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Conserved domains on  [gi|4507065|ref|NP_003055|]
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antileukoproteinase precursor [Homo sapiens]

Protein Classification

WAP domain-containing protein( domain architecture ID 10442878)

WAP domain-containing protein similar to whey acidic protein (WAP) that could be a protease inhibitor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP smart00217
Four-disulfide core domains;
85-130 4.66e-10

Four-disulfide core domains;


:

Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.60  E-value: 4.66e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507065      85 KPGKCP-VTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPV 130
Cdd:smart00217   1 KPGSCPwPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 31-75 4.39e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.56  E-value: 4.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 4507065     31 KAGVCPPKKSAQCLRykkPECQSDWQCPGKKRCCPDTCGIKCLDP 75
Cdd:pfam00095   1 KPGCCPRLGARGCCR---SCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP smart00217
Four-disulfide core domains;
85-130 4.66e-10

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.60  E-value: 4.66e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507065      85 KPGKCP-VTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPV 130
Cdd:smart00217   1 KPGSCPwPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 80-130 1.96e-07

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 45.13  E-value: 1.96e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507065   80 NPTRRKPGKCPV---TYGQCLMLN------PPNFCEMDGQCKRDLKCCMGMCGKSCVSPV 130
Cdd:cd00199   1 GNNMTKPGSCPRpveKPGRCPMVNppslgiPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 31-75 4.39e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.56  E-value: 4.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 4507065     31 KAGVCPPKKSAQCLRykkPECQSDWQCPGKKRCCPDTCGIKCLDP 75
Cdd:pfam00095   1 KPGCCPRLGARGCCR---SCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
31-76 1.34e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 37.35  E-value: 1.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507065      31 KAGVCPPKKSAQC-LRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPV 76
Cdd:smart00217   1 KPGSCPWPTIASCpLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 85-129 8.39e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.09  E-value: 8.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 4507065     85 KPGKCPVTYGQClmlNPPNFCEMDGQCKRDLKCCMGMCGKSCVSP 129
Cdd:pfam00095   1 KPGCCPRLGARG---CCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 31-76 2.05e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 34.35  E-value: 2.05e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4507065   31 KAGVCPpKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPV 76
Cdd:cd00199  16 KPGRCP-MVNPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
 
Name Accession Description Interval E-value
WAP smart00217
Four-disulfide core domains;
85-130 4.66e-10

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 51.60  E-value: 4.66e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507065      85 KPGKCP-VTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPV 130
Cdd:smart00217   1 KPGSCPwPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 80-130 1.96e-07

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 45.13  E-value: 1.96e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507065   80 NPTRRKPGKCPV---TYGQCLMLN------PPNFCEMDGQCKRDLKCCMGMCGKSCVSPV 130
Cdd:cd00199   1 GNNMTKPGSCPRpveKPGRCPMVNppslgiPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 31-75 4.39e-05

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 38.56  E-value: 4.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 4507065     31 KAGVCPPKKSAQCLRykkPECQSDWQCPGKKRCCPDTCGIKCLDP 75
Cdd:pfam00095   1 KPGCCPRLGARGCCR---SCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP smart00217
Four-disulfide core domains;
31-76 1.34e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 37.35  E-value: 1.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4507065      31 KAGVCPPKKSAQC-LRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPV 76
Cdd:smart00217   1 KPGSCPWPTIASCpLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 85-129 8.39e-04

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.09  E-value: 8.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 4507065     85 KPGKCPVTYGQClmlNPPNFCEMDGQCKRDLKCCMGMCGKSCVSP 129
Cdd:pfam00095   1 KPGCCPRLGARG---CCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 31-76 2.05e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 34.35  E-value: 2.05e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 4507065   31 KAGVCPpKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPV 76
Cdd:cd00199  16 KPGRCP-MVNPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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