56K autoantigen [Homo sapiens]
annexin( domain architecture ID 10446041)
annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
204-269 | 6.83e-30 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. : Pssm-ID: 395139 Cd Length: 66 Bit Score: 111.41 E-value: 6.83e-30
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
435-500 | 2.14e-29 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. : Pssm-ID: 395139 Cd Length: 66 Bit Score: 109.87 E-value: 2.14e-29
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
276-341 | 7.62e-26 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. : Pssm-ID: 395139 Cd Length: 66 Bit Score: 99.86 E-value: 7.62e-26
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
359-425 | 1.20e-24 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. : Pssm-ID: 395139 Cd Length: 66 Bit Score: 96.77 E-value: 1.20e-24
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PHA03378 super family | cl33729 | EBNA-3B; Provisional |
75-194 | 5.20e-06 | |||
EBNA-3B; Provisional The actual alignment was detected with superfamily member PHA03378: Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.30 E-value: 5.20e-06
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Name | Accession | Description | Interval | E-value | |||
Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
204-269 | 6.83e-30 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 111.41 E-value: 6.83e-30
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
435-500 | 2.14e-29 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 109.87 E-value: 2.14e-29
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
276-341 | 7.62e-26 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 99.86 E-value: 7.62e-26
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
359-425 | 1.20e-24 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 96.77 E-value: 1.20e-24
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ANX | smart00335 | Annexin repeats; |
448-498 | 1.00e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.93 E-value: 1.00e-22
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ANX | smart00335 | Annexin repeats; |
289-341 | 1.46e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.54 E-value: 1.46e-22
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ANX | smart00335 | Annexin repeats; |
217-269 | 1.88e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.16 E-value: 1.88e-22
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ANX | smart00335 | Annexin repeats; |
373-425 | 3.26e-18 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 78.22 E-value: 3.26e-18
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PHA03378 | PHA03378 | EBNA-3B; Provisional |
75-194 | 5.20e-06 | |||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.30 E-value: 5.20e-06
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Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
75-175 | 4.91e-04 | |||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 40.79 E-value: 4.91e-04
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Name | Accession | Description | Interval | E-value | |||
Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
204-269 | 6.83e-30 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 111.41 E-value: 6.83e-30
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
435-500 | 2.14e-29 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 109.87 E-value: 2.14e-29
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
276-341 | 7.62e-26 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 99.86 E-value: 7.62e-26
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Annexin | pfam00191 | Annexin; This family of annexins also includes giardin that has been shown to function as an ... |
359-425 | 1.20e-24 | |||
Annexin; This family of annexins also includes giardin that has been shown to function as an annexin. Pssm-ID: 395139 Cd Length: 66 Bit Score: 96.77 E-value: 1.20e-24
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ANX | smart00335 | Annexin repeats; |
448-498 | 1.00e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.93 E-value: 1.00e-22
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ANX | smart00335 | Annexin repeats; |
289-341 | 1.46e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.54 E-value: 1.46e-22
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ANX | smart00335 | Annexin repeats; |
217-269 | 1.88e-22 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 90.16 E-value: 1.88e-22
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ANX | smart00335 | Annexin repeats; |
373-425 | 3.26e-18 | |||
Annexin repeats; Pssm-ID: 197661 Cd Length: 53 Bit Score: 78.22 E-value: 3.26e-18
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PHA03378 | PHA03378 | EBNA-3B; Provisional |
75-194 | 5.20e-06 | |||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.30 E-value: 5.20e-06
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Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
75-175 | 4.91e-04 | |||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 40.79 E-value: 4.91e-04
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PAT1 | pfam09770 | Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
75-191 | 2.84e-03 | |||
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division. Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 40.40 E-value: 2.84e-03
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Drf_FH1 | pfam06346 | Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ... |
66-185 | 3.57e-03 | |||
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues. Pssm-ID: 461881 [Multi-domain] Cd Length: 157 Bit Score: 38.31 E-value: 3.57e-03
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SOBP | pfam15279 | Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
62-185 | 4.10e-03 | |||
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein. Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 39.41 E-value: 4.10e-03
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Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
70-203 | 6.82e-03 | |||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 39.37 E-value: 6.82e-03
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Blast search parameters | ||||
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