739 117 ITGHTDAIgpeQAEGAKKGnifYS--EL---RANAVKQALIKQGIPAN---RIIskGAGSSEPVSGLDAKDAKNRRV 185
Cdd:PRK09041 196 LSGHTDAT---PYANGEKG---YSnwELsadRANASRRELVAGGMDEGkvlRVV--GLASTMLLDKKDPLNPVNRRI 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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