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Conserved domains on  [gi|414145826]
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Chain H, CPXV203 protein

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pox_T4_N super family cl04544
Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted ...
 14-61 9.42e-13

Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (pfam04490). M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


The actual alignment was detected with superfamily member pfam04491:

Pssm-ID: 282360  Cd Length: 46  Bit Score: 60.26  E-value: 9.42e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 414145826   14 TWKLKIG*CIQAKDFYSKRTDCsvHRPDVGGGLITEGNGYRVVVHDQC 61
Cdd:pfam04491   1 TWGLKIGLCIIAKDFKPSRTGC--HLPTGPGGLITEGNGFRIFRHDEC 46
Pox_T4_C super family cl04543
Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained ...
 65-197 2.87e-12

Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum. M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


The actual alignment was detected with superfamily member pfam04490:

Pssm-ID: 282359  Cd Length: 146  Bit Score: 61.90  E-value: 2.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414145826   65 NPFIIATTKQTHFGVTHS-YIEFSNsNTGAPENIPDCSKHILISVYCDQ---EASGLDFHTLKyvesNYLHITVKYDTSC 140
Cdd:pfam04490   3 HSFLLTNVREAVYASGHGmYTEISR-NVSYLDLVPKCARNITVIVSCDEvssNAYGKNKDELE----PEVEITTLIDTSC 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 414145826  141 INHLGVNYSF*NECERKLTSiYETDTLTCGAKDIQTRDKYLKTCTNTKFDRSVYKTH 197
Cdd:pfam04490  78 VRHHSFAYSVNTLCTERLSG-ESCEQLTCGFGKGSQHEKYLKPCHHNSPDRRTFKKY 133
 
Name Accession Description Interval E-value
Pox_T4_N pfam04491
Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted ...
 14-61 9.42e-13

Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (pfam04490). M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


Pssm-ID: 282360  Cd Length: 46  Bit Score: 60.26  E-value: 9.42e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 414145826   14 TWKLKIG*CIQAKDFYSKRTDCsvHRPDVGGGLITEGNGYRVVVHDQC 61
Cdd:pfam04491   1 TWGLKIGLCIIAKDFKPSRTGC--HLPTGPGGLITEGNGFRIFRHDEC 46
Pox_T4_C pfam04490
Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained ...
 65-197 2.87e-12

Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum. M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


Pssm-ID: 282359  Cd Length: 146  Bit Score: 61.90  E-value: 2.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414145826   65 NPFIIATTKQTHFGVTHS-YIEFSNsNTGAPENIPDCSKHILISVYCDQ---EASGLDFHTLKyvesNYLHITVKYDTSC 140
Cdd:pfam04490   3 HSFLLTNVREAVYASGHGmYTEISR-NVSYLDLVPKCARNITVIVSCDEvssNAYGKNKDELE----PEVEITTLIDTSC 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 414145826  141 INHLGVNYSF*NECERKLTSiYETDTLTCGAKDIQTRDKYLKTCTNTKFDRSVYKTH 197
Cdd:pfam04490  78 VRHHSFAYSVNTLCTERLSG-ESCEQLTCGFGKGSQHEKYLKPCHHNSPDRRTFKKY 133
 
Name Accession Description Interval E-value
Pox_T4_N pfam04491
Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted ...
 14-61 9.42e-13

Poxvirus T4 protein, N terminus; This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (pfam04490). M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


Pssm-ID: 282360  Cd Length: 46  Bit Score: 60.26  E-value: 9.42e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 414145826   14 TWKLKIG*CIQAKDFYSKRTDCsvHRPDVGGGLITEGNGYRVVVHDQC 61
Cdd:pfam04491   1 TWGLKIGLCIIAKDFKPSRTGC--HLPTGPGGLITEGNGFRIFRHDEC 46
Pox_T4_C pfam04490
Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained ...
 65-197 2.87e-12

Poxvirus T4 protein, C terminus; This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum. M-T4 of myxoma virus is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection.


Pssm-ID: 282359  Cd Length: 146  Bit Score: 61.90  E-value: 2.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414145826   65 NPFIIATTKQTHFGVTHS-YIEFSNsNTGAPENIPDCSKHILISVYCDQ---EASGLDFHTLKyvesNYLHITVKYDTSC 140
Cdd:pfam04490   3 HSFLLTNVREAVYASGHGmYTEISR-NVSYLDLVPKCARNITVIVSCDEvssNAYGKNKDELE----PEVEITTLIDTSC 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 414145826  141 INHLGVNYSF*NECERKLTSiYETDTLTCGAKDIQTRDKYLKTCTNTKFDRSVYKTH 197
Cdd:pfam04490  78 VRHHSFAYSVNTLCTERLSG-ESCEQLTCGFGKGSQHEKYLKPCHHNSPDRRTFKKY 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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